두경부악성종양에서의 전산화단층촬영의 진단적 가치 -비인두업성종양을 중심으로-

이열,서창해,장기현,Lee, Yul,Suh, Chang-Hae,Chang, Kee-Hyun 대한방사선종양학회 1984 Radiation Oncology Journal Vol.2 No.1

The CT findings of 46 cases of nasopharyngeal cancer were analyzed and compared with clinical tumor staging. They are composed of 28 cases $(61\%)$ of squamous cell carcinoma, 13cases $(28\%)$ of undifferentiated carcinoma, 4 cases $(9\%)$of lymphoma and 1 case $(2\%)$ of adenoid cystic carcinoma. The results were as follows : 1. The most common CT findings of nasopharyngeal cancers are air·way asymmetry including obliteration of Rosenmuller fossa, orifice of Eustachian tube and asymmetric obliteration of parapharyngeal fat. 2. Other involved anatomic sites are carotid sheath area, oropharynx, paranasal sinuses especially sphenoid sinus, cervical lymph nodes, nasal cavity and skull base or middle cranial fossa. 3. CT does significantly influence on the tumor staging of the nasopharynx cancers, but has a definite value in evaluating deep tissue invasion of the cancers especially to parapharyngeal space or carotid sheath area. 4. CT seems to be essential for staging work-up, estimating the prognosis, and assessing the effect of radiotherapy of the nasopharyngeal cancer because it clearly shows the whole extent of the tumors including deep tissue invasion.

간세포암의 전산화단층촬영소견과 혈관조영술소견의 비교 분석

이룡,박재형,최병인,이병희,서창해,한만청,Lee, Yong,Park, Jae-Hyung,Choi, Byung-In,Lee, Byung-Hee,Suh, Chang-Hae,Han, Man-Chung 대한영상의학회 1987 대한영상의학회지 Vol.23 No.5

A comparative review of CT and angiographic finding was taken retrospectively from 50 patients with primary hepatocellular carcinoma. Morphological type of tumor could be classified into 3 group as solitary, multinodular, diffuse. 32 cases were concordant in tmor type on both CT and angiography. Location of tumor were concordant in 46 cases. 4 cases were discordant in location of tumor; additional finding such as daughter nodule or extended tumor staining on angiography, small extent of the tumorvascularity on angiography. A majority of tumors showed low density in both pre-contrast CT and post-contrasst CT, and most of which showed hypervascularity on angiography except 8 cases. All isodense tumors showed hypervascularity on angiography. Evaluaton of portal vein invasion were concordant in 30 cases; angiography of 17 cases showed more reliable finding than CT on protal vein evaluation but majority of cases were concordant ono evaluaton of resectability.

유방암의 척추전이 환자에 대한 천수근 약침을 병행한 한의학적 치료 증례 1례

배영현,이종환,김해솔,김호선,서창용,김노현,송주현,염승철,Bae, Young-Hyeon,Lee, Chong-Hwan,Kim, Hae-Sol,Kim, Ho-Sun,Suh, Chang-Yong,Kim, No-Hyeon,Song, Ju-Hyun,Yeom, Seung-Chul 척추신경추나의학회 2015 척추신경추나의학회지 Vol.10 No.1

Objectives : Most of pains are important symptoms caused by cancer transpered to spine. Harpagophyti Radix Pharmacopuncture is highly effective in reducing fever, pain, inflammation but was never used to reduce pain from cancer transpered to spine. So I intended to use Harpagophyti Radix Pharmacopuncture to control pain. The purpose of this study is to evaluate the clinical application of Harpagophyti Radix Pharmacopuncture for Bone Metastasis of Breast Cancer and Spinal Stenosis. Methods : We examined patient with Bone Metastasis of Breast Cancer and Spinal Stenosis who admitted Jaseng Korean Medicine Hospital. The patient was treated by Korean Medicine treatment and Harpagophyti Radix Pharmacopuncture. This case was assessed by Numerical Rating Scale(NRS), Oswestry Low Back Pain Disability Index(ODI), Short-Form 36 Health Survey(SF-36), ROM(Range of Movement) and Special Test. Results : In this study, the patient's pain was controlled and NRS, ODI were decreased. I could identify the improvement in life quality from the positive change of SF-36 and also found out that treatment was successful from the improvement of ROM, Special test. Conclusions : Harpagophyti Radix Pharmacopuncture with Korean Medicine treatment for Bone Metastasis of Breast Cancer and Spinal Stenosis was proved to be useful to the pain relief and function recovery, but further research should take place for clear understanding of the exact amount of dosage and safety. Moreover it must be accompanied by long term follow up research.

