60세 이상의 노인에서 의식하 진정 상부 위장관 내시경 검사시 Propofol의 적정 유도 용량

문형철,홍건영,김두진,최상철,박상욱,임연근 대한소화기내시경학회 2010 Clinical Endoscopy Vol.41 No.3

Background/Aims: Propofol is an effective sedative drug in endoscopic procedures, but it has potentially serious adverse effects, so close monitoring of the vital signs should be performed during endoscopy. This study was undertaken to determine the adequate induction dose of propofol for safe and effective sedation during esophagogastrodudenoscopy (EGD) in persons 60 years or older. Methods: Three hundred patients who visited our hospital for EGD were randomly assigned to three groups (A,B and C). An initial induction dose of 0.5 mg/kg, 0.75 mg/kg and 1.0 mg/kg of propofol was allocated to groups A, B and C, respectively. Results: The 0.5 mg/kg, 0.75 mg/kg and, 1 mg/kg dose of propofol were all safe as an initial dose of propofol for achieving sedation during EGD in persons 60 years or older. There was no difference in the total amount of propofol among the three groups. Group C had a significantly shorter induction time and a lower dose was required for an additional injection of propofol without increasing adverse events, as compared to the two other groups. Conclusions: We suggest that 1 mg/kg of propofol is an effective induction dose for sedation during EGD in persons 60 years or older. 목적: 상부 위장관 내시경에 사용되는 profopol은 효과적이며 안전한 약물이다. 그러나 강력한 진정 작용이 있어 내시경 시행 중 면밀한 관찰이 필요하다. 고령일수록 약물 투여에 따르는 부작용이 높지만 노인에서의 적정한 진정 유도량에 대한 연구는 많지 않았다. 본 연구는 60세 이상의 노인에서 상부 위장관 내시경을 시행시 안전하고 효과적인 propofol의 적정 유도 용량을 알기 위해 연구를 진행하였다. 대상 및 방법: 2009년 6월부터 2010년 2월까지 본원 소화기내과 외래를 내원하여 건강 검진을 목적으로 내시경 검사를 시행한 300명의 대상자를 무작위로 진정 유도를 위한 초기 투여용량에 따라 3군으로 분류하였다. A군은 0.5 mg/kg, B군은 0.75 mg/kg, C군은 1.0 mg/kg의 propofol을 투여하였다. 결과: 60세 이상의 노인에서 상부 위장관 내시경시 초기 유도량으로는 0.5 mg/kg, 0.75 mg/kg, 1 mg/kg 모두 부작용 없이 안전하고 효과적으로 진정 유도 도달하였다. 세 군간에 총사용량은 차이가 없었다. 진정 유도 후 추가적으로 투여된 propofol양은 A군에서 38.6±1.80 mg, B군에서 22.0±1.74 mg, C군에서 11.8±1.66 mg으로 통계적으로 유의할 만큼 C군이 적었다(p<0.001). 진정 유도까지 소요되는 시간도 A군에서 85.14± 32.43초, B군에서 60.34±26.10초, C군이 49.47±29.49초로 C군이 가장 짧은 시간에 진정 유도에 도달하였다(p<0.001). 세 군간 부작용 발생에서 유의한 차이가 없었다. 결론: 60세 이상의 고령에서 의식하진정 내시경 검사에 propofol의 적정 유도 용량은 1 mg/kg이 더 효과적이다.

시설 수박에서 콜레마니진디벌을 이용한 목화진딧물 방제

문형철,김웅,최민경,권성환,신용규,김대향,황창연,Moon, Hyung-Cheol,Kim, Woong,Choi, Min-Kyung,Kwon, Sung-Hwan,Shin, Young-Kyu,Kim, Dae-Hyang,Hwang, Chang-Yeon 한국응용곤충학회 2011 한국응용곤충학회지 Vol.50 No.1

4월부터 6월까지 수박을 재배하며 콜레마니진디벌을 이용하여 목화진딧물 밀도억제효과를 조사하였다. 목화진딧물 방제를 위하여 콜레마니진디벌를 $m^2$당 2마리씩 3회(4월 24일, 5월 8일, 5월 22일) 방사한 결과 목화진딧물 밀도는 잎당 0.6마리 이하로 억제되었고, 최고 기생률은 57.2%이었다, 진딧물 발생엽률은 2.0~10.6% 이었다. 무방사구에서 목화진딧물의 밀도는 5월 초부터 증가하여 5월 29일에는 잎당 653.2마리까지 증가하였다. Biological control of Aphis gossypii by natural enemies was carried out in watermelon from April to June. Aphidius colemani was released 3 times at rate of $2/m^2$ to control A. gossypii(April 24, May 8, and May 22 in 2007). In A. colemani-released plots, A. gossypii showed low population density of < 0.6 per leaf with the highest parasitism of 57.2%, and 2.0~10.6% in the percentage of leaves with aphids. In control, the population of A. gossypii kept on increasing from early May and reached 653.2/leaf on may 29.

