마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

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디지털 및 일반 측방두부규격방사선사진에서 측정 방법에 따른 계측치의 비교

김미자,허경회,이원진,허민석,이삼선,이진구,안병근,최순철 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.1

Purpose : To compare cephalometric measurement between measuring methods in digital and conventional lateral cephalometric radiograph. Materials and Methods : Twenty digital and conventional lateral cephalometric radiographs were selected. In digital group, cephalometric measurements were performed manually using hardcopies and automatically using VCeph^(TM) program on the monitor. In conventional group, the same measurements were performed manually on conventional films, and for automatic measurement conventional films were digitized by scanner. All measurements were performed twice by 4 observers, and 24 cephalometric variables were calculated and the time spent for each measurement was recorded. The differences in measurements data and the time spent for each measurement were compared within each group. Intra-observer and inter-observer comparisons were performed. Results : In both groups, no statistically significant difference between manual and automatic measurements was observed and most of the variables didn’t show statistically significant differences between methods. The observer with less experience tended to show statistically significant differences of measurements between methods, and differences from other observers. The differences of measurements between methods in digital group were lesser than those of conventional group with statistical significance in 8 variables out of 24. With automatic method and in digital group, the spent time was shorter. Conclusion : With direct digital radiograph, automatic method using manually idenitified landmarks can be preferable in cephalometric analysis.

막걸리 농축액의 투여가 흰쥐의 혈중 지질 함량에 미치는 영향

김미향,김원희,배송자 가톨릭대학교 자연과학연구소 2001 自然科學論文集 Vol.9 No.-

동동주, 청맥 농축물의 투여가 흰쥐의 성장률, 혈청 효소활성 혈청 지질에 미치는 영향을 조사하였다. 실험동물의 체중 증가량은 동동주, 청맥 농축물의 농도별 투여가 대조군과 비슷한 경향을 나타내었으므로, 동동주, 청맥의 투여가 성장률에 지장을 주기 않음을 알 수 있었다. 총 콜레스테롤 함량, 중성지질 함향은 DD1군과 CM1군에서 대조군 보다 낮은 경향을 나타냈고, LDL함량은 DD1군에서 대조군 보다 낮은 경향을 나타냈다. 이러한 결과로부터 동동주 8g/kg 투여는 25%(v/v) 에탄올 5g/kg/day 경구 투여가 만성중독을 일으킬 수 있는데 반해 혈중 지질 함량을 감소시키므로 혈중 중성지질 농도 증가로 인한 심질환 예방에 기여 할 것으로 사료된다. Makkoli is a traditional and general alcoholic beverage in Korea. It's brewed from rice, shows an alcohol concentration of about 16%, has a characteristic fragrance, is slightly acidic, and has a sweet taste. Recently, taking these tradition alcoholic beverages are decreased. We examined the effect of Dongdongju and Cheongmaek kinds of Makkoli on serum enzyme activity and lipid concentration in rats. Sparague-Dawley rats were randomly assigned to groups as follows: control group, Dongdongju 8g/kg administered group(DD1), Dongdongju 1.6gkg administered group(DD2), Dongdongju 0.8g/kg administered group(DD3) and Cheongmaek 8g/kg administered group(CM1), Cheongmaek 1.6g/kg administered group(CM2), Cheongmaek 0.8g/kg administered group(CM3). Experimental diets were fed for 6 weeks. The body weight gain, seram enzyme activity and serum lipid values of all groups were compared with control group. There were no differences in growth. Alkaline phosphatase and GPT activities of DD3 and CM2 were lower than control group, but no significant differences. The total cholesterol concentrations of DD1 and CM1 were lower than that of control group. The triglyceride concentration of DD1 and CM1 was the same as results of total cholesterol concentration. These results suggest that Dongdongju and Cheongmaek positively influenced on serum lipid concentration.

도라지가 난소를 절제한 흰쥐의 혈 중 지질 함량 변화에 미치는 영향

김미향,김원희,박미라,한희선,배송자 신라대학교 자연과학연구소 2003 自然科學論文集 Vol.11 No.-

This study was designed to observe the effects of the feeding Platycodon grandiflorum A.DC(PG) extract on the improvement of the lipids on serum in ovariectomized rats. To investigate the effects of ethanol extract, Sprague-Dawley female rats were randomly assigned to groups as follows: Sham, OVX-control and ovariectomized rats supplemented with PG at 50㎎/㎏ bw/day. Body weight gain was not significantly different in groups. The levels of total cholestcrol was higher in ovaiectornized control rats than Sham-operated rats, but supplementation of PG ethanol extracts at 50mg/kg bw/day decreased the level of cholesterol in surum. These results might be expected that ethanol extract of PG is believed to be possible protective effects for the fatty serum increasing serum lipid.

