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기혼여성의 수입의류와 국산의류의 평가기준에 관한 비교 연구
박혜정,박제옥,이연희 漢陽大學校 韓國生活科學硏究所 2002 韓國 生活 科學 硏究 Vol.- No.20
The purpose of this study is to identify differences that might exist between married women's evaluative criteria for imported and domestic clothing and to test the role of socioeconomic variables on those differences. Socioeconomic variables include age, education, income, and spouse's occupation. Sample selection criteria included married women living in Seoul, Korea, between ages 30-59. A purposive sample was obtained to secure respondents with experience with imported apparel (formal two piece suit). Of 400 distributed, 246 usable questionnaires were returned. Statistical analysis of results included mean, standard deviation, and paired t-tests. Purchasers of both imported and domestic clothing considered appearance as the most important evaluative criterion and approval of others and their recommendation as the least important criteria. The country of origin was not an important criterion in purchasing imported clothing. For both imported and domestic clothing, purchasers considered extrinsic criteria to be more important than intrinsic criteria. Respondents indicated significant differences in their criteria for evaluating imported versus domestic clothing for some socioeconomic variables. The results suggest the appropriateness of different marketing strategies for imported clothing and domestic clothing.
Park, Yune-Jung,Yoo, Seung-Ah,Choi, Susanna,Yoo, Hee-Soo,Yoon, Ho-Sung,Cho, Chul-Soo,Yoo, Ki-Dong,Kim, Wan-Uk Journal of Rheumatology 2013 The Journal of rheumatology Vol.40 No.6
<P><B>Objective.</B></P><P>Dyslipidemia, a risk factor for cardiovascular diseases, is more prevalent in patients with rheumatoid arthritis (RA) than in the general population. We investigated whether single-nucleotide polymorphisms (SNP) modulating low-density lipoprotein (LDL) cholesterol affect susceptibility, severity, and progression of RA.</P><P><B>Methods.</B></P><P>We enrolled 302 patients with RA and 1636 healthy controls, and investigated the SNP modulating LDL cholesterol. Clinical characteristics of RA, serum adipocytokine concentrations, and radiographic severity were analyzed according to genotype score based on the number of unfavorable alleles. The influence of genotype score on radiographic progression was also investigated using multivariable logistic models.</P><P><B>Results.</B></P><P>We identified 3 SNP (rs688, rs693, and rs4420638) modulating LDL cholesterol in Koreans, which correlated well with LDL cholesterol levels in both patients with RA and controls. Among them, 2 SNP, rs688 and rs4420638, were more prevalent in patients with RA than in controls. In patients with RA carrying more unfavorable alleles (genotype score ≥ 3), disease activity measures, serum adipocytokine levels, and radiographic severity were all increased. The genotype score was an independent risk factor for radiographic progression of RA over 2 years, and its effect was greater than the influence of conventional risk factors.</P><P><B>Conclusion.</B></P><P>SNP modulating LDL cholesterol influence the risk, activity, and severity of RA. These results provide the first evidence that genetic mechanisms linked to dyslipidemia may directly contribute to the susceptibility and prognosis of RA, a representative of chronic inflammatory diseases, explaining the high incidence of dyslipidemia in RA.</P>
Proteomics in Rheumatoid Arthritis Research
Park, Yune-Jung,Chung, Min Kyung,Hwang, Daehee,Kim, Wan-Uk The Korean Association of Immunobiologists 2015 Immune Network Vol.15 No.4
Although rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease, diagnosis of RA is currently based on clinical manifestations, and there is no simple, practical assessment tool in the clinical field to assess disease activity and severity. Recently, there has been increasing interest in the discovery of new diagnostic RA biomarkers that can assist in evaluating disease activity, severity, and treatment response. Proteomics, the large-scale study of the proteome, has emerged as a powerful technique for protein identification and characterization. For the past 10 years, proteomic techniques have been applied to different biological samples (synovial tissue/fluid, blood, and urine) from RA patients and experimental animal models. In this review, we summarize the current state of the application of proteomics in RA and its importance in identifying biomarkers and treatment targets.
( Yune Jung Park ),( Seong Hye Hwang ),( Seung Hyun Jung ),( Sa Seong Lee ),( Susan Na Choi ),( Seung Ah Yoo ),( Ji Hwan Park ),( Dae Hee Hwang ),( Seung Cheol Shim ),( Chul Soocho ),( Yeun Jun Chung 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Copy number variations (CNVs) have been implicated in human diseases. However, it remains unclear how they affect immune dysfunction and autoimmune diseases, including rheumatoid arthritis (RA). Methods: To de. ne CNVs, we used SNP genotyping data from the 500 discovery set. The Lsp1 plasmid DNA was tagged with GFP and was then transfected into Jurkat cells. Mice genetically de. cient in Lsp1 (Lsp1 ./. mice) were induced of delayed-type hypersensitivity and antigen-induced arthritis. Results: Here, we identi. ed a novel Lsp1 deletion variant for RA susceptibility. Differentially expressed genes in Lsp1-de. cient primary T cells represent cell motility and immune and cytokine responses. Functional assays demonstrated that LSP1, induced by T cell receptor activation, negatively regulates T cell migration by hampering ERK activation in vitro. In mice with T cell-dependent chronic in. ammation, loss of Lsp1 promotes migration of T cells into the target tissues as well as draining lymph nodes, exacerbating disease severity. Moreover, RA patients show diminished expression of LSP1 in peripheral T cells with increased migratory capacity. Conclusions: Our data highlights the importance of Lsp1 CNVs in the pathogenesis of immune diseases and provides novel insights into the mechanisms underlying T cell migration toward the in. amed synovium in RA.
