진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과

정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.

뇌성마비 환아의 발달 평가와 유발 전위, 뇌파,뇌 자기 공명 영상의 비교연구

서정수,김태민,채진목,김영경,김봉옥 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.4

PLD 박막의 물리적 성질

한용진,조봉균,정재훈,이수빈,박해윤,이태기,채희백,홍진수 순천향대학교 기초과학연구소 1998 순천향자연과학연구 논문집 Vol.4 No.2

Thin amorphous carbon films were deposited by a Q-switched Nd;YAG 532nm with beam power density of ?? on the high purity graphite (99.7%). The pressure of vacuum chamber was ?? Torr. In order to estimate the quality of the Pulsed Laser Deposition films one of the most important optical properties, bandgap energy, was characterized by transmission and reflection in the range of the visible, and an optical direct bandgap energy of 2.45eV and indirect bandgap energy 0.36eV were obtained. Surface morphology of amorphous film was investigated by AFM (Atomic Force Microscopy). Its surface roughness is 70nm. Comparing our results with the published values in the literature we have confidence that our films show the good quality for optical properties.

안정된 광 솔리톤 전송영역에 대한 연구

최봉수,이명우,서동선,김석진 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

We numerically investigate stable propagation regimes of 10 ㎓ train of optical solitons with 17.6 ps widths to determine the acceptable variations of periodic amplifier gain(△G), dispersion(△D), and initial chirp(C), as a function of the amplification period LP. We fine that, when LP = 25 km, the acceptable variations are △G = ±4%, △D= ±12%, and C= -0.36 ∼ 0.39. The variations decrease as the amplification period LP increases.

한국어 판 구조화 임상면담도구 개발 : 신뢰도 연구

한오수,안준호,송선희,조맹제,김장규,배재남,조성진,정범수,서동우,함봉진,이동우,박종익,홍진표 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 정신장애의 정확한 진단과 평가는 임상에서뿐만 아니라 신뢰성 있는 연구를 위해서도 매우 중요하다. Structured Clinical Interview for DSM-IV(SCID)는 임상전문가들이 사용하는 진단도구로서, 비교적 짧은 시간에 정확한 진단을 내릴 수 있다. 본 연구는 한국어판SCID를 개발하고 그 신뢰도를 평가하기 위해 수행되었다. 방법: 국문학자가 포함된 번역위원회를 통하여 연구용판 SCID를 번역한 후, 정신과 의사 2인과 임상심리학자 1인에게 한국어판SCID 실시방법을 교육시킨 뒤 한국어판SCID를 이용한 면담의 평가자간 신뢰도 (interrater reliability)를 검증하였다. 면담 대상은 1999년 2월에서 3월까지 2개 병원 정신과에 치료중인 환자 90명(남:41명, 여:29명)이었다. 결과: 현재 장애(current disorder) 평가에서 주요 우울장애, 기분부전장애, 정신분열병, 알코올 남용 및 의존, 기타 물질 남용 또는 의존, 여러 불안장애들 및 섭식장애 등과 같은 대부분 장애의 kappa값은 .70이상으로 매우 높았다. 그 이외의 양극성 장애, 망상장애, 광장공포증, 감별 불능 신체화 장애 및 건강염려증의 kappa값도 .69에서 .40사이로 수용할 수 있는 정도였다. 평생 장애(lifetime disorder)에서는 양극성 장애(k=.69)와 감별 불능 신체화장애(k=.59)를 제외한 다른 모든 장애의 kappa값이 .70이상이었다. K-SCID 면담시 Ⅰ축 질환에 대하여 흔하게 다중 진단이 내려졌으며, 평균 진단 수는 1.5∼1.7개로 나타났다. 결론: 한국어판 SCID는 신뢰도가 높은 진단도구로 생각되며, 향후 정신질환의 정확한 진단과 임상연구에 유용하게 사용될 수 있다. Objectives: Accurate diagnosis and assessment for psychiatric disorders is crucial for research, as well as for clinical practice. Structured Clinical Interview for DSM-Ⅳ(SCID-RV) is a less time-consumimg and more accurate structured diagnostic interview form. It can be used by clinical professions and is known for a reliable diagnostic tool. Present study was conducted to develop Korean version of SCID-RV and to test the inter-rater reliability. Methods: The authors have translated original SCID-RV into Korean, and revised in parallel with sociocultural background of Korea. Ninety patients from two psychiatric hospitals, both outpatient and inpatient, were interviewed and rated independently by three raters. Results: The kappa coefficients for most of illnesses, such as major depressive disorder, dysthymia, schizophrenia, alcohol abuse and dependency, anxiety disorder and eating disorder were excellent(>0.70) in the evaluation of current disorders. And the kappa coefficients for bipolar disorder, delusional disorder, agoraphobia, undifferentiated somatoform disorder, and hypochondriasis were acceptable(>0.40) in the evaluation of current disorders. In the evalua-tion of lifetime disorders, the concordant rates of all the diagnoses except bipolar disorder and undifferentiated somatoform disorder were excellent. Lack of hierarchy in DSM-Ⅳ allows for multiple Axis I diagnoses. Mean numbers of Axis I diagnoses per subject assigned by the three raters were 1.5-1.7. Conclusions: Our findings confirm that SCID-RV yields highly reliable diagnoses. SCID-RV is recommended for accurate diagnosis in clinical practice and research on psychiatric disorders.

