원발성 진챙성 실어증 1례

이애영,오상근,김제,김재문 대한신경과학회 1998 대한신경과학회지 Vol.16 No.2

비안와대뇌형 모균증 치험 3례

문영일,김종남,홍순관,이지애,정옥경,김문정 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.3

Rhinocerebral mucormycosis is a well-described fulminant fungal infection that typically presents in a rapidly fulminant manner. This condition is more likely to occur among patient with diabetes mellitus, malignant tumors, who have long-term steroid treatment, or who suffer from some debilitating diseases. We report 3 cases of rhinoorbitocerebral mucormycosis, all suffered from diabetes mellitus. In all 3 cases, endoscopic sinus surgery was done and the antifungal agent(amphotericin B) was administered intravenously, and two patients died. One survivor who had focal extension of paranasal sinus and orbit, required one surgical intervention without orbital exenteration and he is alive without recurrence disease. The severity of the disease is probably dependent upon the gost resistance to the invasion of phycomycetes. Early diagnosis and immediate, effective treatment are the key for cure of the disease.

일개 병원 간호사의 암환자 통증관리에 대한 지식과 태도 : A Survey from Korean Cancer Pain Management Project

박현애,고명자,이현숙,김영미,김문숙 성인간호학회 2003 성인간호학회지 Vol.15 No.2

This study was conducted to examine the nurses’ knowledge about and attitude toward cancer pain management. Method: Study subjects of this retrospective cross-sectional survey study were 343 nurses sampled conveniently in a tertiary teaching hospital in Seoul. Seven measurement tools were used to collect data on demographic data, knowledge about and attitude toward cancer pain management, barrier to cancer pain management, knowledge about and concerns for the opioid use, and professional education of cancer pain management. Result: Nurses showed knowledge deficient when their knowledge on the cancer pain management and the opiod use was evaluated using two case scenarios and the 15-item questionnaire respectively. Ninety-five percent of the nurses believe that cancer pain management it a major problem. However, inadequate staff knowledge of pain management was rated as the single most important barrier to adequate pain management by 20.4% of nurses. Only 10.9% and 23.2% of the nurses replied that nursing school’s education and professional education in cancer pain management respectively, were adequate. Conclusion: This study confirms the existence of knowledge deficits and attitudinal barriers among Korean nurses that can impede cancer pain management. This study suggests a need for professional education for nurses on cancer pain management.

원발성 간질을 동반한 광과민성 간질

김재문,이애영,김제 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Photosensitive epilepsy (PE) is a well-known type of reflex epilepsy. Among the 1,045 epileptic patients in Chungnam National University Hospital, we experienced 15 patients (1.44%) who had epilepsy and visual stimuli induced epilepsy together. Types of seizures were generalized tonic-clonic seizures (8 patients), JME (2 patients), complex partial seizure (4 patients), benign Rolandic epilepsy (1 patients). Seziureprone precipitating factors were TV (6 patients), computer screen and playing go (3 patients each), flickering light (2 patients), and sunlight (1 patient). Abnormal EEG response to intermittent photic simulation were identified only in seven patients. All patients except one had no etiological diseases. With or without medication, visually induced seizures were well controlled by active prevention in most of patients. Early detection and prevention of precipitating factors in photosensitive epileptic patients is highly recommended.

뇌경막내에 위치한 수막성 골종 증례보고

조영도,조준,문창택,장상근,윤상애 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

This case report deals with a 75-year-old female. The patient was admitted for headache due to passenger traffic accident. Plain radiographs of the skull showed the finding of dense calcified lesion in the right parietal bone. In the Brain CT scan, this lesion showed uniformly hyperdense and non-enhancing mass. The clinical examination showed no gross abnormalities. In the operation field, this lesion attached to the inner surface of the dura by the dense fibrous band and protruded into the cerebral cortex. One fragment was about 1cm×1.4cm×1.6cm and the other about 3mm×2mm×3mm. Histologic examination of the surgical specimen(H/E stain) showed a benign osteoma.

