배양 뼈에 있어서 Calcium 대사에 대한 Hydrocortisone 의 효과

조무연,송정석 생화학분자생물학회 1978 BMB Reports Vol.6 No.3

파일 I/O Interval을 이용한 랜섬웨어 공격 차단 방법론

윤정무(Jung-moo Youn),조제경(Je-geong Jo),류재철(Jae-cheol Ryu) 한국정보보호학회 2016 정보보호학회논문지 Vol.26 No.3

랜섬웨어는 1999년에 처음 만들어 졌지만 우리나라에서는 2015년부터 그 존재가 많이 알려지기 시작했다. 정보통신기술이 점점 발전하고 컴퓨터의 저장용량이 더욱 커지면서 컴퓨터가 저장하는 정보들이 증가했고 이 정보들을 효율적으로 관리하고 보관하는 것이 중요해졌다. 이런 상황에서 랜섬웨어는 타인의 컴퓨터에 무단으로 침입하고 정보를 담은 파일들을 컴퓨터 사용자의 허락 없이 임의로 암호화하기 때문에 사용자에게 심각한 악영향을 끼친다. 본 논문은 커널에서 특정 프로세스가 파일에 접근하는 것을 모니터링하고, 모니터링 한 정보를 바탕으로 파일에 접근하는 행위가 비정상적으로 일어났는지 탐지한다. 탐지한 결과를 통해서 특정 프로세스의 파일접근권한을 차단한다. 이러한 방법을 통해서 랜섬웨어가 비정상적으로 파일에 접근하고 암호화하는 행위를 차단하는 방법을 제시하고자 한다. Ransomware was first created in 1999, but its existence become widely known in Korean by 2015. As information and communication technology have developed, the storage capacity of computer has enlarged, it accordingly is getting more important to effectively manage these information, rather than the information itself. In such situation, the ransomware break into other people’s computer and encrypt an files without a user’s permission. So, it adversely affect the user. In this paper, we monitor an access of a specific process to the file. And on the basis of this monitoring information, we detect whether the abnormal approach happened. Through the detection result, we block the permission about access to the file for a specific process. Using this method, we propose a blocking technique for the ransomeware’s abnormal approach and encryption to the files.

iOS 시간 버그 해결을 위한 파워 기능의 재설계 방안 연구

윤정무 ( Jung-moo Youn ),조제경 ( Je-gyeong Jo ),류재철 ( Jae-cheol Ryou ) 한국정보처리학회 2016 한국정보처리학회 학술대회논문집 Vol.23 No.1

모바일 장치는 사용자에게 편리성을 제공하는 대표적인 장치이다. 따라서 사용자의 많은 정보를 저장하고 있으며, 업무상의 환경에서도 많이 사용되고 있다. 하지만 모바일 장치의 확산이 증가하는 만큼 모바일 장치에 대한 다양한 공격 역시 증가하고 있다. 특히 기존에는 정보 유출과 같은 공격이 이루어졌다면, 추후 서비스 거부공격과 같은 직접적인 피해를 주는 공격이 나타날 것이라고 추측해볼 수 있다. iOS 장치의 시간 값을 변경하는 취약점 같은 경우, 특별한 권한이 필요하지 않으면서 장치를 사용 불능상태로 만들 수 있다. 따라서 본 연구에서는 앞서 설명한 장치의 설정을 바꾸는 공격에 대응하기 위하여 기존의 파워 관련 기능이 작동하기 전 시스템의 설정 값을 확인하는 작업을 수행할 수 있도록 제안하고자 한다. 최근 모바일 장치의 발달로 재부팅을 수행하는 경우는 줄어들고 있기에 이에 대한 기능이 추가됨으로 인한 사용자의 불편함은 문제가 되지 않는다고 생각하였다. 제안한 방법에 대해 iOS 환경에서 실험하고 향후 발전 방향을 제시하고자 한다.

