염색체 7번 장완의 부분적 역위 중복 1례

김현지,이소영,김미영,백청순,김원덕,이동석,김두권,최성민,Kim, Hyun Ji,Lee, So Young,Kim, Mi Young,Baek, Chung Sun,Kim, Won Duck,Lee, Dong Seok,Kim, Doo Kwun,Choi, Sung Min 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.5

Duplication of chromosome 7q has been reported as either partial or complete. Partial 7q duplication was first described by Carpentier in 1972. Pure partial duplication of the long arm of chromosome 7 is extremely rare and only 16 cases with a pure partial duplication of different 7q segment have been described in the literature. Pure partial duplication of the long arm of chromosome 7 is characterized by growth and developmental retardation, muscular hypotonia, distinct craniofacial dysmorphic features, a short neck and skeletal abnormalities. A 3 month-old male was referred to our department of Pediatrics because of dyspnea, hypotonia and delayed development. He shows growth and developmental delay, hypertelorism, a depressed nasal bridge, low set ears, a short neck and muscular hypotonia. Karyotype revealed 46, XY, dup(7)(q36q33) by GTC-banding. We report a case of a partial inverted duplication of chromosome 7q. 저자들은 호흡곤란, 근력저하, 발달지체로 병원에 온 3 개윌된 남아의 염색체 핵형분석에서 46, XY, dup(7)(q36q33)으로 진단된 1례를 경험하였기에 보고하는 바이다.

계획행동이론을 적용한 하동지역 농업유산관광객의 행동의도 - 농업유산에 대한 지각된 가치와 사전적 지식의 역할을 중심으로 -

김현지,황길식,Kim, Hyun-Ji,Hwang, Kil-Sik 한국농촌계획학회 2018 농촌계획 Vol.24 No.2

The study aims to predict the behavior of tourists in Hadong County, which is registered as KIAHS. Based on the theory of planning behavior, we intend to verify the theory of planned behaviour, which adds descriptive parameters of the perceived value and prior knowledge of an agricultural heritage. In detail, first, the perceived value and prior knowledge of tourists about an agricultural heritage understand the influence of tourists' Attitude. Second, we could see the role of the behavioral factors in the causal relationship of the planned behavioral theory. We have identified the planned behavioral theory that attitudes, subjective norms, and perceptual behavior controls affect the intention of the revisit. Hadong should remember that by sending and providing various information about Hadong Green Tea and World Agricultural Heritage sites, it is possible to elicit changes in visitor attitudes and revisit visits.

단독주택 공부방의 조명환경 실태조사

김현지,안옥희,Kim, Hyun-Ji,An, Ok-Hee 한국조명전기설비학회 2005 조명·전기설비학회논문지 Vol.19 No.7

본 연구에서는 단독주택 공부방을 대상으로 조명환경 실태조사를 실시하였다. 그 결과, 공부방은 주로 형광등을 사용하였으며 배광방식은 직접조명 방식을 사용하고 있었다. 또한 국부조명을 사용하는 비율은 48.2[%]로 시작업이 효과적이지 못하였다. 내부공간 조도는 평균 131.41[lx]이며, 책상면 조도는 322.57[lx]로 최저허용조도의 54[%]에 해당하는 열악한 실정이었다. 또한 사용자의 조명환경에 비해 만족도는 높아 조명에 대한 인식이 매우 부족한 것으로 사료된다. In this study, we investigated the actual conditions of illumination environment of study rooms in detached houses. From the results, fluorescent lamp as a lighting source and direct lighting method were mainly used. The additional use of local lighting was 48.2[%], and it was not efficient for detailed work. The average illuminance of general lighting and local lighting were 131.41[lx] and 322.57[lx], respectively, and these level were only 54[%] of the lowest illumination standard. This indicates that the lighting levels and the environment are so poor. The satisfaction level of users, however, was relatively high, suggesting insufficient recognition of importancy of lighting for efficient work.

수질(水蛭)이 THP-1세포의 사이토카인 유전자 발현에 미치는 영향

김현지,김경준,Kim, Hyun-Ji,Kim, Gyung-Jun 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.1

