연약한 점성토 지반의 지지력 결정에 관한 연구

안종필,박상범,김규덕 朝鮮大學校 建設技術硏究所 2004 建設技術硏究 Vol.24 No.2

To find out the variation of bearing capacity due to the plasticity of soils in case of working the unsymmetrical surcharge of ML, CL, and CH, the existing theoretic expression were investigated and were compared with a series of test results The critical surcharge of soft soils was found as q_(cr)=4.22C_(u) in ML, which is slightly larger than the existing expression, but similar to Darragh's expression. The critical surcharge in CL was found as q_(cr)=3.21C_(u), which is the value between JHI and Jaky and in CH was found as qcr=2.60C_(u), which is a the value between Tachebotarioff and Meyerhof. The ultimate bearing capacity of soft soils was found as q_(uIt) = 11.19C_(u) in ML, which was significantly larger than the existing expression. The ultimate bearing capacity of CL was found as q_(ult)=8.41C_(u), which was slightly bigger than the existing expression, but is close to Meyerhof's expression. The ultimate bearing capacity in CH was found as q_(uIt) =4.73C_(u), which is similar to Parndtl's expression.

제품보호용 포장재 개발

김정필,강재현,박대연,유성구,서길수 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

The environment to which a packaged-product is exposed, during handling and transportation, very often includes temporary storage. In the interest of conserving warehouse cube, packaged-products are stacked upon one another to a height which far exceeds that possible in a railcar, truck-trailer, aircraft or other conveyance. the hight to which the height to which a packaged-product may be stacked will vary depending upon the warehouse ceiling height-seldom over twenty feet. This procedure for expirimental covers testing of packaged-products weighing under 100 pounds when prepared for shipment. The BASIC requirements of this procedure consist of vibration and drop tests-which must be performed in that sequence.

鐵道 車輛 緩衝 裝置의 性能 向上에 관한 硏究

朴寧弼,李圭燮,權聖奎 연세대학교 대학원 1988 延世論叢 Vol.24 No.-

In order to improve the performance of the suspension system for mass transport vehicle with prescribed dynamic behavior, a synthesis procedure of eliminating "Hunting" was studied to yield resonant velocities outside the range of most frequent operation. Effect of changing in the spring stiffnesses on the resonant velocities of the system was considered. The effects of damping on the suspension system was analyzed through the Root Locus Analysis. And Root Contours Method was used to obtain the optimal damping values. Hunting is controlled by using a proper damping into the secondary suspension.

관상동맥 질환에서 SDF-1α의 농도

김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.

유카 Ag-aide가 페어리링 병이 발생한 잔디토양의 투수계수 및 한지형 잔디 생육에 미치는 영향

김두환,이재필,함선규,장진혁,김성태 건국대학교 농업자원개발연구소 2000 農資源開發論集 Vol.22 No.-

Yucca Ag-aide extracted from Yucca, Agavaceae, is one of the several surface active agents being marked as a soil conditioner for turfgrass. According to the previous research, Yucca can provide an energy source for soil microbes, improve physical properties, and nutrient efficiency in soil, and enhance water infiltration capacity of soil. Yucca was applied to the tee area with cool-season grass showing fairy ring symptom at the Asiana Country Club from June to July, 1999. Yucca was also applied to "Pencross" creeping bentgrass that was stressed by 15 and 30 times of glass stick once every two months(three time total) in 5cm diameter of PVC pipe in greenhouse and to experiment field, established with 35% Tall fescue+50% Kentucky bluegrass+15%Perennial ryegrass at the Kon-kuk University on June 8, 1999. Infiltration at the tee area showing fairy ring symptom was improved by treatment of 250 and 500 fold of Yucca Ag-aide. Yucca Ag-aide treatment also improved root length and dry weight of creeping bentgrass with the stress by glass stick. Coverage and turf quality of cool-season turfgrass in field trial were increased by Yucca Ag-aide. Clipping dry weight was also increased by the treatment.

