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      • KCI등재

        抗精神病藥物에 依한 無顆粒細胞症 治驗 1例

        吳東財,申榮宇,張煥一,趙京杉,朴康圭 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

        The authors experienced a female schizophrenic patient who revealed severely decreased leucocytes (350/㎣) with the manifestation of high fever, chillness and sore throat after the oral administration of neuroleptics. Agranulocytosis induced with the use of neuroleptic drugs has been well known complication in psychiatric practice although it is quite rare. In this case, following the combined use of neuroleptics (thioridazine halopondol and chlorproonazine), severe decrement of leucocytes (mainly lymphocytes with few neutrophils) was noticed on peripheral blood and marked decrement of erythroid series, especially of myeloid series, with decrement of total cellular elements were confirmed through the biopsy of bone marrow. She did not responded at all to the massive administration of antibiotics, but dramatic improvement was noticed both clinically and in the follow-up biopsy findings of bone marrow after two times trial of leukapheresis.

      • KCI등재

        Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer

        Kyung‑Yoon Jeon,Eun‑Ji Ko,Young Lim Oh,Hongbae Kim,Wan Kyu Eo,김아리,Han Gyu Sun,Meesun Ock,Ki Hyung Kim,Hee‑Jae Cha 한국유전학회 2020 Genes & Genomics Vol.42 No.10

        Background Human endogenous retroviruses (HERVs) constitute around 8% of the human genome and have important roles in human health and disease, including cancers. Previous studies showed that HERV envelope (Env) proteins are highly expressed in cancer tissues and co-related with cancer progression. KAP1 has been reported to play a key role in regulating retrotransposons, including HERV-K, through epigenetic silencing. Objective The relationship between KAP-1 and HERV Envs expressions was analyzed only in tumor cell lines and has not yet been studied in cancer tissues. In this study, we analyzed the expression patterns and relationship between KAP1 and HERV Env proteins in ovarian cancer tissues. Method The expression patterns of KAP-1 and HERV Env proteins, including HERV-K and HERV-R, were analyzed in ovarian cancer tissue microarrays that contained 80 surgical specimens, including normal ovary and malignant ovarian cancers. Results The expression of HERV-R Env and KAP1 proteins is signifcantly higher in ovarian cancer compared with normal ovary tissues. However, the expression of HERV-K Env did not change signifcantly in cancer tissues. The expression patterns of HERV-K Env and HERV-R Env signifcantly increased in early stages of cancer and KAP1 expression was higher in certain stage and types of cancers. However, the expression of HERV-K Env, HERV-R Env, and KAP1 did not change in diferent age groups. The correlation between the expression of KAP1 and HERV-Env, including HERV-K and HERV-R, was not signifcantly correlated. Conclusions The results of this study showed that there was no signifcant correlation between the expression of KAP1 and HERV Env proteins in ovarian cancer tissues, unlike studies with cell lines in vitro. These results suggest that the actual expression of HERV Env proteins in ovarian cancer tissues may be regulated through various complex factors as well as KAP1.

      • HRTF(머리저달함수)의 샘플링률 변환에 따른 입체음향 플레이어

        오재경,이동재,임철수,최범석,이원돈 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

        본 논문에서는 3D사운드 생성 기술 중 대표적인 방법인 원음에 HRTF(머리전달함수)를 콘볼루션(convolution하는 방식으로 음상정위 모듈을 구현하였으며 음장감을 부여하기 위하여 잔향(reverberation)효과를 추가하고 크로스토크 현상을 제거하기 위하여 트랜스오럴 필터를 추가하였다.본 논문에서는 sampling rate conversion을 사용하여 decimation과 interpolation을 수행하여 44.1KHz의 sampling rate로된 coefficient를 downsample하거나 upsample한 HRTR(머리전달함수)를 사용하여 콘볼루션(convolution)을 수행했다.본 논문에서는 3D사운드 생성과정에서 필요한 연산과정을 최소화하여 일반 PC의 computing power로도 sampling rate conversion된 데이터를 처리하여 줄 수 있는 알고리즘을 제시하고 구현하였다.

      • Identification of a Gene Cluster in Streptomyces spectabilis-spectinomycin producer

        오태진,김형준,송재경 선문대학교 대학원 2000 대학원학술논문집 Vol.2 No.-

        Spectinomycin (Spc) is an aminoglycoside antibiotic which shows remarkable broad-spectrum. From a chromosomal cosmid library of Streptomyces spectabills, a Spc producer, a clone (pSPM8) was isolated by homology to the dTDP-glucose 4,6-dehydratase and aminotransferase genes which obtained from S. spectabilis genome using a polymerase chain reaction. From this clone, a 5.8-kb DNA region was sequenced and found to encode four open reading frames and one Incomplete reading frame. The putative orfl protein reveals 29% amino acid sequence homology of putative myo-inosltol-2-dehydrogenase from Vibrio anguillarnm. The orf2 is about 46% homologous to putative myo-inositol-1-monophosphotase of Mycobacterium leprae. The orf3 showed strong homology (67.4%) to putative export protein (spcT) from S. flavopersicus. The amino acid sequence deduced from 0114 showed a high similarity (70.8%) to a spectinomycin resistance gene (spcN) from S. flavoperslcus. Expression of orf4 in E. coti BL21 showed the spectinomycin resistance.