1.5 T 자기공명영상기기에서 수소 자기공명분광법을 이용한 모델용액 내 포도당의 정량분석

이경희,이정희,조순구,김용성,김형진,서창해,Lee, Kyung-Hee,Lee, Jung-Hee,Cho, Soon-Gu,Kim, Yong-Seong,Kim, Hyung-Jin,Suh, Chang-Hae 대한영상의학회 2002 대한영상의학회지 Vol.46 No.1

목적: 1.5T 생체용 자기공명영상기기를 이용한 수소자기공명분광법으로 용액 내 물질의 정량분석에 대한 가능성을 알아보고자 하였다. 대상과 방법: 0.01%에서 50%까지의 여러 농도를 갖는 포도당+증류수 혼합액과 0.01%에서 20%까지의 여러 농도를 갖는 포도당+증류수+에탄올 혼합액의 모델용액을 만들어 생체용 자기공명영상기기와 시험관 nuclear magnetic resonance(NMR)분광기에서 각각 수소자기공명분광법을 시행하여 스펙트럼을 얻었다.스펙트럼 상에서 포도당 농도에 따른 포도당/물, (포도당+에탄올)/물, (포도당+에탄올)/에탄올 피크의 면적 비의 변화를 구하였고, 통계처리는 상관분석과 단순선형회귀분석을 시행하였고 회귀식을 산출 하였다.또한 생체용 자기공명영상기기를 이용하여 얻은 결과가 객관적인지 알아보기 위해 시험관 NMR 분광기에서 얻은 결과와의 상관관계를 분석하였다. 결과: 생체용 자기공명영상기기를 이용한 스펙트럼상 포도당/물, (포도당+에탄올)/물, (포도당+에탄올)/에탄올 피크의 면적 비는 포도당 농도변화에 대하에 일정하게 증가하는 통계적으로 의미 있는 변화를 보였고 그 결과에 따라 회귀식을 구할 수 있었다. 생체용 자기공명영상기기와 시험관 NMR 분광기를 이용하여 얻은 모든 결과에 대한 상관분석에서 통계적으로 의미 있는 상관관계를 보여 생체용 자기공명영상기기에서 얻은 수소자기공명분광 소견을 객관화 할 수 있었다. 따라서 생체용 자기공명영상기기를 이용하여 얻은 스펙트럼에서 용액 내 물질의 피크면적비를 구함으로써 농도를 정량할 수 있는 결과를 얻을 수 있었다. 결론: 생체용 자기공명영상기기를 이용하여 얻은 수소자기공명분광 스펙트럼에서도 시험관 NMR분광기로 얻은 스펙트럼과 마찬가지로 단순 포도당 용액, 포도당에 에탄올을 혼합한 용액에서 포도당/물, (포도당+에탄올)/물, (포도당+에탄올)/에탄올 피크의 면적 비를 측정함으로써 당의 정량분석이 가능하였다. 본 연구의 결과는 생체수소자기공명분광법이 환자의 체액에 대한 정량적 분석에 이용될 수 있다는 가능성을 시사한다고 생각한다. Purpose: To evaluate the feasibility of proton magnetic resonance spectroscopy ($^1H-MRS$) using a 1.5T magnetic resonance (MR) imager for quantification of the contents of model solutions. Materials and Methods: We prepared model solutions of dextrose+water and dextrose+water+ethanol at dextrose concentrations of 0.01% to 50% and 0.01% to 20%, respectively. Using these solutions and a 1.5T MR imager together with a high-resolution nuclear magnetic resonance (NMR) spectroscope, we calculated the ratios of dextrose to water peak, (dextrose+ethanol) to water peak, and (dextrose+ethanol) to ethanol peak, as seen on MR and NMR spectra, analysing the relationships between dextrose concentration and the ratios of peaks, and between the ratios of the peaks seen on MR spectra and those seen on NMR spectra. Results: Changes in the ratios between dextrose concentration and dextrose to water peak, (dextrose+ethanol) to water peak and (dextrose+ethanol) to ethanol peak, as seen on MR spectra, were statistically significant, and there was good linear regression. There was also close correlation between the ratios of the observed on MR and NMR spectra. The results depict the quantification of dextrose concentration according to the ratios of spectral peaks obtained by proton MRS at 1.5T. Conclusion: Using proton MRS at 1.5T, and on the basis of the ratios of spectcal peaks, it was possible to quantify the concentration of dextrose in model solutions of dextrose+water and dextrose+water+ethanol. The results of this study suggest that for quantifying the contents of biofluids, the use of low-tesla $^1H-MRS$ is feasible.

