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Vitamin A와 Ethanol이 Dimethylnitrosamine에 의한 Mouse조직내의 DNA, RNA 및 단백질의 손상도에 미치는 영향
김재현,홍연탁,박정식,김승희,강태규,홍성렬,박창원,권오철,이동권,Kim, Jea-Hyun,Hong, Youn-Tak,Park, Jung-Sik,Kim, Seung-Hee,Kang, Tea-Gyu,Hong, Sung-Roul,Park, Chang-Won,Kweon, O-Cheol,Rhee, Dong-Kwon 생화학분자생물학회 1991 한국생화학회지 Vol.24 No.6
Dimethylnitrosamine(DMN)은 간 및 폐, 신장, 식도 등에 앙을 유발시키는 물질이며 정상인의 혈액 및 뇨에서도 0.1~1 ppb정도가 검출되고 있다. DMN은 DNA를 methylation시켜 비정상적인 adduct를 형성하여 암을 유발하게 된다. 본 연구는 ethanol 또는 vitamin A를 mouse에 전처리 하였을 때 $[^{14}C]$으로 표지된 DMN이 생체내의 DNA, RNA 및 단백질과 어느 정도 공유결함을 형성하여 손상을 주는지 측정하였다. 실험결과 DMN은 뇌 또는 췌장에서 보다는 간에 선택적으로 결합하였으며 이 때 간의 DNA와 결합하는 것이 단백질 또는 RNA와 결합하는 것보다 각각 1.4배와 1.75배 높았다. Ethanol을 전처리 하였을 때는 DMN이 ethanol을 투여하지 않은 군보다 간의 경우 RNA와 단백질이 각각 7.5배, 1.4배 정도 더 결합하였다. Ethanol을 전처리한 뇌의 DNA에 6.7배 많이 결합하였으나 RNA에는 오히려 대조군의 15.9% 정도로 크게 감소되었다. 또한, 췌장의 단백질에는 2.0배, RNA의 경우 1.7배 정도 각각 더 결합한 결과를 나타내었다. 반면에 vitamin A 전처리군에서 간 단백질의 adduct는 35% 유의성 있게 감소되었으나 뇌 DNA에서 는 유의성 있게 9.5배 증가하였다. Dimethylnitrosamine(DMN) has been shown to induce tumors of the liver, kidney, esophagus and lung. Furthermore low levels of DMN (0.1~1 ppb) have been detected in normal human blood as well as urine. The purpose of this study is to determine extent of the covalent binding of DMN to DNA, RNA and protein in ethanol- and vitamin A- pretreated mouse. Ethanol or vitamin A was administered for 3 weeks and $^{14}C$-labeled DMN was administered intraperitoneally. Then DNA, RNA and protein were isolated from liver, brain and pancreas and used for determination of radioactivity. DMN was bound selectively to liver DNA rather than brain or pancreas DNA. DNA damage in liver was 1.4 and 1.7 times greater than protein and RNA damage, respectively. Ethanol pretreatment and vitamin A pretreatment increased DNA damage in brain significantly upto 6.7 and 9.5 times, respectively, than the control group.
Vitamin A 와 Ethanol 이 Dimethylnitrosamine 에 의한 Mouse 조직내의 DNA , RNA 및 단백질의 손상도에 미치는 영향
김재현,홍연탁,박정식,김승희,강태규,홍성렬,박창원,권오철,이동권 ( Jea Hyun Kim,Youn Tak Hong,Jung Sik Park,Seung Hee Kim,Tea Gyu Kang,Sung Roul Hong,Chang Won Park,O Cheol Kweon,Dong Kwon Rhee ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.6
Dimethylnitrosamine(DMN) has been shown to induce tumors of the liver, kidney, esophagus and lung. Furthermore low levels of DMN (0.1∼1 ppb) have been detected in normal human blood as well as urine. The purpose of this study is to determine extent of the covalent binding of DMN to DNA, RNA and protein in ethanol- and vitamin A- pretreated mouse. Ethanol or vitamin A was administered for 3 weeks and ^(14)C-labeled DMN was administered intraperitoneally. Then DNA, RNA and protein were isolated from liver, brain and pancreas and used for determination of radioactivity. DMN was bound selectively to liver DNA rather than brain or pancreas DNA. DNA damage in liver was 1.4 and 1.7 times greater than protein and RNA damage, respectively. Ethanol pretreatment and vitamin A pretreatment increased DNA damage in brain significantly upto 6.7 and 9.5 times, respectively, than the control group.
