Angelica keiskei Koidzumi Extracts Improve Some Markers of Liver Function in Habitual Alcohol Drinkers: A Randomized Double-Blind Clinical Trial

노혜미,안은미,윤재문,조비룡,백유진 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.2

Alcohol induces oxidative stress and inflammatory response, which can lead to hepatitis and cirrhosis. Previous studies reported that the extracts of Angelica keiskei Koidzumi (AKE) have antioxidant and anti-inflammatory properties, suggesting that AKE could improve abnormalities associated with alcoholic liver disease. In this study, the effectiveness of AKE supplementation was assessed in 82 habitual alcohol drinkers (male: more than 14 units per week, female: more than 7 units per week) with abnormal liver biochemistry in a placebo-controlled, randomized double-blind trial over 12 weeks. Among the subjects, 65% (n = 43) were heavy drinkers consuming more than 35 units per week. Among heavy drinkers, gamma-glutamyl transferase levels of 19 subjects per AKE-treated group were significantly decreased (21.16– 37.63, P= .016) with significant differences observed compared to the 24 subjects per placebo group (P = .046). However, no significant differences were observed in aspartate aminotransferase and alanine aminotransferase levels between the AKE- and placebo-treated groups. These results suggest that AKE supplementation might improve liver function in heavy drinkers.

정서지능과 정서노동 전략이 직무관련 태도에 미치는 영향: 개인적 성취감의 매개효과

노혜미,신강현,유태용 한국산업및조직심리학회 2007 한국심리학회지 산업 및 조직 Vol.20 No.4

The purposes of this study was to identify the role of emotional intelligence in predicting deep acting, and the mediating role of personal accomplishment in a relationship between emotional labor strategies (i.e., surface acting and deep acting) and job related attitudes such as job satisfaction and organizational commitment. A total of 253 employees in service industry were surveyed in order to examine the relationships among these constructs. The results showed as follows. First, emotional intelligence was a positive predictor of deep acting after controlling big five personality and positive/negative affectivity. Second, personal accomplishment was fully mediated the relationship between deep acting and job related attitude variables. However, in case of surface acting, it was not. Additionally, it was confirmed a model that emotional intelligence leads to deep acting, which in turn make an effect on personal accomplishment, and finally leads positive job satisfaction and organizational commitment. Based on these results, the implication and limitation of this study and the direction for future research were discussed. 이 연구의 목적은 정서지능이 내면행동을 예측하는 데 있어서의 역할을 알아보고, 정서노동 전략(표면행동, 내면행동)이 직무관련 태도에 미치는 영향에 있어서 개인적 성취감의 매개효과를 검증하는 데 있었다. 이를 위해 병원의 원무과 직원, 간호사, 백화점 판매사원 등 서비스 직무에 근무하고 있는 253명의 종사자들을 대상으로 설문 조사를 실시하였다. 연구 결과, 첫째, 개인의 정서사용 및 관리 능력인 정서지능이 표면행동보다는 인지적 과정이 요구되는 내면행동을 유의하게 예측하는 것으로 밝혀졌다. 둘째, 개인적 성취감이 내면행동과 직무관련 태도 변수들 간의 관계를 매개하는 것으로 나타났다. 반면 표면행동과 직무관련 태도 변수들 간에는 개인적 성취감의 매개효과가 발견되지 않았다. 이러한 구성개념들 간의 관계를 모두 포함하여 구조방정식 모형을 통해 분석한 결과, 정서지능이 높은 개인은 정서노동 장면에서 내면행동을 하며, 그러한 내면행동은 개인적 성취감을 증가시키고, 개인적 성취감을 통해 직무만족과 조직몰입을 경험할 것이라는 전체적인 과정 모형의 타당성이 검증되었다. 이러한 연구결과를 토대로 연구의 의의와 시사점, 앞으로의 연구 과제를 논의하였다.