Clinical Analysis of Primary Eosinophilic Esophagitis

( Jung Ho Lee ),( Moo Jung Kim ),( Jie Hyun Kim ),( Young Hoon Youn ),( Na Young Kim ),( Young Tae Bak ),( Yun Ju Jo ),( Hyo Jin Park ) 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.2

Background/Aims Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus. Similar to asthma, EoE can induce irreversible structural changes in the esophagus as a result of chronic and persistent eosinophilic inflammation. The aim of this study was to analyse changes in symptoms, eosinophil counts and endoscopic findings after treatment. Methods Nine patients with EoE (6 men and 3 women; mean age, 36.44 years) were diagnosed with EoE based on typical symptoms, endoscopic abnormalities and infiltration of the esophageal epithelium with ≥ 15 eosinophils/high-power field. The average endoscopic follow-up period was 10 months, ranging from 1 to 25 months. Symptoms and endoscopic and pathological findings at initial observation and follow-up were evaluated. Results Seven of the 9 patients had dysphagia symptoms, which improved in 4 of 6 patients who were treated with proton pump inhibitor. Two patients were unresponsive to proton pump inhibitor and another 2 patients were treated with corticosteroid, which led to symptomatic relief. In 8 patients, esophageal eosinophilia was improved histologically at follow-up after treatment. Six of the 9 patients had typical endoscopic findings of EoE at initial examination. Despite treatment, these findings remained in 5 of the 6 patients at follow-up endoscopy. Conclusions After treatment, the symptoms and eosinophil counts were temporarily improved, but the endoscopic findings of EoE were generally not improved. This indicates that deformity of esophageal structure due to eosinophilic inflammation might be irreversible despite proper management.

Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults

Jin-Hee Kim,In Ah Choi,Joo Youn Lee,Kyoung-Hwa Kim,김성태,Ki-Tae Koo,Tae-Il Kim,Yang-Jo Seol,Young Ku,In-Chul Rhyu,Yeong Wook Song,Yong-Moo Lee 대한치주과학회 2018 Journal of Periodontal & Implant Science Vol.48 No.6

Purpose: Periodontitis and rheumatoid arthritis (RA) share a similar inflammatory pathogenesis. Porphyromonas gingivalis (Pg) can induce anticyclic-citrullinated peptide autoantibodies (anti-CCP antibodies), a key factor in the development of RA. This study aimed at evaluating the relationships between the 2 diseases and identifying the clinical implications thereof, with a focus on periodontal pathogens in Korean adults. Methods: A total of 260 RA patients and 86 age- and sex-matched control patients without arthritis were enrolled in this prospective cross-sectional study. Periodontal indices and the prevalence and amount of periodontal pathogens were compared between the groups. Correlations between periodontal and RA indices were examined, as were correlations between 9 periodontal pathogens and RA indices. Results: The RA group had significantly higher values than the control group for all investigated periodontal indices (P<0.05) except the number of teeth. The gingival index (GI) was correlated with the disease activity score 28 (DAS28) (r=0.125, P=0.049), RA disease duration (r=0.253, P<0.001), erythrocyte sedimentation rate (ESR) (r=0.162, P=0.010), and anti-CCP antibody titer (r=0.205, P=0.004). Probing pocket depth (PPD) was correlated with ESR (r=0.139, P=0.027) and anti-Pg antibody titer (r=0.203, P=0.001). Bleeding on probing (BOP) was correlated with DAS28 (r=0.137, P=0.030), RA disease duration (r=0.202, P=0.001), ESR (r=0.136, P=0.030), anti-Pg antibody titer (r=0.177, P=0.005), and anti-CCP antibody titer (r=0.188, P=0.007). Clinical attachment level (CAL) and periodontitis severity were correlated with anti-Pg antibody titer (the former r=0.201, P=0.002; the latter r=0.175, P=0.006). The quantity of Pg was positively correlated with the serum anti-Pg antibody titer (r=0.148, P=0.020). Conclusions: The GI, BOP, and PPD showed positive relationships with several RA indices. The anti-Pg antibody titer had positive relationships with PPD, BOP, CAL, and periodontitis severity. Thus, increasing values of periodontal indices could be used as a risk indicator of disease development in RA patients, and an increasing anti-Pg antibody titer could be considered as a warning sign in RA patients suffering with periodontitis.

