烏貝散이 흰쥐 胃의 Gastrin, Histamine, Somatostatin 면역반응세포에 미치는 영향

이시섭,나현욱,고병문,이광규,이창현 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5

To investigate the elects on the administration of Opae-san in rats. Opae-san (500mg/day) and omeprazole(10mg/day) were administration with stomach tube for 4 weeks and 8 weeks. This experiment were investigated numerical change of immunoreactive cells of gastric, histamine and somatostatin in rat stomach mucosa by the immunohistochemical method. The results were as follows : 1. In Opae-san administration group for 4 weeks, the number of gastric immunoreactive cells were increased in one and a half times than that of control group. In omeprazole administration group for 4 weeks, the number of gastric immunoreactive cells were increased in four times than that of control group. In Opae-san administration group for 8 weeks, the number of gastric immunoreactive cells were increased four times than that of control group. In omeprazole administration group for 8 weeks, the number of gastrin immunoreactive cells were increased in six times than that of control group. 2. In Opae-san administration group for 4 weeks, the number of histamine immunoreactive cells were increased in two times than that of control group. In omeprazole administration group for 4 weeks, the number of histamine immunoreactive cells were increased in six times than that of control group. In Opae-san administration group for 8 weeks, the number of histamine immunoreactive cells were increased three times than that of control group. In omeprazole administration group for 8 week, the number of histamine immunoreactive cells were increased in seven times than that of control group. These results suggest that Opae-san extracts inhibit the secretion of gastric acid and this extract use to therapeutic herb of gastric disorders related to the hyperacidity and gastric ulcer.

편두통 환자의 뇌혈류에 대한 침치료의 효과

이시섭,김동원,안교필,엄효진,남영 대한침구학회 2001 대한침구의학회지 Vol.18 No.6

Objective : To investigate the effects of Acupuncture therapy on the migraineur by way of the change of the Cerebral blood flow. Methods : 6 migraineurs were inserted in acupoints on GV16, G20, S8 during 2 weeks. and, Mean Velocity (MV) and Pulsatility Index (PI) of MCA, PCA, ACA, BA were measured before and after treatments of 2 weeks, respectively. Results : MV of MCA of the migraineurs was decreased very much by 13.3%, and P1 was decreased much by 10.4%. However, MV and PI of BA changed little. Conclusion : It is observed that Acupuncture therapy reduces pains of migraineur through decreasing Cerebral blood flow like MCA.

두침(頭鍼)을 시술한 경막하혈종(硬膜下血腫) 환자(患者) 1례에 관한 보고

이시섭,김동원,육태한,Lee, Si-Sup,Kim, Dong-Won,Yook, Tae-Han 대한침구의학회 2001 대한침구의학회지 Vol.18 No.5

Objective : To report one case where Subdural Hematoma(SDH) in operation indication was treated by Scalp Acupuncture therapy. Methods : The changes in clinical symptoms of headache, dizziness, nausea, vommitting were described when this patient was treated with scalp acupuncture therapy and with herb medication. Results : Symptoms (headache, dizziness, nausea, vomiting. etc) at admission decayed gradually with Scalp Acupuncture therapy. The patients could walk alone at discharge. Conclusion : Though she had been in op. indication, the patient's health improved by herbmedications of Dodamcheseup($d{\breve{a}}ot{\acute{a}}nchu{\acute{u}}shi$)-Tang etc. and by Scalp Acupuncture therapy.

Pseudorabies virus를 이용한 신장, 신수 및 경문에서 투사되는 중추신경계내 표지영역에 관한 연구

이창현,이시섭,육태한,Lee, Chang-Hyun,Lee, Si-Sup,Yook, Tae-Han 대한침구의학회 2001 대한침구의학회지 Vol.18 No.3

Objective : To investigate the relation to the organs, shu points and mu points. The labeled common locations of the spinal cord and brain were observed following injection of pseudorabies virus(PRV) into the the kidney, UB23 and GB25. Methods : After survival times of 96 hours following injection of PRV, The fifteen rats were perfused, and their spinal cord and brain were frozen sectioned($30{\mu}m$). These sections were stained by PRV immunohistochemical staining method, and observed with light microscope. Results : In spinal cord, PRV labeled neurons projecting to the kidney, BL23 and GB25 were founded in cervical, thoracic, lumbar and sacral spinal segments. Dense labeled areas of cervical segments were overlap in lateral cervical n. and lamina III-V area. Thoracic segments were overlap in lateral spinal n., intermediolateral n. and lamina V-X areas. Lumbar segments were overlap in lamina I-V areas. Sacral segments were overlap in lamina IV, V and X areas. In brain, PRV labeled areas projecting to the kidney, UB23 and GB25 were overlap in the A1 noradrenalin cells/C1 adrenalin cells/caudoventrolateral reticular n./rostroventrolaterai n., raphe obscurus n,, raphe pallidus n., raphe magnus n., gigantocellular reticular n., locus coeruleus, subcoeruleus n., A5 cell group and paraventricular hypothalamic n.. Conclusions : This results suggest that PRV labeled overlap areas of projecting to the kidney may be correlated to shu and mu points related to the kidney. These morphological results provide that organs-shu(transport) and mu(alarm) points interrelationship may be related to the central autonomic pathways.

