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기술성숙도 측정을 통한 ACTD 과제 전이 결정에 관한 연구
배윤호,최석철,문희승,Bae, Yoon-Ho,Choin, Seok-Cheol,Moon, Hee-Seung 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.1
Recently, request far application of advanced commercial technology to the defense acquisition process, to reduce the budget and shorten development time, has been increased. To accomplish these goals, the Advanced Concept Technology Demonstration(ACTD) is used for the defense acquisition process in Korea. And User Utility Assessment is tested to make a decision for transition to acquisition process. But this process does not include measurement of technology maturity and impacts of interface and interaction among the technologies. In this research, we propose the needs of measurement of TRL and IRL and application of SRL to reduce the risk during development phase, to understand the relations of technologies, and to fulfill the requirement far transition of the ACTD project to system development and demonstration process.
갑상선 기능에 따른 혈액응고인자의 활성도 변화에 대한 고찰
김진석(Jin Seok Kim),문희승(Hee Seung Moon),이석호(Seok Ho Lee),한영찬(Young Chan Han),이윤하(Joun Ha Lee),차경석(Kyung Suk Cha),이정해(Jung Hae Lee),김소연(So Yon Kim),이권전(Gwon Jun Lee) 대한내과학회 1994 대한내과학회지 Vol.47 No.1
N/A Background: Coagulation abnormalities have been reported in patients with thyroid dysfunction. We stud- ied the levels of the coagulation activities in patients with thyroid disorders and the changes of them in response to therapy Methods: Coagulation studies were perfomed in 35 patients with abnormal thyroid function. Nineteen patients had hyperthyroidism and nine patients had hypothyroidism. Seven patients were euthyroid with previous antithyroid therapy. Results: 1) In nineteen patients with hyperthyroidism, the increased activities of factor VIII(170.4±71.3%) showed significant correlations (r=0.73) with increased level of T3 and weak correlations (r=0.50) with the level of T4. All other factors except factor VIII were normal. 2) Seven hyperthyroid patients whose thyroid hormone remained normal with antithyroid therapy showed normal coagulation activities, 3) Nine hypothyroid patients showed decreased activities of several coagulation factors; VIII: 44.2±12. 59%, IX: 56.2±15.0%, XII: 55.0±26.4% 4) Five of them hyperthyroid and two of the hypothyroid patients were followed up. The activities of factor VIII returned to normal after correction of the thyroid function. Conclusion: Hyperthyroidism showed a significant eleevation of factor VIII activity, which returned to normal after antithyroid therapy. Hypothyroidism was associated with subnormal levels of several coagulation factors (factor VIII, IX and XII). It seems unlikely that changes in activities of coagulation factors are caused by a common mechanism in patients with thyroid dysfunction.
HbsAg 양성 간질환에 있어서 혈청 IV 형 Collagen - 7S ( 7S domain ) 의 농도
이종봉(Jong Bong Lee),김진석(Jin Seok Kim),문희승(Hee Seung Moon),이석호(Suk Ho Lee),김소연(So Yon Kim),박병익(Beong Yik Park),조민구(Min Koo Cho),김우호(Woo Ho Kim) 대한내과학회 1992 대한내과학회지 Vol.43 No.1
N/A Background: The purpose of this investigation was to determine the usefulness of serum type IV collagen 7S domain in the evaluation of the extent of hepatic fibrosis. We compared the level of serum collagen 7S domain to the degree of collagen type IV staining of hepatic tissue in various liver diseases. Method: We evaluated 70 cases of HBsAg positive patients and 32 cases of normal controls. Serum 7S domains were measured by CGR gammatic 5310 and collagen type IV 7S kit and each hepatic tissue were stained with monoclonal mouse collagen IV (DAKO-COLLAGEN) staining. Result: 1) Compared to 32 normal volunteers (mean±S.D. = 2.8±1.4ng/ml), 7S domain concentrations were moderately elevated in patients with acute viral hepatitis (mean±S.D=5.4±1.8ng/ml; p<0.001) and chronic persistent hepatitis (meankS.D.=5.5±1.4ng/ml; p<0.001), and significantly elevated in chronic active hepatitis (mean+S.D.=8,4±2.3ng/ml; p<0,001) and liver cirrhosis (mean+S.D.=15,1±6.3ng/ml; p<0,001). 2) Compared to patients with acute viral hepatitis, 7S domain concentrations were not elevated in patients with chronic persistent hepatitis but moderately elevated in patients with chronic active hepatitis (p<0.001) and significantly elevated in patients with liver cirrhosis. 3) Compared to patients with chronic active hepatitis, 7S domain contrations were significantly elevated in patients wih liver cirrhosis. 4) The level of serum type IV collagen 75 domains were correlated to the degree of collagen type IV staining in hepatic tissues. Conclusion: These data suggest that 7S domain of collagen type IV serum levels reliably reflect the degree of hepatic fibrosis in patients with chronic liver disease.
경미한 급성 두부외상환자에서 SPECT , q - EEG 및 CT의 비교
김소연(So Yon Kim),김영중(Young Jung Kim),이석호(Suk Ho Lee),김진석(Jin Seok Kim),문희승(Hee Seung Moon),이숭구(Sung Ku Lee),박병익(Byung Yik Park),이권전(Gwon Jeon Lee),김갑득(Kap Deuk Kim),김호전(Ho Joeng Kim),조경형(Kyeung Hyeung 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2
N/A Functional cerebral impairments have been verified objectively by brain SPECT and q-EEG (quantitative electroencephalography). Microcerebral circulatory defects without anatomical changes cannot be detected by the brain CT or MRI. Brain SPECT using Tc-99m-HMPAO (Hexamethyl propyleneamine oxime) as a key radioisotope may be accepted as the useful method for identifying functional cerebral impairments. We studied 25 patients with mild head trauma to define whether the SPECT was helpful in detecting cerebral impairment. Results were as follows: The SPECT was positive in 23 patients out of 25, q-EEG positive in 16 patients and brain CT was positive in 3 cases. SPECT and q-EEG were more sensitive than CT. SPECT would be more useful method than brain CT to investigate cerebral function after head injury.