이행성 협심증 환자에서 운동부하 심전도 검사

이정우,박형서,박용규,노상필,이유선,정승현,김보영,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 관상동맥의 경련에 의한 이형성 협심증환자에 있어서 운동부하 심전도 검사의 결과는 매우 다양하다. 이에 저자들은 충남대학교병원 순환기내과에서 관상동맥조영술상 이형성 협심증으로 확진된 환자를 대상으로 운동부하 심전도 검사를 시행하여 이에 대한 결과를 연구하였다. 방법 : 1995년 1월부터 2002년 3월까지 흉통을 주소로 충남대학교병원 순환기 내과에 입원하여 관상동맥조영술을 시행하여 관상동맥의 내경이 50% 미만의 협착이 있고, 에르고노빈(ergonovine) 유발검사도 이형성 협심증으로 진단을 받은 233명중 운동부하 심전도 검사를 시행 받은 183명의 환자를 연구 대상으로 하였다. 운동부하 심전도 검사 결과의 판독시 발생할 수 있는 오류를 줄이기 위해서 운동부하 심전도 검사를 시행하기전 심전도상 ST분절의 상승(5예)이나 하강(8예)이 있는 경우 EH한 T파의 역위(19예)가 있는 32명의 환자를 제외한 총 151명의 환자를 대상으로 하였다. 운동부하는 Marquette사의 case 15 답차를 이용하였고, Bruce protocol에 따라 증상이 나타날 때까지 최대로 실시하였으며 각 stage 및 운동후의 혈압을 측정하고 12 유도 심전도를 기록하였다. 결과 : 1) 임상적 특성 - 내원시 임상 상은 안정형 협심증이 39예(25.8%), 불안정형 협심증이 103예(68.2%), 심근경색증이 9예(6.0%)이었다. 운동부하 심전도 검사 결과 양성 군과 음성군간에 있어서 당뇨병, 고혈압, 비만도, 총 혈청콜레스테롤치, 현재의 흡연 여부, 병력상 운동시 흉통의 유무, 내원시 임상적 진단, 협착의 정도, 연축의 수 등을 조사하였는 바 어떠한 인자들도 유의한 차이를 발견할 수 없었다. 2) 운동부하 심전도 검사 - 운동부하 심전도 검사를 시행 받은 151명의 환자중 음성인 경우는 134예(88.8%)이었고, 양성인 경우는 17예(11.2%)이었다. 양성 소견을 보인 환자들중 ST 분절의 상승이 4예(2.6%), ST 분절의 하강이 13예(8.6%)이었다. 3) 관상동맥조영술 - 관상동맥조영술상에서 혈관 경력 위치는 우관상동맥이 70예(46.1%), 좌전하동맥이 44예(28.9%), 좌회선동맥이 17예(11.2%)의 순으로 나타났다. 운동부하 심전도 검사상 ST 분절의 상승이 있었던 예중 Ⅱ, Ⅲ, aVF에서 ST 분절의 상승이 있었던 1예는 관상 동맥조영술상 우관상동맥에서 경련이 발생하였고, V2-V4에서 ST 분절의 상승이 있었던 2예중 관상동맥조영술상에도 좌전하행동맥에서 경련이 나타난 예는 1예이었으며 다른 1예는 좌회선동맥에서 경련이 나타났고, V5-V6에서 ST 분절의 상승이 있었던 1예는 관상동맥조영술상에도 좌회선동맥에서 경련이 나타났다. 운동부하 심전도 검사상 V5 또는 V6에서 ST 분절의 하강이 있엇던 13예중 6예(46.1%)는 관상동맥조영술상 우관상동맥에서 경련이 발생하였고, 3예(23.1%)는 좌전하행동맥에서, 1예(7.7%)는 좌회선동맥에서, 나머지 3예(23.1%)는 2개의 혈관이나 기타 분지에서 경련이 발생하였다. 결론 : 1) 이형성 협심증 환자는 운동부하 심전도 검사에서 11.2%의 양성소견을 보였다. 이중 ST 분절의 상승은 2.6%이었고, ST 분절의 하강은 8.6%이었다. 2) 이형성 환자중 운동부하 심전도 검사를 실시하여 음성을 보이는 경우 다혈관 관상동맥질환이기 보다는 이형성 협심증일 가능성이 더 높다고 예측할 수 있을 것으로 생각된다. 3) 이형성 협심증 환자중 운동부하 심전도 검사를 실시하여 ST 분절의 상승을 보이는 경우 다혈관 관상동맥질환이기 보다는 이형성 협심증일 가능성이 더 높다고 예측할 수 있을 것으로 생각된다. 4) 운동부하 심전도 검사 결과에 대한 당뇨병, 고혈압, 비만도, 총 혈청콜레스테롤치, 현재의 흡연여부, 병력상 운동시 흉통의 유무, 내원시 임상적 진단, 협착의 정도 등 어떠한 인자들도 3그룹(ST 분절의 상승, ST 분절의 하강, 음성)간에 유의한 차이를 발견할 수 없었다. 5) ST 분절의 상승 부위와 관상동맥조영술상 관상동맥의 연축이 일어나는 혈관과의 상관관계는 매우 높았다. No reports in the literature describe the results of exercise testings in a large number of patients with pure variant angina(coronary stenosis <50%) in Korea. In this report, We present the results of treadmil exercise testing in 151 patients with variant angina. 151 patients with angiographically proven coronary artery spasm underwent a treadmil exercise test. The clinical characteristics of variant angina patients classified according to ST-segment response to exercise were analyzed. Of 151 patients underwent a treadmil exercise test, negative result was seen in 134 patients(88.8%) and positive result was in 17 patients(11.2%). Of 17 patients saw positive result, exercise-induced ST segment elevation was present in 4 patients(2.6%) and ST segment depression was seen in 13 patients(8.6%). There was not a significant relationship between the ST segment response to exercise and the clinical variables(diabetes, hypertension, obesity, total cholesterol, current smoking, effort angina, clinical diagnosis, and degree of stenosis) assessed. Of 4 patients with ST segment elevation in treadmil exercise test, 1 patient with ST segment elevation in Ⅰ,Ⅲ,aVF had spasm in right coronary artery(100%) on coronary angiography, of 2 patients in V2-V4 had spasm in left anterior descending coronary artery in 1 patient(50%) and 1 patient in V5-V6 had spasm in left circumflex artery(100%). Positive treadmil exercise test was present in 11.2% of variant angina patient. If we have negative treadmil exercise result in patients with clinical manifestation of unstable angina at admission, we may have a suspicion of variant angina rather than multi-vessel disease. If we have exercise-induced ST segment elevation in patients with clinical manifestation of unstable angina at admission, we have a suspicion of variant angina rather than multi-vessel disease. Our result suggests that the correlation between the site of the ST segment elevation and the artery involved is quite good.