대기모델을 이용한 하수처리장 악취의 영향도 산정에 관한 연구

임봉수,박상진 대전대학교 기초과학연구소 1990 自然科學 Vol.1 No.-

하수처리장에서 발생하는 악취는 근무여건 및 주변생활 환경을 해치고 있어 주요 민원 대상이 되고 있으나 악취가 갖고 있는 특성으로 인해 정량적인 평가가 어려운 실정이다. 본 연구에서는 검지관 및 3점 비교식취대법을 이용하여 악취를 정량적으로 실측하고 TCM-2, TEM-8의 두 대기모델을 이용하여 악취가 주변에 미치는 영향을 정량적으로 파악하였다. 취기물질 성분별 모델링결과 최대농도는 TCM-2,의 경우 H₂S 0.21∼0.38ppb, CH₃NH₂0.24∼0.44ppb, NH₃0.24∼0.43ppb였으며, TEM-8의 경우 H₂S 75.0∼98.0ppb, CH₃NH₂99.6∼129.2ppb, NH₃99.2∼128.7ppb를 나타냈다. 취기농도는 모델링결과 TCM-2는 103∼123, TEM-8은90∼165의 분포를 보였다. Odor from sewage treatment plants has been one of the major civil complaints since it disturbs the working environment and surrounding areas. It has been normal to measure odor using human sense, not using quantitative analysis, due to characteristics of odor. In this study, the odor from the sewage treatment plant at G city was measured using the detection tube method and the triangular sensory test, and the effect of odor to surrounding areas was evaluated quantitatively using two odor models, TCM-2 and TEM-8. In TCM-2 model, maximum concentrations for malodorous substances were as follows : H₂S 0.21∼0.38ppb, CH₃NH₂0.24∼0.44ppb, and NH₃0.24∼0.43ppb. In TEM-8 model, maximum concentrations were as follows : H₂S 75.0∼98.0ppb, CH₃NH₂99.6∼129.2ppb, and NH₃99.2∼128.7ppb. As for the concentration modelling of malodorous substances, TCM-2 showed the distribution range between 103 and 123, and TEM-8 between 90 and 165.

A rare case of extensive papillary muscle calcification in senile cardiac calcification syndrome

김은진;송봉근;강민호;손형래;홍수민;박동원;허승혜;김계연;최석구 인제대학교 2011 仁濟醫學 Vol.32 No.-

광범위 유두근 석회화는 흔하지 앉으며, 원인과 임상적 중요성에 관한 문헌만 드물게 찾아볼 수 있다. 반면에 작은 석회 침착은 노인에서 흔하며 심장 첨부에 주로 나타난다. 유두근 석회화는 관상동맥질환, 확장성 심근병증, 승모관 질환, 고칼슘혈증, 그리고 말기신부전에서 인산칼슘의 중가와 연관성이 있다. 저자는 심장초옴파와 MDCT를 통해 진단된 전외측 유두근의 광범위 석회화의 드문 사례가 있어 보고한다.

식물을 활용한 탐구활동이 초등학생의 과학탐구능력과 과학적 태도 및 관찰능력에 미치는 영향

배진호,김진수,윤봉희 부산교육대학교 과학교육연구소 2005 科學敎育硏究 Vol.30 No.-

In this study, I researched how the inquiry activity through plants results in scientific process skills, science attitude and observation skills for the elementary school students. For that, a comparative group and a experimental group are chosen. After inquiry activity through plants. I compared scientific process skills, science attitude and observation skills of experimental group with those of comparative group. This study showed the followings. 1. inquiry activity through plants is effective in scientific process skills in observation and classification. 2. inquiry activity through plants is successful in the attitude about science in understanding and interest for science. 3. inquiry activity through plants is also effective in scientific attitude in safety, straightforwardness and objectivity of scientific attitudes. 4. inquiry activity through plants is meaningful in observation skills in finding eifferent pictures.

