소아에서 발생한 골수이형성 증후군 2례

홍성진,윤석중,김성우,조형구,오명호,김기혁,이인성 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Myelodysplastic syndrome(MDS) is a group of acquired conditions characterized by progressive bone marrow failure associated with normocellular or hypercellular bone marrow that cannot be attributed to nutritional deficiency, chronic infection, or other chronic systemic illness, and cannot be reversed by the successful treatment of those conditions. Whereas the cases of secondary MDS occur at all ages, primary MDS is essentially a disease of elderly, though no age group is exempt and predomonant in men. The MDS is fundamentally clonal disorders at the level of the haemopoietic totipotent stem cell. Clinically, they are characterized by varing degrees of peripheral cytopenia(s) with morphological and functional abnormalities of blood elements. We have experienced two unrelated pediatric cases, who showed pancytopenia on admission and the characteristic marrow findings of MDS. The first case, a 12 months-old girl, showed increased reticulin with abnormal localization of immature precursor cells(ALIP) in her bone marrow, in addition to dysplastic features such as bi-and multi-nucleation of late normoblasts and internuclear bridging. She also showed 22% of blasts in her bone marrow cells thus classified in the category of RAEB-t after FAB classification. Also found were a chromosomal abnormality namely 46 XX t(14q21q), which was an unusual one. Her family brought her home and, 4 month later, she deceased. The second case, a 12 year-old boy, showed pancytopenia with Pseudo-Pelger-Huet anomaly in neutrophils but no blasts in the peripheral blood. Bone marrow of this case also showed the picture of dyserythropoiesis with binuclearity, internuclear bridging, nuclear fragments, multinuclearity of late normoblasts, in addition to megaloblastoid change in the normoblasts and increased mitosis in granulocytic series. No chromosomal abnormality was found. Classified as RA after FAB classification of MDS. Showed good response to conservative management for anemia for more than one year.

내동정맥루술후의 수지운동이 동정맥루의 혈류와 개존에 미치는 영향

신현석,조원현,이성문,우성구,김현철 大韓脈管外科學會 1995 大韓脈管外科學會誌 Vol.11 No.1

결절성 및 괴상성 간세포암에서 역동적 전산화단층촬영 소견에 따른 경동맥화학색전술결과의 예측

이성문,김홍,지성우,우성구,이정형,서수지,손철호 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.2

Purpose: To evaluate retrospectively whether it is possible to predict the transarterial chemoembolization(TACE) result with the pre-TACE dynamic CT findings. Materials and Methods: The dynamic CT findings of 33 patients with 35 nodular and 8 massive hepatocellular carcinoma(HCCs) who was taken follow up CT after TACE, were reviewed retrospectively. After excluding the diffuse or infiltrative HCCs, the mass was classified into two groups of nodular and massive types. The size, location, degree of enhancement, pseudocapsule, portal vein(PV) thrombosis and arterioportal(AP) shunt were evaluated on the dynamic CT scans. The vascularity, multiple or parasitic blood supply, AP shunt and the possibility of superselection were considered on the angiography. After TACE, the pattern of lipiodol uptake and residual enhancing nodules were evaluated on the follow-up CT scans. Results: The good TACE results could be obtained in 18 of 35 nodular HCCs with dynamic CT findings of small size(mean=2.94cm), peripheral location, hyper-or iso-enhancement, and absence fo PV thrombosis, with angiographic finding of possible superselection, but the pseudocapsule did not give important effect on the result. Most of the massive HCCs had poor TACE results. Conclusion: The prediction of the TACE results of nodular and massive HCCs was possible with dynamic CT findings. If the good prognostic factors were not observed on the pre-TACE dynamic CT, the multiple TACE and/or combination therapy with percutaneous ethanol injection(PEI), surgical resection or others should be considered for the effective control of the HCCs.

