인슐린 비의존형 당뇨병 환자에서 혈장 Endothelin-1농도의 변화

신양수,조희충,김원식,국기용,김용화,정종훈,문철웅,배학연,양성훈 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2

Endothelin(ET) is a 21-residue peptide originally isolated from the cultured porcine endothelial cells. There are at least three genes for endothelin:endothelin-1(ET-1), endothelin-2(ET-2), and endothelin-3(ET-3). Endothelins are present in various human biological fluids including plasma, urine, breast milk, and saliva and have been found elevated plasma ET concentrations in patients with diabetes mellitus, Patients undergoing maintenance hemodialysis due to chronic renal failure, patients with acute myocardial infarction, and patients with subarachnoid hemorrhage. Endothelial cell damage is suspected to occur in diabetic patients and may be one important cause of angiopathy, a major complication in diabetes mellitus. The elevation of ET in diabetic patients may be a marker of, and further exacerbate, their vascular disease. We measured the levels of ET-1 in plasma of 50 patients with non-insulin dependent diabetes mellitus(NIDDM) and 25 normal subjects by radioimmunoassay. The plasma ET-1 concentration (mean±S.D.) in NIDDM was 6.461 A2.510 f㏖/ ㎖, and was significantly higher than in normal subjects (4.567±1.155f㏖/㎖) (P<0.05). The plasma ET-1 concentration (mean±S.D.) in diabetic retinopathy group( 7.15±2.454 f㏖/ml) was significantly elevated than those in otherwise uncomplicated groups (5.348±2.390 f㏖/㎖)(P<0.01). The correlation between any clinical parameters and plasma ET-1 levels in NIDDM was not significant, In conclusion, this study suggest that the elevated levels of ET-1 in diabetic patients may be play a important role in the pathogenesis of diabetic complications.

美國 OHIO地方의 都市造景配置에 관한 硏究 : Ohio Columbus市의 Three nationwide plaza를 中心으로

申永澈,催容福,朴永達 충북대학교 농업과학기술연구소 1996 農業科學硏究 Vol.13 No.-

To investigate garden style of Ohio districts, Three nationwide plaza located in Columbus city was chosen to survey the environmental landscape and planting arrangement and studied with special reference to the function of the plant in site. 1. The design principles are chosen order, unity, rhythm in planting arrangement. 2. Dominant tree species planted in the garden are Juniperus globosa, Pinus thunberigii, Malus floribunda, Gleditsia triacanthos var. inermis, Contoneaster, Rose spp., Acer saccharum etc. 3. Dominant herbaceous plant species in the garden are Hedera spp., Hosta spp., Iris sibirica, Hemerocallis hybride etc. 4. Throughout the present studies it is suggested that housing garden of Columbus city is chosen Malus floribunda, Hemerocallis hybrida, Hosta spp. etc.

Ni-Ti 形狀記憶合金의 變態溫度와 回復擧動에 미치는 熱處理의 影響

申明徹,李龍鎬,金英宰 弘益大學校 1985 弘大論叢 Vol.17 No.2

There are many problems to be solved for more wide practical applications of Ni-Ti Shape Memory Alloys. In this point of view, it was studied to observe the effects of heat-treatment on transformation temperature and recovery behavior of Ni-Ti shape memory alloy in the temperature range of 300℃ to 800℃. Two compositions of 54.9w/o Ni-Ti and 54.4 w/o Ni-Ti were studied in this research. To clarify the effects of heat-treatment on transformation temperature and recovery behavior of Ni-Ti shape memory alloy, Transmission Electron Microscope and Differential Thermal Analysis, Electrical Resistivity technique were employed. The results of this research were as follows: (1) Transformation temperature was decreased with lower annealing temperature below 600℃ and more amount of deformation prior to annealing. (2) In case of annealing above 600℃, transformation temperature depends on only composition and memory properties are not so good. (3) The best annealing temperature for memory properties proved to be around 400℃. (4) In this annealing temperature, the elastic which is lowest and residual deformation has not remained. (5) The width of the twin plate was decreased with increase of the heat treatment temperature.