Objective : This study was performed to evaluate the effect of immune reaction inductive substances such as PMA, LPS, DPE, DNCB and WP, the whitman pigra extracting substance at simultaneously on the translocation of $NF{\kappa}B$ towards to the nucleus and the mRNA expression patterns of various cytokine genes in THP-1 cells, monocytes of human. Methods : To analyze the cytokine genes expressions, the RT-PCR method was used, and measuring TNF-${\alpha}$ that had been secreted during cell culture by the ELISA method. The morphological changes were observed during THP-1 cell by a scanning electron microscope and the quantitative distribution of $NF{\kappa}B$ in the cell that was analyzed through immunocytochemistry and a confocal microscopy. Results : WP showed different influences onto the mRNA expression patterns of cytokine genes with PMA, LPS. DPE and DNCB according to the types of immune inductive substances in the THP-1 cells. Upon treating PMA and DPE on the THP-1 cells at the same time or either additionally treating WP thereon, the movement of $NF{\kappa}B$ increase towards the nucleus from cell cytoplasm was able to be observed. The expressions of IL-$1{\alpha}$ and IFN-${\gamma}$ induced by PMA and PMA+DNCB were suppressed by WP while the expression of TGF-${\beta}$ was promoted. Regarding the secretion pattern of TNF-${\alpha}$ according to the treatment of PMA, its secretion amount was incredibly increased by concurrent treatment of WP, however, in case of co-treatment of WP with PMA and DNCB, it was found that the secretion amount of TNF-${\alpha}$ decreased. Conclusions : In this study, the WP extracting substance was confirmed that it had an influence on expression patterns of cytokine genes according to the actions of a variety kinds of immune reaction inductive substances treated on the THP-1 cells. Especially, WP co-treatment with PMA and DNCB was suppressed the expression of inflammatory cytokines, such as IL-$1{\alpha}$, IFN-${\gamma}$ and TNF-${\alpha}$.

전호(前胡)가 Bleomycin에 의한 폐 섬유화에 미치는 영향

김현지,이해자,박은정,Kim, Hyun-Ji,Lee, Hai-Ja,Park, Eun-Jung 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.2

Objectives : Idiopathic pulmonary fibrosis (IPF) is chronic fibrotic interstitial pneumonia and the pathogenesis is unknown. Peucedani Radix is well-known for the treatment of respiratory diseases and pulmonary hypertension. This study was to evaluate the effectiveness of Peucedani Radix on the bleomycin-induced lung fibrosis model (BLFM) in mouse. Methods : We induced lung fibrosis by intratracheal instillation of bleomycin in C57BL/6J. We compared two groups BLFM without Peucedani Radix (group I) and BLFM with Peucedani Radix (group II). We performed bronchoalveolar lavages (BAL) and obtained lung specimens from both group I and II on the 7th (A) and 21st (B) day, and also for the normal group. We compared with group I and II to find BAL by using ANOVA test and to find pathologic symptoms by using semiquantitative histological index (SHI). Results : In BAL, total cell counts, lymphocytes, and neutrophils was increased in both group I and II comparing with normal group. However, lymphocyte level was decreased more in group IIB than group IB. It was statistically significant. In microscopic findings, scores of SHI in normal group, group IB and IIB were 0.33, 4.47, and 1.96 each. Conclusions : Peucedani Radix might have inhibitory effect on lung fibrosis by reducing inflammatory cells in bleomycin-induced lung fibrosis model in mouse.

적록 색각 이상자를 위한 HSV색공간을 이용한 색변환 기법

김현지,조재영,고성제,Kim, Hyun-Ji,Cho, Jae-Young,Ko, Sung-Jea 대한전자공학회 2013 전자공학회논문지 Vol.49 No.11

본 논문에서는 적록색각 이상자를 위한 색 변환 알고리즘을 제안한다. 적록색각 이상자는 원추세포의 이상으로 인해 색상과 명도를 일반인과 다르게 인지하기 때문에 적색과 녹색의 구분에 어려움을 겪는다. HSV 색공간은 이러한 특성을 파악할 수 있는 인간의 색지각과 유사한 색 공간으로, 제안하는 방법에서는 HSV 색 공간에서 색상과 명도를 보정하여 색을 변환 한다. 이때 색상과 명도 보정정도는 개개인의 색각이상 심각도에 따라 다르게 결정된다. 색각 이상자 개개인에 따라 다른 보정정도를 적용함으로서 기존 이미지의 자연스러움은 유지 하고 구분하기 힘들었던 색상들도 구분 가능하게 변환된다. 제안하는 방법을 색각 이상자에게 적용하여 시뮬레이션으로 확인한 결과, 색각 이상자가 구분하기 힘든 색상들이 색상의 자연스러움을 유지하면도 색차를 인지할 수 있는 색으로 변환되는 것을 확인할 수 있었다. This paper proposes a new re-coloring method for the people with the red-green color vision deficiency (CVD). These people have difficulty in discriminating the red and green colors since they abnormally perceive the hue and luminance value of the colors. We introduce a color transformation that adjusts the hue and luminance value in HSV color space. The color transformation is determined according to the severity of CVD. Our aim is to maintain the color differences in original image while maintaining the recolored image to be natural to the people with normal color vision. Experimental results show that the proposed method can yield more comprehensible images for the people with red-green CVD while maintaining the naturalness of the recolored images.