흉부 종괴로 오인된 선천성 식도열공 탈장 1례

노혜미,문은경,이동철,임혜경,유재홍,설지영,김종철,Rhou, Hye-Mi,Moon, Eun-Kyung,Lee, Dong-Chul,Im, Hye-Kyung,Yu, Jae-Hong,Sul, Ji-Young,Kim, Jong-Chul 대한소아소화기영양학회 1999 Pediatric gastroenterology, hepatology & nutrition Vol.2 No.2

The esophageal hiatal hernia is a herniation of an abdominal organ, usually the stomach, through the esophageal hiatus into thoracic cavity. It is a rare disease, usually congenital and frequently associated with gastroesophageal reflux and other congenital malformations in children. It is classified according to their anatomic characteristics as type I (sliding hiatal hernia), type II (paraesophageal hiatal hernia), type III (combined hiatal hernia) and type IV (multiorgan hiatal hernia). We experienced a case of type III congenital esophageal hiatal hernia simulating chest mass on simple chest x-ray because of right intrathoracic stomach secondary to congenital esophageal hiatal hernia and organoaxial rotation in 10 months male. After the operation, he showed an improved general condition and was discharged at the 14th hospital day. We report the case with the brief review of the related literatures. 식도열공 탈장은 그 형태에 따라 진단 및 치료가 지연될 경우 반복되는 구토, 빈혈, 영양실조, 출혈, 감돈, 위궤양, 급성 위팽만 등의 합병증이 발생하여 치명적일 수 있다. 저자들은 심한 탈수와 영양 실조를 주소로 내원한 10개월 남아에서 단순 흉부촬영에서 우측 흉부 종괴로 오인되었으나 선천성 식도열공 탈장과 위의 회전에 의해 상부 위장관 바륨조영술에서 우측 흉강내에 위가 위치한 것처럼 보였던 경우로 탈장 정복술과 위식도 역류방지술을 시행한 후 상기 증상이 호전된 제 3형의 선천성 식도열공 탈장 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Eating Alone and Cognitive Decline in Korean Older Adults: A 3-Year Prospective Study

노혜미,Junhee Han,노용균,Hong Ji Song 대한노인병학회 2021 Annals of geriatric medicine and research Vol.25 No.1

Background: Eating alone is a critical factor in nutritional risk screening among older adults. We investigated whether changes in eating status (eating alone or with others) in late-life affected cognitive decline in community-dwelling older adults. Methods: We used data from the Survey of the Living Conditions and Welfare Needs of Korean Older Persons. Nutritional risk, including eating status, was assessed using seven questions from the Nutrition Screening Initiative checklist, and cognitive function was measured using the Mini-Mental State Examination (MMSE). On the basis of changes in eating status between baseline (2008) and the 3-year follow-up (2011), the subjects were divided into four groups: group 1 (eating with others at both visits), group 2 (eating alone in 2008 and eating with others in 2011), group 3 (eating with others in 2008 and eating alone in 2011), and group 4 (eating alone at both visits). Generalized linear models were used to compare the changes in MMSE scores over the 3-year period among the four groups. Results: Among older women, group 2 had the least decline in MMSE scores (-0.55±0.46), whereas group 3 had the greatest decline (-1.76±0.37) (p=0.034). We observed no difference in the change in MMSE scores among the four eating groups in older men. Conclusion: Deprivation of mealtime partners in late life enhanced cognitive decline compared with gaining mealtime partners. Eating alone may be a risk factor for cognitive impairment; thus, meal programs reinforcing social integration might help preserve cognitive function.