태권도 우수선수들의 정신력 특성

최상진,조옥성,백우석,이갑철,고봉수 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

The purpose of this study was to investigate the mental toughness of Taekwondo players and to suggest way of performance enhancement using Loehr's Psychological Performance Inventory. Subjects were 188 Taekwondo elite players. Each factor's mean and standard deviation of Mental Toughness were calculated, and ANOVA were used for statistical analyses of the difference of mean. The results are as follow;: 1. On the level of self-confidence, it shows that the man players is higher than the woman players (school career F=5.846, P<.05: sex distinction F=8.876, P<.01). 2. On the level of attention control, it shows that the woman players is higher than the man players (school career F=4.483, P<.05: sex distinction F=9.814, P<.01). 3. On the level of visual and imagery control, it shows that the man players is higher than the woman players (school career F=7.790, P<.01: sex distinction F=5.000. P<.05). 4. On the level of arousal control, motivation, positive energy and attitude control, it was not significant difference according to the sexual and school career.

도시 거주 노인 수면 습관 및 불면증상의 요인 : 인구학적,질병 및 정신증상의 관련성

홍진표,안준호,윤영국,박종익,이소영,함봉진,김장규,한오수,조맹제 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구목적 : 본 연구는 국내 노인의 습관을 조사하고 불면 증상과 연관 있는 인구학적, 질병학적 요인을 알고자 했다. 방 법 : 1997년 12월부터 1998년 1월까지 약 1개월에 걸쳐 2단계 층화집락표본추출의 역학조사법을 통해 선정된 3개 4개동 거주의 만 65세 이상 노인을 대상으로 수행되었다. 대상자 중 723명에서 등답을 받았으며 응답률은 73.8였다. 대학생인 설문조사요원들을 훈련시킨 뒤, 이들로 하여금 대상지역의 노인거주가정을 방문하여 개개 노인을 대상으로 반구조화된 면담으로 수면습관 및 불면증상 설문을 실시하였으며 그 외 한국어판 노인정신장애평가척도, 삶의 질 척도를 이용한 설문조사와 과거 질병력을 청취조사하게 하였다. 결 과 : 국내 노인들은 평균 오후 10시 16분에 자리에 누워 오전 5시22분에 일어나서 총 7시간 6분의 수면시간을 보였다. 노인의 11.7%가 거의 매일 밤 불면증을 14.8%가 간헐적 불면증을 호소하였다. 남자에서는 연령이 증가할수록 침상에 누워있는 시간이 증가하고, 또, 입면시까지 소요되는 시간과 수면 중의 각성회수가 증가되었으나 여성에서는 명확하지 않았다. 단변수 분석에서 요통, 중풍 병력의 환자에서 불면증상이 심했다. 다변량분석 결과 불면 증상과 관련 깊은 요인으로 남자에게서는 고령과 우울증상이 여자에게서는 남자의 위험요인에다 신체통증과 피부병력이 추가로 관련이 있었다. 결 론 : 지역 거주 노인에서 불면 증상은 매우 흔한 증상이며 우울증상과 명확한 상관관계를 보이고 있었다. 불면증을 극복하기 위해 불면증 위험요인의 인과관계에 대한 추후 연구가 필요하다. Objectives : The purpose of this study is to analyze sleep habit and investigate the association between insomnia and demographic, health and psycho-behavioral symptomatology in Korean urban elderly Method : A total of 723 community residents aged 65 years or older were surveyed by two stage, random cluster sampling method. The response rate was 76.2%. Interviewers performed door to door visits and administered a questionnaire about sleep, past medical history, and several scales as the Psychogeriatric Assessment Scale(PAS), the short form Quality of Life Scale (SF-36) and etc. Results : The mean scores are as follows : retiring time was ten-sixteen p.m., wake-up time was five twenty two a.m., duration of sleep was seven hours and six minutes. Among the elderly, 11.6% and 14.8% of the subjects reported chronic and intermittent difficulty in sleeping, respectively. The patients with back pain and history of stroke complained of more insomnia symptoms in univariate analysis. In ANCOVA analysis, insomnia symptoms were associated with an old age, depressive symptoms in male. Bodily pain and history of dermatologic disease were additional risk factors in female. Conclusions : The data suggest insomnia is one of most common health problems among elderly Koreans living in the community. Strong positive relationship between depressive symptoms and insomnia were found. Further research is needed to explore the causal relationship between insomnia and risk factors.