건염의 한의학적 치료에 대한 국내 연구 동향

배영현(Young Hyeon Bae),김해솔(Hae Sol Kim),김호선(Ho Sun Kim),김노현(No Hyeon Kim),서창용(Chang Yong Suh),양규진(Kyu Jin Yang),이기범(Gi Bum Lee),염승철( Seung Chul Yeom),이준석(Joon Seok Lee) 대한스포츠한의학회 2016 대한스포츠한의학회지 Vol.16 No.1

Objectives The purpose of this review is to investigate the trends of traditional Korean medicine treatments on tendinitis. Methods We investigated the studies on traditional Korean medicine treatments for tendinitis via searching 5 Korean web databases. Results Nineteen papers were published since 2004. The studies on traditional Korean medicine treatments about tendinitis were mainly published in the journal of Korean spine & joint. Nineteen papers had been under research. In most of the research, the number of the cases were not enough. In 8 cases of the studies, special methods were used to treat the symptoms. Whereas in 11 cases of the studies, various traditional Korean medicine treatments were used to treat the symptoms. Range of motion(ROM) and visual analogue scale(VAS) were used most frequently as primary assessments. Conclusions In this study, we analyzed the trends of traditional Korean medicine treatments on tendinitis. Reviewing the domestic trends of studies on traditional Korean medicine treatments on tendinitis and examining the strong and weak points of those treatments are essential for the further studies.

황달형 간암 ( Icteric Type Hepatocellular Carcinoma )

이기형(Kee Hyung Lee),문태훈(Tai Hoon Moon),이진우(Jin Woo Lee),이기훈(Ki Hoon Lee),김여주(Yeo Joo Kim),정원재(Won Jai Chung),신용운(Yong Woon shin),김미영(Mi Young Kim),서창해(Chang Hae Suh),김준미(Joon Mee Kim) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2

Intra-biliary growth of hepatocellular carcinoma(icteric type or cholestatic type hepatoma) is rare disease. In large series, this type of hepatoma has been reported with the incidence of 1.2 1.5%. Hepatocellular carcinoma can induce obstructive jaundice by intrabile duct tumor growth. This findings in most reported cases and, rarely, is recognized ante mortem. The average survival time of the cases was significantly shorter than that of hepatocellular carci- noma patients without intrabile duct tumor growth. There were rare reports in Korea. We present a case of icteric type of hepatocellular carcinoma with literature review.(Korean J Gastroenterol 1994; 26: 373 377)