신생아 경련의 원인과 예후 인자

노혜미,이건수 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

The etiology of neonatal seizure has specialized characteristics such as association with perinatal problems, obstetric problems, metabolic disorders, etc. But, since the seizure occurrs during the neonatal periods is very variable, and subtle, and can be overlooked or not be identified The presence of neonatal seizure is correlated with morbidity and mortality in the form of postnatal epilepsy, cerebral palsy, and mental retardation, death, or a combination of these sequelae. Hence, the seizure is a significant clinical problem in the care of newborn. We carried out this study in order to identify the neonatal variables that correlate with prognosis. Method : Clinical observations were made in 80 cases of neonatal seizure who were admitted to the Department of Pediatrics, Chunguam National University Hospital during the period of 5 years from July, 1992 to July, 1997. Result : The results were as follows : 1. The male to female ratio was 2.1:1 2. The onset of 23 cases(25%) of neonatal seizure appeared within 1 day of life, 17.5% in second day, and 12.5% in third day. 66.3% of neonatal seizure occured within 7 days of life. 3. The most frequent type was generalized tonic-clonic type(31.3%) followed by generalized clonic type(25%), and subtle type(22.5%) in order of frequency. 4. The most frequent cause of neonatal seizure was neonatal asphyxia(30%), sepsis(27.6%), followed by hypocalcemia(17.1%), hypoglycemia(11.3%), hyponatremia(6.4%), and meningitis (5.1%) in order of frequency. 5. The follow ups were made on 56 patients during the period from 8 months to 5 years. Thirty-six cases(64.3%.) improved and 13 cases(23.2%) showed neurologic sequelae, which were cerebral palsy in 5 cases, epilepsy in 6 cases, and mental retardation in 2 cases. Seven cases died. 6. The onset of neonatal seizure, the number of used anticonvulsant, and the electroencephalographic finding had statistically significant correlation with the outcome of the seizure patient. Conclusion : Clinical factors that showed a statistically significant relationship with the prognosis included the onset of seizure, number of anticonvulsant, and electroencephalographic severity.

브로카 실어증 환자의 음향 스펙트럴 시간적 특성

노혜미,강은영 국제다문화의사소통학회 2014 다문화의사소통 Vol.3 No.-

The purpose of this study was to explore the Spectral times of the Broca's Aphasic patients' stops caused by a stroke. A survey was conducted on 5 Broca's Aphasic patients and 7 people in control group. Spectral times were analized using Praat (version 4.4.22) and a microphone (shure PG48) was directly connected to a notebook PC for recording. The results were as follows: 1) The Broca's Aphasic patients' VOT, post-vowel length and utterance length of whole word were longer than those of the control group. 2) The VOT of the control group and the Broca's Aphasic patient group showed a significant difference in all of bilabial consonants, alveolar consonants, velar consonants and fortis consonants. The VOT lengths of the control group were all shorter than those of the Broca's Aphasic patient group.

Pilocarpine으로 유발된 간질중첩증에서 케톤생성 식이요법의 해마세포 손상 방어에 관한 연구

노혜미(Hye Mi Rhou),이건수(Keon Su Lee),김재문(Jae Moon Kim),김동욱(Dong Wook Kim) 대한소아신경학회 2003 대한소아신경학회지 Vol.11 No.1

