접형동에 발생한 악성 흑색종 1예

박철언,신승엽,이건희,김수진 대한비과학회 2013 Journal of rhinology Vol.20 No.1

Sinonasal malignant melanoma comprises 0.5% ~ 1.5% of all malignant melanomas. Malignant melanoma in the nasal cavity is relatively more predominant than in the paranasal sinus. The maxillary sinus is the most common sinus cavity affected by malignant melanoma, and the sphenoid sinus is a very rare site regardless of a primary or secondary origin. We encountered a patient with frequent epistaxis who was found to have malignant melanoma at the nasal septum and sphenoid sinus. She was treated successfully with endoscopic sinus surgery, and we report this case, along with the associated literature.

비강 및 부비동에서 발생한 악성 흑색종 1례

도남용,최지윤,이홍영 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Malignant melanoma aries from melanocyte, which has the ability to synthesize the pigment melanin. Melanocytes are derivations of neural crest cells and widely distributed throughout all cutaneous and mucosal surfaces. Overall, 20% of all malignant melanomas arise in the head and neck, of which only 10% affect the mucous membranes. Less than 1% of all malignant melanomas affect the nasal cavity. The authors experienced a case of primary malignant melanoma originated in left nasal cavity and paranasal sinus, and the patient had been treated by wide excision of the tumor with Weber-Furguson approach and postoperative irradiation. We report a case of primary malignant melanoma on the nasal cavity and paranasal sinus of 49 years old female patient with review of literature.

Ki67 Antigen as a Predictive Factor for Prognosis of Sinonasal Mucosal Melanoma

김동규,김대우,김시환,김동영,이철희,이재서 대한이비인후과학회 2008 Clinical and Experimental Otorhinolaryngology Vol.1 No.4

Objectives. Sinonasal mucosal melanoma is a rare and aggressive disease. The aim of this study was to analyze the clinical features of patients with sinonasal mucosal melanoma and to determine the role of Ki67 antigen as a predictor of prognosis in sinonasal mucosal melanoma. Methods. This was a retrospective case- series study at a single institution, an academic tertiary referral center. From 1995 to 2007, 27 patients with sinonasal mucosal melanoma were reviewed retrospectively, and the expression of Ki67 antigen was assessed by immunohistochemistry. Results. The overall 5-yr survival rate was 33.9%. No significant differences were observed in 5-yr survival according to age, sex, stage, or the presence of melanin. The rates of local failure, regional failure, and distant failure were 37.0%, 14.8%, and 11.1%, respectively. Patients with spindle or mixed cell types had better prognoses than those with other cell types. At a cut-off value of 35%, patients with lower Ki67 scores showed better survival than those with higher Ki67 scores. Conclusion. The presence of spindle or mixed cell types may indicate a better prognosis than other cell types. Ki67 immunostaining may be a useful predictor of prognosis in patients with mucosal malignant melanoma of the sinonasal tract. Objectives. Sinonasal mucosal melanoma is a rare and aggressive disease. The aim of this study was to analyze the clinical features of patients with sinonasal mucosal melanoma and to determine the role of Ki67 antigen as a predictor of prognosis in sinonasal mucosal melanoma. Methods. This was a retrospective case- series study at a single institution, an academic tertiary referral center. From 1995 to 2007, 27 patients with sinonasal mucosal melanoma were reviewed retrospectively, and the expression of Ki67 antigen was assessed by immunohistochemistry. Results. The overall 5-yr survival rate was 33.9%. No significant differences were observed in 5-yr survival according to age, sex, stage, or the presence of melanin. The rates of local failure, regional failure, and distant failure were 37.0%, 14.8%, and 11.1%, respectively. Patients with spindle or mixed cell types had better prognoses than those with other cell types. At a cut-off value of 35%, patients with lower Ki67 scores showed better survival than those with higher Ki67 scores. Conclusion. The presence of spindle or mixed cell types may indicate a better prognosis than other cell types. Ki67 immunostaining may be a useful predictor of prognosis in patients with mucosal malignant melanoma of the sinonasal tract.

