학교 따돌림 피해 경험이 청소년의 우울 증상에 미치는 영향 : 회복탄력성의 조절 효과를 중심으로

배정은,홍현미,김경민,정영은,김문두,윤보현,Bae, Jungeun,Hong, Hyeonmi,Kim, Kyung-Min,Jung, Young-Eun,Kim, Moon-Doo,Yoon, Bo-Hyun 대한불안의학회 2020 대한불안의학회지 Vol.16 No.1

Objective : The purpose of this study was to examine the effects of bullying victimization on depressive symptoms in adolescents, and to determine how depression depends on resilience. Methods : A total of 4,160 students were recruited, from middle and high schools in Goheung, Yeosu, and the Jangheung area of Jeollanam-do Province. All participants completed self-report questionnaires, that included demographic variables, the Beck Depression inventory (BDI) the School Bullying Self-Rating Questionnaire (SBSRQ), and the Resilience Test (RT). Results : Prevalence of depression was 30.3%. A total of 220 (5.3%) students were evaluated likely to be bullied and 45 (1.1%) students were evaluated very likely to be bullied. Depressive symptoms positively correlated with bullying victimization. Depressive symptoms and resilience, bullying victimization and resilience negatively correlated. Results from regression analyses indicated that, while controlling for a range of demographic variables, resilience moderated the association between bullying victimization and depressive symptoms. Conclusion : Based on the results, professionals must consider resilience for treatment to reduce depression in adolescents of bullying victimization.

내력밀도법을 포함하는 아치형 트러스의 통합설계최적화

배정은,이상진,Bae, Jung-Eun,Lee, Sang-Jin 대한건축학회 2011 대한건축학회논문집 Vol.27 No.2

This paper describes a structural design process of arch-like truss based on the integrated design optimization (IDO) with force density method (FDM). The FDM has been considered as a very efficient traditional form-finding method and so it is consistently introduced as an individual technique in the present IDO process to decide a shape of the structure. The present IDO process includes several individual optimization techniques such as size optimization and topology optimization and additionally the intermediate processes connecting between two individual optimization techniques. Finally, numerical results of IDO for arch-like truss are described.

Virus Inactivation during the Manufacture of a Collagen Type I from Bovine Hides

배정은,김찬경,김성포,양은경,김인섭,Bae, Jung Eun,Kim, Chan Kyung,Kim, Sungpo,Yang, Eun Kyung,Kim, In Seop The Microbiological Society of Korea 2012 미생물학회지 Vol.48 No.4

세포치료제 또는 조직공학제제에 사용되는 동물 유래 콜라겐은 원료물질 유래 바이러스가 오염될 가능성이 있기 때문에 생산과정 중 바이러스가 오염되지 않도록 하여야 한다. 이를 위해 콜라겐 생산공정은 오염될 가능성이 있는 바이러스들을 불활화 하거나 제거하는 과정을 포함하여야 하며, 바이러스 불활화/제거 능력은 제품의 안전성을 보증하는 중요한 지표로 사용된다. 본 연구의 목적은 소 가죽을 원료로 하여 type I 콜라겐을 생산하는 공정에서 소 유래 바이러스들의 불활화/제거 효능을 평가하는 데 있다. 이를 위해 70% 에탄올 처리 공정과 펩신 처리 공정(pH 2)에서 바이러스 불활화 효과를 평가하였다. 바이러스 불활화 효과 평가를 위해 bovine herpes virus (BHV), bovine viral diarrhoea virus (BVDV), bovine parainfluenza 3 virus (BPIV-3), bovine parvovirus (BPV)를 모델 바이러스로 선정하였다. 바이러스 불활화를 위해 24시간 동안 70% 에탄올을 처리하는 공정에서 BHV, BVDV, BPIV-3, BPV 모두 처리 1시간 안에 검출 한계 이하로 불활화되었으며, 바이러스 로그 감소 값은 각각 ${\geq}5.58$, ${\geq}5.32$, ${\geq}5.11$, ${\geq}3.42$이었다. 또한 소 조직으로부터 콜라겐을 추출하기 위한 14일간의 펩신 처리 공정에서 BHV, BVDV, BPIV-3, BPV 모두 처리 5일 안에 검출한계 이하로 불활화되었으며, 바이러스 로그 감소 값은 각각 ${\geq}7.08$, ${\geq}6.60$, ${\geq}5.60$, ${\geq}3.59$이었다. 두 공정에서 BHV, BVDV, BPIV-3, BPV의 누적 바이러스 로그 감소 값은 각각 ${\geq}12.66$, ${\geq}11.92$, ${\geq}10.71$, ${\geq}7.01$이었다. 이상의 결과에 의하면, 소 가죽 유래 type I 콜라겐제조공정은 바이러스 안전성 보증을 위한 충분한 바이러스 불활화 능력을 가지고 있는 것으로 판단된다. Most types of collagen used for biomedical applications, such as cell therapy and tissue engineering, are derived from animal tissues. Therefore, special precautions must be taken during the production of these proteins in order to assure against the possibility of the products transmitting infectious diseases to the recipients. The ability to remove and/or inactivate known and potential viral contaminants during the manufacturing process is an ever-increasingly important parameter in assessing the safety of biomedical products. The purpose of this study was to evaluate the efficacies of the 70% ethanol treatment and pepsin treatment at pH 2.0 for the inactivation of bovine viruses during the manufacture of collagen type I from bovine hides. A variety of experimental model viruses for bovine viruses including bovine herpes virus (BHV), bovine viral diarrhea virus (BVDV), bovine parainfluenza 3 virus (BPIV-3), and bovine parvovirus (BPV), were chosen for the evaluation of viral inactivation efficacy. BHV, BVDV, BPIV-3, and BPV were effectively inactivated to undetectable levels within 1 h of 70% ethanol treatment for 24 h, with log reduction factors of ${\geq}5.58$, ${\geq}5.32$, ${\geq}5.11$, and ${\geq}3.42$, respectively. BHV, BVDV, BPIV-3, and BPV were also effectively inactivated to undetectable levels within 5 days of pepsin treatment for 14 days, with the log reduction factors of ${\geq}7.08$, ${\geq}6.60$, ${\geq}5.60$, and ${\geq}3.59$, respectively. The cumulative virus reduction factors of BHV, BVDV, BPIV-3, and BPV were ${\geq}12.66$, ${\geq}11.92$, ${\geq}10.71$, and ${\geq}7.01$. These results indicate that the production process for collagen type I from bovine hides has a sufficient virus-reducing capacity to achieve a high margin of virus safety.

