골형성유도단백질의 첨가가 ${\Delta}^{12}-PGJ_2$가 유도하는 석회화에 미치는 영향

김원경,김경화,김종진,이영규,구영,Kim, Won-Kyung,Kim, Kyoung-Hwa,Kim, Jong-Jin,Lee, Young-Kyu,Ku, Young 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.2

Prostaglandin plays a significant role in the local control of bone metabolism associated with periodontal disease. ${\Delta}^{12}-PGJ_2$ is a natural $PGD_2$ metabolite that is formed in vivo in the presence of plasma. It is known for ${\Delta}^{12}-PGJ_2$ to stimulate calcification in osteoblastic cells. Bone morphogenetic protein(BMP) stimulated osteoblastic differentiation in various types of cells and greatly enhanced healing of bony defects. The purpose of this study was to evaluate the effect of rhEMP-2 on ${\Delta}^{12}-PGJ_2$ induced osteoblastic differentiation and mineralization in vitro. A human osteosarcoma cells line Saos-2 were cultured. In the test groups, 10-7M of ${\Delta}^{12}-PGJ_2$ or mixture of 10-8M of ${\Delta}^{12}-PGJ_2$ and 100ng/ml of rhBMP-2 or 100ng/ml of rhEMP-2 were added to culture media. After 1 day, 2 days and 4 days of culture period, the cell number was measured. Alkaline phosphatase activity was measure at 3 days. Reverse transcription polymerase chain reaction(RT-PCR) was performed to determine the expression of mRNA of bone matrix protein at 8 hours, 1 day and 7 days. The ability to produce mineralized nodules in rat osteoblasts(MC3T3-E1) was evaluated at 21 days. The results were as follows : 1. rhEMP-2 or mixture of rhBMP-2 and ${\Delta}^{12}-PGJ_2$ inhibited cell proliferation of human osteosarcoma cells. 2. rhEMP-2 or mixture of rhBMP-2 and ${\Delta}^{12}-PGJ_2$ stimulated alkaline phosphatase activity significantly higher than ${\Delta}^{12}-PGJ_2$ alone. 3. rhBMP-2 or mixture of rhEMP-2 and ${\Delta}^{12}-PGJ_2$ stimulated mineralization compared to ${\Delta}^{12}-PGJ_2$ alone. 4. mRNA of alkaline phosphatase, BMP-2, cbfa 1, Type I collagen were detected in the group treated with ${\Delta}^{12}-PGJ_2$/rhBMP-2, rhBMP-2 alone, ${\Delta}^{12}-PGJ_2$ alone. These results show that mixture of ${\Delta}^{12}-PGJ_2$ and rhBMP-2 causes more bone formation than ${\Delta}^{12}-PGJ_2$ alone while the bone formation effects of mixture of ${\Delta}^{12}-PGJ_2$ and rhBMP-2 are less than those of rhBMP-2 alone. Further researches would be necessary to clarify the interactions of these agents.

하수처리장 적용을 위한Semi-카플란 수차가 장착된 마이크로수력발전 시스템

채규정(Kyu Jung Chae),김동수(Dong Soo Kim),천경호(Kyung Ho Cheon),김원경(Won Kyoung Kim),김정연(Jung Yeon Kim),이철형(Chul Hyung Lee),박완순(Wan Soon Park) 大韓環境工學會 2013 대한환경공학회지 Vol.35 No.5