조기(早期) 한방치료(韓方治療)를 시행한 요추수핵탈출증(腰椎髓核脫出症) 환자(患者)의 C-T 상(上) 5-7년 후의 추간판(椎間板)의 변화(變化)

문형철,황우준,이건목,조남근,강성도,조재운,장병선,진경선,Mun, Hyung-Cheal,Hwang, Woo-Jun,Lee, Geon-Mok,Cho, Nam-Geun,Gang, Sung-Do,Cho, Jae-Woon,Chang, Byoung-Sun,Jin, Kyong-Son 대한침구의학회 2001 대한침구의학회지 Vol.18 No.4

Study design : A retrospective study of lumbar disc herniations using results of follow-up computed tomographic scan examinations. Objective : Lumbar disc herniations is one of the cause low back pain and lower extremity pain. To clarify the lumbar disc herniations morphological changes over time(mean 5.3 years) in order to establish a strategy for treatment. Methods : Sixteen patients with lumbar disc herniations who underwent follow-up computed tomographic scan examinations were studied. The changes over time in herniated disc size(herniation ratio) were evaluated using this scan technique. The initial computed tomographic scan allowed classification of the herniations according to herniation ratio: small, medium and large. Results : Comparison with follow-up computed tomographic scans showed that of the 16 patients, in 14 patients(88%), the herniation ratio(HR) was decreased and among them, 8 patients had complet resolution of herniated disc. In 2 patients with small herniations, the HR of one case was increased, the other was decreased. In 8 patients with medium herniations, the HR of one case had no change, the others was decreased. In 6 patients with large herniation, the HR of all patients was decreased. Interestingly, 4 of the 16 patients showed calcification change of herniated disc. Conclusion : There is no doubt that herniated disc size is decreased over time. The largest herniations were those which had the greatest tendency to decrease in size. But in some cases, the HR was increased, or calcification change was showed.

뽕나무발효톱밥 급여에 따른 흰점박이꽃무지의 발육 및 산란 특성

문형철,임주락,박나영,전형권,Moon, Hyung-Cheol,Lim, Ju-Rak,Park, Na-Young,Chon, Hyong-Gwon 한국응용곤충학회 2018 한국응용곤충학회지 Vol.57 No.4

뽕나무발효톱밥을 이용한 흰점박이꽃무지의 사육 가능성을 검토하기 위하여 발육 및 산란 특성을 조사하였다. 흰점박이꽃무지 유충의 발육기간은 25, 28, $30^{\circ}C$에서 각각 164.0일, 73.3일, 64.8일로 온도가 높을수록 짧아졌다. 평균 유충 최고 무게는 $25^{\circ}C$에서 2.94 g으로 가장 높았으며 온도가 높아질수록 유충 무게는 감소하는 경향이었다. 우화한 암컷 성충의 평균 무게는 25, 28, $30^{\circ}C$에서 각각 0.94 g, 0.51 g, 0.54 g이었으며 수컷 성충 무게가 암컷보다 무거웠다. 뽕나무톱밥에 밀기울을 10% 또는 30% 첨가하여 발효시킨 것이 흰점박이꽃무지 유충 발육에 양호하였다. 유충 집단 사육시 2.5 g 이상인 유충의 누적비율이 75% 정도인 사육 후 75일부터 유충 판매가 가능하였다. 흰점박이꽃무지의 평균 산란수는 83.2개이었으며, 우화 후 3~8주 사이에 전체 산란수의 73%가 산란되었고, 5주째 산란수가 가장 많았다. This study investigated the developmental and ovipositional characteristics of Protaetia brevitarsis individuals that were fed with fermented mulberry sawdust. The developmental periods of larvae were 164.0, 73.3, and 64.8 days at 25, 28, and $30^{\circ}C$, respectively. The maximum larval weight was 2.94 g at $25^{\circ}C$, and the weight of larvae decreased as temperature increased. The average weight of female adults were 0.94, 0.51, and 0.54 g at 25, 28, and $30^{\circ}C$, respectively. The weight of male adults was higher than that of females. The addition of 10% or 30% wheat bran to the fermented mulberry sawdust increased larval weight. It was possible to sell larvae from 75 days after mass rearing, when the cumulative rate of larvae that were heavier than 2.5 g was approximately 75%. The average number of eggs per female was 83.2 at $25^{\circ}C$, and this was the highest in the 5th week. Most of the eggs (73%) were oviposited between 3 and 8 weeks after adults emergence.