이식을 위한 사람 양막의 소독 및 멸균공정에 의한 감염성 위해인자 불활화 효과

배정은,김찬경,김인섭,Bae, Jung-Eun,Kim, Chan-Kyung,Kim, In-Seop 한국미생물학회 2009 미생물학회지 Vol.45 No.4

이식을 위해 사용하는 사람 양막은 기증자로부터 수혜자에게 바이러스, 세균, 진균과 같은 감염성 위해인자를 전파할 위험이 있다. 따라서 적절한 소독 및 멸균 공정을 통해 이식용 양막 내재 또는 혼입 가능한 감염성 위해인자를 완벽하게 불활화하여야 한다. 본 연구에서는 인체조직은행에서 사용하고 있는 소독 공정과 멸균 공정의 바이러스 및 세균, 진균 불활화 효과를 검증하기 위해 국제적 가이드에 따라 5종의 바이러스[human immunodeficiency virus type 1 (HIV-1), bovine herpes virus (BHV), bovine viral diarrhoea virus (BVDV), hepatitis A virus (HAV), porcine parvovirus (PPV)]와 2종의 세균(Escherichia coli, Bacillus subtilis), 1종의 진균(Candida albicans)을 생물학적 지표로 사용하였다. 양막에 각 생물학적 지표를 첨가한 후 70% 에탄올 소독 공정, 감마선 조사 공정, 산화에틸렌 가스 멸균 공정을 실시한 다음 각 바이러스, 세균, 진균을 회수하여 정량한 후 불활화 정도를 비교하였다. 70% 에탄올 처리 공정에서 HIV-1, BHV, BVDV 같은 외피 바이러스는 처리 시간 2.5분 안에 불활화되었지만, HAV와 PPV 같은 비-외피 바이러스는 에탄올에 매우 큰 저항성을 나타내었다. 감마선 2.5 kGy 조사에 의해 HIV-1, BHV, BVDV는 검출한계 이하로 완벽하게 불활화되었다. HAV와 PPV는 각각 5 kGy와 25 kGy 조사에 의해 검출한계 이하로 불활화되었다. 산화에틸렌 가스 처리에 의해 본 연구에 사용한 모든 바이러스가 검출한계 이하로 불활화되었다. 70% 에탄올 처리 공정에서 E. coli와 C. albicans는 모두 5분 안에 완벽하게 사멸하였다. 하지만 B. subtilis는 큰 저항성을 나타내었다. 감마선 조사 공정과 산화에틸렌 가스 멸균 공정에서 E. coli, B. subtilis, C. albicans 모두 완벽하게 불활화되었다. Viral, bacterial, and fungal infection can be transmitted from donor to recipient via transplantation of human amniotic membrane. Therefore human amniotic membrane for transplantation should be disinfected and sterilized before use. The purpose of this study was to examine the efficacy of the disinfection process and sterilization processes used at human tissue bank in the inactivation of viruses, bacteria, and fungi. A variety of experimental model viruses, bacteria, and fungus for human pathogens, including the human immunodeficiency virus type 1 (HIV-1), bovine herpes virus (BHV), bovine viral diarrhoea virus (BVDV), hepatitis A virus (HAV), porcine parvovirus (PPV), Escherichia coli, Bacillus subtilis, and Candida albicans were all selected for this study. Enveloped viruses such as HIV-1, BHV, and BVDV were effectively inactivated to undetectable levels by 70% ethanol treatment, gamma irradiation process, and ethylene oxide (EO) gas sterilization process. Also non-enveloped viruses such as HAV and PPV were effectively inactivated to undetectable levels by gamma irradiation and EO gas treatment. However HAV and PPV showed high resistance to 70% ethanol treatment. E. coli and C. albicans were effectively inactivated to undetectable levels by 70% ethanol treatment, gamma irradiation process, and EO gas treatment. Also B. subtilis was effectively inactivated to undetectable levels by gamma irradiation process and EO gas treatment. However it showed high resistance to 70% ethanol treatment.

