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RISS 인기검색어
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- 저자 : Sung Seob Yun (검색결과 351 건)
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테헤란로 高層事務所 建物 저층부의 公共空間에 관한 연구
윤한섭,김성홍 대한건축학회 2003 대한건축학회논문집 Vol.19 No.3
This paper discusses the public space of the high-rise office buildings on Teheranno street. Since the 1980s, there has been a rapid growth in the construction of high-rise buildings due to the development of architectural technology and the increase of land price along this street. The ground level of high-rise office building is the buffer space between private and public realm and its roles in urban space becomes considerable. Nine buildings between Samsung and Kangnam subway station were chosen and classified according to their site areas and their relationships to the adjacent streets. Three aspects were primarily analyzed and interpreted. 1) the ratio of the public space and site area, 2) the programs of the ground level, 3) the spatial accessibility and permeability between buildings and streets. The paper reports that the buildings generally meet the legal requirements, yet their functions as public space were limited, and argues the importance of the linkage between urban and architectural design.
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원형섭,황성연,박정배,이준형,박철완,이근 대한응급의학회 1996 대한응급의학회지 Vol.7 No.2
It has been known that sternal fracture increases the risk of potentially life-threatening injuries, such as myocardial, pulmonary, and thoracic vascular injuries, and it has 25% to 45% of mortality, primarily resulting from these underlying injuries. The authors reviewed retrospectively the medical records and radiographic findings of the patients who admitted with sternal fracture at Chung Ang Gil Hospital from 1 June 1994 to 31 December 1995 to evaluate the significance and clinical course of sternal fracture. The results were followings: 1. The male to female ratio was 3:2 and the mean age was 43.1 and 45.4 years old in male and female, respectively. 2. Motor vehicle occupant accident was the most common cause of sternal fracture. 3. Of 33 cases, there was no death, but common associated injuries which were rib fracture, hemothorax, lung contusion, vertebral fracture, penumothorax, long bone fracture, myocardial contusion, flail chest, facial chest, facial bone fracture, and pericardial effusion, in order. 4. The clinical course of sternal fracture was determined primarily by associated injuries except for communited sternal fracture. 5. The patients with isolated sternal fracture, who had an otherwise normal chest x-ray, normal electrocardiogram, no other significant associated injuries and are hemodynamically stable, had a benign clinical course.
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발기부전 검사에서 천연색 복합초음파촬영술과 야간음경발기검사의 일치도
송윤섭,구자현,김민의,이혜경,김두상,박영호,이남규 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1
We intended to know that the result of color duplex ultrasonography corresponded to that nocturnal penile tumescence rigidity in the diagnosis of erctile dysfunction. We performed both color duplex ultrasonography and nocturnal penile tumescence rigidity in 15 erectile dysfunction men. Colr duplex ultrasonography was done with a 7 MHz. color Doppler unit after intracorporeal pharmacological injection and measured maximal arterail diameter, peak systolic velocity, end-diastolic velocity and the results were compared with rigidity and tumescence in nocturnal penile tumescence rigidity using RigiScan. The positive predictive value, negative predictive value, sensitivity, specificity, overall accuracy of color duplex ultrasonography was reasonable when the result of color duplex ultrasonography was compared with the that of nocturnal penile tumescence rigidity. According to this results, color duplex ultrasonography could not only predict but also correspond to nocturnal penile tumescence. Therefore, we suggest that color duplex ultrasonography can relpace nocturnal penile tumescence rigidity if psychogenic and neurogenic erectile dysfunction are distinguished by history and neurologic examination.
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김유근,박상철,문윤섭,오인보,황미경 부산대학교 환경문제연구소 2002 環境硏究報 Vol.20 No.-
Emissions of air pollutants (TSP, SO2, NO2, CO, and HC) was estimated in Changwon city that has the industrial complex and basin terrain. We found that the emissions of TSP, SO2, NO2, CO, and HC were 897 tons, 3,287 tons, 5,706 tons, 10,057 tons, and 1,470 tons for a year, respectively and the main source of air pollutants were vehicle. The ratios of vehicle emissions to total emissions ware TSP 63.8%, SO2 26.1%, NO2 65.5%, CO 91.0%, HC 94.4%. The ratios of industry emissions to total emissions were TSP 30.8%, SO2 60.2%, NO2 25.2%, CO 6.4%, HC 3.7%. The ratio of life emissions to total emissions are TSP 5.4%, SO2 13.7%, NO2 9.3%, CO 2.6%, HC 1.9%. The concentration distributions of air pollutants simulated by ISCST3 model were similar to its emission distributions, and relatively high concentrations of air pollutants occurred in the Palyong-dong (industrial area) and Banlim and Chungang (residual area).