태권도선수 및 스포츠선수의 슬관절 연골장해에 관한 연구

이재봉 ( Jae Bong Lee ),육조영 ( Jo Young Yuk ),이무연 ( Moo Youn Lee ) 한국스포츠리서치 2007 한국 스포츠 리서치 Vol.18 No.4

The articular of the femoral condyles in athletes was analyzed by the arthrograms of 301 knees. We classified those knees into 3groups: group A consisting of knee pain with known pathology, group B consising of knee pain with unknown pathology and group C consisting of opposite knees as control. The thickness of the articular cartilage measured in group C averaged 2.7mm medial and 2.8mm in lateral femoral condyles. The abnormality of the shapes of the articular cartilage on arthrograms was divided into 3 types, straight, concave and irregular. The abnormality of the cartilage was found in 48 knees (10.3%) in group A, 15 knees (7.3%) in group B and 24 knees (4.6%) in group C. We observed some cases by arthroscopy. Advanced degenerative changes were found in these cases. Those findings suggested that the cartilage injury in athletes intimately related to the knee pain.

肺炎樣疾患의 臨床的 觀察

김기호,홍순조,이효식,강문원,김호연,정규원,정희영,전종휘,김선무,이종무,김정진 대한의학협회 1976 대한의학협회지 Vol.19 No.4

Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults

Kim, Jin-Hee,Choi, In Ah,Lee, Joo Youn,Kim, Kyoung-Hwa,Kim, Sungtae,Koo, Ki-Tae,Kim, Tae-Il,Seol, Yang-Jo,Ku, Young,Rhyu, In-Chul,Song, Yeong Wook,Lee, Yong-Moo Korean Academy of Periodontology 2018 Journal of Periodontal & Implant Science Vol.48 No.6

Purpose: Periodontitis and rheumatoid arthritis (RA) share a similar inflammatory pathogenesis. Porphyromonas gingivalis (Pg) can induce anticyclic-citrullinated peptide autoantibodies (anti-CCP antibodies), a key factor in the development of RA. This study aimed at evaluating the relationships between the 2 diseases and identifying the clinical implications thereof, with a focus on periodontal pathogens in Korean adults. Methods: A total of 260 RA patients and 86 age- and sex-matched control patients without arthritis were enrolled in this prospective cross-sectional study. Periodontal indices and the prevalence and amount of periodontal pathogens were compared between the groups. Correlations between periodontal and RA indices were examined, as were correlations between 9 periodontal pathogens and RA indices. Results: The RA group had significantly higher values than the control group for all investigated periodontal indices (P<0.05) except the number of teeth. The gingival index (GI) was correlated with the disease activity score 28 (DAS28) (r=0.125, P=0.049), RA disease duration (r=0.253, P<0.001), erythrocyte sedimentation rate (ESR) (r=0.162, P=0.010), and anti-CCP antibody titer (r=0.205, P=0.004). Probing pocket depth (PPD) was correlated with ESR (r=0.139, P=0.027) and anti-Pg antibody titer (r=0.203, P=0.001). Bleeding on probing (BOP) was correlated with DAS28 (r=0.137, P=0.030), RA disease duration (r=0.202, P=0.001), ESR (r=0.136, P=0.030), anti-Pg antibody titer (r=0.177, P=0.005), and anti-CCP antibody titer (r=0.188, P=0.007). Clinical attachment level (CAL) and periodontitis severity were correlated with anti-Pg antibody titer (the former r=0.201, P=0.002; the latter r=0.175, P=0.006). The quantity of Pg was positively correlated with the serum anti-Pg antibody titer (r=0.148, P=0.020). Conclusions: The GI, BOP, and PPD showed positive relationships with several RA indices. The anti-Pg antibody titer had positive relationships with PPD, BOP, CAL, and periodontitis severity. Thus, increasing values of periodontal indices could be used as a risk indicator of disease development in RA patients, and an increasing anti-Pg antibody titer could be considered as a warning sign in RA patients suffering with periodontitis.