치매환자에서 acetyl-L-carnitine (nicetile^�)의 임상적 효능 및 안전성에 관한 연구

이애영,김재문 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Background and Objectives : The increasing number of dementia patient in our society is a problematic due to the burden for families and social services. There is no cure for the degenerative dementia or vascular dementia resulting from stroke so far. Recently, Acetyl -L-carnitine (ALC) has been proved to improve learning and memory abilities in aging rats. To verify the clinical efficacy and safety of ALC for the patients with dementia, we evaluated 20 stroke-related dementia patients and 4 patients with the dementia of Alzheimer's type by using various neuropsychological assessments. Methods : All patients were assessed before taking the ALC with structured neuropsychological battery for determining their initial cognitive status. The drug was given orally with the dose of 500 mg b.i.d for longer than 6 months. Since then, clinical and neuropsychological re-evaluations were performed and checked out any side effects related with medication. Results : 1) The mean duration of medication was 246.8±61.4 days 2) The multi-infarct dementia was the most common type of vascular dementia 3) After six months of medication, 9 of 14 tests on the cognitive functions were improved in the patients with vascular dementia 4) There was no serious clinical or laboratory side effects related with ALC. Conclusion : ALC can be effective and safe agent for cognitive improvement in patients with vascular dementia via a cholinergic and oxidative brain metabolism.

Gerbera(Gerbera hybrida Hort)의 형태적 특징과 유전적 유연관계 분석

김현애,임현희,양원진,이재헌,이병영,이용문,권오창 동아대학교 농업생명과학연구소 2001 農業生命資援硏究 Vol.10 No.1

This study was conducted to analyze the morphological characteristics and genetic relationships among 24 species of Gerbera. Most of flower colors were pink. The numerical order of flower color was pink, orange, red, double-colored, and milk-white. Majority of flower types were single or semidouble flowers. A few species were double flowers. Flower diameters were from 7cm to 12cm, showed significant differences compared to other characteristics. Flower stalks were ranged from 55cm to 65cm. Only one species was the shortest as 55cm. The others were similar size as about 65cm. Main annual production yields were between 190 and 400 blossoms. Fifty seven reproducible polymorphic bands from eighty primers were used for analyses of genetic similarity. The genetic similarity of 24 collected Gerberas was largely classified into five groups. The average similarity coefficient was 0.72 ranged from 0.50 to 0.90. The highest similarity coefficient was shown between 'Sardana' with red/white flower color and double flower type, and 'Tamara' with orange flower color and double flower type as 0.90.

파킨슨씨병 환자의 행동신경학적 특성에 관한 연구

이애영,김재문,신석철 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

Research with respect to the neurobehavioral features in patients with idiopathic parkinson's disease can provide new insights about the responsible neural substrates for human cognitive and emotional functions. These evaluation allow us to define how these symptoms after on the overall functions in parkinsonian patients, to assess side effects of antiparkinsonian drugs, and to determine the efficacy of clinical management. However, there have been arguing about the prevalence, nature, and courese of nuropsychological deficits in Parkinson's disease. Especially, there is no studies deling with neuropsychological properties in Parkinson's disease with using structured protocols in Korea. To define the neurobehavioral characteristics in patients with idiopathic parkinson's disease, the author have used the structured protocol consisting with Mini Mental State Examination, Korean Wechsler Adult Intelligence Scale, Beck Depression, Inventory, Raven's Colored Progressive Matrice Test, Rey Complex Figure Test with free recall after 30 minutes, Finger Tapping, Grooved Pegboard Test, Hand, Dynamometer, and Stroop test. All these tests cover in the general intelligence, memory, visuospatial and visuomanual functions, depression, and mental flexibility in the patients. Ninety two consecutive patients with idiopathic parkinson's disease were studied prospectively, comprising 46 men and 46 women. To compare their results of neuropsychological tests, 20 age- and education-matched controls were evaluated with using the same neuropsychological battery. Forty one percent of them began the Parkinson's disease between 50 to 70 years of age. The presence of visual of even auditory hallucinations was more common among the elderly patients with cognitive impairments. Clinically, bradykinesia, rigidity, postural instability an gait abnormality not tremor were positively correlated with the Hoehn-Yahr stage. The mean score of Mini-Mental State Examination and Korean Wechsler Adult Intelligence Scale were 22.8 and 92.2(verbal IQ: 96.0 performance IQ: 87.7), respectvely. The mean Beck Depression Inventory score was 22.3. With regard to these scores, the patients on this study showed mild cognitive impairment and depressive mood in general. The dementia was more common in patients who were older and more advanced stages in the Hoehn-Yahr classification. Cognitively impaired patients showed worse mental flexibility on Stroop test and delayed P_300 latencies on Event-Related Potential study. The tests results of fine and rapid finger movement and visuo-menual cooperation indicated that patients in advanced stage in the Hoehn=Yahr classification were more impaired than patients in the earlier stage on the disease. The depressed Parkinson’s patients performed significantly worse than the non-visual memory, and visuo-spatial reasoning. Among the late-onset Parkinson’s patients, cognitive impairments and depression were more common and showed poor mental flexibility.

