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Disorders of Small and Large Intestine : Patient Nonadherence To Medication In Crohn`s Disease
( Sang Bong Ahn ),( Dong Soo Han ),( Hyun Seok Cho ),( Tae Joon Byun ),( Tae Yeob Kim ),( Chang Soo Eun ),( Yong Cheol Jeon ),( Joo Hyun Sohn ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background Aims: Crohn`s disease is a risky situation for nonadherence to treatment. Adherence to medication are directly related to therapeutic success. The aim of this study was to idendify the patients characteristics and determinants of nonadherence to medication Crohn`s disease patients in Korea. Methods: Six hundred seven patients of Crohn`s disease participated in this study. Individual characteristics, disease activity, kinds of medication, side effects of medication, as well as factor to adherence, were assessed by questionnaire survey. Results: Of the 607 enrolled patients, 243 (40%) patients have stopped taking medication for more than one month. The main reasons for discontinuing medication were forgetfulness (59.1%), change of feeling (62.3%). Over 60% of patients complained side effects related with medications. Of these, 32.3% of patients changed or stopped the medication due to side effects. Adherence to medication was significantly associated with old age at diagnosis (OR=1.03), recent diagnosis (OR=0.94), non-alcoholics (OR=1.41), non-smokers (OR=0.46), the severity of abdominal pain (OR=0.66), low disease activity (OR=0.99), low level of stress (OR=0.85), steroid medication (OR=1.98), regular (OR=1.83) short-term follow-up (OR=3.21). And, adherence was higher in patients with familial support (OR=1.44), internet search (OR=0.55), patient support group (OR=1.70) and no experience of alternative medicines (OR=2.25). Conclusions: Understanding of characteristics of Crohn`s disease patients and correction of factors associated to poor adherence could lead to higher therapeutic success.
Sung Hee Yoon,Sun Ok Yun,Jung Yong Park,Hee Yeun Won,Eun-Kyung Kim,Hyun-Jung Sohn,Hyun-Il Cho,김태규 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.3
Increasing importance is being given to the stimulation of Th1 response in cancer immunotherapy because its presence can shift the direction of adaptive immune responses toward protective immunity. Based on chemokine receptor expression, CXCR3+CCR4-CD4+ T cells as Th1-type cells were investigated its capacity in monocyte-derived dendritic cell (DC) maturation and polarization, and induction of antigen specific cytotoxic T lymphocytes (CTL) in vitro. The levels of IL-4, IL-5 and IL-10 were decreased to the basal level compared with high production of IFN-γ, TNF-α, and IL-2 in CXCR3+CCR4-CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies. Co-incubation of activated CD4+ or CXCR3+CCR4-CD4+ T cells with DC (CD4+/DC or CXCR3+CD4+/DC, respectively) particularly up-regulated IL-12 and CD80 expression compared with DC matured with TNF-α and LPS (mDC). Although there was no significant difference between the effects of the CXCR3+CCR4-CD4+ and CD4+ T cells on DC phenotype expression, CXCR3+CD4+/DC in CTL culture were able to expand number of CD8+ T cells and increased frequencies of IFN-γ secreting cells and overall cytolytic activity against tumor antigen WT-1. These results demonstrated that the selective addition of CXCR3+ CCR4- CD4+ T cells to CTL cultures could enhance the induction of CTLs by DC in vitro, and implicated on a novel strategy for adoptive T cell therapy. Increasing importance is being given to the stimulation of Th1 response in cancer immunotherapy because its presence can shift the direction of adaptive immune responses toward protective immunity. Based on chemokine receptor expression, CXCR3+CCR4-CD4+ T cells as Th1-type cells were investigated its capacity in monocyte-derived dendritic cell (DC) maturation and polarization, and induction of antigen specific cytotoxic T lymphocytes (CTL) in vitro. The levels of IL-4, IL-5 and IL-10 were decreased to the basal level compared with high production of IFN-γ, TNF-α, and IL-2 in CXCR3+CCR4-CD4+ T cells stimulated with anti-CD3 and anti-CD28 antibodies. Co-incubation of activated CD4+ or CXCR3+CCR4-CD4+ T cells with DC (CD4+/DC or CXCR3+CD4+/DC, respectively) particularly up-regulated IL-12 and CD80 expression compared with DC matured with TNF-α and LPS (mDC). Although there was no significant difference between the effects of the CXCR3+CCR4-CD4+ and CD4+ T cells on DC phenotype expression, CXCR3+CD4+/DC in CTL culture were able to expand number of CD8+ T cells and increased frequencies of IFN-γ secreting cells and overall cytolytic activity against tumor antigen WT-1. These results demonstrated that the selective addition of CXCR3+ CCR4- CD4+ T cells to CTL cultures could enhance the induction of CTLs by DC in vitro, and implicated on a novel strategy for adoptive T cell therapy.
