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Lee, In Hee,Park, Jae-Bok,Cheong, Minseon,Choi, Youn Seok,Park, Daehan,Sin, Jeong-Im Mary Ann Liebert, Inc 2011 DNA and Cell Biology Vol.30 No.12
<P>DNA vaccines are known to be lacking in immunogenicity in humans. Presently, electroporation (EP) is thought to overcome this limitation. Here, we investigate whether human papillomavirus 16 E7 DNA vaccines delivered by EP might elicit potent antitumor activity in animal cervical cancer models, with a focus on the underlying mechanism(s). Intramuscular (IM)-EP delivery of E7 DNA vaccines induced more potent antitumor therapeutic and antimetastatic activity compared with IM delivery. Moreover, the tumor-controlled animals by IM-EP possessed long-term memory responses to parental tumor cells. This improved antitumor effect was concomitant with augmented Ag-specific CTL activities. IM-EP also induced IgG and Th-cell responses higher than IM delivery. Finally, IM-EP resulted in more antigen production in and more attraction of immune cells into the site of DNA injection, suggesting that these biological and immunological changes made by IM-EP might be responsible for enhanced CTL activities and antitumor resistance. Thus, this study shows that IM-EP can induce more potent antitumor activity by augmenting CTL responses possibly through more antigen production in and more attraction of immune cells into the muscle sites. This study also suggests that IM-EP of E7 DNA vaccines might be a potential approach toward treating patients with cervical cancer.</P>
Sin, Jeong-Im,Park, Jae-Bok,Lee, In Hee,Park, Daehan,Choi, Youn Seok,Choe, Jongseon,Celis, Esteban Springer International 2012 Cancer immunology, immunotherapy Vol.61 No.10
<P>Intratumoral electroporation (IT-EP) with IL-12 cDNA (IT-EP/IL12) can lead to the eradication of established B16 melanoma tumors in mice. Here, we explore the immunological mechanism of the antitumor effects generated by this therapy. The results show that IT-EP/IL12 applied only once resulted in eradication in 70% animals with large established B16 tumors. Tumor eradication required the participation of CD8+ T cells, but not CD4+ T cells and NK cells. IT-EP/IL12 induced antigen-specific CD8+ T cell responses against the immunodominant Trp2(180-188) epitope and generated a systemic response, resulting in significant therapeutic effects against distal, untreated tumors. The therapeutic effect of IT-EP/IL12 was absent in perforin-deficient mice, indicating that tumor elimination occurred through conventional perforin/granzyme lysis by CTLs. Moreover, this therapy induced some degree of immunological memory that protected approximately one-third of the cured mice against a subsequent tumor challenge. Moreover, antitumor efficacy and long-term protection against B16 were significantly improved by concurrent Trp2 peptide immunization through more induction of Ag-specific CTL responses and more attraction of IFN-γ-expressing CD8+ T cells into tumor sites. The antitumor effect of IT-EP/IL12 required the participation of IFN-γ, which was shown to induce MHC class I expression on B16 cells and increase the lytic activity of the CD8+ CTL generated by IT-EP/IL12. The results from these animal studies may help in the development of IT-EP/IL12 for cancer patients.</P>
Sin, Jeong-Im,Kim, Jung-Min,Bae, Sung Hwa,Lee, In Hee,Park, Jong Sup,Ryoo, Hun Mo Elsevier 2009 Molecular therapy Vol.17 No.5
