정상청력인에서 나이와 성별에 따른 DPOAE의 특성

홍빛나,남상길,김진숙 한국음성과학회 2004 음성과학 Vol.11 No.4

The primary goal of the present study was to explore more detailed evidence for the influence of aging and gender effects on the capability of Korean healthy, ears to generate DPOAEs. DPOAEs were examined in series of human subjects, with clinically normal hearing, ranging in age from 10 to 65 years. All 60 Koreans were divided into 6 age groups. Each age group included 10 participants, 5 females and 5 males. The gender effects on the difference between the absolute amplitude and noise floor value in DPOAEs did not exist. The difference increased as the frequency increased. The aging effects on the difference between the absolute amplitude and noise floor value in DPOAEs did exist. The difference increased as the frequency increased but orderly age effects could not be found. The principle finding was that, when compared between emissions in young and old ears, DPOAEs accurately tracked the systematic deterioration of high-frequency hearing in aging individuals. Such results support the need to reestablish the criterion for interpretation of DPOAEs in the elderly.

전기자극이 건의 치유에 미치는 영향에 관한 실험연구

홍성철,김덕래,김태연,정전은,박길홍 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1

The mechanism of tendon healing has been a controversial issue. Although there seems to be a dipolarizing opinion regarding the tendon healing, it is well known to us that the tendon has both intrinsic and extrinsic healing capacity which has proved in vivo and in vitro studies. Tendon adhesion is a common sequella after tendon repair, particularly after the ling period of immobilization. This can be explained by one wound concept or extrinsic tendon healing. If we can modify the natural healing process of the tendon by augmenting the intrinsic capacity, we can reduce the period of immobilization to allow early motion for better gliding. in this study, we used the electrical stimulation technique, which has been known to have good growth stimulatory effect on the living cells, to investigate its effect on tendon healing in organic culture for 6 weeks. Total 64 flexor tendons were harvested from 8 rabbit paws and they were cultured in separate petri-dishes.: 32 tendons were used for the control group and the rest 32 were used for the electric stimulation group. Tendons through which a continuous 7 μAmp current was passed at the repair site were compared with the non stimulated controls. In reference to the histologic study with Hematoxylin ?? Eosin stain and van Gieson stain, the following results were obtained. 1. There was found no necrosis in the specimens of the control as well as the elctrical stimulation group during 6 weeks' culture period. 2. Starting from 1 week, there was prominent increase of fibroblastic proliferation and collagen production in electrical stimulation group and these active repair processes persisted up to 6 weeks. Accordingly, I conclude that the intrinsic tendon healing capacity can be enhanced by the electrical stimulation in vitro.

A. 高校 科學 (生物·地球科學) 및 數學科 探究學習의 評價模型 定立과 評價紙 開發

李相協,權炳奎,林在圭,孫文求,吳岱燮,楊洪準,梁承榮,姜用熙,林成圭,金正遠,金吉民,兪正在 경북대학교 과학교육연구소 1982 科學敎育硏究誌 Vol.6 No.-

Currently the evaluation of high school science and mathematics learning has been too much knowledge-centered without concerning the inquiring ability or scientific attitude. This study, therefore, was made for the purpose of establishing of evaluation model for high school science (biology and earth science) and mathematics learning and its evaluation items. In this paper, the research was done about three fields, biology, earth science and mathematics. 1. For the biology, the evaluation methods of inquiry learning were studied with the foreign references, and proper evaluation items were suggested. 2. For the earth science, after analizing 5 kinds of earth science textbook of current using in high school, essential 19 items were selected. 5 of them were tested in test group and control group, then, the results were analized. 3. For the mathematice, the teaching elements of「Set」and「Flow chart」in mathematics (Ⅰ) were selected and structured. Detailed teaching objects were established and evaluation items were introduced.

