경피신경 전기자극이 β-Endorphin 및 Catecholamines치에 미치는 영향

吳洙根,김완식 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.1

The development of a method for the detection or highly specific opiate receptors in neural memberances and the discovery of such receptors in animal brains opened the current era of explosively rapid progress in understanding the fundamental mechanisms of action of the opiate narcotics. Furthermore a second advance was the discovery of two endogenuous opioid peptides, Met-and Leu-enkephalin which was recognized as a component of a larger peptide malecule, β-lipotropin. Immediately, scientists became interested in the possible physiologic function of these components in animal and humans, so active research in the rea was begun, and is continuing today. And also the relation-ships of endorphin to other neurotransmitter systems. Recently major efforts have been undertaken to develop assays for β-endorphin and catecholamines in plasma to study possible effcts of pain, stress, diurnal variation and acticity. It was a well known fact that βendorphin and catecholamines were secreted concomitantly by the pituitary gland. However, reserachers have noted an increase or decrease of β-endorphin and catecholamines in plasma after TENS, there may or may not be the correlation between acute and chronic pain. This study has undertaken the correlation between β-endorphin and catecholamines level changes by the TENS in the chronic pain and normal healthy volunter subjects with twelve cases each. We measured and observed β-endorphin levels with RIA KIT and catecholamines levels with High Performance Liquied Chomatography with Electrochemical Detection and also observed the changes of the blood pressure and pulsa rate before, after 30 minutes, and after 60 minutes with TENS. The results were as follows: 1. There were no significant differences on age, heigh and weight in compared with groups. (Table 1) 2. The pain intensity was markedly improved in the experimental gorups. (Table 1) 3. The changes of blood pressure were observed with slight decrease (P>0.05) and pulse rate were significantly decreased (P<0.05) in both groups before and after TENS. (Table 2) 4. Some changes with β-endorphin were observed with a slight increase or decrease in both groups before and after TENS< but there was no statistically significant changes in both gourps. (P>0.05) (Table 3) 5. Some changes in the catecholamines level were observed with a slight increase or decrease in both goups before and after TENS< but there was no constant tendency. (p>0.05) (Table 4). These results show that the relief of pain intensith with TENS were not correlated with β-endorphin and catecholamines level which has no constant tendency.

유전자 알고리즘 기반 퍼지 다항식 뉴럴네트워크의 설계

吳聖權,李寅太,金完洙 水原大學校 2005 論文集 Vol.23 No.-

In this paper we propose a new architecture of Fuzzy Polynomial Neural Networks(FPNN) by means of genetically optimized Fuzzy Polynomial Neuron(FPN) and discuss its comprehensive design methodology involving mechanisms of genetic optimization. especially Genetic Algorithms (GAs). The conventional FPNNs developed so far are based on mechanisms of self-organization and evolutionary optimization. The design of the network exploits the extended Group Method of Data Handling(GMDH) with some essential parameters of the network being provided by the designer and kept fixed throughout the overall development process. This restriction may hamper a possibility of producing an optimal architecture of the model The proposed FPNN gives rise to a structurally optimized network and comes with a substantial level of flexibility in comparison to the one we encounter in conventional FPNNS. It is shown that the proposed genetic algorithms-based Fuzzy Polynomial Neural Networks is more useful and effective than the existing models for nonlinear process. We experimented with Medical Imaging System(MIS) dataset to evaluate the performance of the proposed model.

자궁경부 소세포암 4예의 임상적 특징과 예후에 관한 연구

오영림,김흥열,어완규,김홍배 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Background : To investigate clinicopathologic finding of patients with small cell carcinoma of uterine cervix, and to evaluate the recurrence pattern and survival time of small cell carcinoma of uterine cervix Methods : The medical records of four patients who were diagnosed with small cell carcinoma of the uterine cervix and whose initial treatment was between January 1990 and December 2006 were studied retrospectively Results : Patient ages ranged between 43 and 50 years. The clinical stages at diagnosis were Ib, IIa, IIb, IIIa. All patients presented with abnormal vaginal bleeding. Tumor size at diagnosis was under 2cm in 1 patient and over 2cm in 3 patients. Disease recurred in 3 patients at 5~26 months and all of them died. Through analyzing overall survival time, FIGO stage and tumor size were significant prognostic factors in small cell carcinoma of the uterus Conclusion : Small cell carcinoma of uterine cervix revealed poor prognosis. Our study found FIGO stage and tumor size were significant prognostic factors in small cell carcinoma of the uterine cervix. Because of limitation of number of patients, further large scaled multicenter studies are needed.

생리식염수 전기분해에 의한 세균 오염된 콘택트렌즈의 살균

김완석, 박준오, 최영기, 이영민, 김형규, 차은종, 김석용 충북대학교 동물의학연구소 2007 Journal of Biomedical and Translational Research Vol.8 No.1

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歸因相談과 能力別 豫習課題의 活用을 通한 歸因性向의 變化가 數學學習 能力에 미치는 效果

오후진,구완규 공주대학교 사범대학 과학교육연구소 1999 과학교육연구 Vol.30 No.1

This study is trying to specifically search for the best approach ot learning motivation which is one of the most significant factors in improving learning ability, based on attribution theory (locus of control theory). As a result, the conclusions are as follows: 1. The procedure of Individual counseling for learning attribution based on individual standard grades and data of the variable order of merit apparently shows learners that if learners are to try their best in learning, they will surely go far in terms of learning in the near future. 2. The procedure of Individual counseling for learning attribution based on achievement distribution in individual behavior-oriented fields suggests to learners that how to learn is as important as how much effort they make. Surely enough, learners are required to make more effective and efficient efforts, considering their own learning abilities. 3. Above all, it was confirmed that the learners' struggling attitude might well have a significant correlation with achievement sucess.

