조현병 환자의 유병기간에 따른 강박증상

서주현,백인호,김임렬,김수룡,조정민,Seo, Ju-Hyun,Paik, In-Ho,Kim, Im-Yel,Kim, Su-Ryong,Jo, Jung-Min 대한생물정신의학회 2018 생물정신의학 Vol.25 No.2

Objectives The aim of this study was to evaluate the psychopathological features such as depression and anxiety in schizophrenics with obsessive-compulsive symptoms (OCS) as well as the severity of OCS according to duration of schizophrenia. Methods We randomly selected sixty four inpatients with schizophrenia. We classified the patients into two groups (OCS group, non-OCS group) according to the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Clinical and demographic features were evaluated. To assess OCS, Y-BOCS were performed. The Korean version of the Positive and Negative Syndrome Scale(K-PANSS), the Brief Psychiatric Rating Scale (BPRS), the Korean version of the Calgary Depression Scale for Schizophrenia (K-CDSS), the Beck Anxiety Inventory (BAI) and the Satisfaction With Life Scale (SWLS) were conducted. Independent t-test and chi-square test were conducted to compare the two groups. Pearson correlation analysis was performed to examine the relationship between the duration of schizophrenia and the Y-BOCS score. Results The Y-BOCS, K-CDSS, and BAI scores were higher in the OCS group. There was a significant correlation between the duration of schizophrenia and the Y-BOCS score. Conclusions Anxiety and depression symptoms were severe in the OCS group. In addition, the results of this study indicate that the longer duration of schizophrenia, the more severe the OCS. Therefore, the evaluation of OCS in schizophrenics should be accompanied by treatment intervention.

한국인 정신분열병 환자의 안구추적운동 이상과 COMT 유전자의 Val108/158Met 다형성의 연합 연구

장호준,문현일,이연정,김임렬,이인상,서한길,김기훈,신태민,박병래,신형두,한선호,한상우,우성일,Jang, Ho Joon,Moon, Hyun-Il,Lee, Yeon Jung,Kim, Im-Yel,Lee, In-Sang,Seo, Han-Gil,Kim, Ki-Hoon,Shin, Tae-Min,Park, Byung-Lae,Shin, Hyung Doo,Han, Sun 대한생물정신의학회 2008 생물정신의학 Vol.15 No.4

Objectives : We investigated the association of Val108/158Met polymorphism on catechol-O-methyl transferase(COMT) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenia patients. Methods : We measured SPEM in 217 Korean schizophrenia patients(male 116, female 101) and divided them into two groups, one was a good SPEM function group and the other was a poor SPEM function group. Then we analyzed Val108/158Met polymorphism on COMT gene. We compared the differences of genotype and allele distributions of the polymorphism on COMT gene between the two groups. Results : The natural logarithm value of signal/noise ratio(Ln S/N ratio) of the good SPEM function group was $4.39{\pm}0.33$(mean${\pm}$s.d.) and that of poor SPEM function group was $3.17{\pm}0.71$. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the Val108/158Met polymorphism on COMT gene between the two schizophrenic groups. Conclusions : The results suggest that Val108/158Met polymorphism on COMT gene is not related to SPEM function abnormality in schizophrenia.

한국인 정신분열병 환자의 안구추적운동 이상과 Dystrobrevin Binding Protein 1(DTNBP1) 유전자의 SNP A와 P1763 다형성의 연합에 대한 연구

이창희,박병래,김령효,김동현,조숙현,박진수,김임렬,이인상,서한길,변기욱,김봉조,한규희,김기훈,신태민,신형두,우성일,Lee, Chang Hee,Park, Byung-Lae,Kim, Lyoung Hyo,Kim, Dong Hyeon,Cho, Sook Hyun,Park, Jin-Soo,Kim, Im-Yel,Lee, In-Sang,Seo, Han-Gil,Byun, 대한생물정신의학회 2006 생물정신의학 Vol.13 No.4

목 적: 정신분열병 환자의 안구추적운동 이상은 유력한 생물학적인 지표이나 유전자적인 원인에 대한 연구가 활발히 진행되지 못하였다. 최근 여러 연구들에서 dystrobrevin binding protein 1(DTNBP1, dysbindin)이 정신분열병의 원인 유전자의 후보 유전자로서 시사되었으나 정신분열병 환자의 안구운동 이상의 원인으로 작용할 것인지에 대한 연구는 거의 없었다. 본 연구의 목적은 DTNBP1 유전자상에 존재한 비교적 인접한 두개의 단염기 다형성들인 SNP A와 P1763이 정신분열병 환자의 안구추적운동 이상의 유전자적인 원인으로 작용할 것인지를 알아보고자 시행되었다. 방 법: 대상군은 217명의 입원한 만성 정신분열병 환자들이며 안구운동(SPEM)을 측정하였고, 신호/잡음의 자연대수 값(Ln S/N ratio)을 구하여 안구운동이 우수한 군과 열등한 군으로 구분하였다. 이후 대상군의 혈액에서 추출한 DNA로부터 DTNBP1 유전자상의 단 염기 다형성들인 SNP A와 P1763를 분석하여 유전자형과 대립인자형을 알아낸 후, 안구운동 이상 유무에 따른 두 군사이의 분포의 차이를 조사하였다. 결 과: 정신분열병 환자들 중 안구운동이 우수한 군의 신호/잡음의 자연대수 값(Ln S/N ratio)의 평균과 표준편차는 $4.39{\pm}0.33$이었고, 안구운동이 열등한 군의 신호/잡음의 자연 대수 값(Ln S/N ratio)의 평균과 표준편차는 $3.17{\pm}0.71$이었다. 두 군 사이에 나이나 성별비율의 차이는 통계적으로 의미가 없었다. SNP A와 P1763의 유전자형과 대립인자형의 분포의 차이는 안구운동 이상 유무에 따라 구분한 두군 사이에 나타나지 않았다. 결 론: DTNBP1 유전자상에 존재한 SNP A와 P1763은 정신분열병 환자의 안구추적운동 이상의 유전자적인 원인으로 작용한다는 증거를 얻지 못하였다. Objectives : We investigated the association of SNP A and P1763 polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenic patients. Methods : We measured SPEM function in 217 Korean schizophrenics(male 116, female 101) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. We then analyzed SNP A polymorphism and P1763 polymorphism on DTNBP1 gene from their DNAs extracted from their blood. We compared the differences of genotype and allele distributions of the two polymorphisms on DTNBP1 gene between the two groups. Results : The Ln S/N ratio(mean${\pm}$SD) of the good SPEM function group was $4.39{\pm}0.33$ and the ratio of poor SPEM function group was $3.17{\pm}0.71$. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the SNP A polymorphism and P1763 polymorphism on DTNBP1 gene between the two schizophrenic groups divided by SPEM function. Conclusion : The results suggest that SNP A polymorphism and P1763 polymorphism on DTNBP1 gene might not be related to SPEM function abnormality in schizophrenia.