전자금융 서비스 이용자 특성에 관한 연구

김형길,홍성효 제주대학교 관광산업연구소 2001 産經論集 Vol.15 No.1

혼합형 자가면역성용혈성빈혈과 동반된 Evans 증후군 1례

선길홍,윤찬영,박상곤,박경희,우정주,한경택,김진화,김영훈,정춘해,박치영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Evans syndrome is defined as a simultaneous or sequential occurrence of autoimmune hemolytic anemia and autoimmune thrombocytopenia. Autoimmune hemolytic anemia (AIHA) is usually induced by IgG warm autoantibody or cold-active IgM antibodies reacting specifically with antigens associated with a patient's RBC. AIHA is a fairly uncommon disorder, with estimates of the incidence at 1 to 3 cases per 100,000 per year. Mixed-type AIHA is a relatively uncommon form of AIHA, with studies noting the incidence of 7-8% among cases of AIHA. We experienced a patient, 46-year-old woman who was diagnosed having a very rare clinical presentation of mixed warm and cold antibody mediated Evans syndrome. She was treated with corticosteroid therapy only and has been maintaining a complete response for 15 weeks. 저자들은 혼합형의 자가면역성 용혈성 빈혈과 자가면역성 혈소판 감소증이 동시에 발생한 혼합형 Evans 증후군으로 진단하고 스테로이드 요법 후 혈액학적으로 회복된 상태로 15주가 지난 현재 steroid 5 mg/일 까지 감량한 상태에서 추적 관찰 치료중인 46세 여자 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

특징 형상기반의 CAIP에 관한 연구

윤길상,조명우,이홍희 한국공작기계학회 2003 한국생산제조학회지 Vol.12 No.5

A feature-based inspection planning system is proposed in this research to develop more efficient measuring mthodolog for the OMM(On-Machine Measurement) or CMM(Coordinate Measuring Machine) for complicated workpiece having man; primitive form features. This paper is proposed solution that optimum inspection sequence of the objective features. The sequences are determined by analyzing the feature information such as the nearest relationship and the possible probe-approach direction(PAD) of the features, and forming feature groups. A series of heuristic rules are developed to accomplish in Also. each feature is decomposed into its constituent geometric elements for inspection process, and then the number c sampling points, location of the measuring points, optimum probing path are determined.

Thrombolytic Era에서의 급성 심근 경색증의 임상적 고찰 : An Analysis for Cause of Death in the Thrombolytic Era