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The Ability of Anti-$TNF-{\alpha}$ Antibodies Produced in Sheep Colostrums
Yun, Sung-Seob Korean Society of Milk Science and Biotechnology 2007 Journal of Dairy Science and Biotechnology (JMSB) Vol.25 No.2
The present study was performed to elucidate the ability of anti-$TNF-{\alpha}$ antibodies produced in sheep colostrums to neutralise $TNF-{\alpha}$ action in a cell-based bioassay and in a small animal model of intestinal inflammation. Colostrums from sheep immunized against $TNF-{\alpha}$ significantly inhibited $TNF-{\alpha}$ bioactivity in the cell based assay. The higher than anticipated variability in the two animal models precluded assessment of the ability of antibody to prevent $TNF-{\alpha}$ induced intestinal damage in the intact animal.
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The Ability of Anti-tumor Necrosis Factor Alpha(TNF- a) Antibodies Produced in Sheep Colostrums
( Yun Sung Seob ) 한국유가공기술과학회 2007 추계 학술대회 Vol.2007 No.-
Inflammatory process leads to the well-known mucosal damage and therefore a further disturbance of the epithelial barrier function, resulting abnormal intestinal wall function, even further accelerating the inflammatory process[l]. Despite of the records, etiology and pathogenesis of IBD remain rather unclear. There are many studies over the past couple of years have led to great advanced in understanding the inflammatory bowel disease(1BD) and their underlying pathophysiologic mechanisms. From the current understanding, it is likely that chronic inflammation in IBD is due to aggressive cellular immune responses including increased serum concentrations of different cytokines. Therefore, targeted molecules can be specifically eliminated in their expression directly on the transcriptional level. Interesting therapeutic trials are expected against adhesion molecules and pro-inflammatory cytokines such as TNF- a. The future development of immune therapies in IBD therefore holds great promises for better treatment modalities of IBD but will also open important new insights into a further understanding of inflammation pathophysiology. Treatment of cytokine inhibitors such as Immunex(Enbre1) and J&J/Centocor(Remicade) which are mouse-derived monoclonal antibodies have been shown in several studies to modulate the symptoms of patients, however, theses TNF inhibitors also have an adverse effect immune-related problems and also are costly and must be administered by injection. Because of the eventual development of unwanted side effects, these two products are used in only a select patient population. The present study was performed to elucidate the ability of TNF- a antibodies produced in sheep colostrums to neutralize TNF- a action in a cell-based bioassay and in a small animal model of intestinal inflammation. In vitro study, inhibitory effect of anti-TNF- a antibody from the sheep was determined by cell bioassay. The antibody from the sheep at 1 in 10,000 dilution was able to completely inhibit TNFa activity in the cell bioassay. The antibodies from the same sheep, but different milkings, exhibited some variability in inhibition of TNF- a activity, but were all greater than the control sample. In vivo study, the degree of inflammation was severe to experiment, despite of the initial pilot trial, main trial 1 was unable to figure out of any effect of antibody to reduce the impact of PAF and LPS. Main rat trial 2 resulted no significant symptoms like characteristic acute diarrhea and weight loss of colitis. This study suggested that colostrums from sheep immunized against TNF-a significantly inhibited TNF- a bioactivity in the cell based assay. And the higher than anticipated variability in the two animal models precluded assessment of the ability of antibody to prevent TNF- a induced intestinal damage in the intact animal. Further study will require to find out an alternative animal model, which is more acceptable to test anti-TNF- a IgA therapy for reducing the impact of inflammation on gut dysfunction. And subsequent pre-clinical and clinical testing also need generation of more antibody as current supplies are low.
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