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이민화,곽효성,송영준,조용백,신광범 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.2
The study was performed to compare the dissolution, diffusion and absorption characteristics using Sartorius dissolution and absorption simulator and in vivo bioavailability of commercially available rifampicin capsules. Both brands C and F showed similar dissolution patterns and absorption properties through artificial gastric barrier in Sartorius simulator. Diffusion rate constants through the membrane of brands C and F were 3.04×40^(-3) and 2.88×10^(-3)㎝/min, respectively. Rifampicin capsules were administered orally to six fasted healthy volunteers according to cross-over design. The pharmacokinetic parameters between brands C and F, maximum plasma drug concentration (C_(max)), the time to reach C_(max), absorption rate constant and area under the curve (AUC_(0-24hr)), elimination rate constant, and amount of drug excreted in urine were 6.11 and 7.27 ㎍/㎖, 2.71 and 1.52 hr, 0.6371 and 1.6456 hr^(-1), 57.84 and 57.28㎍·hr/㎖, 0.1891 and 0.1734 hr^(-1), 119.98 and 119.93 ㎎, respectively. On the basis of experimental results, it was concluded that the bioavailability of brand C rifampicin capsules was almost the same as that of brand F rifampicin capsules.