혈중 감마지티피 상승의 임상적 의의

신주연,김용규,박신구,이지나,김환철,임종한,홍윤철 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.1

목적: 혈중 감마지티피는 주로 알코올 섭취와 간세포 손상의 지표로서 이용되어져 왔으나 최근에는 혈중 감마지티피가 체내의 산소성 스트레스를 민감하게 반영하는 지표이며, 혈중 감미지티피를 이용하여 만성질환의 발생을 조기에 예측할 수 있다는 주장들이 있다. 이에 본 연구에서는 일반 인구 집단을 대상으로 한 건강검진 자료를 분석하여 혈중 감마지티피의 상승에 영향을 미치는 요인들을 분석하고 혈중 감마지티피와 산소성 스트레스와의 관련성 및 임상적인 이용 가능성을 알아보고자 한다. 방법: 2001년부터 2003년까지 한 대학병원 산업의학과에서 건강검진을 실시한 15,546명을 대상으로 하였고 신체계측, 혈액검사 그리고 설문지의 정보를 분석하였다. 총 15,546명 중 남성은 9,660명 이었고 여성은 5,886명 이었다. 연령, 성별, 체질량지수, 흡연, 음주, 운동량 비타민 복용 여부에 따른 혈중 감마지티피의 평균을 분석하였고, 성별에 따른 다변량 분석을 실시하였다. 다변량 분석에는 연령, 체질량지수, 음주빈도, 흡연량, 혈색소, 이완기혈압, 공복시혈당, 총콜레스테롤, ALT를 포함하였다. 결과: 연구 대상자들의 혈중 감마지티피의 평균은 남성에서 평균(±2SD)이 47.51(±111.62)이었고, 여성에서는 19.09(±42.02) 으로서, 대체적으로 정상 범위에 있다고 보여 지나 개인차가 상당히 크다는 사실을 알 수 있었다. 다변량 분석의 결과에서는 혈중 감마지티피의 상승에 영향을 미치는 요인이 성별에 따라 다소 달랐으나 남녀 모두에게 연령, 음주빈도, 흡연량, 이완기혈압, 공복시혈당, 총콜레스테롤, ALT가 유의한 영향이 있음을 확인할 수 있었다. 그리고 다변량 로지스틱회귀분석의 결과에서 '임상적 비정상'을 예측함에 있어 혈중 감마지티피가 진단적 유용성이 있음을 확인하였다. 결론: 긴존에 일반적으로 알려져 있는 것처럼 혈중 감마지티피를 단순히 알코올 섭취와 간세포 손상의 지표로서만 볼 수 없으며, 성별, 연령, 흡연, 고지혈증, 당뇨, 고혈압 등 많은 다른 요인들에 의해서 영향을 받으며, 혈중 감마지티피를 산소성 스트레스를 반영하는 생물학적 지표로 해석할 수도 있다. 따라서 혈중 감마지티피의 상승을 임상적으로 해석할 때는 (비록 정상인 범위에 있다하더라도), 알코올 섭취나 간세포 손상 뿐 아니라 다른 여러 요인들을 함께 고려해야 한다. 더욱이 혈중 감미지티피의 상승을 만성질환 즉, 고혈압, 당뇨, 고지혈증 등의 발생을 조기에 발견할 수 있는 지표로서 임상영역이나 건강검진시 유용하게 활용할 수 있을 것이다. Objectives: Incresed gamma-glutamyltransferase (GGT) concentration has mainly been used as a biologic marker of alcohol drinking and liver diseases. However, some recent reports have suggested that serum GGT concentration may be an early biomarker of oxidative stress and associated with chronic diseases like hypertension, DM, hyperlipidemia, CHD, stroke etc. In this study, we analysed the factors associated with increased serum GGT level and evaluated the clinical application of serum GGT in predicting the risk of chronic diseases. Methods: The data were collected from 15,546 periodic health examinations, 9,660 males and 5,886 females, done at one university hospital from 2001 to 2003. We analysed self-questionnaire, physical examination and laboratory data. Statistical analyses(t-test, ANOVA, Pearson's correlation analysis, multiple regression analysis and logistic regression analysis) were done by SPSS for windows 10.0. Results: Mean serum GGT levels were quite different according to age, sex, BMI, smoking and alcohol drinking (all P-value <0.001), but were not different by regular vitamin intake or not (P-value = 0.117). There was significant correlation between serum GGT level and the variables (of age, BMI, blood pressure, Hb, fasting blood sugar, total cholesterol, AST and ALT) (all P-value <0.001). In sex-specific multiple regression analysis, increased serum GGT level was significantly associated with age, alcohol drinking, smoking, blood pressure, fasting blood sugar and ALT in males (all P-value <0.001), and with age, alcohol drinking, smoking, Hb, blood pressure, total cholesterol and ALT in females (all P-value <0.05). In sex-specific logistic regression analysis, increased serum GGT level was significantly associated with risk of 'clinical abnormalities'. This risk increased about 13-fold in males and 4.6-fold in females for serum GGT level over the third quatile, compared with under the first quartile. Conclusions: Serum GGT level is increased not only by alcohol drinking or liver diseases, but also by many other factors associated with chronic diseases and behavioral factors. Thus many factors should be considered in evaluating an increase in GGT level, even when within the upper normal range. Serum GGT level may be a predictor for the early development of chronic diseases.