자궁경부에 발생한 암육종 : 1례 보고 A case Report

이미자,양영원,임성철 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

간호학생이 임상실습시 경험하는 스트레스요인에 관한 분석적 연구

차영자,김미원 최신의학사 1994 最新醫學 Vol.37 No.8

병원의 고객만족 결정요인과 그 결과에 관한 연구 : 1차와 2·3차 진료기관의 비교를 중심으로 with comparison between Clinics and Hospitals

유성진,원미자 인제대학교 2004 仁濟論叢 Vol.19 No.1

This study examines on deteminants of costomer satisfaction with clinics and hospitals to serve the medical services and whether there are some difference according to the institutions. Specially, we extended target of the research to clinic and applied SERVQUAL to the medical services a kind of the services. This study measured medical services as Variable of 6 dimension adding dimension called expense in 5 measure of SERVQUAL. Major findings of the study are as follows ; First, In clinics the deteminants of customer satisfaction are aspects connected with the Tangibles, the Responsiveness and the Empathy of the services. Therefore, it is a important role to improve operating profits to cooperate with others for facility investments or to be conveniently located for access. Also, we can know it is a important determinant the fator connected with the Expenses and the Reliability. Especially the Reliability may guide to establish Competitive Strategy for hospitals. So disagreement with hospital labor union may act for cause that receive outward appearance from customer deteriorating authoritativeness preferably recently. Third, In clinics customer satisfaction can do to maintain affimative result being connected by affirmative Word of Mouth and revisit. But in hospitals customer satisfaction is no relation with revisit. When see the result of this study, customer satisfaction invents an opportunity that can secure new customer and revisit customer who become motive power that pemit creation of stable profit by continuous management. In hospitals, customers are going to revisit to hospital which authoritativeness and fame about disease are. This does not get effect that it will be profitable but inbent new customer to secure stable customer layer. Therefore, customers satisfaction is going become a right opportunity of new customer’s security and hospitals.

Fluorescence Polarization Immunoassay을 이용한 Therapeutic Drug Monitoring에 대한 고찰

김각현,이미경,이경자,윤갑준,이경원 대한임상병리사협회 2001 대한임상병리사회지 Vol.21 No.1

상아질 접착제가 상아질 변연누출에 미치는 영향

채수경,김미자,이광원,손호현 全北大學校 齒醫學硏究所 1991 전북치대논문집 Vol.9 No.1

The purpose of this study was to evaluate the effect of various dentin adhesives on the incisal and gingival marginal leakage of class Ⅴ cavity. V-shape cavities with enamel bevel (0.7-1㎜) were prepared on the faciocervical area of 72 extracted human anterior teeth. Gingival margin of cavities was placed on dentin or cementum. Including 1 group with no dentin treatment, they were divided into 6 groups according to dentin surface treatment with Scotchprep(3M Co.), Prisma Universal Bond 2(Dentsply Inter. Inc.), Gluma(Cloumbus/Bayer), All BOND 2(Bisco inc.) and Denthesive(Kulzer Co.). After dentin treatment, Dentin adhesive(3M Co.) was applied on the treated dentin surface and Silux("U" shade, 3M Co.) was filled and polished. Dye penetration technique using 2% methylene blue solution was adopted to assess incisal and gingival marginal leakage. The following results were obtained 1. The degree of incisal marginal leakage in the non-treated group was greater than that in other groups(p<0.01), and incisal marginal leakage in the groups treated with All BOND 2, and Denthesive was less than that in the group treated with Gluma(P<0.01). 2. Incisal marginal leakage in the groups treated with Prisma Universal Bond 2, and Scotchprep was less than that in the group treated with Gluma(p<0.01). 3. Incisal marginal leakage among the groups treated with Scotchprep, Prisma Universal Bond 2, All BOND 2 and Denthesive was not different(p>0.05). 4. The degree of gingival marginal leakage in the non-treated group was significantly greater than that in other groups(p<0.01). 5. Gingival marginal leakage among the groups treated with Scotchprep, Prisma Universal Bond 2, Gluma, All BOND 2, and Denthesive was not statistically significant(p>0.05). But gingival marginal leakage was significantly less in the All BOND 2 treated group compared with Gluma treated group(p<0.05).

위장관의 원발성 B 세포 악성 림프종의 재분류와 bcl-2, cyclin D1, bcl-6 및 p53 발현의 의미

서정균,김태원,김병수,조은택,박찬국,김만우,이미자,전호종 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : In recent years, the REAL (Revised European American Lymphoma) classification provided a new category of MALT (mucosa-associated lymphoid tissue) lymphoma and mantle cell lymphoma in B cell lymphomas. We have analyzed the expression of bcl-2, cyclin D1, bcl-6 and p53 and correlated with the subtypes and histologic grade of primary gastrointestinal B cell lymphoma. Also we investigated the usefulness of immunophenotypic features in diagnosis of low grade B cell lymphoma. Materials and Methods : Twenty-two cases of primary gastrointestinal B cell lymphoma were recategorized in low grade MALT lymphoma, low/high grade MALT lymphoma, high grade MALT lymphoma, and diffuse large cell lymphoma according to the morphological findings. We investigated the expression of bcl-2, cyclin D1, bcl-6 and p53 by immunohistochemical method. Results : The bcl-2 protein expression was higher in the low grade MALT lymphoma than in the high grade lymphoma. The cyclin D1 protein expression was negative in all cases. The expression of bcl-6 and p53 protein was negative in all low grade MALT lymphoma. Conclusion : The results suggest that we can differentiate the low grade lymphoma from the high grade lymphoma by immunohistochemical staining for bcl-2, bcl-6, and p53 protien.