간내위치에 따른 담관결석의 초음파 소견

서창해,임태환,김미영,이용 대한초음파의학회 1988 ULTRASONOGRAPHY Vol.7 No.2

한약재(산약과 반하)에 의한 직업성 알레르기 1 예

박해심,박원,서창인,정연태,유수웅 대한내과학회 1994 대한내과학회지 Vol.46 No.6

There has been no case report of occupational allergy induced by herb materials. We report a case of occupational asthma and rhinintis caused by herb materials, Sanyak (Radix Discorae) and Banha (Rhizoma pinelliae). He has worked to cut herb mateials for three years. He began to feel sneezing, rhinorrhea, coughing and chest tightness since one year ago. Allergy skin prick test revealed positive responses to cat fur (6×4/ 25×24), orchard grass (3×3/23×16), timothy grass (7×7/30×22), rye grass (4×3/25×20), ragweed (2×2/l4×14), Banha extract (2×2/30×25), Sanyak extract (3×3/32×28) and histamine (3×3/25×20), Banha extract (2×2/30×25), Sanyak extract (3×3/32×28) and histamine (3×3/26×$lt;mm$gt;). RAST revealed positive results to g₃(class 2) and e₁, (class 1). The broncho-provocation test showed dual asthmatic response with Sanyak, and early asthmatic response with Banha. Although the initial methacholine bronchial challenge test showed a negative result, airway hyperresponsive ness to methacholine developed at first day after Banha bronchoprovocation test and recovered to normal at seventh day. Specific IgE and IgG₄antibody to Sanyak extract were detected by enzyme linked immunosorbent assay and there was no binding of specific IgG and IgG₄antibody to Banha extract. It is suggested that Sanyak can induce IgE-mediate bronchoconstriction in an exposed worker, and non- immunologic mechanism is suggested on Banha-induced bronchoconstriction.

유방종괴의 감별에 있어서 초음파 소견의 진단척도 타당성

한헌,이창근,이경희,김형진,서창해 대한초음파의학회 1998 ULTRASONOGRAPHY Vol.17 No.2

일차성 성선기능 저하증과 동반된 말단비대증 1예

정영숙,임형은,정민화,김기수,서창해 대한내과학회 1992 대한내과학회지 Vol.42 No.1

저자등은 일차성 성선기능저하증을 동반된 말단 비대증 1예를 경험하였기에 보고하는 바이다. Acromegaly is frequently complicated by hypogonadism, which is mostly due to either hyperprolactinemia or anterior pirtuitary failure as adenoma expands. The asscosiation of acromegaly and primary hypogonadism has not been commonly observed. We report a case with acromegaly and primary hypogonadism. The patient was a 39-year-old man who presented with fever and arthralgia for 4 days. Blood pressure was 120/80㎜Hg, body temperature 38.8℃, body weight 83.5㎏, and height 175㎝. Ok. oss appearance was typical of acromegaly and included thickening of the soft tissue on the face, hands, and feet, thick and puffy eyelids, prominent cheek bones, and prognathism. The thyroid was slightly enlarged (about 25 grams) and soft. A grade 3/6 holosystolic murmur was heard at the apex. The liver was palpable, 2-3 FB velow the right costal margin. The jonts of the upper extremities were associated with a slight swelling, redness, and limitation of motion due to pain. Testes were absent in the right side and small (1.5×1㎝) in the left side. Hormonal assay revealed a high GH level (27ng/㎖) which was not suppressed by glucose loading, norami thyroid function (T₃ 100ng/㎗, T₄ 9.6ug/㎗, TSH 0.5uU/㎖), increased LH (45.2mIU/㎖), and FSH (78.8 mIU/㎖) with low testosterone (1.3ng/㎖) and normal prolactin levels (6.9㎎/㎖). Combined pituitary stimupation test revealed no evedence of anterior pituitary failure. A Brain CT showed a 2.0×1.2㎝ sized pituitary tumor and several areas of low density with irregular margins in both parietal lobes. Blood culture revealed Staphylococcus aureus. Echocardiogram suggested vegetation on the mitral valve, partial rupture of the mitral valve associated with grade 2 mitral regurgitation, and eccentricleft ventricular hypertrophy. The patient was deagnosed as haveing acromegaly, primary hypogonadism, and bacterial endocard itis complicated with brain abscess, he developed multiple hematomas in the previously noted hypodense lesions of and both parietal lobes. Emergency evacuation of the hematomas resulted in partial neurologic improvement. However, he was discharged without treatment for acromegaly and primary hypogonadism because of poor economic status. This case shows us that hypogonadism in a patient with acromegaly is not necessarily related with acromegaly itself, and the rare possibility of its coexistence with primary hypogonadism should be considered.