식도에 발생한 위장관 간질종양

박영우,원용순,신화균,임재웅,고은석,김희경 대한흉부외과학회 2006 Journal of Chest Surgery (J Chest Surg) Vol.39 No.7

46세 남자환자가 건강검진에서 발견된 식도 종양을 수술받기 위해 내원하였다. 수술 전 검사 및 수술소견에서 평활근종과 유사한 소견을 보여 적출술을 시행하였으나 면역조직화학적 염색에서 위장관 간질종양으로 확인되었다. 식도에 발생하는 위장관 간질종양은 매우 드문 질환이다. 평활근종과는 다른 병리생물학적 소견과 임상양상을 보이므로 다른 치료방법 및 경과관찰이 필요하다. 환자는 재발 및 전이에 대한 지속적인 추적관찰 중이다.

Endoscopic management of ampullary neoplasm

Sunguk Jang 소화기인터벤션의학회 2019 Gastrointestinal Intervention Vol.8 No.3

Neoplastic lesions of ampulla, although infrequent, represent a significant portion of precancerous lesions arising within duodenum. Occurring either as sporadic, solitary lesion, or as a part of multiple adenomas within duodenum, due to its potential for malignant transformation, ampullary adeno-ma warrants a careful evaluation with the intention of curative resection when possible. The removal of ampullary lesion can be accomplished either surgically, or endoscopically if feasible. Here, we provide a brief review of endoscopic management of ampullary neoplasm.

Endoscopic management of ampullary neoplasm

Sunguk Jang 소화기인터벤션의학회 2019 International journal of gastrointestinal interven Vol.8 No.3

Neoplastic lesions of ampulla, although infrequent, represent a significant portion of precancerous lesions arising within duodenum. Occurring either as sporadic, solitary lesion, or as a part of multiple adenomas within duodenum, due to its potential for malignant transformation, ampullary adeno-ma warrants a careful evaluation with the intention of curative resection when possible. The removal of ampullary lesion can be accomplished either surgically, or endoscopically if feasible. Here, we provide a brief review of endoscopic management of ampullary neoplasm.

증례 : 혈액종양 ; 제1형 신경섬유종증 환자에서 발생한 다발성 암 1예: 위장관기질종양, 유방암 및 바터팽대부암

김효은 ( Hyoeun Kim ),조재용 ( Jae Yong Cho ),황창혁 ( Chang Hyeok Hwang ),양서연 ( Seo Yeon Yang ),천유진 ( You Jin Chun ),최성민 ( Sung Min Choi ),최성은 ( Sung Eun Choi ) 대한내과학회 2016 대한내과학회지 Vol.90 No.2

저자는 제1형 신경섬유종증 환자에서 동반된 세 종류의 종양(위장관기질종양, 유방암 및 바터팽대부암) 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder with a prevalence of approximately 1 in 3,500 live births. NF-1 predisposes to various benign and malignant neoplasms. Neurological malignancies are most frequent, but the risks of non-nervous system tumors, such as of the esophagus, stomach, colon, liver, biliary tract, pancreas, lung, melanoma, thyroid gland, female breast and ovaries, are also increased. Malignant tumors are the most common cause of death in patients with NF-1. Cases with double primary tumors have been reported, but cases involving three or more primary cancers are rarely reported. Therefore, we present the case of a NF-1 patient diagnosed with gastrointestinal stromal tumor, breast cancer and ampulla of Vater cancer. (Korean J Med 2016;90:154-158)

Management of Complications of Colorectal Submucosal Dissection

Eun Ran Kim,Dong Kyung Chang 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.2

Endoscopic submucosal dissection (ESD) is a useful procedure for the treatment of superficial gastrointestinal neoplasm. Comparedwith endoscopic mucosal resection (EMR), ESD has several benefits, which include resectability of various diffcult lesion, accuratehistologic assessment of specimen, and lower recurrence rate. However, the risk of procedure- related complications is higher withESD than with EMR. Moreover, because the colon has a thin wall and limited endoscopic maneuverability, ESD is considered a morechallenging and risky procedure when performed in the colon than in the stomach. ESD-related complications are more likely to occur. The significant complications associated with ESD are bleeding, perforation, coagulation syndrome and stenosis, most of which can betreated and prevented by endoscopic intervention and preparation. Therefore, it is important to know how to occur and manage theESD related complication.

S자 결장에 생긴 원발성 반지 세포암 : 1예 보고 A case report

김순,오연희,김승현,이성우,이종임 東國大學校醫學硏究所 2003 東國醫學 Vol.10 No.2

S자 결장에 발생한 원발성 반지세포암은 매우 드문 악성종양으로 방사선학적 보고는 많지 않다. 저자들은 16 ㎝가량의 S자 결장을 침범하여 임상적 및 방사선학적 소견에서 염증성 장질환으로 오인된 원발성 S자 결장 반지세포암의 전산화 단층촬영소견(Computed Tomography: CT)을 보고하고자 한다. Primary signet-ring cell adenocarcinoma of the sigmoid colon is uncommon, high-grade neoplasm. The radiologic feature of this neoplasm have rarely teen described in the literature. We report a case of primary signet-ring cell carcinoma of the sigmoid colon presenting as 16㎝ in length of concentric bowel thickening with peritoneal carcinomatosis.