Continuous renal replacement therapy for the treatment of acute kidney injury

( Woo Kyun Bae ),( Dae Hun Lim ),( Ji Min Jeong ),( Hae Young Jung ),( Seong Ku Kim ),( Jeong Woo Park ),( Eun Hui Bae ),( Seong Kwon Ma ),( Soo Wan Kim ),( Nam Ho Kim ),( Ki Chul Choi ) 대한내과학회 2008 The Korean Journal of Internal Medicine Vol.23 No.2

Background/Aims: Continuous renal replacement therapy (CRRT) has been widely used for treating critically ill patients with acute kidney injury (AKI). Whether CRRT is better than intermittent hemodialysis for the treatment of AKI remains controversial. We sought to identify the clinical features that can predict survival for the patients who are treated with CRRT. Methods: We analyzed the data of 125 patients who received CRRT between 2005 and 2007. We identified the demographic variables, the underlying diagnoses, the duration of CRRT, the mean arterial blood pressure (ABP) and the Simplified Acute Physiology Score (SAPS) II. The classification/staging system for acute kidney injury (AKI) was applied to all the patients, who were then divided into stage 1-3 subgroups. Results: The average age of the patients was 61.414.3 years and the mortality rate was 60% (75 of 125 patients). The survivors had a significantly higher mean ABP and a higher mean serum bicarbonate level, which were measured the day after CRRT, than the nonsurvivors (86.723.7 vs. 69.224.6 mm Hg, respectively, 21.43.5 vs. 16.45.4 mmol/L, respectively,; p<0.05 for each). The stage 3 AKI patients showed the worst parameters for the SAPS II score and the serum levels of creatinine and blood urea nitrogen. The mortality rate was higher for the stage 3 subgroup than the other groups (70.5%, p<0.05). Conclusions: The patients with AKI and who require CRRT continue to have a high mortality rate. A higher mean ABP and a higher serum bicarbonate level measured the day after CRRT may predict a more favorable prognosis. The staging system for AKI can improve the ability to predict the outcomes of CRRT patients.

Color-Flow Doppler Sonography in Diffuse Thyroid Diseases

Woo, Seong Ku,Kim, Jung Sik,Lee, In Kyu,Oh, Yeon Hee 대한초음파의학회 1991 ULTRASONOGRAPHY Vol.10 No.2

Measurement of UV radiation of LED lighting

Seong-Mo Ku,Jong-Min Im,Chin-Woo Yi 한국조명·전기설비학회 2011 조명·전기설비학회논문지 Vol.25 No.3

Many countries and researchers in the lighting field have focused on the LED light source as a solution to energy savings and environmental pollution. The LED light source consumes less power, has a long life and is highly economical. It is vibration and shock-resistant, and environment friendly as well. But LED lighting has some problems. In particular, the photobiological safety of LED light sources is emerging as an issue. Ultraviolet radiation from the LED light source emitted directly to the human body over a long period of time is harmful. In this paper, UV radiation from white LED was measured. Finally, the LED light source emits UV radiation, but it is relatively small when compared to others.

腎移植후 발생하는 急性腎拒否症의 複合도플러超音波檢査

禹聖龜,金玄撤,朴成培 대한초음파의학회 1988 ULTRASONOGRAPHY Vol.7 No.2

Measurement of UV radiation of LED lighting

Ku, Seong-Mo,Im, Jong-Min,Yi, Chin-Woo The Korean Institute of IIIuminating and Electrica 2011 조명·전기설비학회논문지 Vol.25 No.3

Many countries and researchers in the lighting field have focused on the LED light source as a solution to energy savings and environmental pollution. The LED light source consumes less power, has a long life and is highly economical. It is vibration and shock-resistant, and environment friendly as well. But LED lighting has some problems. In particular, the photobiological safety of LED light sources is emerging as an issue. Ultraviolet radiation from the LED light source emitted directly to the human body over a long period of time is harmful. In this paper, UV radiation from white LED was measured. Finally, the LED light source emits UV radiation, but it is relatively small when compared to others.

