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Da-Young Park,Kyung-Jin Lee,Yangkang So,Zhe Lu,Seulki Lee,Jung-Hwan Lee,Seung Han Oh,Yeon Soo Han,Doo-Byoung Oh,Youngkwan Kim,Kisung Ko 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1
Plant genetic engineering has led to production of plant-derived mAb (mAbP), which can provides a safe and economically effective alternative to the conventional antibody expression methods. In this study, the expression levels of mAbP SO57 with or without ER-retention peptide extensions signal (Lys-Asp-Glu-Leu; KDEL) in transgenic tobacco plants were analysed in transgenic plant. The expression levels of mAbP SO57 with KDEL were significantly higher than that without KDEL regardless of transcription level. mAbP SO57 with KDEL localized surround to the nucleus suggesting that the mAbP with KDEL is localized in ER. The mAbP without KDEL and mAbH had mainly Golgi type glycans, whereas the ER-localized mAbP with KDEL had glycan profile with both oligomannose type (47.6%) and Golgi type (52.4%). The Fc domains of both purified mAbP (with and without KDEL) and human-derived mAb (mAbH) had similar bingding activity to the Fcγ RI receptor (CD64). Both mAbP (with and without KDEL) had a shorter half-life than mAbH. However, both mAbP with and without KDEL was as effective at neutralizing activity of the rabies virus CVS-11 as the mAbH. These results suggest that ER localization of recombinant mAbP by KDEL reprograms glycosylation and enhances production of the functional antivirus therapeutic antibody in the plant.
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오윤경,장진영,박상학,류소연 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1
Pmpose: To investigate the characteristics of Myers-Briggs Type Indicator (MBTI) in premedical students of one medical college and to compare the personality profiles of them with those of other studies which involved the K-orean university students and other country population. Mateiials and Methods: The MBTI was used to measure the personality profiles of premedical students at the Center for Teaching & Leaming of Chosun University. One hundred and twenty five premedical students participated in this study and the MBTI profiles of them were compared to those of K-orean university students (1,441 persons), i.e. their potential patients and those of the United Kingdom (UK.) Population (1,634 persons) and a sample of UK- doctors (313 persons) of one medical college involved in other studies. Results: The premedical students had a preference for Introversion (62%) rather than Extraversion (38%), Sensing (70%) rather than Intuition (30%), Thinking (66%) rather than Feeling (34%), and Judging (57%) rather than Perceiving (43%). There were more Thinking (66% vs 57%, p=0.071) in the premedical students than in K-orean university students with borderline significance. There were significantly more Thinking (66% vs 46%, P=0.000) and more Introversion (62% vs 48%, p=0.002) than in UK- adult population. Also there were significantly more Sensing (62% vs 48%, p=0.002), significantly less Judging (57% vs 68%, P=0.034), and more Introversion (62% vs 53%, 0=0.094) with borderline significance than in UK doctors. But no difference was shown in Thinking between the premedical students and UK- doctors, Conclusion: The personality profiles of the premedical students in this study differed in Thinking with borderline significance from K-orean university students and significantly differed from the UK adult population in Thinking and Introversion showing the cultural difference. No difference of Thinking between the premedical students and UK doctors despite of cultural difference suggests the correlation between the Thinking and medical professional choice.
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김소연,박동진,권오성,임채영,김판경,이상화,김창진 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2
제주도지역, 충청남도 서해안지역, 강원도 및 충청북도 자연 동굴지역, 그리고 충청북도 청원군 등지에서 채집한 205점의 토양시료로부터 분리된 총 1,322주의 방선균을 대상으로 Eschericia coli KCTC 1924, Salmonella typhimurium KCTC 1926, Staphylococcus aureus KCTC 1926, Staphylococcus aureus KCTC 1928, Candida albicans KCTC 1940등 5종의 시험균주에 대하여 항균활성을 조사하였다. 액체배양을 위해서는 G.S.S(glucose-soybean meal-starch) 배지와 fish meal 배지등 2종류의 배지를 사용하였으며 그 결과를 균분리원 지역별, 배지별, 시험균주별, 그리고 방선균 종류별로 비교하였다. It is well known that actinomycetes would be useful for screening of biologically active compounds. Not only to isolate diverse actinomycete strains but to ferment those strains effectively would be important. Seven hundred and forty six strains were isolated from Cheju province, 216 strains were from Chungnam province, 158 strains were from the natural caves at Chungbuk and Kangwon provinces and 202 strains were from Chungwon area at Chungbuk province. All of these 1,322 strains were fermented on a small scale using two different media and tested for their antimicrobial activities against four bacterial strains and one yeast strain. As the result, 12.3% of those isolates were active against Staphylococcus aureus KCTC 1916, 7.6% were Staphylococcus aureus KCTC 1928, 3.9% were Eschericia coli KCTC 1924, 3.0% were Canida albicans KCTC 1940, and 2.2% were Salmonella typhimurium KCTC 1926. About 40% of those isolates showed antimicrobial activities at both two media but the others showed at either one. According to the genus of isolated strains, Streptomyces and Micromonospora showed activities with higher frequencies than others.
