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노학재,안무영 순천향대학교 순천향의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.15 No.2
Guillain-Barre syndrome (GBS) is one of the acute flaccid paralysis syndromes in human and consisting of different subtypes including acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor and sensory axonal neuropathy (AMSAN), acute sensory neuropathy, acute pandysautonomia and Fisher syndrome. The most striking feature different from other neuropathy is elevated protein level with a normal cell count in the cerebrospinal fluid known as albuminocytologic dissociation. AMAN and AMSAN may be mediated by specific anti-ganglioside antibodies that inhibit transient sodium Na+ channels. The efficacy of plasmapheresis and intravenous immunoglobulin has been established in large international randomized trials, with corticosteroids proven ineffective. Although axonal demyelination is an established pathophysiological process in GBS, the rapid improvement of clinical deficits with treatment is consistent with Na+ channel blockade by antibodies or other circulating factors, such as cytokines. This review provides an update on the epidemiology, clinical features, diagnosis, pathogenesis and treatment of GBS.
Tolosa-Hunt 증후군으로 발현한 간세포암의 비전형적 대뇌전이 1예
노학재,안무영 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Hepatocellular carcinoma (HCC) is one of the most common malignant neoplasias in Asia. Although extrahepatic metastasis of HCC is not uncommon, intracranial metastasis is relatively rare. Most common site of cerebral metastasis of HCC is supratentorial watershed area and most common symptom is hemiparesis. According to the literature, incidence of intracerebral hemorrhage (ICH) is low but current reports reveal that the incidence of ICH is relatively high. We report a case of nonhemorrhagic cerebral metastasis of HCC in lateral wall of cavernous sinus presenting as Tolosa-Hunt syndrome.
노학재,봉춘근,봉하경,김용구,조명행,김상화,김대성,Noh, Hakjae,Bong, Choonkeun,Bong, Hakyung,Kim, Yonggu,Cho, Myunghaing,Kim, Sanghwa,Kim, Daesung 한국입자에어로졸학회 2016 Particle and Aerosol Research Vol.12 No.1
In this work, we evaluated the characteristics of flow field and uniformity of the nose-only exposure chambers for the inhalation toxicity test. Computational fluid dynamics (CFD) modeling was carried out to demonstrate uniformity of the nose-only exposure chambers. Because it is very important in the inhalation toxicity experiments that test materials are distributed uniformly to each holder of the chamber. The test was done with these 3 types of chamber with different form to develop inhalation toxicity evaluation system, easy-to-operate system among exposure chamber used for evaluating inhalation toxicity of environmental chemical mixtures. Through CFD interpretation, nose-only exposure chamber was made with the selection of the optimal conditions. For its evaluation, one type of fragrance was selected and measured particle size distribution of each port. The gene becoming luminous to green fluorescence was combined with GPT-SPE, a type of tGFP vector, to be inhaled to the mouse. Based on this, luminous intensity was checked. As a result, total particle number concentration of each port had average value of $3.17{\times}10^6{\sharp}/cm^3$ and range of the highest and lowest concentration value was approximately ${\pm}4.8%$. Autopsy of lung tissues of mouse showed that it had clearly better delivery of gene compared to the control group.
목 및 가슴신경뿌리병증의 임상적 고찰: 비침습적 중재시술치료
노학재,이상헌,김병조 대한임상신경생리학회 2008 Annals of Clinical Neurophysiology Vol.10 No.2
Cervical and thoracic radiculopathies are among the most common causes of neck pain. The most common causes are cervical disc herniation and cervical spondylosis in patients with cervical radiculopathy, and diabetes mellitus and thoracic disc herniation in thoracic radiculopathy. A thorough history, physical examination, and testing that includes electrodiagnostic examination and imaging studies may distinguish radiculopathy from other pain sources. Although various electrodiagnostic examinations may help evaluate radiculopathy, needle electromyography is the most important, sensitive, and specific method. Outcome studies of conservative treatments have shown varying results and have not been well controlled or systematic. When legitimate incapacitating symptoms continue despite conservative treatment attempts, more invasive spinal procedures and intradiscal treatment may be appropriate. Surgery has been shown to have excellent clinical outcomes in patients with disc extrusion and neurological deficits. However, patients with minimal disc herniation have fair or poor surgical outcomes. In addition, conventional open disc surgery entails various inadvertent surgical related risks. Although there has not yet been a non-surgical interventional procedure developed with the therapeutic efficacy of open surgery, conservative procedures can offer substantial benefits, are less invasive, and avoid surgical complications. While more invasive procedures may be appropriate when conservative treatment fails, prospective studies evaluating cervical and thoracic radiculopathies treatment options would help guide practitioners toward optimally cost-effective patient evaluation and care.
이정곤,노학재,장일미,이경복,안무영 대한뇌졸중학회 2012 Journal of stroke Vol.14 No.3
Hypertensive brainstem encephalopathy (HBE) is a variant of hypertensive encephalopathy characterized by brainstem and cerebellar involvement. Simultaneous supratentorial involvement in HBE is rarely reported as a vasogenic edema in subcortex and/or periventricular white matter. A 36-year-old woman visited hospital due to headache lasting 7 days before admission. Initial blood pressure was 270/170mmHg. T2-weighted and fluid-attenuated inversion recovery magnetic resonance imaging revealed multifocal high signal intensity lesions in upper medulla, pons, midbrain and cerebellar hemisphere. Especially, atypical periventricular lesions were shown as perpendicular fingers to the lateral ventricle like multiple sclerosis. Her clinical symptoms and radiological lesions were subsided with lowering blood pressure. We herein report a HBE with unusual supratentorial involvement mimicking multiple sclerosis.