소수력발전은 하수처리장 에너지 자립을 위한 효과적인 대안이다. 본 연구는 유량변동이 크고 유효낙차가 낮은 중소형하수처리장(기흥레스피아) 적용을 위해 피치조절형 세미카플란(semi-kaplan) 마이크로수력발전의 적용 타당성을 평가하였다. 가변피치 semi-kaplan 수차는 유량조절을 위한 가이드베인은 생략하고 피치조절형 런너를 장착하여 기계적 결함은 줄이면서 유량변동이 큰 처리장에 특화된 기술이다. 마이크로수력발전 시스템은 설계조건(유량 0.35 m3/s, 유효낙차 4.7 m)에서 90.2%의 수차효율 달성이 가능하였고 발전용량은 13.4 kW로 산정되었다. 설비가동률 74%로 가동 시 연간 약 86.8 MWh 에너지 생산을 통해 2.1%의 에너지 자립이 가능하고 이는 연간 49톤의 CO₂ 감축효과와 맞먹는다. 경제성 평가결과 초기 건설공사비가 200,000,000원 이하인 경우에는 내부수익률은 6.1%, 순현가는 15,539,000원, 편익-비용률은 1.08, 투자회수년은 15.5년으로 경제성이 충분한 것으로 나타났다. Small scale hydropower is one of most attractive and cost-effective energy technologies for installation within sewage treatment plants. This study was conducted to evaluate the potential of a semi-kaplan micro-hydropower (MHP) system for application to sewage treatment plants with high flow fluctuations and a low head. The semi-kaplan MHP is equipped with an adjustable runner blade, and is without a guide vane, so as to reduce the incidence of mechanical problems. A MHP rating 13.4 kWp with a semi-kaplan turbine has been considered for Kiheung Respia sewage treatment plant, and this installation is estimated to generate 86.8 MWh of electricity annually, which is enough to supply electricity to over 25 households, and equivalent to an annual reduction of 49 ton CO₂. The semi-kaplan turbine showed a 90.2% energy conversion efficiency at the design flow rate of 0.35 m3/s and net head of 4.7 m, and was adaptable to a wide range of flow fluctuations. Through the MHP operation, approximately 2.1% of total electricity demand of Kiheung Respia sewage treatment plant will be achievable. Based on financial analysis, an exploiting MHP is considered economically acceptable with an internal rate of return of 6.1%, net present value of 15,539,000 Korean Won, benefit- cost ratio of 1.08, and payback year of 15.5, respectively, if initial investment cost is 200,000,000 Korean Won.

치주치료가 약물성 치은비대 환자의 치은두께에 미치는 효과에 관한 연구

김원경,백진,이영규,Kim, Won-Kyung,Baek, Jin,Lee, Young-Kyoo 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.4

The purpose of this study was to observe the effects of periodontal therapy, including nonsurgical periodontal therapy with azithromycin, surgical therapy, and maintenace therapy on the drug-induced gingival enlargement, by means of measuring gingival thickness. The test group of 18 patients with drug-induced gingival enlargement received scaling, root planing with azithromycin for 5 days, with or without surgical periodontal treatment. The control group of 18 patients who had not taken any medication, received scaling and root planing, with or without surgical periodontal treatment. Both groups received supportive periodontal therapy every 3 months for 2 years. The mean period of total treatment is 32 months in the test group and 31 months in the control group. The thickness of the buccal gingiva was measured using an ultrasonic device of $SDM^{(R)}$(Krupp Corp., Essen, Germany). The results revealed that the test $group(1.21{\pm}0.51mm)$ showed statistically thicker buccal gingiva than the control $group(1.01{\pm}0.3mm)$. In the test group, the buccal gingiva was thickest on 2nd molars and was thinnest on canines of both dental arches. In the control group, the buccal gingiva was thickest on central incisors in the maxilla and 2nd molars in the mandible, while the thinnest areas were on canines in the maxilla and 1st premolars in the mandible. It would be concluded that the periodontal treatment with azithromycin aids in decreasing the degree of the gingival enlargement but cannot prevent the recurrence completely.

알루미늄메쉬커튼과 2류체 포그시스템을 적용한 개방형축사의 에너지 절감시스템에 관한 연구

김원경,강민우,양지웅,이은숙,신홍건,박진규,최원식,Kim, Won-Kyung,Kang, Min-Woo,Yang, Ji-Woong,Lee, Eun-Suk,Shin, Hong-Gun,Park, Jin-Gyu,Choi, Won-Sik 한국산업융합학회 2020 한국산업융합학회 논문집 Vol.23 No.6

The control on temperature and humidity on the cow-house is essential to assure production efficiency and the control on disease of cows. Fog system and screen fence are typical methods to drop the temperature inside of cow-house during the summer season. This study focused on the change in temperature and humidity under the condition of application of those methods. The results indicate that the installation of atomizer and insulation curtain cause decrease in temperature and increase in humidity. However, Using both of methods at the same time doesn't make any additional meaningful effects on temperature and humidity.

2007 특수교육법의 쟁점과 과제

김원경 ( Won Kyung Kim ),한현민 ( Hyun Min Han ) 한국특수교육문제연구소 2007 특수교육저널 : 이론과 실천 Vol.8 No.4