Metastatic Cutaneous Duodenal Gastrointestinal Stromal Tumor: A Possible Clue to Multiple Metastases

( Young Jae Kim ),( Woo Jin Lee ),( Chong Hyun Won ),( Jee Ho Choi ),( Mi Woo Lee ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.3

We report a case of a 69-year-old man with metastatic cutaneous duodenal gastrointestinal stromal tumor, which led to find multiple metastases on orbital muscle and scalp. The patient presented with a rapidly growing chest nodule with mild tenderness. He underwent surgical resection for duodenal gastrointestinal stromal tumor and had been treated with imatinib for three years. Histopathological examination of the chest nodule was consistent with gastrointestinal stromal tumor. A brain magnetic resonance imaging of follow work-up revealed multiple metastases at the left superior rectus muscle and occipital scalp. Under the diagnosis with imatinib-resistant duodenal gastrointestinal stromal tumors, a second- line therapy with sunitinib was tried. After six weeks, his skin lesion was completely improved and other metastatic cancers showed a response of stable disease. This is the first reported case of a cutaneous metastasis from duodenal GIST. This report emphasizes the importance of a full-skin examination in patients with a medical history of gastrointestinal stromal tumor which leads to find multiple metastases. (Ann Dermatol 30(3) 345∼347, 2018)

REVIEW : The Role of Cellular Senescence in the Gastrointestinal Mucosa

( Joshua D Penfield ),( Marlys Anderson ),( Lori Lutzke ),( Kenneth K Wang ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.3

Cellular senescence is a biologically irreversible state of cell-growth arrest that occurs following either a replicative or an oncogenic stimulus. This phenomenon occurs as a response to the presence of premalignant cells and appears to be an important anticancer mechanism that keeps these transformed cells at bay. Many exogenous and endogenous triggers for senescence have been recognized to act via genomic or epigenomic pathways. The most common stimulus for senescence is progressive loss of telomeric DNA, which results in the loss of chromosomal stability and eventual unregulated growth and malignancy. Senescence is activated through an interaction between the p16 and p53 tumor suppressor genes. Senescent cells can be identified in vitro because they express senescence-associated β-galactosidase, a marker of increased lysosomal activity. Cellular senescence plays an integral role in the prevention and development of both benign and malignant gastrointestinal diseases. The senescence cascade and the cell-cycle checkpoints that dictate the progression and maintenance of senescence are important in all types of gastrointestinal cancers, including pancreatic, liver, gastric, colon, and esophageal cancers. Understanding the pathogenic mechanisms involved in cellular senescence is important for the development of agents targeted toward the treatment of gastrointestinal tumors. (Gut Liver 2013; 7:270-277)

병리의사를 위한 소화기계 암등록에 대한 제안(Ⅰ)

조미연,강윤경,김경미,장희경,장희진,장미수,김준미,강대영,박찬일,손진희 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.3

Background : Cancer registries are fundamental for cancer control and multicenter collaborative research. However, there have been discrepancies among pathologists in classifying cancer and assigning the codes according to the International Classification of Disease Oncology 3 (ICD-O3). To improve the quality of cancer registries as well as to prevent the conflict with medical insurance compensation, a guideline for the coding of cancer is mandatory. Methods and Results : Funded by the Management Center for Health Promotion, 40 members of the Gastrointestinal Pathology Study Group and the Cancer Registration Committee of the Korean Society of Pathologists participated in the 1st workshop for gastrointestinal tumor registration. The subjects of gastric epithelial tumor, intramucosal carcinoma of the colon, carcinoid tumor, gastrointestinal stromal tumor and appendiceal mucinous tumor were discussed to create a guideline. A survey to obtain consensus for the guideline proposed by the workshop was carried out by the members of the Korean Society of Pathologists and 240 members completed the questionnaire. Conclusion : Although there are some issues to be discussed further, such as coding of high grade dysplasia/adenoma and intramucosal carcinoma of stomach and colon, the members agreed upon most parts of the proposed guideline. Therefore, we suggest using the ICD-O3 coding guideline for gastrointestinal tumor.

오가노이드를 활용한 약물 검색 플랫폼

맹주은,김순찬,송명현,정나현,구자록,Ju Eun Maeng,Soon-Chan Kim,Myoung-Hyun Song,Nahyun Jeong,Ja-Lok Ku 대한소화기암연구학회 2022 Journal of digestive cancer reports Vol.10 No.2

Gastrointestinal cancer accounts for one-third of the overall cancer occurrence worldwide. Pancreatic ductal adenocarcinoma (PDAC) is a type of gastrointestinal cancer that is known to be one of the most fatal among all cancer types, with a 5-year survival rate of less than 8%. Chemotherapy combined with surgical resection is its probable curative option. However, surgery is accessible for only 10-15% of patients diagnosed with PDAC. Organoids show self-organizing capacities and resemble the original tissue in terms of morphology and function. Organoids can also be cultured with high effectiveness from tumor tissues derived from each patient, making them an extremely fitting model for translational uses and improving personalized cancer medicine. Enhancing drug screening platforms is necessary to apply personalized medicinebased organoids in clinical settings.