포스타 전시 발표 : 내분비-대사, 신장 ; Adrenal Incidentaloma 18예의 임상적 특징

남경재,김희진,박도준,박경수,김성연,조보연,이홍규 대한내과학회 1998 대한내과학회 추계학술대회 Vol.1998 No.1

제 50 차 대한내과학회 추계학술대회 초록집 : Adrenal Incidentaloma 18 예의 임상적 특징

남경재,박도준,박경수,김성연,조보연,이홍규,김희진 대한내과학회 1998 대한내과학회 추계학술대회 Vol.55 No.-

상용 김발 카메라의 시선각 변화율 추정을 위한 김발 시스템 식별

남경재(KyungJae Nam),김도완(Dowan Kim) 한국항공우주학회 2023 한국항공우주학회 학술발표회 논문집 Vol.2023 No.4

Mitoxantrone as a Single Agent for the Salvage Treatment of Refractory or Recurrent Acute Myeloblastic Leukemia

Nam, Kyung Jae,Kim, Chul Soo,Kim, Re Hwe 인제대학교 1996 仁濟醫學 Vol.17 No.4

배경: 급성골수성 백혈병은 궁극적으로 완치가 어려운 병이며 그 가장 큰 원인은 약제에 의한 내성으로 간주되고 있다. 따라서 더 나은 결과를 위한 새로운 약제 개발의 필요성이 요구되고 있다. 방법: Cytosine arabinoside 와 Daunorubicin을 포함한 항암화학요법으로 표준관해유도에 도달한 18명의 초기내성 또는 재발된 급성골수성 백혈병 환자(남:여=5:13, 연령 16-65세, 평균연령 32세)에게 하루에 Mitoxantrone 20mg을 5일 동안 정맥주사하였다. 결과: 3명(18%)의 환자가 골수회복전 초기에 사망하였다. 백혈구감소 최저치까지 도달일수는 10-20일(평균16일)이었고 이때 호중구수는 중앙치는 0이었다. 한명을 제외한 모든 환자에서 백혈구 감소와 동반된 발열이 있었다. 재발한 8명중 6명(75%)와 초기 불응환자 10명중 2명(20%)을 포함한 8명(44%)에서 완전관해가 유도되었다. 완전관해 도달까지의 기간은 2-40일(평균 32일)이었다. 생존기간은 완전관해유도군에서는 4-50주였고 모든 환자에서는 2-50주였다(평균 10주). 결론: Mitoxantrone이 불응성 또는 재발성 급성골수성 벅혈병환자의 생존에 의미있는 영향을 주는 것 같지는 않지만 이들 예후가 나쁜 군에서의 항암반응율은 표준위험군에서의 다제병합화학요법에서 시도되어야 할 가치가 있다고 여겨진다. Background: Only a small fraction of acute myeloblastic leukemia (AML) patients can be cured wish current chemotherapy because of drug resistance in the majority. Newer drugs are needed for better therapeutic outcome. Methods: Daily dose of mitoxantrone 20 mg was given IV bolus for 5 days regardless of body surface to 18 primary refractory or relapsed AML patients (male:female=5:13, ages 16-65 wish a median of 32) who had been exposed to standard remission induction chemotherapy consisting of cytosine arabinoside and daunorubicin. Results: Three (18%) patients died earlier of bone marrow aplasia. The days to leukopenic nadir ranged 10-20 (median 16) with a median absolute neutrophil count of o/uL. All patients except one had neutropenic fever. Eight (44%) patients achieved complete remission (CR) including 6 of 8 (75%) relapsed patients and 2 of 10 (20%) primary refractory patients. The days to CR ranged 27-40 (median 32). The duration of CH was short ranging 4-26 weeks (median 10). The overall survival duration ranged 4-50 weeks (median 12) in patients who achieved CR and 2-50 weeks (median 10) in all patients. Conclusion: Although mitoxantrone did not seemed to give meaningful impact on survival duration of refractory or relapsed AML patients, the activity in this poor prognosis group warrants further studies including incorporation into combination chemotherapies in standard risk group.

Monoclonal Gammopathy of Undetermined Significance 를 동반한 베체트 병(Behcet`s Disease) 1 예

정성광,남경재,전영빈,이윤우,한성훈,김정수,김현대 대한내과학회 1996 대한내과학회지 Vol.51 No.4

The term $quot;monoclonal gammopathy of undetermined significance (MGUS)$quot; denotes the presence of a M-protein in patients without multiple myeloma, macroglobulinemia, amyloidosis, or other related disease. MGUS is characterized by a serum M-protein concentration $lt;3.0g/dL, $lt;5% plasma cells in the bone marrow, either a small amount of M-protein or none at all in the urine, absence of lytic bone lesion, anemia, hypercalcemia, and renal insufficiency, and, most importantly, stability of the M-protein and failure of development of additional abnormalities. Recently we experienced one ease of MGUS associated with Behcet's disease confirmed by electrophoresis, immunoelectrophoresis and bone marrow biopsy. A 37-year-old woman was admitted to our hospital in 1991 because of migratory joint pain for 2 years. On physical examination oral and genital ulcers were found, and erythematous palpable tender subcutaneous nodules were found also in the forearms and legs. The level of IgG K fraction in the serum was 0.52g/dl and the bone marrow biopsy was normal. Initially she had been treated with ibuprofen, prednisolone, colchicine and azathioprine under the diagnosis of Behcet's disease with MSUS. The concentration of serum M-protein after treatment of four years was 2.69g/dL and she complained only migratory pain in back and extremity, and easy fatigability. Lately she has been managed with the combination of colchicine and azathioprine.

