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옻나무 칠액성분 중 Urushiol 의 암세포 증식억제 효과 - in vitro 세포독성효과 -
나천수,정남철,오광인 ( Chun Soo Na,Nam Chul Jung,Kwang In Oh ) 한국산림과학회 1998 한국산림과학회지 Vol.87 No.2
This study was conducted to screen the biological activity of urushiol in the sap of lac tree(Rhus verniciflua STOKES) which has been used in traditional folk remedies. Cytotoxic activity of urushiol was screened with L1210(mouse luekemia cell), PC-9(human lung adenocarcinoma cell), A427(human lung adenocarcinoma cell) and KATO IlI(human stomach adenocarcinoma cell) The stepwise hexane : acetone eluent fractions of the urushiol were obtained by the silica gel adsorption column chromatography and added to the culture media containing L1210, PC-9. A427, and KATO III, respectively. A hexane : acetone(90 : 10, v/v) eluent fraction of them showed the lowest 50% inhibition concentration(IC_(50)) of 0.018㎍/㎖ for the cell line of A427. Much lower level of IC_(50) of the hexane : acetone(90 : 10, v/v) eluent fraction of the urushiol showed the equal inhibition effect with tetraplatin(i.e., anti-cancer drug of platinum complexes) on the cancer cell lines as follows ; 3.4 times lower for L1210, 3.9 times lower for PC-9, and 105.5 times lower for A427. However, IC_(50) of the hexane : acetone(90 : 10 v/v) eluent fraction for KATO III was exceptionally 3.9 times higher than that of tetraplatin.
나주지역 동학관련 구술자료 수집과 그 의의 - 나주시, 세계적 동학 명소를 위한 試論 -
나천수(羅千洙),이영기(李英紀) 원광대학교 원불교사상연구원 2020 원불교사상과 종교문화 Vol.86 No.-
2019년도「 나주시-원광대학교-일본측 동학 유적지 답사단」 3자가 나주시에서 나주 동학농민운동 연구에 뜻을 같이하고 장차 일본측이 위령탑을 건립키로 뜻을 모아 3자가 MOU를 체결한 바 있다. 문제는 1894년부터 현재까지 동학 관련 참여자 현황을 한번도 전수 조사한 적이 없다는 것이다. 현재까지 찾아낸 동학농민군이 겨우 3,670명이고, 채록된 증언도 겨우 97건에 불과하다. 과연 동학농민군 총 참여 인원을 알 수 있을까? 그중에 죽은 자는 몇 명인지, 후손이 누구인지 조사하지 않은 상황에서 비록 일본측에서 위령탑을 세운다 하여도 한(恨)이 흥(興)으로 승화될 수는 없다. 이 연구는 동학 구술 수집의 의의를 피력하고 구술 찾기 방안을 제시하고자 한다. 연구의 내용은 첫 번째, 기존 동학 관련 기록 문서를 바탕으로 동학참여자 전체를 추정해 보고, 두 번째, 이와 같은 동학 참여자가 일제강점기 동안 역사의 뒤안길에 숨을 수밖에 없는 이유를 들어 구술 찾기 방안을 제시하고자 한다. 세 번째, 2019년 제1회 나주 동학 한일 학술대회 때 슬로건을 ‘한에서 흥으로 승화하다’로 정한 바, 한을 흥으로 승화하는 방안을 제시하고자 한다. 구전 수집을 통해 동학농민군과 그들 후손들의 한의 소리를 아울러 채록할 수 있다면, 이것을 편석판(片石板)에 새겨 위령탑 주변에 비군(碑群)으로 배치하면 마침내 한이 흥으로 승화되지 않을까? 이 연구의 결과를 나주시가 행정적으로 실천할 경우 나주는 명소로 부각될 것이다. 나주에 가면 동학으로 죽은 자의 한의 소리, 살아남은 자의 한의 소리, 그들 후손들의 한의 소리를 들을 수 있기 때문이다. In 2019, the MOU was executed by three parties—Naju city, Wonkwang University, Japanese exploration group —who agreed to study Naju Donghak Peasant Movement and have the Japanese group to build a memorial tower in the future. The status of participants for Donghak Peasant Movement has never been completely investigated until now. Only 3,670 names of Donghak Peasant Army have been found so far and only 97 testimonies have been recorded. Even if the memorial tower is set up by Japanese, the peasant army’s resentment cannot be sublimated into excitement without investigating the total number of participants, the number of deaths and who their descendants are. The study seeks to express the significance of collecting verbal evidences as well as the voices of deep sorrow of Donghak Peasant Army and suggest solutions to find them. The content of this study is to estimate the entire Donghak participants based on the existing Donghak-related documents and suggest solutions to find verbal evidences about the them who were forced to hide in the back of history during Japanese colonial era. Lastly, the study would propose plans to sublimate the resentment into excitement as stated in the slogan—“Sublimate the resentment into excitement”—from the first Korea-Japan academic conference for Donghak which took place in Naju in 2019. Once the collected verbal evidences of Donghak Peasant Army are engraved on the piece of stone plate and placed around the memorial tower, their resentment will finally be sublimated into joy. Naju City would become a landmark for Donghak if its administration put the plans into practice. People will be able to feel the resentment of Donghak Peasant Army and their descendants when visiting Naju.