김승정,박시훈,조홍근,신길자 梨花女子大學校 醫科大學 醫科學硏究所 1998 EMJ (Ewha medical journal) Vol.21 No.2

목적: 급성 심근 경색증에서 혈전용해 치료를 시행하여 관상 동맥의 재관류가 이루어진 경우 뚜렷하게 사망률이 감소된 결과를 보고한 많은 연구들이 있었다. 재관류가 이루어진 경우와 그렇지 않은 경우에 각각의 사망률이 TIMI-1 trial(1987)에서는 8.1%와 14.8%, TAMI tir-al(1993)에서는 4.5%와 17.5%로 뚜렷한 차이를 보여주었다. 그에 따라 최근에 혈전용해 치료는 급성 심근경색증 환자의 초기 치료에서 가장 중요한 치료방법의 하나로 정착되었다. 그러나 아직까지 심인성 쇽으로 발현한 경우 등에 있어서는 혈전용해치료의 유용성이 인정되고 있지 않다. 따라서 본 연구에서는 급성 심근 경색증 환자들에게서 임상적 경과를 분석하여 환자들의 사망에 관계되는 요소들을 발견하여 치료방법의 개선점을 밝혀보고자 하였다. 방법: 본 연구는 1993년 9월부터 1995년 8월까지 이화여자대학교 의과대학 부속 목동병원에 급성 심근 경색증으로 내원하였던 112명의 환자들을 대상으로 하였다. 모든 환자들에 대해서 관상동맥 질환의 위험요인, 심전도 소견, 내원시의 Killip class, 혈전용해제 투여 여부 및 합병증 등에 대해서 조사하여 다음과 같은 결과를 얻었다. 결과: 1) 환자들의 평균연령은 59±11세였고 남녀비는 2.1:1 이었다. 2) 환자들의 내우너 당시의 Killip class는 Ⅰ이 58명(52%), Ⅱ 43명(38%), Ⅲ 7명(6%), Ⅳ가 4명(4%)이었다. 3) 환자들이 흉통의 발현후 병원에 도착하기까지 지연된 평균 시간은 2시간 40분이었고 48%인 54명의 환자에서 흉통 발생후 2시간 이내에 병원에 도착하였다. 4) 심근경색의 부위는 하벽 42명(37.5%), 전벽 24명(21.4%), 전측벽 22명(19.6%), 하후벽 9명(8.0%), 측벽 4명(3.6%), 전하벽 3명(2.7%), 후벽 1명(0.9%), 측후벽 1명(0.9%), 전측하벽 1명(0.9%), 전측후벽 1명(0.9%), 비Q파 경색이 4명(3.6%) 이었다. 5) 총 112명의 환자 중 80명(71%)에서 관상 동맥 조영술을 시행하였다. 평균 좌심실 구혈율은 48±11%였다. 단일 혈관 질환이 49명(61%), 이혈관 질환은 18명(23%), 삼혈관 질환이 7명(8%)이었고 정상 관동맥 조영 소견을 보인 경우가 6명(8%)이 있었다. 6) 환자들의 치료는 보존적인 치료를 받았던 경우가 23명(21%)이었고 80명(71%)에서 혈전용해제 투여를 하였다. 9명(8%)의 환자에서는 응급 경피적 관상동맥 풍선 성형술(direct percutaneous coronary angiop-lasty)을 시행하였다. 7) 심근 경색증의 합병증으로는 심낭 삼출이 9명(8%), 좌심실류가 7명(6%), 심실성 부정맥이 5명(4%)이 있었다. 8) 12명의 환자들이 사망하여 사망율은 10.7%였다. 사망한 환자들의 평균 연령은 67±10세였고 평균 병원 도착 시간 지연은 3시간 30분이었다. 12명중 7명의 환자에서 혈전용해제를 투여하였다. 내원 당시의 환자들의 Killip class는 Ⅰ은 없었고 Ⅱ 6명, Ⅲ 4명, Ⅳ가 2명으로 사망한 환자들과 생존 환자들 사이에 p 값이 0.05이하로 의의있는 차이를 보였던 것은 환자들의 연령 및 내원 당시의 환자의 Killip class였다. 본 연구를 통해 급성 심근 경색증의 사망률이 국내의 다른 보고와 비교해 볼 때 비교적 낮음을 관찰하였다. 이는 환자들의 응급실 도착 시간이 다른 보고에 비해 빨랐으며 이에 따라 혈전용해제 치료를 받은 예가 많았기 때문으로 분석된다. 본 연구에서 급성 심근 경색증 환자들의 사망에 관여한 가장 중요한 인자는 환자들의 연령과 내원 당시의 Killip class이다. 최근과 같이 혈전용해제 투여가 급성 심근 경색증의 치료의 근간이 되고 있는 시점에서 특히 고 위험군의 환자들에게는 혈전용해제 치료 뿐 아니라 다른 치료 방법, 즉 응급 경피적 관상 동맥 풍선 성형술이나 관상동맥 우회술(coronary artery bypass graft)등을 강구해야 할 것이다. Background : Many studies have reported that successful reperfusion with intravenous throm-bolytic therapy in acute myocardial infarction(MI) decrease in-hospital and longterm mortality. Therefore thrombolytic therapy is used as an important treatment of early acute myocardial infarction. But the thrombolytic therapy has not been established in the patients representing cardiogenic shock. The purposes of the article are to characterize the clinical findings and to analyze the causes of death in the thrombolytic era, and therefore to improve the treatment modalities. Methods : A retrospective clinical study was done on 112 patients with acute myocardial infarction, who had been admitted to Ewha Womans University Mokdong Hospital from September 1993 to August 1995. All patients was evaluated for coronary risk factors, EKG findings, Killip class on admission, coronary angiographic findings, treatment modality such as thrombolytic therapy, direct percutaneous transluminal coronary angioplasty(PTCA) and conservative treatment, and complications. Result : 1) Patients' mean age was 59±11 years, and the male:female ratio was 2.1:1. 2) Patients' Killip class on arrival at emergency room was Ⅰin 52%, Ⅱ in 38%, Ⅲ in 6% and Ⅳ in 4%. 3) The mean pre-hospital time delay was 2 hours and 40 minutes, and 54 patients(48%) arrived at emergency room within 2 hours after onset of chest pain. 4) The location of the infarction were inferior wall(37.5%), anterior wall(21.4%), anterolateral wall(19.6%), inferoposterior wall(8.0%), lateral wall(3.6%), anteroinferior wall(2.7%), lateroposterior wall(0.9%), posterior wall(0.9%), anterolateroinferior wall(0.9%), anterolateroposterior wall(0.9%), and Non-Q infarction(3.6%). 5) Coronary angiography were performed in 80 patients(71%), and mean ejection fraction was 48±11%, and mean wall motion score index was 1.9±0.6. One vessel disease was 49(61%), two vessel disease was 18(23%), three vessel disease was 7(8%), and normal finding was 6(8%). 6) The conservative treatment was done in 23(21%), and thrombolytic therapy in 80(71%). The nine patients(8%) were treated with direct percutaneous transluminal coronary angioplasty(PTCA). 7) The complications of infarction were pericardial effusion(8%), left ventricular aneurysm(6%), and ventricular tachycardia(4%). 8) Twelve patients(10.7%) were expired. Their mean age was 67±10 years, and mean pre-hospital time delay was 3 hours 30 minutes. The thrombolytic therapy was used in seven patients. Mortalities were observed 0%, 50%, 33%, and 18% in patients with Killip classification Ⅰ,Ⅱ,Ⅲ, and Ⅳ, respectively. Patient's age and Killip class on admission were the most important prognostic factors were patients' age and Killip class on arrival at emergency room. Thus, even in the thrombolytic era, other treatment modality(e.g. direct percutaneous transluminal coronary angioplasty and coronary artery bypass graft) would be considered.