Sung Joon Cho,Jungmee Kim,Yeon Ju Kang,Seung Yeon Lee,Hwo Yeon Seo,Jee Eun Park,Haebin Kim,Kyoung-Nam Kim,Jin Yong Lee,Jee Hoon Sohn 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.1
Objective: We conducted this study to address the incidence and prevalence of schizophrenia and similar psychosis in South Korea with Health Insurance Review and Assessment (HIRA) database. Methods: We used HIRA database, which includes diagnostic information of nearly all Korean nationals to collect number of cases with diagnosis of schizophrenia and schizophrenia-similar disorders (SSP), including schizophreniform, acute/transient psychotic disorders, schizoaffective disorders, and other/unspecific nonorganic psychosis (ICD-10 codes F20/23/25/28/29) between 2010 and 2015. The annual prevalence and incidence were calculated using the population data from the Korean Statistical Office. Results: The 12-month prevalence of SSP of Korea between 2010 and 2015 were 0.48-0.66%. The 12-month prevalence of schizophrenia were 0.40-0.52%; The annual incidence rates (IR) of SSP between 2010 and 2015 were 118.8-148.7 per 100,000 person-year (PY). For schizophrenia, IR per 100,000 PY were 77.6-88.5 between 2010 and 2015. Conclusion: The 12-month prevalence found in the present study was higher than that reported in community-based epidemiologic studies in South Korea but similar to those from other countries. The annual incidence of SSP and schizophrenia was found to steadily increase and was higher than that of other countries. The high incidence rate observed in the current study needs to be studied further.
COVID-19 Vaccine Induced Systemic Inflammatory Response Syndrome
( Sang-heon Kim ),( Soo Jin Lee ),( Sung Jun Chung ),( Yoomi Yeo ),( Hyun Lee ),( Tai Sun Park ),( Dong Won Park ),( Ji-Yong Moon ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
To protect people from coronavirus disease 2019 (COVID-19), various types of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and administered. Adverse reactions to COVID-19 vaccines include various local and systemic adverse reactions which may occur immediately or weeks later. Here we report a case of systemic inflammatory response syndrome induced by COVID-19 vaccine. A 65-year-old man with a history of hypertension presented with 5 days of fever. On admission, he was febrile to 38.3℃ with mild dyspnea when experiencing febrile sensation. Six days ago, he was vaccinated with the BNT162b2 mRNA COVID-19 vaccine. Fever with chill developed one day after vaccination and persisted. Chest radiography and a CT scan showed bilateral pleural effusion. Abdomen CT showed interstitial edematous pancreatitis at pancreas tail and perinephric infiltration. PET/CT revealed diffuse hypermetabolic infiltration or activity in mediastinal fat tissue, pericardial and peritoneal thickening. Laboratory Results documented leukocytosis, elevated levels of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and C-reactive protein. There was no evidence of possible infectious diseases or rheumatic diseases after a full examination and consultation with the specialists. With the administration of high-dose oral corticosteroids, fever and pleural effusion disappeared gradually. These findings suggest systemic inflammatory response syndrome induced by COVID-19 mRNA vaccine.