여성 알코올중독 환자의 인격 특성에 관한 연구

성상경(Sang-Kyung Sung),강지언(Ji-Eon Kang),김임렬(Im-yel Kim),함웅(Woong Hahm) 한국중독정신의학회 1998 중독정신의학 Vol.2 No.1

Objectives:This study was performed to identify the characteristics of alcoholics by comparing the characteristics of male and female alcoholics with those of a control group and to make therapeutic consideration for female alcoholics by using the identified characteristics of female alcoholics. Subjects and Methods:1) Subjects:We made two experimental groups composed of male alcoholics (N=34) and female alcoholics (N=34) who had been admitted to Keyo Hospital from January 1992 to May 1996 and one control (normal female adult) group (N=34) composed of students, the hospital personnel, and their family members. We controlled the age and the number to compare the groups. The average age of female alcoholics was 41.12±9.9, male alcoholics 41.23±10.22, and the control group 39.47±12.80. All male and female patients satisfied the DSM-Ⅲ-R criteria of alcohol dependence. 2) Method:We reviewed the patients’ charts and used a demographic statistical questionnaire and MMPI questionnaire. 3) Data analysis:Student’s t-test and chi-square test were used where appropriate. All statistical analyses were carried out with SPSSPC+Version 4.0 software. A probability of p<0.05 (two-tailed) was accepted as statistically significant. Result:1) The demographical statistics showed that the education level, economic status, and occupational status of the male and female patient groups were significantly different from those of the female control group. 2) As regards the drinking history, the reason for alcohol drinking and use of other substances, there was no difference between the male and female patient groups. But the female patient group was significantly different from the female control group. 3) When the characteristics of the male and female patient groups were compared through mean MMPI T-scores, they were not significantly different from each other. But the female patient group was significantly different from the female control group. 4) The code type comparison showed that the female and male patient groups marked higher frequency of Pd scale score on one code digit than the female control group. Also the female patient group had higher frequency of characterological profile by Lachar classification on two code digit than the female control group. Conclusion:Therefore female alcoholics are different from normal female adults. They are more impulsive and antisocial. And they have marital problem, anxiety, insomnia, and affective problem.

양극성 장애의 인지적 병식 및 역기능적 태도와 증상 간의 관계

배정은(Jung Eun Bae),손인기(In-Ki Sohn),김임렬(Im-Yel Kim),양승호(Seung Ho Yang),이종훈(Jong Hun Lee),원성두(Seong-Du Won) 대한생물치료정신의학회 2010 생물치료정신의학 Vol.16 No.2

Objectives : There are several reports that patients with bipolar disorder have the negative cognitive style such as depressive disorder and it affect the course of illness. The insight of his or her own illness is also contribute to the course of it. In this research, We would like to investigate the relationship between symptoms, cognitive insight and dysfunctional attitudes of bipolar disorder. Methods : A total of 29 Bipolar patients and matched normal controls were recruited. All subjects completed the following questionnaires : Korean version of mood disorder questionnaire(K-MDQ), Korean version of Dysfunctional Attitude Style(K-DAS), and Korean version of Beck cognitive insight scale(K-BCIS), Korean version of Young Mania Rating Scales(K-YMRS) and Korean version of Hamilton Depression Rating Scale(K-HDRS) were administered to all patient by clinicians. Results : Compared with normal controls, patients with bipolar disorder showed significantly higher cognitive dysfunctional attitude scores. In subscales, scores of evaluation and perfection were significant differences. K-YMRS scores were negatively correlated with K-MDQ scores and K-BCIS scores. K-YMRS scores and K-MDQ scores had no correlation with scores of the dysfunctional attitudes. But K-YMRS scores were positively correlated with the self-esteem subscale of the dysfunctional attitude. Conclusion :Our results suggest that mood symptoms in bipolar disorder may affect subjective experience and cognitive insight of illness, but may not correlate with dysfunctional attitudes. The cognitive insight also do not correlate with dysfuctioanl attitudes. But compared with normal control, patient with bipolar disorder showed higher cognitive dysfunctional attitudes, especially evaluation and perfection.