김재현(Jae-Hyun Kim),전현재(Hyun-Jae Jeon),유재근(Jae-Geun Yoo),서상규(Sang-Gyu Seo),박호(Ho Park) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.11
The receiver detects magnetic field and/or ground potiential which are induced by the signal of the transmitter in some underground cables locating systems. In these systems magnetic field sensor is a vital component. It is very important to make magnetic field sensor economically in development of underground cables locating systems. It was verified that the detection of magnetic fields can be done in locating underground cables by using magnetic field sensor which consists of a LC resonant circuit and a High Impedance differential amplifier. It can be manufactured easily and economically.
병원 전문화가 건당 재원일수와 건당 의료비에 미치는 영향
김재현 ( Jae-hyun Kim ),박은철 ( Eun-cheol Park ),김태현 ( Tae Hyun Kim ),이광수 ( Kwang Soo Lee ),김영훈 ( Young Hoon Kim ),이상규 ( Sang Gyu Lee ) 한국보건행정학회 2016 보건행정학회지 Vol.26 No.2
Background: Over the last few decades, because hospitals in South Korea also have undergone dramatic changes, Korean hospitals traditionally have provided specialized health care services in the health care market. Inner Herfindahl-Hirschman Index (IHI) measures hospital caseloads based on patient proportions, independent of patient volumes. However, IHI that rely solely on patient proportions might be problematic for larger hospitals that provide a high number of diagnosis categories, as the patient proportions in each category are naturally relatively smaller in such hospitals. Therefore, recently developed novel measure, category medical specialization (CMS) is based on patient volumes as well as patient proportions. Methods: We examine the distribution of hospital specialization score by hospital size and investigate association between each hospital specialization and length of stay per case and hospital cost per case using Korean National Health Insurance Service-cohort sample data from 2002 to 2013. Results: Our results show that IHI show a decreasing trend according to the number of beds and hospital type but CMS show an increasing trend according to the number of beds and hospital type. Further, inpatients admitted at hospitals with higher IHI and CMS had a shorter length of stay per case (IHI: B=-0.104, p<0.0001; CMS: B=-0.044, p=0.001) and inpatients admitted at hospitals with higher IHI and CMS had a shorter hospital cost per case (IHI: B=-0.110, p=0.002; CMS: B=-0.118, p=<0.0001). Conclusion: This study may help hospital policymakers and hospital administrators to understand the effects of hospital specialization strategy on hospital performance under recent changes in the Korean health care environment.
전이성 대장암에서 1차 치료로 FOLFOX-4 또는 FOLFIRI 복합화학약물 치료 후의 예후 인자 분석
김재현 ( Jae Hyun Kim ),최평락 ( Pyoung Rak Choi ),박선자 ( Seun Ja Park ),박무인 ( Moo In Park ),문원 ( Won Moon ),김성은 ( Sung Eun Kim ),이규원 ( Gyu Won Lee ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.4
Background/Aims: Information on prognostic factors for metastatic colorectal cancer is an important basis for planning the treatment and predicting the outcomes of the patients; however, it has not been well established. The aim of this study was to identify factors that predict results of chemotherapy and to establish a plan for treatment of patients whose tumors are inoperable due to metastatic colorectal cancer. Methods: We conducted a retrospective review of records from 75 patients treated for colorectal cancer in Kosin University Gospel Hospital, from October 2004 to September 2008. Patients with inoperable tumors due to metastasis at the time of diagnosis who were treated with oxaliplatin or irinotecan as the first-line treatment were included in this study. We investigated the factors that might have an effect on overall survival. Results: A total of 75 patients were included in this study. Results of univariate analysis showed that hemoglobin (Hb) ≥10 g/dL at the time of diagnosis, no increase in CEA on the follow-up examination after chemotherapy, chemotherapy plus surgery, and better response to chemotherapy were significant prognostic factors. Results of multivariate analysis showed that Hb ≥10 g/dL at the time of diagnosis (p<0.001), surgery after chemotherapy (p=0.001), and better response to chemotherapy (p=0.014) were significant prognostic factors. Conclusions: In this study, Hb ≥10 g/dL at the time of diagnosis, surgery after chemotherapy, and better response to chemotherapy were significant prognostic factors for metastatic colorectal cancer.