<P>Adoptive cytotoxic T lymphocyte (CTL) therapy has an important implication in treating cancer patients. Here, we investigate whether adoptive transfer of human papillomavirus (HPV) E7-specific CTL can enhance tumor chemoresponse using an established cervical cancer animal model. Cisplatin-based chemotherapy plus CTL therapy showed an improved therapeutic effectiveness, along with antitumor protective responses to a parental tumor cell rechallenge. Cisplatin treatment dose-dependently increased the expression of Fas, intercellular adhesion molecule (ICAM)-1, and major histocompatibility complex (MHC) class I antigens (Ags) on tumor cells in vitro. However, CTL-expressing FasL failed to improve antitumor activity in vitro and in animals, resulting from nonfunctional Fas expressed on tumor cells. In contrast, ethylene glycol tetraacetic acid (EGTA) treatment blocked increased sensitivity of cisplatin-treated tumor cells to CTL-mediated killing in vitro, suggesting an important role of the perforin/granzyme-mediated pathway for improved therapeutic effectiveness. This notion was further confirmed by perforin knockout animal studies. Thus, this study shows that (i) modulation of Ag (Fas, ICAM-1) expression by tumor cells has little effect on their increased sensitivity to CTL-mediated killing, (ii) improved therapeutic effectiveness is mediated mainly through the perforin/granzyme-mediated tumor killing pathway, and (iii) a combination of chemotherapy and adoptive E7-specific CTL transfer augments antitumor therapeutic activity in vivo. This finding may have important implications for treating HPV-associated cervical cancer.</P>
복막염이 동반되지 않으면서 복막투석 도관에 증식한 진균 (Alternaria species)
신도현 ( Sin Do Hyeon ),안상미 ( An Sang Mi ),임선교 ( Im Seon Gyo ),정희선 ( Jeong Hui Seon ),김명성 ( Kim Myeong Seong ),신규태 ( Sin Gyu Tae ),이위교 ( Lee Wi Gyo ),임현이 ( Im Hyeon I ),길혜련 ( Gil Hye Lyeon ),김흥수 ( Kim He 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.3
Visible fungal colonization on peritoneal dialysis catheter is a rare complication and it was not reported yet in Korea. We here report a case of Alternaria spp. colonization on peritoneal dialysis catheter without peritonitis. A 58-year-old man on continuous ambulatory peritoneal dialysis for 2 years, noticed 3..4 mm sized two black-brown immobile fungal colonization plaque on peritoneal catheter lumen (15 cm distal from catheter exit site). The dialysate effluent was clear and culture for fungus and bacteria was negative. Peritoneal catheter was removed and culture from the plaque revealed saprophytic fungus, Alternaria species. The catheter removal alone was sufficient for the treatment. He is on hemodialysis thereafter. (Korean J Nephrol 2004;23(3):523-527)
인체 췌장암세포(Capan1)의 증식에 미치는 Curcumin의 억제효과
임대관 ( Im Dae Gwan ),이신화 ( Lee Sin Hwa ),김신 ( Kim Sin ),김유리 ( Kim Yu Li ),김선정 ( Kim Seon Jeong ),박정필 ( Park Jeong Pil ),김지연 ( Kim Ji Yeon ),박무인 ( Park Mu In ),박선자 ( Park Seon Ja ),정근옥 ( Jeong Geun Og ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 음식첨가제에 포함되어 있는 성분인 curcumin이 인체 췌장암세포(Capan1)의 증식에 미치는 효과를 좀더 자세히 알기 위해, 세포배양실험을 통하여 curcumin의 증식효과를 조사하고, 5-fluorouracil (5-FU)와의 병용효과를 조사하였으며, 증식억제에 따르는 각 세포주기별 변화를 조사하였다. <재료 및 방법> 증식기의 인체 췌장암세포(Capan1)를 6 well plate에 각 well당 20×10(4)개의 세포를 분주하여 c
제5차 대한간학회 춘계학술대회 초록집 : 포스터 전시 순서 ; 다발성 신농양을 동반한 원발성 담즙성 간경변증 1예
신정우 ( Sin Jeong U ),김인호 ( Kim In Ho ),최정 ( Choe Jeong ),송일한 ( Song Il Han ),임창영 ( Im Chang Yeong ),김정원 ( Kim Jeong Won ),노임환 ( No Im Hwan ),조종태 ( Jo Jong Tae ),조정희 ( Jo Jeong Hui ) 대한간학회 1999 Clinical and Molecular Hepatology(대한간학회지) Vol.5 No.1(S)