두침을 시술한 경막하혈종 환자 1례에 관한 보고

육태한,이시섭,김동원 대한침구학회 2001 대한침구의학회지 Vol.18 No.5

Objective : To report one case where Subdural Hematoma(SDH) in operation indication was treated by Scalp Acupuncture therapy. Methods : The changes in clinical symptoms of headache, dizziness, nausea, vommitting were described when this patient was treated with scalp acupuncture therapy and with herb medication. Results : Symptoms (headache, dizziness, nausea, vomiting. etc) at admission decayed gradually with Scalp Acupuncture therapy. The patients could walk alone at discharge. Conclusion : Though she had been in op. indication, the patient's health improved by herbmedications of Dodamcheseup(da˘ota'nchuu'shi￣)-Tang etc. and by Scalp Acupuncture therapy.

分心氣飮으로 治癒된 退行性 椎間板脫出症 患者의 治驗1例

김동원,안교필,이시섭,송경섭 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1

Objectives : To report one case where Herniation of an Interverterbral Disc(HIVD) in operation indication was treated by Bunsimki-um. Methods : The changes in clinical symptoms of low back pain dysuria, HTN, etc. were described when this patient was treated with herb-medications of Bunsimki-um, etc. and with Acupuncture treatment. Results : Symptoms (low back pain, dysuria, HTN, etc) at admission decayed gradually with Bunsimki-um. The patients could walk alone at discharge. Conclusions : Though she had been in op. indication, the patient's health improved by herbmedications of Bunsimki-um, etc. and by Acupuncture treatment.

만성 두통에 대한 뇌청혈해독탕의 임상적 효과

김제영 ( Jae Young Kim ),이시섭 ( Si Sup Lee ),유정석 ( Jung Suk Yu ),송범용 ( Beom Yong Song ),김락형 ( Lak Hyung Kim ),육태한 ( Tae Han Yook ) 대한한방신경정신과학회 2007 동의신경정신과학회지 Vol.18 No.1

Objective : Chronic headache is the most common headache. The objective of this study is to find the clinical manifestation of chronic headache and has been carried out to investigate the effects of Noechongyolhaedok-tang on the chronic headache.Method : This observation was carried out on 73 patients with chronic headache. They were applied to Noechongyolhaedok-tang and the degree of improvement of chronic headache was evaluated by VAS. Results : 1. Distribution of study population by sex, age : male : female = 1 : 3, 30s-50s group = 81% Duration of onset : over 10years = 48% Reported site of chronic headache : the whole = 28% Clinical pain characteristics : be torn = 25% Frequency of headache : everyday = 72% Time of attack : irregular = 52% 2. In VAS scores, there were significant differences between before and after Noechongyolhaedok-tang treatment. There were no differences between before and after treatment in each sex and the duration of onset Conclusion : The effectiveness of Noechongyolhaedok-tang on the chronic headache was shown through VAS Further study is needed about Noechongyolhaedok-tang.

홍화약침을 이용한 수근관증후군치료

신민섭,박민호,임성택,신진철,이부영,이시섭,육태한,최석우,Shin, Min-Seop,Park, Min-Ho,Lim, Sung-Taek,Shin, Jin-Cheol,Lee, Bu-Young,Lee, Si-Seop,Yook, Tae-Han,Choi, Seok-Woo 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.2

Objective : The purpose of the study was to evaluate if CF herbal acupuncture is more effective than simple acupuncture in the carpal tunnel syndrome. Methods : We classified two groups: CF group(patients treated by CF herbal acupuncture and then treated by acupuncture) and N-CF group(patients treated entirely by acupuncture without other treatment). We evaluated subjective symptoms and Phalen's test of patients after executing, and then analyzed those. Results : 1. Both CF group and N-CF group were statistically significant(p<0.05) in improvement of symptoms and Phalen's test since third times of treatment. 2. It appears that CF group was more effective than N-CF group for treatment of carpal tunnel syndrome. That was statistically significant(p<0.05) since third times of treatment.