( Seung Min Jung ),( Yune-jung Park ),( Kyung-su Park ),( Ki-jo Kim ) 대한류마티스학회 2022 대한류마티스학회지 Vol.29 No.3
Objective: The shared epitope (SE) and anti-citrullinated peptide antibody (ACPA) are involved in the pathogenesis of rheumatoid arthritis (RA). This study evaluated the clinical implications of SE and ACPA in terms of disease manifestation and response to biologic disease modifying anti-rheumatic drugs (DMARDs). Methods: Patients with identified human leukocyte antigen (HLA)-DRB1 alleles were included to compare the clinical characteristics and drug survival rate of tumor necrosis factor (TNF) inhibitors or abatacept based on the presence of SE and ACPA. Results: Of the 533 patients with identified HLA-DRB1 alleles, 329 patients (61.7%) with SE alleles showed higher disease activity and erosive changes compared to patients without SE alleles. SE-positive patients were more likely to start biologic (b-) or targeted synthetic DMARDs (tsDMARDs) within the first 5 years (p=0.020). The presence of SE, smoking, dyslipidemia, and higher erythrocyte sedimentation rate were independently associated with the initiation of b- or tsDMARDs (p=0.016, 0.028, 0.031, and 0.001, respectively). The presence of SE and ACPA did not affect the drug survival rate of TNF inhibitors, whereas the abatacept retention rate was higher in ACPA-positive patients (p=0.024). Conclusion: The presence of SE affected disease characteristics and prognosis in Korean patients with RA without a significant impact on drug survival rate of TNF inhibitors and abatacept. ACPA positivity was associated with abatacept drug retention, suggesting that abatacept may be helpful in ACPA-positive patients than in ACPA-negative patients.
( Jung Hee Koh ),( Yune-jung Park ),( Saseong Lee ),( Young-shick Hong ),( Kwan Soo Hong ),( Seung-ah Yoo ),( Chul-soo Cho ),( Wan-uk Kim ) 대한류마티스학회 2019 대한류마티스학회지 Vol.26 No.1
Objective. We undertook this study to investigate the discriminant metabolites in urine from patients with established rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and from healthy individuals. Methods. Urine samples were collected from 148 RA patients, 41 SLE patients and 104 healthy participants. The urinary metabolomic profiles were assessed using <sup>1</sup>H nuclear magnetic resonance spectroscopy. The relationships between discriminant metabolites and clinical variables were assessed. Collagen-induced arthritis was induced in mice to determine if a choline-rich diet reduces arthritis progression. Results. The urinary metabolic fingerprint of patients with established RA differs from that of healthy controls and SLE patients. Markers of altered gut microbiota (trimethylamine-N-oxide, TMAO), and oxidative stress (dimethylamine) were upregulated in patients with RA. In contrast, markers of mitochondrial dysfunction (citrate and succinate) and metabolic waste products (p-cresol sulfate, p-CS) were downregulated in patients with RA. TMAO and dimethylamine were negatively associated with serum inflammatory markers in RA patients. In particular, patients with lower p-CS levels exhibited a more rapid radiographic progression over two years than did those with higher p-CS levels. The in vivo functional study demonstrated that mice fed with 1% choline, a source of TMAO experienced a less severe form of collagen-induced arthritis than did those fed a control diet. Conclusion. Patients with RA showed a distinct urinary metabolomics pattern. Urinary metabolites can reflect a pattern indicative of inflammation and accelerated radiographic progression of RA. A choline-rich diet reduces experimentally-induced arthritis. This finding suggests that the interaction between diet and the intestinal microbiota contributes to the RA phenotype. (J Rheum Dis 2019;26:46-56)
Amodiaquine improves insulin resistance and lipid metabolism in diabetic model mice
Jung, Hoe‐,Yune,Kim, Bobae,Ryu, Hye Guk,Ji, Yosep,Park, Soyoung,Choi, Seung Hee,Lee, Dohyun,Lee, In‐,Kyu,Kim, Munki,Lee, You Jeong,Song, Woojin,Lee, Young Hee,Choi, Hyung Jin,Hyun, Chang Blackwell Publishing Ltd 2018 Diabetes, obesity & metabolism Vol.20 No.7
<P>Conclusion: Our findings suggest that amodiaquine exerts beneficial effects on glucose and lipid metabolism by concurrent activation of PPAR alpha/gamma. Furthermore, amodiaquine acts as an alternative insulin-sensitizing agent with a positive influence on lipid metabolism and has potential to prevent and treat type 2 diabetes while reducing the risk of lipid abnormalities.</P>