A Vitronectin-Derived Peptide Restores Ovariectomy-Induced Bone Loss by Dual Regulation of Bone Remodeling

Kang Hyun Ki,Park Cho Yeon,Jung Sung Youn,Jo Seung Bin,Min Byung-Moo 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.6

BACKGROUND: Bone remodeling is tightly regulated through bone resorption and bone formation; imbalances in bone remodeling can cause various pathological conditions such as osteoporosis. Antiresorptive agents commonly used for treating osteoporosis do not substantially reverse osteoporotic bone loss. METHODS: We evaluated the effects of the RVYFFKGKQYWE motif (residues 270–281; VnP-16) of human vitronectin on the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and osteoclastogenesis of bone marrowderived macrophages. The effects of VnP-16 were also assessed in a mouse model of estrogen deficiency-induced osteoporosis (ovariectomized female C57BL/6 mice). To assay whether VnP-16 can reverse ovariectomy-induced bone loss, synthetic peptides or vehicle were subcutaneously injected into ovariectomized mice once a week for 4 weeks (n = 10/group). To evaluate the bone restorative effects of VnP-16, in-vivo micro-computed tomography analysis and histological staining were performed. RESULTS: VnP-16 induced osteogenic differentiation of hMSCs and inhibited the RANKL–RANK–TRAF6 axis in the osteoclastogenesis signaling pathway. Furthermore, systemic administration of VnP-16 reversed ovariectomy-induced bone loss in the femoral neck, distal femur and lumbar spine by increasing osteoblast differentiation and promoting bone formation, and concomitantly decreasing osteoclastogenesis and inhibiting bone resorption. The bone restorative effect of VnP-16 was observed one week after subcutaneous administration, and although the timing of the effect differed according to bone location, it persisted for at least 3 weeks. CONCLUSION: Our findings suggest that VnP-16 is a potential therapeutic agent for treating osteoporosis that mediates its effects through dual regulation of bone remodeling.

PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue

Choi, Sun-Sil,Kim, Eun-Sun,Jung, Ji-Eun,Marciano, David P.,Jo, Ala,Koo, Ja Young,Choi, Soo Youn,Yang, Yong Ryoul,Jang, Hyun-Jun,Kim, Eung-Kyun,Park, Jiyoung,Kwon, Hyug Moo,Lee, In Hee,Park, Seung Bum American Diabetes Association 2016 Diabetes Vol.65 No.4

<P>Blocking phosphorylation of peroxisome proliferator–activated receptor (PPAR)γ at Ser<SUP>273</SUP> is one of the key mechanisms for antidiabetes drugs to target PPARγ. Using high-throughput phosphorylation screening, we here describe that Gleevec blocks cyclin-dependent kinase 5–mediated PPARγ phosphorylation devoid of classical agonism as a PPARγ antagonist ligand. In high fat–fed mice, Gleevec improved insulin sensitivity without causing severe side effects associated with other PPARγ-targeting drugs. Furthermore, Gleevec reduces lipogenic and gluconeogenic gene expression in liver and ameliorates inflammation in adipose tissues. Interestingly, Gleevec increases browning of white adipose tissue and energy expenditure. Taken together, the results indicate that Gleevec exhibits greater beneficial effects on both glucose/lipid metabolism and energy homeostasis by blocking PPARγ phosphorylation. These data illustrate that Gleevec could be a novel therapeutic agent for use in insulin resistance and type 2 diabetes.</P>