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Park, Myoung-Rin,Park, Yeon-Hee,Choi, Jae-Woo,Park, Dong-Il,Chung, Chae-Uk,Moon, Jae-Young,Park, Hee-Sun,Jung, Sung-Soo,Kim, Ju-Ock,Kim, Sun-Young,Lee, Jeong-Eun The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.76 No.5
Background: Small cell lung cancer (SCLC) is an extremely aggressive tumor with a poor clinical course. Although many efforts have been made to improve patients' survival rates, patients who survive longer than 2 years after chemotherapy are still very rare. We examined the baseline characteristics of patients with long-term survival rates in order to identify the prognostic factors for overall survivals. Methods: A total of 242 patients with cytologically or histologically diagnosed SCLC were enrolled into this study. The patients were categorized into long- and short-term survival groups by using a survival cut-off of 2 years after diagnosis. Cox's analyses were performed to identify the independent factors. Results: The mean patient age was 65.66 years, and 85.5% were males; among the patients, 61 of them (25.2%) survived longer than 2 years. In the multivariate analyses, CRP (hazard ratio [HR], 2.75; 95% confidence interval [CI], 1.25-6.06; p=0.012), TNM staging (HR, 3.29; 95% CI, 1.59-6.80; p=0.001), and progression-free survival (PFS) (HR, 11.14; 95% CI, 2.98-41.73; p<0.001) were independent prognostic markers for poor survival rates. Conclusion: In addition to other well-known prognostic factors, this study discovered relationships between the long-term survival rates and serum CRP levels, TNM staging, and PFS. In situations with unfavorable conditions, the PFS would be particularly helpful for managing SCLC patients.
Lee, Jae Won,In, Jung Hoon,Park, Joon-Bum,Shin, Jonghyeok,Park, Jin Hwan,Sung, Bong Hyun,Sohn, Jung-Hoon,Seo, Jin-Ho,Park, Jin-Byoung,Kim, Soo Rin,Kweon, Dae-Hyuk Elsevier 2017 Journal of biotechnology Vol.241 No.-
<P>Lactic acid (LA) is a versatile compound used in the food, pharmaceutical, textile, leather, and chemical industries. Biological production of LA is possible by yeast strains expressing a bacterial gene encoding L-lactate dehydrogenase (LDH). Kluyveromyces marxianus is an emerging non-conventional yeast with various phenotypes of industrial interest. However, it has not been extensively studied for LA production. In this study, K. marxianus was engineered to express and co-express various heterologous LDH enzymes that were reported to have different pH optimums. Specifically, three LDH enzymes originating from Staphylococcus epidermidis (SeLDH; optimal at pH 5.6), Lactobacillus acidophilus (LaLDH; optimal at pH 5.3), and Bos taurus (BtLDH; optimal at pH 9.8) were functionally expressed individually and in combination in K. marxianus, and the resulting strains were compared in terms of LA production. A strain co-expressing SeLDH and LaLDH (KM5 La + SeLDH) produced 16.0 g/L LA, whereas the strains expressing those enzymes individually produced only 8.4 and 6.8 g/L, respectively. This co-expressing strain produced 24.0 g/LA with a yield of 0.48 gig glucose in the presence of CaCO3. Our results suggest that co-expression of LDH enzymes with different pH optimums provides sufficient LDH activity under dynamic intracellular pH conditions, leading to enhanced production of LA compared to individual expression of the LDH enzymes. (C) 2016 Elsevier B.V. All rights reserved.</P>
( Myoung Rin Park ),( Yeon Hee Park ),( Jae Woo Choi ),( Dong Il Park ),( Chae Uk Chung ),( Jae Young Moon ),( Hee Sun Park ),( Sung Soo Jung ),( Ju Ock Kim ),( Sun Young Kim ),( Jeong Eun Lee ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.76 No.5
Background: Small cell lung cancer (SCLC) is an extremely aggressive tumor with a poor clinical course. Although many efforts have been made to improve patients` survival rates, patients who survive longer than 2 years after chemotherapy are still very rare. We examined the baseline characteristics of patients with long-term survival rates in order to identify the prognostic factors for overall survivals. Methods: A total of 242 patients with cytologically or histologically diagnosed SCLC were enrolled into this study. The patients were categorized into long- and short-term survival groups by using a survival cut-off of 2 years after diagnosis. Cox`s analyses were performed to identify the independent factors. Results: The mean patient age was 65.66 years, and 85.5% were males; among the patients, 61 of them (25.2%) survived longer than 2 years. In the multivariate analyses, CRP (hazard ratio [HR], 2.75; 95% confidence interval [CI], 1.25-6.06; p=0.012), TNM staging (HR, 3.29; 95% CI, 1.59-6.80; p=0.001), and progression-free survival (PFS) (HR, 11.14; 95% CI, 2.98-41.73; p<0.001) were independent prognostic markers for poor survival rates. Conclusion: In addition to other well-known prognostic factors, this study discovered relationships between the long-term survival rates and serum CRP levels, TNM staging, and PFS. In situations with unfavorable conditions, the PFS would be particularly helpful for managing SCLC patients.
척추 마취 후 발생한 마미증후군 환자 1례에 대한 임상적 고찰
박소현,노해린,이재영,한상엽,신동재,박재영,김창연,Park, So-Hyun,Ro, Hae-Rin,Lee, Jae-Young,Han, Sang-Yup,Shin, Dong-Jae,Park, Jae-Young,Kim, Chang-Yeon 척추신경추나의학회 2012 척추신경추나의학회지 Vol.7 No.2
Objective : The purpose of this study is to report clinical effect of oriental meical treatments for Cauda Equina Syndrome Patient induced spinal anesthesia. Methods : The patient was treated by Oriental medical treatments including acupuncture, ShinBaro pharmacopuncture treatment, herbal medication. The improvement of the clinical symptoms was observed by Visual analog scale(VAS) and Oswestry disability index(ODI). Results : After treatments, VAS and ODI. were improved in case. Conclusions : Oriental medical treatment might be an effective method to improve the clinical symptoms of Cauda Equina Syndrome Patient induced spinal anesthesia.