치과용 실험 레진에서 광 기시제와 중합억제제 함량이 광중합에 주는 영향

신현철,임범순,최재윤,이용근 大韓齒科器材學會 2004 대한치과재료학회지 Vol.31 No.4

The purpose of this study was to evaluate the effect of fraction of photo-initiator and inhibitor in the experimental resins on the degree of polymerization using a FT-IR and dynamic mechanical analyzer (DMA). Eight experimental dental resins, four different concentrations of photo-initiator (EXP-A, EXP-B, EXP-C, EXP-D) and four different concentrations of inhibitor (EXP-E, EXP-F, EXP-G, EXP-H), were tested. Storage modulus was measured by using DMA (StressTech Rheometer, Rheologica Instrument, Sweden) with fast oscillation mode (1 Hz). After disk-typed (4 ㎜×1 ㎜) samples were irradiated with Halogen light curing unit at 500 ㎽/㎠ for 30 sec, the storage modulus was recorded continuously for 60 min. The degree of conversion was also measured using the FT-IR spectroscopy (FTS-165, Biorad Win-IR, Perkin-Elmer, USA) at 1 hr and 24 hrs after irradiation with the same curing condition as DMA test. The average of results for five specimens was analyzed using Tukey multiple comparison test (p=0.05). From the results, the minimum concentration of photo-initiator was 0.35 wt.% and the maximum concentration of inhibitor was 0.15-0.20 wt.% to obtain the proper polymerization. To enhance the biocompatibility, the concentration of photo-initiator should be added to dental resins as low as possible. To prolong the shelf-life, the concentration of inhibitor should be added to dental resins as much as possible, but biocompatibility due to the inhibitor should be considered to determine the optimum concentration.

증후성 단일 소심부뇌경색의 임상적 및 방사선학적 양상

신원철,이태규,노용우,오재욱,장대일,정경천 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

쇼트피닝 가공 최적조건 탐색을 위한 실험적 연구

신용승,김태형,윤종학,노승남,이철구 서울産業大學校 2002 논문집 Vol.53 No.1

The shot peening process is most often used to improve fatigue properties of metal parts. In order to achieve optimum, repeatable and reliable fatigue enhancement from the shot peening process, the important shot peening parameters must be controlled. In this paper, the optimum shot peening condition is investigated. Rotary bending fatigue test was accomplished to investigate the effects of shot peening on the fatigue strength. Experimental results show that the fatigue strength was tremendously increased by optimum peening.

도금공정 6가 크롬 미스트의 공기중 및 시료채취 여과지상 환원속도에 관한 연구 : 시료채취중 환원속도와 손실 보정 Reduction Rate during Sampling and Correction for the Loss

신용철,이병규,김선자,김향순 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

Hexavalent chromium, Cr(Ⅵ),may reduce on polyvinyl chloride (PVC) filter during air sampling. This study was conducted to cstimate the reduction rate of Cr(Ⅵ) on PVC filter during air sampling and an correction equation for th loss of Cr(Ⅵ) by feduction in an industrial plating process. The reduction of Cr(Ⅵ) was progressed rapidly in 60 minutes and slowly thereafter. The empirical reduction rate of Cr(Ⅵ) (Y) over sampling time (X, min) was the following : Y= 0.916 -0.0208√x (r=0.73, p〈0.05). The loss of Cr(Ⅵ) caused by reduction during sampling can be corrected using the following empirical equation : Sc = S x 1/Y. where Sc = corrected value, S = analytical result, and Y= reduction rate of Cr(Ⅵ).