중·고등학교 아랍어 교재 집필 및 교재 내용에 관한 연구 보고서

오명근,송경숙,전완경,사희만,이규철,조희선,정규영,최진영 한국아랍어아랍문학회 1999 아랍어와 아랍문학 Vol.3 No.1

급성 백혈병 환자에서 수두양 피부병변을 보인 파종성 Fusarium 감염 1예와 국내 파종성 Fusarium 감염증에 대한 고찰

오수진,정희선,김준성,김태석,조병식,최수미,김명신,이연수,이석,신완식 대한감염학회 2007 감염과 화학요법 Vol.39 No.5

최근 면역저하환자의 증가와 함에 국내에서도 점차 침습성, 파종성 Fusarium 감염증 보고가 증가하고 있다. Fusarium 감염은 아스페르길루스 감염과 유사한 임상양상을 보이지만 특징적인 피부병변을 동반하고 혈액배양에서 균이 분리되는 경우가 더 많다. 저자들은 급성 림프구성 백혈병으로 진단받고 치료중인 30세 남자 환자에서 중증의 호중구 감소 상태에서 비특이적인 피부병변을 동반한 파종성 Fusarium 혈류감염을 경험하였기에 국내 증례 고찰과 함께 보고하는 바이다. 환자의 초기 피부병변은 구진에서 시작하여 주로 소포성 병변과 일부 통증을 동반한 결절 등 여러 형태로 나타났고, Tzank 도말검사 양성으로 비정형 수두로 오인되었다. 이후 피부병변은 농포로 변하였고, 혈액배양 및 피부 조직검사에서 파종성 Fusarium 감염으로 진단받았다. 환자는 liposomal amphotericin B, voriconazole 병합요법과 G-CSF 투여, 과립구 수혈을 받았으나, 호중구 감소증에서 회복하지 못하고 급성 호흡곤란증후군과 다장기 기능부전으로 사망하였다. 본 증례는 파종성 Fusarium 감염의 경우에도 수두양 병변으로 비특이적인 양상으로 나타날 수 있으므로, 감별진단을 위해 적극적으로 혈액배양과 피부조직검사를 시행해야 함을 보여준다. Recently, we experienced a case of disseminated fusarial blood stream infection with varicelloid skin eruptions, who had suffered from persistent neutropenic fever after salvage chemotherapy for relapsed acute lymphocytic leukemia (ALL). Neutropenia continued in spite of G-CSF and granulocyte transfusion, and he failed to respond to conventional amphotericin B initially, and then liposomal amphotericin B and voriconazole combination therapy. Disseminated fusariosis can be diagnosed by blood cultures in 50% of patients and present skin lesions in more than 80% of patients. So, typical skin lesions are important clue to diagnose of the disseminated fusariosis. However, many skin lesions in immunocompromised hosts are due to various infectious and non-infectious causes. So, this case shows that it is important to obtain biopsy specimens of skin lesions for histopathologic examination, culture and staining. Here, we present our case with the review of the literatures reported in our country, so far.

간 발생과정에 따른 Metallothionein 발현에 관한 연구

오승한,고정식,김완종 순천향대학교 기초과학연구소 2004 순천향자연과학연구 논문집 Vol.10 No.2

Metallothionein(MT) is a group of low molecular weight proteins, with a unique amino acid composition such as a large content (approximately 30%) of cysteine residues. The protein has been shown to play a physiological role in the absorption, transport, and metabolism, such as zinc, copper, and cadmium, but its actual functions are still not clear. This study was carried out to examine the expression of MT in developing or growing rat liver through immunohistochemical and RT-PCR method. Positive reactions against MT started to appear predominantly in the parenchmal cells of liver from the 13th day after gestation. Reaction products, or brown colorations, were localized at both the nucleus and the cytoplasm of the parenchymal cells. The intensity of this reaction gradually increased, and exhibited the strongest at birth. The intensity of MT staining diminished with growth, and by the 15th day after birth weak positive reaction was observed in the cells. In brief, positive reactions for MT were observed in the oval cells and the parenchymal cells during fetal stage, meanwhile they were present only in the parenchymal cells after birth. MT mRNA by RT-PCR seemed to be expressed from the 15th day after gestation till 15 days after birth and it was highest in the neonatal rats. These expression pattern showed similar to those that shown in the immunoistochemical results.The present results suggest that MT possibly contributes to parenchyma cell proliferation and differentiation through the storage or the supply of various metal ions in the developing rat liver.

최근 한반도 여름철 강수량 특성 분석

오완탁 조선대학교 환경공해연구소 2004 環境公害硏究 Vol.18 No.-

The recent Korean summertime weather characteristics is investigated with focus on heavy rainfall. It is found that the variation of the summertime pressure system in Korean Peninsula recently shows a different feature from its climatological variation, affecting the summertime rainfall pattern. Climatologically, the summertime rainfall concentrated in Changma period. Recently, the activity of Changma shows an irregular pattern and there are more rainfall in post-Changma period than in Changma period. Moreover, in terms of the rainfall mechanism, the heavy rainfall induced by the unstable atmospheric condition and topographic effect occurs more frequently than the rainfall induced by the lasting and regular system associated with the Changma.

수돗물염수액 전기분해에 의한 살균소독

박준오, 김완석, 최영기, 이영민, 김형규, 차은종, 김석용 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.2

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