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절수에 의한 mongolian gerbil의 체중 변화에 관한 연구
이경열,송치원,김무강,조성환,류시윤,김상근,박배근 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
Recently, the mongolian gerbils have been used in neurology and the study of water metabolism because of their easy onset of epileptic seizure and typical resistance to water deprivation. The sebaceous glands which are under the control of the gonadal hrmones are differently developed from the other laboratory animals. However the physiological data on the changes of body weight following water deprivation in mongolian gerbils is not available until now. In order to investigate the effect of the water deprivation on the body weight, the animals were deprived of water for 15 days. The body weights were measured daily by the torsion balance. The mean, the standard deviation, the standard error and the coefficient of variance of the body weights were calculated. The correlation was examined. The potential regression equation was y = 61.5458 - 2.0533 * x + 0.0487 * x^2. The regression coefficient was 0.993. The results obtained were as follows : 1. The body weights of the mongolian gerbils were continuously decrased from the 1st day to the 15th day after the water deprivation. 2. The mean body weight on the water deprivation was 63.0±7.00g and that at the 15th day was 41.4 ± 5.42g. 3. The coefficients of the variance showed the highest (13.09) at the 15th day and the lowest (10.10) at the 10th day. the coefficients of the variance kept decreasing until the 10th day and thereafter gradually increased until the 15th day. 4. The changing rate of the body weight kept continuously decreasing from the 1st day to the 15th day showing the daily loss of 1.0 - 3.3%. 5.The deviations (M - QBW) between the measured values (m) and the theorical values (QBW) using the regression equation showed the highest (1.494) at the 1st day and the lowest (0.053) at the 13th day. 6. The sum of the devitions was 0.179 and that of the deviation square was 1.15. The sum of the deviation rates between the mesaured body weights and the theorical ones was 0.484. 7. The daily body weight loss showed the highest at the 1st day by 2.053g and the lowest at the 15th day by 0.591g. 8. The specific body weight changing rates which were the rate of the body weight changing velocity to the changed body weight were decreased from 0.033% at the 1st day to 0.014% at the 15th day.
DNA-Recombinant Azurin Conjugation as a Biomemory Platform with Enhanced Sensitivity
Chen, Qi,Yoo, Si-Youl,Lee, Taek,Kim, Sang-Uk,Nam, Eun Sook,Min, Junhong,Choi, Jeong-Woo American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.11
<P>Biocomputing devices with DNA, protein/enzymes and other biomaterials have been studied to develop unconventional computing devices. However, the high sensitivity of these devices is still in doubt due to difficulty detecting the efficient electron transfer between biomolecules and the device surface. In this study, oligonucleotides were introduced to the recombinant azurin to enhance the current signal. The recombinant azurin self-assembled on the gold surface due to the formation of gold-sulfur covalent bonds. Single stranded DNA (ssDNA) sequences were further conjugated with self-assembled recombinant azurin via a chemical linker. The fabricated biofilm was confirmed by cyclic voltammetry (CV) and atomic force microscopy (AFM). Moreover, enhancement of the electrochemical signal sensitivity and durability to harsh pH conditions were achieved by conjugation with biomolecular oligonucleotides that can contain Pb2+. The biofilm consisting of DNA and recombinant azurin was further verified to be a suitable platform for biomemory. The sensitivity and durability of the biomemory platform was enhanced by simply by introducing DNA into the system, without any other labels or nanoparticles. The proposed biofilm can be applied to bioelectronics devices such as bioprocessors and biocomputers.</P>
Lee, Won-Kyu,Lee, Sang-Yeop,Na, Jung-Hyun,Jang, Sung-Woo,Park, Chan-Ryang,Kim, Soo-Youl,Lee, Si-Hyeong,Han, Kyou-Hoon,Yu, Yeon-Gyu Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.6
Nopp140 is a highly phosphorylated protein that resides in the nucleolus of mammalian cell and is involved in the biogenesis of the nucleolus. It interacts with a variety of proteins related to the synthesis and assembly of the ribosome. It also can bind to a ubiquitous protein kinase CK2 that mediates cell growth and prevents apoptosis. We found that Nopp140 is an intrinsically unfolded protein (IUP) lacking stable secondary structures over its entire sequence of 709 residues. We discovered that mitoxantrone, an anticancer agent, was able to enhance the interaction between Nopp140 and CK2 and maintain suppressed activity of CK2. Surface plasma resonance studies on different domains of Nopp140 show that the C-terminal region of Nopp140 is responsible for binding with mitoxantrone. Our results present an interesting example where a small chemical compound binds to an intrinsically unfolded protein (IUP) and enhances protein-protein interactions.