人蔘이 중추신경계 손상 동물 모델의 재생에 미치는 영향

문형철,김윤욱,송봉근 대한침구의학회 2007 대한침구의학회지 Vol.24 No.6

Objectives : Following central nervous system (CNS) injury, inhibitory influences at the site of axonal damage occur. Glial cells become reactive and form a glial scar, know as gliosis. As well,myelin debris such as MAG inhibits axonal regeneration. Astrocyte-rich gliosis relates to up-regulation of GFAP and CD81, and eventually becomes a physical and mechanical barrier to axonal regeneration. It is postulated that when the astrocytic reaction is absent, regeneration of axons can occur. It was reported that treatment with anti CD81 antibodies enhanced functional recovery in rats with spinal cord injury. Methods : MAG is one of several endogenous axon regeneration inhibitors that limit recovery from central nervous system injury and disease. It was reported that molecules which block such inhibitors enhanced axon regeneration and functional recovery. Results : In this current study, the author investigated the effect of the water extract of Ginseng Radix on the regulation of CD81, GFAP and MAG which increases when gliosis occurs. MTT analysis was performed to examine cell viability, and cell based ELISA, Western Blot and PCR were used to detect the expression of CD81, GFAP and MAG. Immunohistochemistry was also performed to confirm in vivo. Conclusions : We observed that Ginseng Radix significantly down-regulates the expression of CD81, GFAP and MAG by means of cell based ELISA, Western Blot and PCR. In immunohistochemistry, expression of CD81, GFAP and MAG also decreased. Taken together, these results suggest that Ginseng Radix can be a candidate for regenerating CNS injury.

멀티미디어 환경을 고려한 다중 칩율 DS / CDMA 시스템의 성능 분석 ( Performance Analysis of Multi-Chip Rate DS/CDMA Systems )

문형철,박상규 대한전자공학회 1997 대한전자공학회 학술대회 Vol.1997 No.11

왕사마귀의 실내 발육 및 산란 특성

문형철,임주락,김동완,권석주,한수곤 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.10

약용 및 정서애완학습용 곤충으로 개발 가능한 왕사마귀의 실내사육을 위하여 발육 및 산란 특성을 조사하였다. 쌍별귀뚜라미와 갈색거저리를 먹이로 하여 왕사마귀 약충의 발육기간을 조사한 결과 각각 60.8일과 63.6일이었으며, 갈색거저리 공급시 2~4령 약충의 발육 기간이 쌍별귀뚜라미를 먹이로 할 때 보다 길어지는 경향이었다. 왕사마귀 4령 약충를 우화시까지 사육상자 크기를 달리하여 사육한 결과 20x20x30cm 크기의 사육상자에서 사육할 때 생존율이 77.5%로 가장 높았다. 왕사마귀 암컷 수명은 평균 82일이었으며, 평균 3.2개의 난괴를 산란하였다. 산란전기간은 41일이었으며 산란 간격은 11.7~18.7일 이었다. 산란 시기별 난괴의 크기와 무게를 조사한 결과 처음 산란된 난괴의 길이가 40.5mm, 폭 22.0mm, 두께 17.3mm로 가장 컸으며 무게도 1.75g으로 가장 무거웠다.