도로포장체의 동결에 영향을 미치는 통계적 요인

김현지,이제영,김병두,조규태,Kim, Hyun-Ji,Lee, Jea-Young,Kim, Byung-Doo,Cho, Gyu-Tae 한국데이터정보과학회 2016 한국데이터정보과학회지 Vol.27 No.1

우리나라의 기후적 특성으로 토지가 동절기에는 동결작용을 받고 해빙기에는 융해작용을 받는다. 이러한 동결융해작용의 피해를 최소화하기 위하여 도로 포장 분야에서는 도로 포장 두께에 관한 많은 연구들이 진행 중에 있다. 본 연구는 도로포장 현장계측 온도데이터를 이용하여, 도로 포장 두께를 위해 사용되는 변수들의 적절성을 확인하기 위해 엔트로피 지수를 이용한 의사결정나무 분석을 시행한다. 각 층 온도를 이용하여 생성한 최저동결층 (순서형 변수)을 목표변수로 분석하며, 분석에 사용된 독립변수는 동결지수에 따라 $350{\sim}450^{\circ}C{\cdot}$일, $450{\sim}550^{\circ}C{\cdot}$일, $550{\sim}650^{\circ}C{\cdot}$일로 구분된 지역 변수, 절토부, 절성경계부, 2m 이하 성토부 구간으로 이루어진 단면 변수 그리고 동상방지층 설치 유무이다. 또한, 월과 대기온도도 독립변수에 포함시킨다. 그 결과, 월, 동상방지층 유무, 대기온도, 지역 순으로 최저동결층에 영향을 주는 것으로 나타났다. Due to the character of the climate of Korea, the pavement of a road is Influenced by freezing in winter season and thawing in thawing season. In the last few years, several articles have been devoted to the study to minimize the damage of freezing and thawing action. The purpose of this paper is to identify appropriacy of factors that influence road pavement thickness. We conduct the decision tree analysis on the field data of road pavement. The target variable is 'Frost penetration'. This value was calculated from the temperature data. The input variables are 'Region', 'Type of road pavement', 'Anti-frost layer', 'Month' and 'Air temperature'. The region was divided into 9 regions by freezing index $350{\sim}450^{\circ}C{\cdot}day$, $450{\sim}550^{\circ}C{\cdot}day$, $550{\sim}650^{\circ}C{\cdot}day$. The type of road pavement has three-section such as area of cutting, boundary area of cutting and bankin, lower area of banking. As the result, the variables that influence 'Frost penetration' are Month, followed by anti-frost layer, air temperature and region.

빛공해의 인식 및 문제점에 관한 조명전문가 의식조사

김현지,Kim, Hyun-Ji 한국조명전기설비학회 2010 조명.전기설비 Vol.24 No.5

골연령 측정을 통한 한방 성장 치료의 임상적 연구

김현지,이해자,박은정,Kim, Hyun-Ji,Lee, Hai-Ja,Park, Eun-Jung 대한한방소아과학회 2006 대한한방소아과학회지 Vol.20 No.3

Objectives : The object of this study was to evaluate the effect of oriental medical treatment to the growth of children using bone age as measurer. Methods : This clinical study has been carried out with 32 cases(male 15, female 17 of children) aging from 7 to 15 years old, who visited to the Department of Pediatrics growth clinic, ○○ medical center from January 2004 to August 2006 and were treated for more than 12 months. Their height, body weight, body mass index(BMI) and bone age were estimated at two points: Before and after oriental medical treatment was applied. Bone age is measured by X-ray image of growth plate in inferior radiocarpal joint. Results : Bone age correlated with choronological age, height, weight. Difference between bone and choronological age was correlated with percentile of height and weight. The mean growth of children showed 4.03 percentile upwardly(p=.046), and difference between bone and choronological age was reduced from $0.23{\pm}1.62$ to $-0.026{\pm}1.64(p=.040)$ after treatment. Conclusions : This study shows that oriental medical treatment helped growth of children using bone age as measurer.

허약아(虛弱兒) 증상 연구를 통한 인터넷 중독의 한의학적 접근

김현지,박은정,Kim, Hyun-Ji,Park, Eun-Jung 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.2

Objectives : The purpose of this study is to research the internet addiction and the Weak children. Methods : Total 400 of 5th and 6th grade JeonJu Elementary student children consisted with 203 men, 197 women were chosen for this study. They answered questionnaires of the internet addiction and the Weak children on June 12th, 2008. Results : 75% were general internet user, latent danger user group was 14.7%, high danger user group was 10.3%. The mean of the general weak children was the highest and then the group of children who had Heart, the Lung, the Liver, the Spleen, the Kidney problems were followed. These showed the relationships with living styles, especially eating patterns and parents' concerns about children's internet use. The more serious internet addiction was, the more the weaker children symptoms were answered significantly. The heart weak children symptoms were found in latent-high danger internet user group. Conclusions : In conclusion, the physical and psychological symptoms of the internet addiction children were resulted by the disturbance of Qi and the pathological change of internal organs.