금년은 한국의 특수교육(학)사에서 참으로 유의한 해로 기록될 것이다. 이것은 1977년 제정 이후 30년간 특수교육 발전의 근거였던 .특수교육진흥법.이 .장애인등에대한특수교육법.이란 제명으로 2007년 5월 대체 입법되었기 때문이다. 소위 당사자주의에 입각한 의원입법안.장애인의교육지원에관한법률.과 정부입법안 .특수교육진흥법전부개정안.이 각각 제출되었으나, 국회교육위원회가 대안으로 제시한 .장애인등에대한특수교육법.으로 확정되는 과정을 거쳤다. 이러한 과정을 거친 특수교육법의 공포는 ① 치료교육의 삭제, ② 치료교육 관련 대학의학과 폐과, ③ 특수학교 교육과정의 미확정 등으로 특수교육계에 큰 혼란을 초래하였다. 특히 경과조치조차 없는 치료교육의 후속조치와 관련한 관련단체들과 정부의 대치상황, 일부단체들의 시행령 입안 참여 요구 등은 교육현장을 불안케 하고 있다. 이와 같은 극도의 혼란상황에서 2007년 .장애인등에대한특수교육법.을 제대로 시행하기위해서는 그간 한국 특수교육법제연구를 통해 거둔 성과를 재조명하여 앞으로 제정될 하위규정(시행령과 시행규칙)의 제정방안을 제시할 필요성이 절실히 제기되고 있다. 이에 본 연구에서는 그간 국내 특수교육법 관련연구들을 종합 검토하여 2007년 전부 개정된 특수교육법의 내용을 효율적으로 시행할 수 있는 방안을 제안하고자 하였다. 이러한 목적에 따라 최근 20년간 국내 특수교육법제연구의 역사와 논의의 동향을 우선 검토하였다. 이러한 논의의 결과를 바탕으로 법 제명, 의무교육 등 교육수권, 특수교육대상자,치료교육, 개별화교육, 교사 등 6가지 쟁점을 선정하였으며, 이들 주요 쟁점의 내용을 전.후비교하여 제시한 다음 그 문제점을 집중적으로 검토하고 그 개정의 방향을 구체적으로 제안하였다. The year of 2007 is a meaningful year in the history of special education in Korea. The Special Education Promotion Law that had been a foundation of the development of special education for the past three decades since its legislation in 1977 was changed into the Special Education Law of Individuals with Disabilitiesand the Like (Special Education Law) in May, 2007. The Special Education Support Act for Individuals with Disabilities, the bill by the National Assembly based on the Consumerism for people with disability and the total revision bill of the Special Education Promotion Law by government wereproposed, respectively. The Special Education Law has been enacted as the alternative bill given by the Committee on Education. The promulgation of the Special Education Law leads to a huge confusion on the system of Korean special education because of the contents including specifically the elimination of the remedial education, the abolition of the department of remedial education, and the extension of notification of the 2007 Special School Curriculum.Especially, conflicts between related groups and the government concerning the follow-up measures of remedial education without interim measures and the demands for having a voice in legislation of enforcement ordinance has caused the confusion of the special education fields. Thus, for the proper enforcement of Special Education Law in 2007, there are needs to readjust the products of the previous studies on the special education-related laws in Korea for the purpose of presenting the establishment plan of subordinate regulations, that is enforcement ordinance and enforcement regulation. The purpose of the present study is to present the plan to enforce effectively the overall revised regulations of the Special Education Law in 2007 on the basis of the results from all-around investigation into the related studies of the domestic special education-related laws. This study has investigated and examined the tendency of arguments and the history in the domestic special education laws during recent 20 years. On the basis of these analysis, the study found six main issues; the law title, the compulsory education, students having special needs, remedial education, individualized education, and special education teachers. Then, the study compared the details of the above six issues before and after the revision and presented the direction of revision and the concentration of argument.

한국 특수교육의 변화경향과 미래전망

김원경 ( Won Kyung Kim ) 한국정신지체아교육학회 2007 지적장애연구 Vol.9 No.2

수경재배 토마토의 계절 변화에 따른 생식생장 특성 연구

김원경 ( Won-kyung Kim ),조병효 ( Byeong-hyo Cho ),홍영기 ( Youngki Hong ),김경철 ( Kyoung-chul Kim ) 한국농업기계학회 2022 한국농업기계학회 학술발표논문집 Vol.27 No.2