미세 생명ㆍ화학시스템의 새로운 응용분야

우성일,김기웅,노점임,전민구,김태석 한국공업화학회 2003 공업화학 Vol.14 No.5

현재 화학공학은 생산설비 구축 및 R&D의 고비용화와 환경 및 에너지 측면의 문제의 중첩으로 인해 화학공업 자체의 저부가가치화를 가속화시켜 전자 산업 등 여타산업과의 경쟁력에서 뒤쳐지는 결과를 초래하였다. 이러한 화학공업의 문제에 대한 해결방안으로 초미세화학공정(process-on-chip) 이 새로운 대안으로 제시되고 있고, 이와 더불어 신소재 개발의 혁신적인 방법 중의 하나인 조합화학기법의 중요성이 부각되고 있다. 조합화학 기술은 한 번에 많은 조합 연구시료를 값싸게 제작하고 이들의 특성 및 성능을 고속으로 측정, 평가함으로써 "더 빨리, 더 싸게, 더 성공적으로" 첨단 기능성 화학재료를 개발할 수 있는 고속 R&D 기법과 이 기법을 이용하여 실제로 첨단 기능성 화학재료를 창출하는 응용연구로 구성되어 있다. 고속 R&D 기법은 최적 조합 시료의 작성, 고집적 조합 시료 합성, 합성된 고집적 시료의 고속 성능 평가, 고집적 시료의 고속 특성 분석의 4단계로 이루어진다. 초미세화학공정(Process-on-chip) 은 복잡한 촉매 화학 반응과 유독물질의 반응 등을 수행할 수 있는 초미세 유체 반응기를 분석 장비와 통합하여 신개념의 화학공정을 칩 상에 구현한 것을 의미하는 것이다. 이는 Lab-on-chip에서 확장된 개념으로서 단지 화학공학 분야에 국한된 것이 아니라, DNA sensor와 같은 생물분야부터 micro-fuel cell 같은 차세대 에너지원 개발분야까지 다양하게 접목할 수 있다. 특히, 이러한 기술은 최근에 시작한 미개척분야로서 우리나라로서는 충분히 도전해 볼 만한 분야이며 이로 인해 현재 낙후된 화학공업은 새로운 활력소를 가질 수 있을 것으로 예상된다. Nowadays, chemical engineering has faced fatal problems including the high cost of R&D, the environmental pollution, and high energy consumption. This is one of reasons that chemical industry is behind other industries such as electronic industry in competitive edge. To overcome these problems in chemical industry, process-on-chip is suggested as the counterproposal and combinatorial technology in discovering new materials has drawn an interest. Combinatorial technology is involved in high-throughput screening that can find novel high-performance materials and catalysts more quickly, less costly and more successfully by using rapid characterization of physical and chemical properties. This consists of four steps, (1) making optimal combinatorial samples, (2) synthesis of combinatorial chip or samples at one time, (3) primary screening for combinatorial chip or samples and (4) rapid characterization of physical and chemical properties of samples. Process-on-chip means the chemical factory built on the chip. Therefore, this combines the microfluidic reactor with analytic systems to carry out complex catalytic chemical reactions and the reaction of harmful materials that is impossible in conventional chemical process. This is the expansion of Lab-on-a-chip and can be applied into various fields from the DNA sensor to micro-fuel cell. In particular, it is challengeable in our country because process-on-chip is undeveloped field until now, and therefore it is expected that this technique can stimulate our chemical industry.

Clinical characteristics of psoriasis in the elderly: a single center experience

( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Seong-min Park ),( Hyun-ju Lee ),( Tae-wook Kim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Psoriasis of the elderly is not rare and also has a chronic relapsing course, and affects quality of life. However, there has been a paucity of data regarding the characteristics of psoriasis in the elderly. Objectives: The purpose of this study was to investigate clinico-epidemiological and therapeutic aspects of psoriasis in the elderly. Methods: We retrospectively reviewed medical records and clinical photos of psoriasis in the elderly (≥65 years) visiting department of dermatology at Pusan National University from January 2014 to December 2017. A total of 83 patients who aged 65 or older with psoriasis were included (elderly group), and we analyzed clinico-epidemiological, and therapeutic aspects comparing with patients who aged under 65 years (non-elderly group) with psoriasis visiting same period. Results: The Mean age of the elderly and non-elderly group was 72.8 and 37.7 years old. The ratio of male to female patients was significantly higher in the elderly group. The mean PASI score had no statistical difference between two groups (5.9±4.03, 6.4±5, respectively). Pruritus, obesity, metabolic syndrome and psoriatic arthritis were statistically more frequent in the elderly group. Systemic agents were more frequently prescribed to the elderly group than non-elderly group during the treatment. Conclusion: This study shows various characteristics of psoriasis in the elderly. Our data would be helpful for dermatologists managing the elderly with psoriasis.