철근콘크리트 원형유공보의 비탄성해석

배정은(Bae, Jung-Eun),이범식(Lee, Bum-Sik),김용부(Kim, Yong-Boo),이상진(Lee, Sang-Jin) 대한건축학회 2017 大韓建築學會論文集 : 構造系 Vol.33 No.10

Reinforced concrete (RC) beam with openings has been the subject of interest for many years in structural design. So, there have been numerous experiments to find out the capacity of the RC beam with opening. In their experiment, the size, location and shape of opening have been considered as important parameters. In spite of many experiment result, a few inelastic analysis result has been provided for RC beam with opening. In this context, we revisit the experimental results and try to provide an inelastic finite element (FE) analysis procedures and the corresponding numerical results. From the comparison between experimental and present numerical results, it is found to be that the appropriate FE analysis procedure can produce reliable numerical results close to experimental result and it can predict the capacity of RC beam with opening in efficient way.

발효, 세포배양, 생물공정 인체이식용 무세포 진피 제조를 위한 바이러스 불활화 공정

배정은 ( Jung Eun Bae ),김진영 ( Jin Young Kim ),안재형 ( Jae Hyoung Ahn ),최다미 ( Da Mi Choi ),정효선 ( Hyo Sun Jeong ),이동혁 ( Dong Hyuck Lee ),김인섭 ( In Seop Kim ) 한국미생물생명공학회 2010 한국미생물·생명공학회지 Vol.38 No.2

내력밀도법을 포함하는 아치형 트러스의 통합설계최적화

배정은(Bae Jung-Eun),이상진(Lee Sang-Jin) 대한건축학회 2011 大韓建築學會論文集 : 構造系 Vol.27 No.2

This paper describes a structural design process of arch-like truss based on the integrated design optimization (IDO) with force density method (FDM). The FDM has been considered as a very efficient traditional form-finding method and so it is consistently introduced as an individual technique in the present IDO process to decide a shape of the structure. The present IDO process includes several individual optimization techniques such as size optimization and topology optimization and additionally the intermediate processes connecting between two individual optimization techniques. Finally, numerical results of IDO for arch-like truss are described.

발효, 세포배양, 생물공정 연속 유동 Uitraviolet-C 반응기(UVivatec)의 바이러스 불활화 효과 평가

배정은 ( Jung Eun Bae ),정은교 ( Eun Kyo Jeong ),이재일 ( Jae Il Lee ),이정임 ( Jeong Im Lee ),김인섭 ( In Seop Kim ),김종수 ( Jong Su Kim ) 한국미생물생명공학회 2009 한국미생물·생명공학회지 Vol.37 No.4

수확 후 전처리에 따른 수출 감귤의 품질변화

배정은(Jung-Eun Bae),정대성(Dae Sung Chung),이진수(Jin Su Lee),임병선(Byung-Seon Lim) 한국원예학회 2014 한국원예학회 학술발표요지 Vol.2014 No.10

양극성 장애의 인지적 병식 및 역기능적 태도와 증상 간의 관계

배정은(Jung Eun Bae),손인기(In-Ki Sohn),김임렬(Im-Yel Kim),양승호(Seung Ho Yang),이종훈(Jong Hun Lee),원성두(Seong-Du Won) 대한생물치료정신의학회 2010 생물치료정신의학 Vol.16 No.2

Objectives : There are several reports that patients with bipolar disorder have the negative cognitive style such as depressive disorder and it affect the course of illness. The insight of his or her own illness is also contribute to the course of it. In this research, We would like to investigate the relationship between symptoms, cognitive insight and dysfunctional attitudes of bipolar disorder. Methods : A total of 29 Bipolar patients and matched normal controls were recruited. All subjects completed the following questionnaires : Korean version of mood disorder questionnaire(K-MDQ), Korean version of Dysfunctional Attitude Style(K-DAS), and Korean version of Beck cognitive insight scale(K-BCIS), Korean version of Young Mania Rating Scales(K-YMRS) and Korean version of Hamilton Depression Rating Scale(K-HDRS) were administered to all patient by clinicians. Results : Compared with normal controls, patients with bipolar disorder showed significantly higher cognitive dysfunctional attitude scores. In subscales, scores of evaluation and perfection were significant differences. K-YMRS scores were negatively correlated with K-MDQ scores and K-BCIS scores. K-YMRS scores and K-MDQ scores had no correlation with scores of the dysfunctional attitudes. But K-YMRS scores were positively correlated with the self-esteem subscale of the dysfunctional attitude. Conclusion :Our results suggest that mood symptoms in bipolar disorder may affect subjective experience and cognitive insight of illness, but may not correlate with dysfunctional attitudes. The cognitive insight also do not correlate with dysfuctioanl attitudes. But compared with normal control, patient with bipolar disorder showed higher cognitive dysfunctional attitudes, especially evaluation and perfection.