청소년 범죄 기사 내용 분석

신용규,나철,이길홍 중앙대학교 의과대학 의과학연구소 1997 中央醫大誌 Vol.22 No.4

The present study was performed to identify the socio-psychiatric aspects of adolescent criminal offences reported on daily newspapers and to use them as basic materials for prevention of adolescent criminal offences. The author analysed 609 cases of adolescent criminal offence who reported on Dong-a Ilbo and Chung-Cheong Ilbo, from 1991 to 1995. The total numbers of cases were 609, including 573 males and 36 females. In data analysis, the subjects were devided into three subgroups as the student group(221 cases), the working group(70 cases), and the jobless group (318 cases). and the result of the study were as follows. 1. The cases of adolescent criminal offences were more common in male. Their mean ages were the youngest in the student in contrast to late subgroup of the working or the jobless. 2. The antisocial personality was the most common in the jobless, while the dramatic cluster including the borderline or masochistic personality was more prevalent in the working, and the anxious cluster was more in the student. In psycho-social stressors, the student was suffered from various stress in school, home and their social life, while the working showed more serious stress in their hetero-sexual and business life, or more experienced maladjustment in their social and job life, and the jobless group showed more stressful burden due to economical problems, or more experienced maladjustment in their family life. 3. In subtypes of criminal offences, violence, fatal assult, fatal injury, parricide, and their or group offences were more common in the student, while murder, rape and raising the penalty or solitary offences were more frequently observed in the working, and felony was the most prominent offence in the jobless. 4. The incidence of student's offences reported in daily newspapers was remarkably increased, while those of the working or the jobless were decreased. The most vulnerable time of criminal offence in adolescents was from 7-12 PM, and these trends were prominent in the jobless compared with the student in afternoon, and the working in midnight. 5. In motivation of crimes, the psychological conflicts were the most in the student, while the curiosity, the various personality problems, and the heterosexual conflicts were common in the working, and the economical problems or the absence of motivations were prominent in the jobless. 6. In the tools of crime, the sharp materials were the most ones in the student compared with the fists, knives or guns in the working, and the absence of tools in the jobless. In the methods of crime, the latent aggression or physical aggression were the most ones in the student, compared with the forced aggression or direct aggression in the working. 7. In terms of accompanied person participating in criminal offence, group offence was prevalent(60.9%). The numbers of accompanied persons were more than 4 persons in the student, compared with the 2 persons in the working group, and the 1 person in the jobless. In the age ranges of accompanied persons, the student showed the youngest, while the jobless showed the oldest ones. 8. Males(63.2%) were more common in victims of adolescent criminal offences, about 40% of victims was the absence of job, and adults older than 21 years old(34.6%) was the most prevalent, followed by children younger than 11 years old(21.8%). Most of the victims in the student were their friends, lovers or parent with minor injury, while those in the working were passengers with more serious injury. The 67.8% of abusers was unknown persons with victims, and these trends were prominent in the jobless compared with more known persons in the student. 9. In the characteristics of the abuser, the working used more various psychoactive substances or alcohols, and more frequently experienced hallucination or delusion at the time of criminal offence compared with the other groups.

남북 화해 시대에 있어서 인문학의 역할과 과제 : 역사학과 역사 교육을 중심으로

신용철 경희대학교 인문학연구소 2000 인문학연구 Vol.4 No.-

After the World War Ⅱ in 1945, the world was divided into two according to the ideology and politics. Germany in West Europe and Korea in East Asia represented 'the Divided Nations in the Parted World'. However, Germany was united in 1990, and the country is in the process of the integration of its history, now. Though the political unification of divided nations is not an easy project, it is even more difficult to achieve the cultural, conscious, historical integration; nevertheless, Germany has been accomplishing the difficult task successfully. Since Korea was divided in 1945, the relation between South Korea and North Korea was worsened because of the Korean war which lasted for three years from 1950. South Korea and North Korea hated each other for fifty-five years, considering the other as an enemy, and the separated people could not even meet together. It was not until in the year of 2000, when the president Kim, Dae-Jung visited Pyoung-Yang for the Summit Conference of South Korea and North Korea, that the first step of reconciliation took place. We should prepare for the political unification and cultural integration from now on, and histography and history education is significant for the cultural integration. Therefore, we have to study the history educations in South Korea and North Korea, and compare the differences. For the mutual understanding of the history, we should be concerned for some points as follow. First, we should understand the Marxian division of periods in the North Korean history education. Secondly, in ancient history, North Korea sets a high value on Tan-goon, the founder of the nation, and Koguryo, which was a powerful kingdom, claiming that North Korea succeeded Koguryo. Third, North Korea emphasized Marxism in the first stage of the foundation of the country; however, it commends highly the Jucheology, recently, and worships the political leaders as Kim, Il-Sung and Kim, Jung-il as if they are gods. Fourth, North Korea emphasizes that history is made by the people in working class. Lastly, the spiritual culture in our history, as Confucianism, Buddhism, is considered Idealism, so it is denounced. We should find the possible common features, as comparing North Korean history with ours. In cultural assets, in customs, in music, in dances, in recreation and sports, we will be able to find the same qualities, and the both Koreans have to confirm and develop the qualities. We should pursue the regional integration, and the cultural community. Also, the history education which understands, accepts, interchanges with each other should be reinforced.