Fabrication of optoacoustic transmitters by using pulsed laser irradiation and localized photothermal curing process

Pil Gyu SANG,Hyoung Won BAAC 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Study of the Transmission Error Prediction of a Five-speed Manual Transmission System

Sang-Pil Cho(조상필),Dong-Gyu Lee(이동규),Lae-Sung Kim(김래성),Zhe-zhu Xu(허철수),Sung-ki Lyu(류성기) 한국기계가공학회 2016 한국기계가공학회지 Vol.15 No.2

For the manual transmission gearbox used in the automotive industry, gear meshing transmission error is the main source of noise known as gear whine, and radiated gear whine noise plays an important role in the whole gearbox. Therefore, in order to keep competitive in the automotive market, the NVH performance of transmission gearboxes is increasingly important for automotive manufacturers when a new product is developed. In this paper, in order to achieve an optimized tooth contact pattern, gear tooth modification is applied to make up for the deformation of the teeth owing to load. A five-speed MT gearbox is firstly modeled in RomaxDesign software and the prediction of transmission error under the loaded torques is studied and compared. From the simulation, the transmission error and maximum contact stress are also simulated and compared after tooth modification of the loaded torques. Finally, the simulation results are used to optimize the whole gearbox design and the final gearbox prototype is testified to obtain NVH performance in a semi-anechoic room.