      • 초등학생의 구강보건 지식수준과 구강보건 행동에 관한 연구

        오경재,김정숙 원광대학교 대학원 2009 論文集 Vol.42 No.-

        Among chronic diseases in Korean adults, dental canes is third most common, following arthritis and hypertension. Elementary students use medical services frequently for cold, ophthalmic diseases and dental canes, and dental caries appears to be experienced by all age groups. In Korea, dental canes prevention programs are increasing, and through such programs, health teachers responsible for students' health need to manage oral health as one of their important tasks. Desirable oral health programs should develop teaching methods for oral health education and induce people's interest in oral health and voluntary oral health management habits, and by doing so, promote oral health knowledge and behavior and make oral health prevention and treatment activities more effective. The present study purposed to survey oral health knowledge level and oral health behavior among 12 year old children in their mixed dentition period who may experience caries of permanent teeth, and to provide basic materials necessary to set directions for oral health education in school. For this, we collected data from 240 fifth graders (12 year old children) at an elementary school in Iksan, Jollabuk do during the period from the 13^(th) to 20^(th) of May, 2008, and excluding 12 respondents who answered inappropriately, we analyzed data from 228 children and drew conclusions as follows. 1. As to oral health knowledge level, 95.6% of the students knew that 'chocolate, cookie and candy cause caries easily.' 2. As to oral health knowledge level according to general characteristics, there were significant differences in oral health knowledge level according to father's academic qualification and mother's academic qualification(p<.05). Oral health knowledge level was significantly different according to the condition of teeth, but in the results of posterior analysis, no notable difference was observed among the groups(p<.05). 3. As to oral health behavior related to toothbrush according to general characteristics, a significant difference was observed only according to gender(p<.05). 4. As to experience in preventive dental treatment according to general characteristics, a significant difference was observed only according to father's academic qualification(p<.05). 5. As to oral health knowledge level according to the installation and operation of oral health room in school, there was no significant difference in the necessity for the installation of oral health room, and there was a significant difference in the necessity for oral health teachers(p<.05). 6. As to the necessity for oral health teachers according to general characteristics, it was significantly different only according to gender and the condition of teeth(p<.05). According to gender, while 57.6% of male students replied 'Necessary,' 28.8% 'Don't know' and 13.6% 'Not necessary,' 71.8% of female students replied 'Necessary,' 14.6% 'Don't know' and 13.6% 'Not necessary.' This shows that both male and female students think that oral health teachers are necessary.

      • KCI등재

        폐목재로 제조된 파티클보드의 성능평가

        오용성,차재경,곽준혁 한국목재공학회 2002 목재공학 Vol.30 No.4

        현재 폐목재의 발생량은 국내의 연간 목재사용량의 40% 정도의 수준으로 국내의 목재자급율을 고려해볼 때, 목재패널산업에서의 이런 폐목재의 재활용은 많이 장려되어야 한다. 본 연구는 폐목재로부터 얻어진 파티클과 실험실에서 합성한 요소수지를 폐목재파티클의 전건무게에 대해 6% 첨가하여 열압온도 162℃와 열압시간 5분에서 파티클보드를 제조하고 ASTM D 1037 방법에 의해 파티클보드의 성능을 평가하였다. 파티클보드의 성능을 평가한 결과는 KS F 3104 파티클보드 8.0형의 최소요구를 만족시키는 것이다. 이런 파티클보드의 성능평가 결과는 폐목재가 파티클보드의 원료로 적합하다는 것을 보여준다. The generation of wastewood is currently about 40% level of the amount of domestic wood use. When the rate of wood self-supply is considered, the recycling of wastewood in wood panel products industry should be encouraged. This study was evaluated the performance of particleboard (PB) made from wastewood. PBs were manufactured with the synthesized urea-formaldehyde resin at 5 minutes hot-press time, and at 162℃ press temperature with 6 percent resin solids level on an ovendry wastewood particle weight basis. The PBs were tested by the procedure of ASTM D 1037. Test results exceeded the minimum strength requirement according to KS F 3104 Particleboard type 8.0. The PB's performance showed that wastewood is suitable raw material for PB.

      • SCOPUSKCI등재

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