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박소연,오덕성 충남대학교 지역개발연구소 2002 地域開發論叢 Vol.14 No.-
Housing environment Program has contributed to improve the living condition of urban poor in squatters to the extent. It results the increase in the portion of housing unit and number of rooms that the inhabitants used. And the program has ameliorated housing facilities and residential circumstance. The purpose of this study is to offer improvement and investigate problems appeared under progressing rehabilitation project in the housing environment to accomplish the amelioration for the improvement of poor area. This case study area is poor area Daejeon by the name of jungchon, hapsukso, yongun, yongdu, seongnam, sinheung, indong, samseong area area where a renewal program is going on under housing environment progress. The result of this study is to offer the appraisement and improvement of Housing environment program.
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방사선 치료를 받는 암 환자들의 사회적 지지와 삶의 질과의 관계
정주희,류소연,윤혜은,남택근,오윤경,안현옥,박계남,이영선 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2
Objective : This study was performed to investigate the relationship between social support and quality of life among cancer patients receiving radiation therapy. Matehals and Methods : The data were collected from 98 patients, who were receiving radiation therapy at two university hospitals located in GwangUJu, used by structured questionnaire. For statistical analyses of the association between quality of life and various characteristics, data were analyzed using t-test, ANOVA, Pearson 's correlation, and multiple regression analysis. Results: 1. There were 56(57.1%) males and 42(42.9%) females. Age ranged from 21 to 82 years. The primary sites of cancer were gastrointestinal tract (24.5%), lung (23.5%), breast (21.4%), and head and neck (11.2%) in order. 2. The mean scores of social, family, and medical support were 4.30 0.58, 4.49 0.78, 4.11 0.65, respectively. The score of quality of life was 5.83 1.63 (range: 1.95 ~ 9.05). 3. An analysis of the association between several factors of patients and quality of life showed that the statistically significant factors were age, the presence of distant metastasis, family support, medical support and social support. 4. As a result of the multiple regression analysis, only social support was significant (β=0.932, P=0.02) with quality of life, but age and presence of distant metastasis were not significant. Conclusion : This suggests that quality of life in cancer patients could be improved by strengthening the social support which consists of family and medical support. Further study would be necessary to evaluate separately several aspects of quality of life among cancer patients.
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씨름선수에서 체중 감량과 회복기의 Leptin과 PAI-1 변화
김용운,도경오,권태동,박덕일,장응찬,박소영,김종연,이석강 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2
Obesity which is defined as accumulation of excess body fat, is central factor of insulin resistance syndrome. Recently, it is revealed tat adipose tissue is not simply an energy storage organ but it also secretes a variety of molecules which affect the metabolism of the whole body, those are leptin and plasminogen activator inhibitor-1(PAI-1). Therefore, leptin and PAI-1 are increased in the obese state. Leptin regulates energy homeostasis and satiety and PAI-1 regulates fibrinolytic system. For these reasons, elevated levels of leptin and PAI-1 are considered as link factors between obesity and insulin resistance syndrome. However, the exact regulating mechanism for serum levels of leptin and PAI-1 is not fully understood yet. In this study, to evaluate the regulating mechanisms of serum levels of leptin and PAI-1 according to the weight changes, we measured leptin, PAI-1, physical, metabolic, and endocrine parameters during 10 days of weight reduction and 10 days of regain period in 7 young athletes. The mean body weight change was -4.7 kg(5.0%) in the weight reduction period and -2.4 kg(2.5%) in the weight regain period compared to baseline value. Baseline level of leptin in athletes was 1.7±0.66 ng/ml, which was significantly correlated with body weight, BMI, percent body fat, body fat mass, triglyceride, insulin, and PAI-1. Baseline level of PAI-1 in athletes was 16.6±5.26 ng/ml, which was significantly correlated with body weight, BMI, triglyceride, insulin, and leptin. Leptin was decreased to 0.7±0.39(44% of the basaline value) in the weight reduction period, and increased to 1.9±0.64(119% of the baseline value) in the regain period. PAI-1 was decreased to 7.4±2.72(44% of the basaline value) in the weight reduction period, and increased to 22.8±7.33(138% of the baseline value) in the regain period. The changes of leptin during weight reduction period were significantly correlated with the changes of insulin(r=0.890, P<0.01) and triglycerides(r=0.874, P<0.01). The changes of PAI-1 during weight reduction period were significantly correlated with the changes of FFA(r=0.889, P<0.01) and triglycerides(r=0.869, P<0.05). The changes of both leptin and AAI-1 during weight regain period were significantly correlated with the changes of insulin(r=0.755 and 0.849, P<0.05, respectively). In summary, these results suggest that serum levels of leptin and PAI-1 were affected by weight cycling, the percentages of change were more greater than that of weight change, and rebound phenomena were occurred during weight regain period.
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