미토콘드리아 DNA 결핍이 당 대상에 미치는 영향

박규상,남경재,김준우,이연복,한창엽,정준기,이홍규,김영미 국립보건연구원 2000 국립보건원보 Vol.37 No.-

폐경기 여성에서의 골밀도와 체지방과의 상관관계

한성훈,남경재,김정수,하태완,임경호 인제대학교 1996 仁濟醫學 Vol.17 No.3

골량은 30대에 최고치를 보이고 이후 노년기까지 지속적으로 감소하나, 여성에서는 특히 폐경 직후 감소의 속도가 급격히 증가하여 골절, 골다공증 등의 골질환을 유발한다. 에스트로겐 결핍이 폐경기 이후의 골소실을 촉진하기는 하지만, 연령 증가에 따른 지방의 증가도 골소실과 관계하며 골절 등을 유발시킨다. 비만한 사람은 고혈압, 당뇨병, 동맥경화성 심혈관 질환 등의 성인병을 갖게 되며 최근의 보고는 체지방 분포상태가 질병발생과 관계된다고 알려져 있으므로 이미 알려진 지방과 골밀도와의 관련성 뿐 아니라 지방분포와 골밀도와의 관계를 알아보기 위하여 폐경기 이후 여성환자 67명을 대상으로 DEXA(dual energy X-ray absorptiometry)를 이용하여 전신골밀도, 지방량을 측정하여 상관관계를 조사하였다. We studied the relation of whole body bone mineral density to body fat. To accomplish this, we examined the total bone mineral density, fat distribution, body mass index and body weight with dens-itometry(Dual Energy X-ray Absorptiometry) in 67 postmenopausal women who had been followed up between 1992 and 1995. The results are summarized as follows : 1) The whole body bone mineral density increases with age(r = 0.54). 2) There is a good relation between the whole body bone mineral density and body weight(r= 0.54, p<0.001). 3) There is a relation between the whole body bone mineral density and body mass index(r = 0.28, p<0.01). 4) There is a poor relation between the whole body bone mineral density and total body fat(r =0.24, p<0.01). 5) The trunkal fat shows stronger correlations with the whole body bone mineral density than either the extremity fat or the whole body fat(r = 0.339, p<0.001).

항Ro(SS-A) 및 항La(SS-B)항체 양성인 전신성 경피증 환자에서 태어난 환아로 선천성 완전 심장차단을 가졌던 1례

정광호,남경재,이윤우,박용원 인제대학교 1994 仁濟醫學 Vol.15 No.4

선천성 완전 심장차단의 중요한 원인 중의 하나는 모체의 항 Ro(SSA) 항체가 태반을 통과하는 것이다. 26세의 항 Ro(SSA) 항체 및 항 La(SS-B) 항체가 양성인 전신성경피증 산모로부터 태어난 18개월된 여아에게서 선천성 완전 심장 차단을 관찰하였기에 보고하는 바이다. One of the important causes of congenital heart block is the transplacental transmission of maternal ants-Ro(SSA) antibody. An 18 month old girl was brought to our hospital because of dyspnea from which she had been suffered after birth. A complete heart block, atrial septal defect(secundum type) and patent ductus arteriosus were found. Closure of defects was done and permanent pace maker installed. She died of pneumonia and congestive heart failure at the age of 30 months. Her mother had this baby at the age of 26 years old and had suffered from systemic sclerosis since her early twenties. The laboratory studies on her revealed as follows. ANA 1 : 2650, anti-nRNP Ab (-), anti-Scl 70 Ab (-), anti-centromere Ab (-), rheumatoid factor (-), anti-Ro(SSA) Ab (+), anti-La(SSB) Ab (+), interstitial pulmonary fibrosis (DLCO : 50% of predicted value).

갑상선 기능항진증을 동반한 임신오조에 수반된 Wernicke`s Encephalopathy

임경호,이승진,남경재 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.3

Wernickes encephalopathy is an illness characterized by mental disturbance, paralysis of eye movements and ataxia of gait. The specific factor for most, if not all, of these symptoms is a deficiency of thiamine. Wemicke's encephalopathy mostly occurs in developing countries when the patient is in a state such as nutritionally deprived state, anorexia nervosa, stomach cancer, long duration of parenteral nutrition. Wernickes encephalopathy was recognized as a complication of hyperemesis of pregnancy in 1914. Unfortunately, cases continue to occur. We present here a case of Wernickes encephalopathy in a 36-year-old pregnant woman. We discuss the clinical picture, histopathology, radiology, therapeutic management and prognosis with review of the literature(J Kor Soc Endocrinol 13:489-494, 1998).

수산염(oxalate) 섭취에 의한 급성 신부전 1례

경쾌수,송영수,김현대,남경재,노승현,고행일 인제대학교 1994 仁濟醫學 Vol.15 No.4

수산염에 의한 신장애는 신장에서 수산칼슘 형태의 결정체가 세뇨관에 침착되어 신장애 및 대사성 산증 등을 드물게 일으킨다. 저자들은 우연히 수산염을 성취하여 질소혈증 및 단백뇨를 보여 신조직 검사상 옥살산증을 보인 예를 경험하여 보고한다. Acute renal failure caused by oxalate ingestion is very rare. The authors experienced a case of a 17 year old male patient who ingested oxalate incidently and developed acute renal failure. Crystalline deposition of oxalate within tubule and necrosis of tubular epithelium were seen on kidney biopsy. The insult was recovered uneventfully with conservative managent for renal failure.