헛개나무(Hovenia dulcis var. koreana) 과병 열수추출분획물의 간보호 및 혈중 알콜 저하 작용
나천수,정남철,양규환,김세현,정하숙,동미숙 대한약학회 2004 약학회지 Vol.48 No.1
Hovenia dulcis which is distributed in Korea, China and Japan is known to show hepatoprotctive effect and reduce the acute alcohol toxicity. In this study, the hepatoprotective effect against the chemically induced experimental liver injury models and lowering effect of blood alcohol level in animal models acutely administered alcohol by the peduncle extracts of Hovenia dulcis var. koreana were investigated. HdfHW-1, and HdfM-1 which are the extracts of fruit peduncles and young branches with hot water or 70% methanol and followed with 100% methanol, were significantly reduced the $CCl_4$ or D-galactosamine/LPS induced damage in sliced liver. The hot water or methanol extracts of fruit peduncle protected dose-dependently against $CCl_4$ induced toxicity in primary hepatocyte culture and particularly, the amount of LDH release was reduced to the control level at 500 $\mu\textrm{g}$/ml of hot water extracts. HdfHW-1 also decreased the hepatotoxicity induced by $CCl_4$ in rats. The active components of HdfHW-1 seemed to be high molecular weights because 0.2 M NaCl HdfHW-1 fraction was the most effective among NaCl fractions of HdfHW-1 eluted with various concentrations of NaCl on DEAE 650C column chromatography. HdfM and HdfHW were significantly reduced the levels of blood alcohol in rats and mice administered 40% alcohol. These results indicated that the hot water or methanol extracts of fruit peduncle of Hovenia dulcis var. koreana have hepatoprotective effect and may be reduce alcohol toxicity.
랫드를 이용한 헛개나무과병 열수추출물 투여가 운동에 의한 피로회복과 운동수행능력에 미치는 기전 규명
나천수,김희경,김진범,노현정,엄나나,노혜지,나대승,동미숙,홍철이 대한약학회 2013 약학회지 Vol.57 No.5
The present study investigated the effects of Hovenia Dulcis (HD) fruit extract powder on the improvement of physical activity, especially exercise capacity. Forty mice were divided into 4 groups including normal controls, negative controls, 100 (HD-100) and 200 (HD-200) mg/kg HD fruit extract powder groups for 5-times exercises using treadmill. Nor- mal control did not performed treadmill running but others did 5-times for 10 days. HD fruit extract powders were admin- istrated orally one-times per day for 10 days before treadmill exercise and normal and negative controls were fed with excipient water. After 5-times exercise, blood biochemical analysis showed that aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine phosphokinase (CK) activities and blood lactate concentration were statistically increased in negative controls than in normal controls. They were decreased in HD fruit extract powder groups, compared with negative controls. These results were considered as the effects of HD fruit extract powders on reduced tissue damages during exercise. Other measured indices did not reveal remarkable differences. All together, these results suggest that HD fruit extract powders may enhance the exercise performance by recovering the exercise-fatigue via blood lactate con- centration by reducing blood LDH activity and via reduction of blood CK and AST activity.