하비갑개의 악성흑색종 치험 1례

맹창환(Chang Hwan Maeng),윤동구(Dong Gu Yun),김춘동(Choon Dong Kim),노영수(Young Soo Rho) 대한두경부종양학회 2002 대한두경부 종양학회지 Vol.18 No.1

Malignant melanoma of the nasal cavity occurs rarely. Malignant melanoma, originated from the upper respiratory tract including nasal cavity, has clinical feature of local recurrence and easily metastasizes to regional or distant lymph nodes, lung, and liver. Malignant melanoma originated from nasal cavity frequently shows tumor cell invasion, ulceration, or infection. Owing to these characteristics, complete surgical excision of the malignant melanoma in nasal cavity is not easy. And also the prognosis of this tumor is not so good because of a high recurrence rate. Recently the authors have recently experienced a case of malignant melanoma originated from the inferior turbinate, which was treated with lateral rhinectomy, total maxillectomy. The defect developed after surgical extirpation was reconstructed with rotational forehead flap.

비강 및 부비동에 발생하는 점막형 악성 흑색종의임상 양상 및 치료 결과

홍성룡,김시환,원태빈,심우섭,김용민,김정훈,이철희,민양기,이재서 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.12

Background and Objectives:Mucosal malignant melanoma of the nasal cavity and paranasal sinuses is an uncommon tumorwith poorer prognosis compared with its cutaneous counterpart. The purpose of this study is to investigate the clinical features andtreatment outcomes of mucosal malignant melanoma of the nasal cavity and paranasal sinuses. Subjects and Method:Eighteenpatients who were diagnosed and treated as mucosal malignant melanoma of nasal cavity and paranasal sinuses from 1995 to 2004were included. Male to female ratio was 10 to 8. Their ages ranged from 43 to 87 years with median of 62 years. The medicalrecords were reviewed retrospectively with respect to presenting symptoms, stage, treatment modalities and outcome. Result:The most common symptoms were epistaxis and nasal obstruction. The mean duration of symptom was 4.2 months. Commonlyinvolved sites were middle turbinate, inferior turbinate, maxillary sinus and ethmoid sinus. Eight cases belonged to stage I, ninecases to stage II and only one case to stage III. Among them, seventeen patients underwent surgery with or without radiotherapyand immunotherapy. Of the seventeen patients who underwent surgery, twelve had recurrence and the mean period for recurrencewas 8.2 months. During the follow-up periods, five had distant metastases. Five-year survival rate was 27.2% and the survivalrates according to age, sex, tumor size and stage were not statistically significant. Conclusion:Mucosal malignant melanomas ofthe nasal cavity and paranasal sinuses developed commonly in the 6th to 8th decades. Epistaxis and nasal obstruction were the mostcommon presenting symptoms. Almost all cases belonged to the stage I or II and the mainstay of the treatment was surgery.However, it was associated with frequent recurrences and a poor prognosis. (Korean J Otolaryngol 2006;49:1176-80)

비강 및 부비동에 발생한 점막형 악성흑색종의 임상적 특성 및 치료결과

남정권,김상윤,김용재,김재호,이봉재 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.4

비용종으로 오인된 무색소성 악성 흑색종 1예

이재은,구수권,노환중,조규섭 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.6

Mucosal malignant melanomas (MM) within the nose and paranasal sinuses are rare, representing 1-3% of MM and 3-4% of malignant sinonasal tumors. The incidence of amelanotic MM with primary lesions in the sinonasal cavity is also extremely rare. The absence of pigmentation in the tumor may result in diagnostic confusion. Amelanotic MM may masquerade as a variety of other conditions leading to a delay in the diagnosis and worsen the prognosis. In this report,we present, along a brief review of the literature, an interesting case of amelanotic MM misconceived as a nasal polyp. Although paranasal MRI and endoscopy showed no evidence of remnant mass after surgery, positron emission tomography/computed tomography (PET/CT) image showed an area of increaed fluorodeoxyglucose (FDG) uptake. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:366-70