가토에서 일측 요관 부분 및 완전폐색시 신장과 요관의 조직학적 변화

김상현,김용웅,육승모,한동석,노안식,임재성,김홍식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

This study was designed to clarify histologic changes in the experimental rabbit kidney and ureter after unilateral partial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, the partial obstruction followed by 4 weeks, the complete obstruction followed by 2 weeks, and the complete obstruction followed by 4 weeks. The normal control group was consisted of 5 adult white rabbits. The kidneys and ureters for light microscopy were fixed in 10% neutral formalin, embedded in paraffin and stained with hematoxylin and eosin. Abnormal histologic fingings showed in ipsilateral kidney and ureter of all subgroups(such as dilatation of uriniferous tubule, focal necrosis and desquamation of epithelium, interstitial fibrosis, glomerular congestion, widening of Bowman's space, dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis and interstitial inflammation). These findings were most severe in the group of the complete-obstructed ureter for 4 weeks. No significant changes showed in contralateral ureter of all subgroups. The degree of obstruction was severe and period of obstruction was long, the histological changes in ipsilateral side were severe. Despite of changes in ipsilateral side no abnormal findings showed in contralateral side. We suggest that long term experimental investigation of histologic changes in ipsilateral side and compensatory changes in contralateral side have to be studied.

근전도 신호의 패턴인식을 통한 의수의 컴퓨터 제어

柳祥桓,洪錫敎,高永吉 亞洲大學校 1987 論文集 Vol.10 No.-

This paper deals with the decision of 7 primitive motions of the arm by EMG pattern recognition using IMB PC. The EMG signals are detected from silver/silver Chloride surface electrodes, and IBM PC calculates the likelyhood probability and the decision function on the feature space of integral absolute value. Multiclass decision rule and learning algorithm are introduced for high decision rate. All procedures are programmed in assembly language for the real time implementation and the co-processor 8087(numeric data processor) is used for the exponential function and the probability calculation. On our experimental results from the experted simulator, the decision rate of more than 90 percent can be obtained.

교류전해에칭용 에틸렌글리콜의 알루미늄박판의 부식억제 효과

박성민, 양정진, 김홍일, 김한주, 김성한, 신진식, 박수길 충북대학교 건설기술연구소 2008 충북대학교 건설기술연구소 논문집 Vol.27 No.1

In this study, additions of aluminium foil eching characteristics were compared with sulfuric acid for capacitor. sulfuric acid and ethylene glycol is used as addition, characteristics of funtional group from addition were guessed by comparing of aluminium foil eching characteristics. When sulfuric acid was added in HCI etching solution, corrosion of aluminum metal was inhibited by the chemical adsorption of sulfate ion, when ethylen glycol was added in HCI etching solution, corrosion inhibited by the chemical adsorption of OH­^ion.