http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A Novel Reciprocal Crosstalk between RNF168 and PARP1 to Regulate DNA Repair Processes
김재진,이서윤,김소연,정지민,권미라,윤정현,박상욱,황이슬,박동선,이종수,강호철 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.8
Emerging evidence has suggested that cellular crosstalk between RNF168 and poly(ADP-ribose) polymerase 1 (PARP1) contributes to the precise control of the DNA damage response (DDR). However, the direct and reciprocal functional link between them remains unclear. In this report, we identified that RNF168 ubiquitinates PARP1 via direct interaction and accelerates PARP1 degradation in the presence of poly (ADP-ribose) (PAR) chains, metabolites of activated PARP1. Through mass spectrometric analysis, we revealed that RNF168 ubiquitinated multiple lysine residues on PARP1 via K48-linked ubiquitin chain formation. Consistent with this, micro-irradiation-induced PARP1 accumulation at damaged chromatin was significantly increased by knockdown of en-dogenous RNF168. In addition, it was confirmed that abnormal changes of HR and HNEJ due to knockdown of RNF168 were restored by overex-pression of WT RNF168 but not by reintroduction of mutants lacking E3 ligase activity or PAR binding ability. The comet assay also revealed that both PAR-binding and ubiquitin-conjugation activities are indispensable for the RNF168-mediated DNA repair process. Taken together, our results suggest that RNF168 acts as a counterpart of PARP1 in DDR and regulates the HR/NHEJ repair processes through the ubiquitination of PARP1.
김재진,이화영,이기준,강희동 한국화학공학회 1976 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.14 No.3
염화비닐 합성공정의 부산물로 생산되고 있는 1,1,2-삼염화에탄을 接觸分解하여 염화비닐리덴을 만들고 이 과정에서 생산되는 염화수소 가스를 이용하여 염화비닐리덴으로부터 1,1,1-삼염화에탄을 합성하는 공정에 대하여 연구하였다. 1,1,2-삼염화에탄의 분해에 사용된 촉매는 활성탄에 擔持시킨 鹽化바륨 및 鹽化銅으로서 20∼30% 염화바륨 담지촉매가 염화비닐리덴의 선택도에 가장 좋은 결과를 보여주었다. 반응온도 400∼500℃ 범위에서 염화비닐리덴의 선택도는 최고 35%까지 얻을수 있었다. 1,1,1-삼염화에탄의 합성에는 Friedel-Craft 촉매를 사용하였으며 1,1,1-삼염화에탄의 합성 반응은 염화수소 가스를 계속해서 과잉으로 공급할때 염화비닐리덴의 농도에 대하여 一次 반응이며 0.6%의 촉매농도 범위에서 촉매농도에 비례하는 것을 확인하였다. A process is developed for the synthesis of 1,1,1-trichoroethane from 1,1,2-trichloroethane, a byproduct produced in the vinyl chloride process. Catalytic dehydrochlorination of the 1,1,2-trichloroethane produces vinylidene chloride, 1,2-dichloroethylene and hydrogen chloride of these vinylidene chloride and hydrogen chlo ride react subsequently to form the 1,1,1-trichloroethane in a Friedel-Craft catalytic process. Barium chloride or copper chloride of 5 to 30 percent by weight supported on the activated carbon is used as catalyst. The selectivity for vinylidene chloride is attained up to 35 percent in the reaction temprature range of 400℃ to 500℃ using 20 to 30 percent barium chloride catalyst. It is also confirmed that the synthesis of 1.1.1-trichloroethane is a first order reaction with respect to the concentration of vinylidene chloride when excess hydrogen chloride gas is bubbled continuousley into the catalytic slurry reactor, and its rate is linearly proportional to the concentration of anhydrous aluminum chloride catalyst.
커튼 월에 적용하는 플랙시블 태양전지의 모양에 따른 성능 비교
김재진 (사)디지털산업정보학회 2018 디지털산업정보학회논문지 Vol.14 No.4
In this paper presents comparison of performance of flexible solar cells construction applied to curtain walls. The proposed paper compares power generation for curtain walls of various shapes using flexible PV. Through the comparison of performance, the power generation was compared by installing various types of flexible PV on the air layer of double windows. By comparing the measured power generation, it is possible to find an optimal flexible PV shape that can be applied to a curtain wall. Flexible PV installation was divided into diagonal, S and W shapes. As a result of comparison, the amount of power generation when there was no flexure of flexible PV was large. Also, as the angle with the light source increased, the power generation decreased. Therefore, it is necessary to study the structure which can fix the PV more than the flexible PV and to be able to direct the sun without distortion.
김재진 (사)디지털산업정보학회 2019 디지털산업정보학회논문지 Vol.15 No.4
In this paper, we study the BESS of a standalone hybrid street light. The proposed BESS proposed a BESS with the function of efficiently charging irregularly generated power from two or more generators. AC generated by wind power is converted to DC using an AC / DC converter and then to a voltage that can charge the battery through the DC / DC converter. The lack of voltage and current, which is a disadvantage of the MPPT method used in solar power generation, is compensated by the DC value of wind power generation. The compensation method is to convert the DC generated from solar power into a voltage suitable for charging the battery through a DC / DC converter, and then connect the DC generated in wind power in parallel to compensate for the insufficient current to charge the battery in a short time. Allow this to begin. By securing the maximum charging time, the usage time of the stand-alone hybrid street light is huge. Experimental results show that the battery has a short charging time and can be efficiently applied to battery-dependent standalone hybrid street lights.
Organized Hematoma in the Maxillary Sinus
김재진,Kim, Jae-Jin Korean Association of Maxillofacial Plastic and Re 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.5
Organized hematoma of the maxillary sinus is a rare, nonneoplastic benign lesion with locally destructive behavior that may mimic a malignancy. Clinically, symptoms do not usually occur while the lesion remains localized to the maxillary sinus. Because there is gradual enlargement of the lesion causing erosion and displacement of the adjacent bony structures, symptoms such as epistaxis, cheek swelling, nasal obstruc-tion, headache, and exophthalmos become manifest. Radiologically, unilateral cases are much more fre-quent than bilateral, and Waters' view shows complete opacity of the expanded maxillary sinus and some masses. CT scan shows a large heterogeneous enhancing mass causing considerable expansion of the max-illary sinus with bony erosion. On MR imaging, the mass usually has a variable signal intensity on T1- and T2- weighted images, ranging from low to high. After contrast administration, discrete areas of enhance-ment are present within the mass. Although the disease is essentially benign and nonneoplastic, differen-tial diagnosis from neoplastic disease including malignancy both clinically and radiologically has been always problematic. Accurate preoperative diagnosis of organized hematoma of the maxillary sinus is important to avoid unnecessary extensive surgery, because this condition is curative with a simple, conservative surgical approach and rarely recur. Organized hematoma of the maxillary sinus should be included in the differential diagnosis when patients have recurrent epistaxis, slow-growing mass of the cheek, nasal obstruction, and expansile mass in the maxillary sinus. A 33-year-old man was referred to the department of oral and maxillofacial surgery with a three-month history of slowly growing painful swelling of the left cheek. The mass of the maxillary sinus was resected by a Caldwell-Luc approach. Histopahtoly showed only a fibous encapsulated organized hematoma. To our knowledge, organized hematoma of the maxillary sinus has not been previously described in the Korean literature of the oral and maxillofacial surgery. We report a case of organized hematoma of the maxillary sinus presenting with an enlarging maxillary sinus mass.