관해 상태인 크론병 환자에서 Saccharomyces Boulardii 복용 후 Crohn's Disease Activity Index의 변화: 단일 기관 후향적 연구
오규만 ( Gyu Man Oh ),문원 ( Won Moon ),서광일 ( Kwang Il Seo ),정경원 ( Kyoungwon Jung ),김재현 ( Jae Hyun Kim ),김성은 ( Sung Eun Kim ),박무인 ( Moo In Park ),박선자 ( Seun Ja Park ) 대한소화기학회 2020 대한소화기학회지 Vol.76 No.6
Background/Aims: Crohn’s disease (CD) is characterized by uncontrolled inflammation of the intestine. Saccharomyces boulardii (S. boulardii), a probiotic, stabilizes the intestinal wall. This study examined the changes in the CD activity index (CDAI) after taking S. boulardii in patients with CD in clinical remission. Methods: In this single hospital-based retrospective cohort study, the medical records of CD patients in clinical remission, who had received S. boulardii for more than 6 months, were reviewed. The CDAI, BMI, and serum levels of hemoglobin (Hb), ferritin, iron, vitamin B12, folate, total protein, albumin, total cholesterol, CRP, and fecal calprotectin (FC) between the initiation and the 6th month were compared. The timing and reasons for the discontinuation were also investigated. Results: One hundred and fifty-four patients were included, and 92 patients, who received for more than 6 months, were analyzed. The changes in CDAI, BMI, Hb, and total cholesterol were significant as follows: CDAI from 38.52 to 30.53 (p<0.01), BMI (kg/m<sup>2</sup>) from 23.38 to 23.97 (p<0.01), Hb (g/dL) from 13.73 to 14.03 (p<0.01), and total cholesterol (mg/dL) from 154.9 to 161.5 (p<0.01). On the other hand, the changes in FC, CRP, ferritin, vitamin B12, folate, total protein, and albumin were not statistically significant. Only one patient stopped due to a flare-up, but this was not believed to be related to the drug. Conclusions: In patients with CD in remission, S. boulardii appears to improve the CDAI, BMI, serum Hb, and total cholesterol level without safety issues. Further randomized controlled studies will be needed. (Korean J Gastroenterol 2020;76:314-321)
임상적 관해기의 궤양성 대장염 환자에서 Escherchia coli Nissle 1917의 치료 효과: 단일 병원 코호트 연구
오규만 ( Gyu Man Oh ),문원 ( Won Moon ),서광일 ( Kwang Il Seo ),정경원 ( Kyoungwon Jung ),김재현 ( Jae Hyun Kim ),김성은 ( Sung Eun Kim ),박무인 ( Moo In Park ),박선자 ( Seun Ja Park ) 대한소화기학회 2021 대한소화기학회지 Vol.77 No.1
Background/Aims: Escherichia coli Nissle 1917 (EcN) alone therapy is as effective as mesalamine in inducing and maintaining remission in ulcerative colitis (UC). The efficacy and safety of EcN in combination with standard therapies have not been studied. This study examined the changes in the inflammation markers and symptoms following the additional administration of EcN to patients showing the clinical remission of UC. Methods: UC patients who received EcN after being in clinical remission for more than 3 months at Kosin University Gospel Hospital between 2013 and 2018 were evaluated through the retrospective medical-record-based review. The partial Mayo score, fecal calprotectin (FC), BMI, hemoglobin, serum cholesterol, serum albumin levels, and the safety profiles were examined at 3rd and 6th months after initiating EcN. Results: Ninety-four patients were included. After 3 months of treatment, there was no significant change in FC (156.3 μg/g to 141.1 μg/g) (p=0.653). On the other hand, partial Mayo score decreased significantly from 0.085 to 0.014 (p=0.025), and the bodyweight (p=0.001), BMI (p<0.001), hemoglobin (p=0.009), and cholesterol level increased (p=0.148). One patient (1.1%) experienced a serious adverse event with UC flare-up, and 14 patients (14.9%) discontinued EcN due to adverse events; all developed within 3 months. Conclusions: Additional administration of EcN to clinically remission-attained UC patients may improve the UC symptoms without changing the FC levels. EcN-associated adverse events develop within the early few weeks. (Korean J Gastroenterol 2021;77:12 -21)