1) KD는 pilocarpine에 의하여 유발되는 간질중첩증의 발현, 경련의 정도, 자발적인 완화에 영향을 미치지 않았다. 2) 3주간의 KD 식이는 충분한 정도의 케톤증을 유발하였다. 3) 3주간의 KD 식이는 흰쥐의 간질중첩증 2주 후에 시행된 병리학적 검사에서 H-E 염색 및 C-V 염색에서 RD를 식이한 흰쥐에 비하여 세포사가 현저히 적었으며 이러한 차이는 CA3, 치상회, CA1의 순서로 뚜렷하였다. 4) KD 식이는 Timm 과립의 형성을 억제하였으며 이는 특히 간질중첩증 유발 이전에 시행된 KD 식이에 의하여만 억제되었다. 즉, 3주간의 KD 식이 후 간질중첩증을 유발한 이후에 RD 식이로 변환한 경우나 간질중첩증 전후 모두 KD를 시행한 경우는 Timm 과립의 형성이 뚜렷이 억제되었으나, 3주간의 RD 식이 후 간질중첩증을 유발한 다음 KD로 식이를 변환하거나 RD를 유지한 경우는 Timm 과립의 형성이 뚜렷하였다. 이상의 결과로 KD는 간질중첩증으로 인한 세포사를 억제할 뿐만 아니라 그 이후에 나타나는 간질형성기전을 억제하는 효과가 있는 것으로 판단되었다. Purpose : Although ketogenic diet(KD) is an old method of treating epilepsies, its outstanding antiepileptic effect in some epileptic patients need re-evaluation. This study was performed to evaluate the anti-epiletogenic effect of KD. Methods : In the preliminary experiment, to select a proper animal model of status epilepticus(SE), an evaluation of EEG and behavioral characteristics of pilocarpine-induced SE model was done in 12 Sprague-Dawley rats. As the aim of the first experiment was to evaluate neuronal death in the hippocampus of similarly convulsed rats, the 10-20 mg/kg of diazepam ip. injection was given to cease SE in each stage of SE in KD and regular diet(RD) rats. Previous diet was maintained for two weeks until the evaluation of pathological changes with H-E and C-V stainings(64 rats, second experiments). In order to investigate whether the differences in the neuronal damage cause different mossy fiber sprouting or not, 40 rats were fed with KD and RD(20 rats each) 4 hours before pilocarpine-induced SE. After the treatment of SE with diazepam, half of previous KD rats maintained with KD and remaining 10 rats were fed with RD. Also previous RD rats were fed with RD and KD in the same way. Mossy fiber sprouting and synaptic reorganization was determined by Timm's staining 4 weeks after SE. Results : Pilocarpine-induced SE showed reliable EEG and behavioral patterns in all rats. Also, KD did not have any influence on SE induced by pilocarpine in terms of SE induction time and severity. Neuronal damages in CA1, CA3, and dentate gyrus were less prominent in the KD rats in every SE stage. Rats with RD before their SE showed significant Timm's(+) bands, whereas rats with KD after the SE did not show any differences. Conclusion : KD consistently protect neuronal damage caused by seizures in the hipocampus. this neuroprotection causes less mossy fiber synaptic reorganization.

뇌성마비 환자에서의 뇌유발전위 평가

노혜미(Hye Mi Rhou),이건수(Keon Su Lee),안인철(Ren Zhe An) 대한소아신경학회 1999 대한소아신경학회지 Vol.7 No.2

목 적 : 뇌성마비는 주산기부터 영유아기 사이의 미숙한 뇌에 발생한 손상에 의해 초래되는 동작과 자세의 질환으로 소아장애의 주원인으로 방사선학적 검사법을 이용한 뇌손상 부위의 정확한 해부학적 진단과 뇌유발전위 검사법과 같은 신경생리 검사를 이용한 뇌기능 평가가 가능해졌다. 따라서 본 연구에서는 뇌성마비 환아에서 뇌유발전위 검사의 평가 결과 및 뇌파와 뇌전산화단층촬영이나 자기공명영상기술 결과와의 상관성에 대해 조사하였다. 방 법 : 충남대학교 병원 소아과 및 재활의학과에서 병력 및 이학적 소견으로 뇌성마비를 진단 받은 환아 중 1995년 7월부터 1999년 6월까지 뇌유발전위 검사를 시행받았던 환아 86명을 대상으로 의무기록을 검토하여 뇌유발전위 검사 결과를 조사하였으며 뇌성마비의 유형, 뇌파 및 방사선학적 검사 결과와의 통계적 상관성을 분석하였다. 결 과 : 1) 대상 환아의 뇌성마비 임상형은 강직형 85%, 무정위형 3.5%, 혼합형 3.5%, 임상형이 정확히 명기되지 않았던 예가 8.1%였다. 2) 뇌유발전위 검사결과 시각유발전위 검사 29.47%, 청각유발전위 검사 18.8%, 정중신경유발전위 검사 37.8%, 경골신경유발전위 검사 52.7%에서 비정상 소견을 보였다. 3) 뇌파 검사, 자기공명영상술, 뇌전산화촬영 결과와 뇌유발전위 검사 결과는 통계학적으로 유의한 상관성이 없었다(P>0.05). 결 론 : 뇌유발전위 검사는 비침습적인 신경 검사로써 뇌파 검사나 방사선학적 검사와의 독립적으로 뇌성마비 환아에서 향후 신경학적 발달 경과와 감각 장애의 조기 진단과 치료에 도움이 될 것으로 사료된다. Purpose : Cerebral palsy is a group of conditions characterized by nonprogressive motor and posture dysfunction developing during perinatal period due to brain damage. Combined sensory and cognitive disorders can evolve the secondary mental retardation or speech disorder. Brain evoked potential can evaluate the visual, auditory, somatosensory neuropathway, and the response of frontal, temporal, occipital lobe. We studied the usefulness of brain pvoked votential as a tool in the early diagnosis and treatment of sensory disorders in cerebral palsy. Methods : We retrospectively reviewed the records of 86 cerebral palsy patients who were practiced brain evoked potential study in Chungnam National University Hospital from July, 1995 to June, 1999. We analyzed the visual, auditory, somatosensory evoked potential result and the correlations between the electroencephalography, radiologic brain imaging study and the brain evoked potential. Results : 1) Clinical types of cerebral palsy were spastic type(85.0%), athetoid type(3.5%), mixed type(3.5%) and the remaining cases did not manifest any one the types above. 2) Abnormal evoked potential fingings were 25 cases(29.4%) in visual evoked potential, 16 cases(18.8%) in auditory evoked potential, 28 cases(37.8%) in median nerve evoked potential, 39 cases(52.7%) in tibial nerve evoked potential. 3) Electroencephalography, radiologic brain imaging study manifested no statistically significant correlations with the brain evoked potential result(P>0.05). Conclusion : As a noninnvasive neurophysiologic study, Brain evoked potential is a useful method predicting neurologic developmental progress and helpful to early diagnosis of sensory disorder in cerebral palsy patients.