외부 계절 환경조건에 따라 온실 내부 작물의 온도, 습도, 광량이 달라진다. 따라서 본 연구에서는 외부 환경변화에 따른 온실토마토의 생식특성을 구명하기 위해 비파괴적인 방법으로 시계열 데이터를 취득하였다. 실험에 사용된 토마토 (Dafnis)는 국립농업과학원 전라북도 완주군의 스마트 온실에서 수경재배 방식으로 재배되었다. 착과 후 7일 이후부터 완숙기까지 토마토 생육의 전 주기 동안, 토마토의 표면 색상 값(L*a*b*)과 토마토의 둘레를 측정하였고, 각각 색차계(CR20, KONICA MINOLTA, Tokyo, Japan)와 줄자를 이용하여 3번씩 반복하여 데이터를 취득하였다. 실험은 2022. 02.14.~2022.03.31. 기간과 2022.08.11.~2022.10.04. 기간동안 수행하였고 각각의 샘플 수는 20개와 24개씩 선정하여 진행하였다. 또한 기존 연구에서 구축한 온실환경 모니터링 시스템을 이용하여 온실내 환경데이터 온도, 상대습도, 10min 간격으로 수집하였다. 일사량를 그결과두 기간의 시계열 데이터 모두 적산온도 600~700℃ 구간에서 a* 값은 증가하고 둘레의 팽창이 멈추는 경향이 나타났다. 하지만 8~10월 데이터의 경우 샘플들 간의 성숙시기의 차이가 크게 나타났는데, 가장 빨리 익은 샘플과 가장 늦게 익은 샘플의 적산온도 차가 약 200 ℃로, 약 60 ℃인 2~3월 데이터보다 현저하게 큰 것을 확인할 수 있었다. 또한 올해 긴 장마로 인해 실내 온도와 일사량은 두 기간이 유사하게 나타났고 습도는 8~10월 데이터가 평균 20% 정도 더 높게 나타나는 경향을 확인하였는데, 이러한 환경인자의 차이가 복합적으로 작용하여 나타난 결과로 사료된다. 추후 본 연구에서 얻은 데이터를 기반으로 토마토 숙도 예측모델을 개발하여 모니터링 로봇에 활용할 계획이다.

실시간 토양 판별을 위한 근적외선 분광기술과 인공신경망 기술의 적용

김원경(Won-Kyung Kim),홍석주(Suk-Ju Hong),최금실(Jinshi Cui),김학진(Hak-Jin Kim),박종민(Jongmin Park),양승환(Seung-Hwan Yang),김기석(Ghiseok Kim) 한국비파괴검사학회 2017 한국비파괴검사학회지 Vol.37 No.3

본 연구에서는 농업용 노외기계가 노지 작업 중에 실시간으로 토양의 유형을 판별할 수 있는 기술을 개발하기 위해서 근적외선 분광기술과 인공신경망 분석기술을 적용하였다. 이를 위해, 노지의 상태에 따라 토양과 검출기 사이의 측정거리가 변화되는 현상을 보정하고 측정 중 유입될 수 있는 잡음 성분들을 제거할 수 있는 전처리기술을 구현하였고 측정된 반사광의 스펙트럼 정보를 이용하여 토양의 유형을 판별할 수 있는 통계학적 모델과 인공신경망 분석모델을 개발하여 그 성능을 평가하였다. 본 연구를 통해 개발된 실시간 토양 유형 판별기술은 ICT 기반 지능형 농작업 기계의 주요한 요소기술로서 적용될 수 있을 것이며 향후에는 토양 유형의 판별뿐만 아니라 토양 성분을 예측하고 분석할 수 있는 비파괴검사 기술의 원천기술로서 활용될 수 있으리라 판단된다. In this study, we employed both near-infrared spectroscopy and artificial neural network analysis methods to develop a real-time discrimination technique for soil categories for use in agricultural machinery. For this purpose, we implemented the preprocessing methods that could eliminate noise components during measurement. In addition, a distance correction method was devised to calibrate the spectra difference using the change in measuring distance between the soil surface and detector end. We developed the PLS-DA model and artificial neural network model for the discrimination of soil categories using the preprocessed spectra. Based on the results, we expect that the developed discrimination method for soil categories could be used as a practical nondestructive evaluation technique for soil categories as well as a key element technique of ICT-based agricultural machinery.

생산성 향상을 위한 자동차 도장공정 시뮬레이션

김원경 ( Won Kyung Kim ) 대한설비관리학회 2003 대한설비관리학회지 Vol.8 No.1

In this Paper, the estimation method of painting process in the automobile plant using computer simulation techniques is studied to improve the bottle neck process, the weak point and the productivity. For model and analysis, Promodel is used which is a manufacturing orientid simulation software developed by Promodel corporation in the USA. Firstly, the result of the simulation shows that we can obtain capability improvement in the system performance using computer simulation. Secondly, the optimum system specification is decided by comparing reports generated by scenario in simulation program to find out the suitable conditions. Finally, the speed of conveyor and a pitch of painting body as the most critical parameters are chosen on the basis of exhaustive field evaluation to study their effects on the capacity of the process. The best alternative condition for the maximum capacity of the process is selected by computer simulation.

지수 분포의 규모 모수에 대한 우도비 검정 ( 제2종 검열 자료에 의하여 )

김원경 ( Won Kyung Kim ) 한국수학교육학회 1989 수학교육 Vol.28 No.1