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PRISMA 2020 지침에 근거한 한방재활의학과학회지 체계적 문헌고찰 보고의 질 평가 연구
나현욱,박신혁,우현준,한윤희,금지혜,이정한,하원배 한방재활의학과학회 2022 한방재활의학과학회지 Vol.32 No.3
Objectives The purpose of this study was to assess the reporting quality of systematic reviews and meta-analyses in the Journal of Korean Medicine Rehabilitation (JKMR) using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Methods Systematic reviews and meta-analyses in JKMR, published from January 1991 to January 2022, were selected by searching the Korean studies Information Service System and JKMR homepage. Two independent researchers searched and selected systematic reviews and meta-analyses and evaluated the reporting quality of abstracts and main texts using the PRISMA 2020 guidelines. Results Of 1,515 articles, 39 systematic reviews were finally included for assessment. Evaluation of abstracts resulted in 2 studies rated as high, 11 studies rated as moderate, and 26 studies rated as low. A maximum of 83.3% and a minimum of 25.0% of the items were reported in the abstracts. Evaluation of the manuscripts resulted in no studies rated as high, 14 studies rated as moderate, and 25 studies rated as low. A maximum of 67.9% and a minimum of 34.1% of the items were reported in the manuscripts. Conclusions To improve the quality of systematic reviews published in JKMR, it is necessary to conduct systematic reviews based on the PRISMA 2020 guidelines.
이상헌,나현욱,안성호,김종성,강동화,권순억 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.2
Background and Purpose The absence of acute ischemic lesions in diffusion-weighted imaging (DWI) in transient ischemic attack (TIA) patients makes it difficult to diagnose the true vascular etiologies. Among patients with DWI-negative TIA, we investigated whether the presence of a perfusion-weighted imaging (PWI) abnormality implied a true vascular event by identifying new acute ischemic lesions in follow-up magnetic resonance imaging (MRI) in areas corresponding to the initial PWI abnormality. Methods The included patients underwent DWI and PWI within 72 hours of TIA and also follow-up DWI at 3 days after the initial MRI. These patients had visited the emergency room between July 2009 and May 2015. Patients who demonstrated initial DWI lesions were ex¬cluded. The initial PWI abnormalities in the corresponding vascular territory were visually classified into three patterns: no abnormality, focal abnormality, and territorial abnormality. Results No DWI lesions were evident in initial MRI in 345 of the 443 TIA patients. Follow-up DWI was applied to 87 of these 345 DWI-negative TIA patients. Initial PWI abnormali¬ties were significantly associated with follow-up DWI abnormalities: 8 of 43 patients with no PWI abnormalities (18.6%) had new ischemic lesions, whereas 13 of 16 patients with focal perfusion abnormalities (81.2%) had new ischemic lesions in the areas of initial PWI abnor¬malities [odds ratio (OR)=15.1, 95% confidence interval (CI)=3.6–62.9], and 14 of 28 pa¬tients with territorial perfusion abnormalities (50%) had new lesions (OR=3.7, 95% CI=1.2–11.5). Conclusions PWI is useful in defining whether or not the transient neurological symptoms in DWI-negative TIA are true vascular events, and will help to improve the understanding of the pathomechanism of TIA.
烏貝散이 흰쥐 胃의 Gastrin, Histamine, Somatostatin 면역반응세포에 미치는 영향
이시섭,나현욱,고병문,이광규,이창현 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5
To investigate the elects on the administration of Opae-san in rats. Opae-san (500mg/day) and omeprazole(10mg/day) were administration with stomach tube for 4 weeks and 8 weeks. This experiment were investigated numerical change of immunoreactive cells of gastric, histamine and somatostatin in rat stomach mucosa by the immunohistochemical method. The results were as follows : 1. In Opae-san administration group for 4 weeks, the number of gastric immunoreactive cells were increased in one and a half times than that of control group. In omeprazole administration group for 4 weeks, the number of gastric immunoreactive cells were increased in four times than that of control group. In Opae-san administration group for 8 weeks, the number of gastric immunoreactive cells were increased four times than that of control group. In omeprazole administration group for 8 weeks, the number of gastrin immunoreactive cells were increased in six times than that of control group. 2. In Opae-san administration group for 4 weeks, the number of histamine immunoreactive cells were increased in two times than that of control group. In omeprazole administration group for 4 weeks, the number of histamine immunoreactive cells were increased in six times than that of control group. In Opae-san administration group for 8 weeks, the number of histamine immunoreactive cells were increased three times than that of control group. In omeprazole administration group for 8 week, the number of histamine immunoreactive cells were increased in seven times than that of control group. These results suggest that Opae-san extracts inhibit the secretion of gastric acid and this extract use to therapeutic herb of gastric disorders related to the hyperacidity and gastric ulcer.