포스터 전시 : 호흡기, 내분비-대사 ; 금속 색전 코일을 이용한 폐동맥색전술로 치료된 Rasmussen 동맥류 1예

문형철,표성봉,신창준,유경완,윤성훈,박오성,강동구,고영춘,이승욱,조상기 대한내과학회 2005 대한내과학회 추계학술대회 Vol.69 No.10

시단위 포장도로의 포장평가지수개발

문형철,서영찬 한국도로학회 2008 한국도로학회논문집 Vol.10 No.3

In Korea, Expressway and National Highway System has been continually managed by their own pavement management system. The pavement condition evaluation system has not been developed for the municipal roads except for Seoul city. Therefore, this study focuses on analyzing the characteristics of distress in major city's pavement and developing the pavement condition index for the municipal PMS. Panel rating and pavement condition survey for the selected pavement sections were conducted for developing pavement condition index. Municipal level pavement condition index(MPCI) was developed by statistical analysis. Also, a sensitivity analysis for each independent variable of the MPCI and comparison with other pavement condition indicies, such as SPI and HPCI, were performed. In Korea, Expressway and National Highway System has been continually managed by their own pavement management system. The pavement condition evaluation system has not been developed for the municipal roads except for Seoul city. Therefore, this study focuses on analyzing the characteristics of distress in major city's pavement and developing the pavement condition index for the municipal PMS. Panel rating and pavement condition survey for the selected pavement sections were conducted for developing pavement condition index. Municipal level pavement condition index(MPCI) was developed by statistical analysis. Also, a sensitivity analysis for each independent variable of the MPCI and comparison with other pavement condition indicies, such as SPI and HPCI, were performed.

온도가 열대거세미나방 산란에 미치는 영향 및 옥수수 포장에서의 산란 특성

문형철,최민경,장수지,이장호,김주희,전형권 한국환경생물학회 2022 환경생물 : 환경생물학회지 Vol.40 No.3

The effect of five different constant temperatures (18, 21, 24, 27, and 30±1°C) and a photoperiod of 14 : 10 (L : D) h on the reproduction parameters of Spodoptera frugiperda was studied. The longevity of adult female S. frugiperda decreased with increasing temperature (22.4 days at 21°C and 13.9 days at 30°C) but not at 18°C. The pre-oviposition period and oviposition period was the shortest at 30°C compared to the other temperatures. The total fecundity egg count was 887.4, 1,246.4, 1,348.9, 1,154.9, and 1,034.2 at 18, 21, 24, 27 and 30°C, respectively, during its life span. The survival rate of female S. frugiperda decreased rapidly after 13 days at 18°C, after 14 days at 21°C, after 15 days at 27°C, and after 9 days at 24°C, and 30°C. On the third day after the start of oviposition, 50% of the total fecundity was accomplished. In corn fields at less than the 10-leaf stage, the distribution of S. frugiperda egg masses was observed in the middle and lower plant regions, corresponding to 46.8% and 41.4% of the total egg masses, respectively. Egg masses were mostly found on the underside of the leaf blade (abaxial) of corn (66.7%). After releasing S. frugiperda adults on May 12, May 17, May 25, and May 30, the number of eggs per egg mass was 89.9, 88.5, 126.6, and 127.9, respectively. Egg masses of the subsequent generations of S. frugiperda were observed from late June, and the number of eggs per egg mass was 155.8 in late June, 270.7 in early July, and 303.5 in mid-July. 본 연구에서는 온도에 따른 열대거세미나방의 산란 특성을 조사하였다. 18, 21, 24, 27, 30°C에서 열대거세미나방의 암컷 성충의 수명기간은 각각 19.2일, 22.4일, 20.4일, 19.0일 및 13.9일이었으며, 산란 전 기간은 각각 5.2일, 4.9일, 5.2일, 5.3일 및 3.5일이었고, 총산란 수는 각각 887.4개, 1,246.4개, 1,348.9개, 1,154.9개 및 1,034.2개였다. 온도 별 열대거세미나방의 암컷 생존율은 18°C에서 13일 이후, 21°C에서 14일 이후, 27°C에서 15일 이후 및 24°C와 30°C에서는 9일 이후 급속하게 감소하였다. 산란 시작 후 3일째에 전체 산란의 50%가 이루어졌고, 18~24°C에서는 산란 시작 후 7일째, 27~30°C에서는 5일째에 전체 산란의 90%가 완료되었다. 10엽기 이하의 옥수수 포장에서 열대거세미나방 성충은 하위엽에 41.4%, 중위엽에 46.8% 및 상위엽에 11.7%를 산란하였으며, 산란된 난괴의 66.7%가 잎 뒷면에 산란되었다. 열대거세미나방 성충을 5월 12일, 5월 17일, 5월 25일 및 5월 30일에 방사한 결과, 난괴당 알 수는 각각 89.9개, 88.5개, 126.6개 및 127.9개였다. 접종 후 세대 성충의 산란은 6월 하순부터 관찰되었으며, 6월 하순에 산란된 난괴당 알 수는 155.8개, 7월 상순에 270.7개 및 7월 중순에 303.5개였다. 본 연구에서 보고한 열대거세미나방의 산란 특성은 성충 비래 시기에 따른 발생 예측 분석 및 방제 대책을 마련하는 데 활용될 수 있을 것이다.