뇌졸중 환자 음성언어의 Spectral times 연구

노혜미(Hye Mi Noh),강은영(Eun yeong Kang),김현기(Hyun Gi Kim) 한국언어치료학회 2016 한국언어치료학회 학술발표대회 논문집 Vol.2016 No.12

Purpose: Cerebrovascular accident(CVA) is caused by a lesion blocking an artery. The aim of this study is delineate the Acoustic characteristics in Basal ganglia intracerebral hemorrhage (BG) and Middle cerebral artery infarction (MCA) patients. Methods: Seven Basal ganglia intracerebral hemorrhages and seven Middle cerebral artery infarctions participated in this study. Average age is 54.2±8.4 years old. Fourteen control group were selected random by average 49.7±9.9 years old. The collection of speech and analysis of acoustics Praat was done for acoustic analysis. The test words were composed meaningful words. Results: 1) Spectral times of all the consonsnts in patients with the BG and the MCA patients were longer than control group. 2) The VOT of the stop consonants in BG and MCA patients showed a meaningful difference in the bilabial fortis stops and aspirated stops, alveolar fortis stops, and velar fortis stops and aspirated stops.

의학교육평가로서 전문의자격시험 실기시험의 국내외 현황과 발전방안

조정진,노혜미,김승호,권호,박영민,최병민 대한의사협회 2014 대한의사협회지 Vol.57 No.5

The Specialty Certification Examination is an important part of the assessment of medical education. However, thestep 2 skill examinations of 26 medical specialties in Korea are insufficient with respect to achieving the objective ofpractical examinations that evaluate clinical skill and competence. Among the current step 2 skill examination methods,picture testing using slides or reading of pathology slides/radiologic images is more suitable for testing cognition andknowledge than for testing performance. The oral examination has low reliability because of its relatively short testingperiod and absence of scoring criteria. In addition, the Specialty Certification Examination is a high-stakes test and theperformance during the training course is not reflected in the skill examination. We have reviewed the various skillexaminations including clinical practice examinations, objective structured clinical examinations of the United Statesand Canada, and work-based assessments of the United Kingdom. Based on the review, we suggest some plans forimproving the Korean Specialty Certification Examination.