Original Article : Rifaximin Plus Levofloxacin-Based Rescue Regimen for the Eradication of Helicobacter pylori

( Sang Pil Yun ),( Han Gyung Seon ),( Chang Soo Ok ),( Kwang Ho Yoo ),( Min Kyung Kang ),( Won Hee Kim ),( Chang Il Kwon ),( Kwang Hyun Ko ),( Seong Gyu Hwang ),( Pil Won Park ),( Sung Pyo Hong ) The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.4

Background/Aims: This study assessed the efficacy of a rifaximin plus levofloxacin-based rescue regimen in patients that had failed both triple and quadruple standard regimens for the eradication of Helicobacter pylori. Methods: We treated patients for H. pylori between August 2009 and April 2011. The triple regimen consisted of combined treatment with amoxicillin, clarithromycin, and pantoprazole for 1 week. For failed cases, a quadruple regimen of tetracycline, metronidazole, bismuth dicitrate, and lansoprazole for 1 week was administered. The rescue regimen for persistently refractory cases was rifaximin 200 mg t.i.d., levofloxacin 500 mg q.d., and lansoprazole 15 mg b.i.d. for 1 week. Results: In total, 482 patients were enrolled in this study. The eradication rates associated with the first and second regimens were 58% and 60%, respectively. Forty-seven out of 58 patients who failed with the second-line regimen received rifaximin plus levofloxacin-based third-line therapy. The eradication rate for the third regimen was 65%. The cumulative eradication rates were 58%, 85%, and 96% for each regimen, respectively. Conclusions: A rifaximin plus levofloxacin-based regimen could be an alternative rescue therapy in patients with resistance to both triple and quadruple regimens for the eradication of H. pylori. (Gut Liver 2012;6:452-456)

Frequency of Killer Cell Immunoglobulin-like Receptors (KIRs) in Korean Patients with Chronic HCV Infection

Sung, Pil Soo,Choi, Hee Baeg,Kim, Su-Yeon,Hong, Sung Woo,Park, Chung-Hwa,Song, Myeong Jun,Lee, Sung Won,Yoo, Chan Ran,Choi, Sang Wook,Han, Nam Ik,Kim, Tai-Gyu,Yoon, Seung Kew The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.11

<P>Natural killer (NK) cells play an important role in innate immunity, especially in the response to viral infections, such as hepatitis C virus (HCV). Killer cell immunoglobulin-like receptors (KIRs) are the primary receptors of NK cells that mediate innate immunity. KIRs are also involved in acquired immunity, because some KIRs are expressed on the surface of certain subsets of T cells. In this study, the frequency of KIR genes, <I>HLA-C</I> allotypes, and combinations of KIR genes with their <I>HLA-C</I> ligands were evaluated in two different groups of the Korean population: controls and patients with chronic HCV infection. The study population consisted of 147 Korean patients with chronic HCV infection. The frequency of KIR2DS2 in patients with chronic HCV infection was 9.5% which was significantly lower than 19.5% of the control (<I>P</I> < 0.01). However, there were no significant differences in the frequency of other KIR genes, <I>HLA-C</I> allotypes or different combinations of KIR genes with their <I>HLA-C</I> ligands. This study can contribute to the further prospective study with a larger scale, suggesting the assumption that <I>KIR2DS2</I> might aid in HCV clearance by enhancing both the innate and acquired immune responses of people in Korea.</P>