자색고구마가 사염화탄소 투여에 의한 흰쥐의 간손상 보호에 미치는 영향

조영자,김현아,방미애,오용비,정병춘,문윤호,정우진 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.3

The purpose of this study was to investigate the effects of dietary purple sweet potato(lpomoea batatas) powder on serum lipid levels and antioxidative enzymes in normal and pretective effect on hepatotoxicity rats induced by carbon tetrachlolide. Four groups of rats (3-week-old inbred Sprague-Dawley male rats) were normal rats fed control diet(C)_(1) induced hepatotoxicity rats fed control diet(EC)_(1) normal rats fed purple sweet potato diet(P), and induced hepatotoxicity rats fed purple potato sweet diet(EP). Rats were induced by single injection of 50% carbon tetrachloide(0.1 mL/100 g B.W., i.p.). The rats were fed ad libitum each of the experimental diet for 5 weeks. After 5 weeks the rats were sacrificed and activities of antioxidant enzymes and lipid peroxidation products were determined in their liver homogenates. But serum concentrations of lipid was not significant in all groups. Serum alanine aminotransferase(ALT/GPT) and aspartate aminotransferase(ALT/GPT)of the EC and EP groups were heigher than the C and P groups. The hepatic glucose 6-phosphatase(G9Pase) activity of the group fed purple potato diet(P) was lower than the other groups(p<0.05). However, The glutathione peroxidase(GPx) activities was not statistically different between the groups. Renal glutathione S-transferase(GST) activity of the EC and EP groups were lower than the C and P groups(p<0.05). In conclusion, these results suggest that purple sweet potato is believed to be possible protective effect on hepatotoxicity rats induced by carbon tetrachlolide.

발작유발인자에 관한 연구

김재문,최영철,김재성,이애영 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Background and Objectives : Control of seizure inducing factors (SIFs) is essential in the management of epilepsy. To clarify the common SIFs and the natures of the SIFs, we analyzed 641 patients. Methods : Inclusion criteria were as follows : 1) Older than seven years of age, 2) Followed up more than six months, and 3) Seizures occurred more than three times. Situations those associated with seizures at least half of the attaks were regarded as their SIFs. Results : SIFs were detected in 36.7% (235 patients, 275 SIFs) of patients. Controllable SIFs were 104 (37.8%), intermediately controllable SIFs were 74 (26.9%), and uncontrollable SIFs were 97 (35.3%). Noncompliance and alcohol ingestion were the common controllable SIFs (24.0% and 9.8% each). Alcohol was frequently associated with focal symptomatic epilepsy, while sleep and visual stimulation were common SIFs in idiopathic epilepsy. Noncompliance was common in patients with focal seizure who experienced the adverse effects of antiepileptic drugs. SIFs were rarely associated with older epileptic patients. Conclusion : Early detection and education of the possible SIFs in each epileptic patients is considered as an important therapeutic modality in managing the epileptic patients.