Phosphodiesterase inhibitor improves renal tubulointerstitial Hypoxia of the Diabetic rat Kidney

( Hui Kyoung Sun ),( Yun Mi Lee ),( Kum Hyun Han ),( Han Seong Kim ),( Seon Ho Ahn ),( Sang Youb Han ) 대한내과학회 2012 The Korean Journal of Internal Medicine Vol.27 No.2

Background/Aims: Renal hypoxia is involved in the pathogenesis of diabetic nephropathy. Pentoxifyllin (PTX), a nonselective phosphodiesterase inhibitor, is used to attenuate peripheral vascular diseases. To determine whether PTX can improve renal hypoxia, we investigated its effect in the streptozocin (STZ)-induced diabetic kidney. Methods: PTX (40 mg/kg, PO) was administered to STZ-induced diabetic rats for 8 weeks. To determine tissue hypoxia, we examined hypoxic inducible factor-1α (HIF-1α), heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), and glucose transporter-1 (GLUT-1) levels. We also tested the effect of PTX on HIF-1α in renal tubule cells. Results: PTX reduced the increased protein creatinine ratio in diabetic rats at 8 weeks. HIF-1α, VEGF, and GLUT-1 mRNA expression increased significantly, and the expression of HO-1 also tended to increase in diabetic rats. PTX significantly decreased mRNA expression of HIF-1α and VEGF at 4 and 8 weeks, and decreased HO-1 and GLUT-1 at 4 weeks. The expression of HIF-1α protein was significantly increased at 4 and 8 weeks in tubules in the diabetic rat kidney. PTX tended to decrease HIF-1α protein expression at 8 weeks. To examine whether PTX had a direct effect on renal tubules, normal rat kidney cells were stimulated with CoCl2 (100 μM), which enhanced HIF-1α mRNA and protein levels under low glucose conditions (5.5 mM). Their expressions were similar even after high glucose (30 mM) treatment. PTX had no effect on HIF-1α expression. Conclusions: PTX attenuates tubular hypoxia in the diabetic kidney.

국민학교 주변도로 특성을 고려한 어린이보호구역에 관한 기초연구

이호무,금기정 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

This paper furnish valid techno-data on traffic-safety. The basic object ive of this study is about to techno-data which has been used complete equipment of school zone. o Grasp the actual condition, considering character of elementary school. o Analysis of risk on the adjoining street. o Research into a child's safety-consciousness on inquiry.

이면(지구)도로특성을 고려한 과속방지턱에 관한 기초연구

이호무,금기정,최정한 명지대학교 공학기술연구소 1994 공학기술연구소 논문집 Vol.9 No.-

This paper describes the hump. It is a kind of traffic safety construction which is estabished in the community road. Its function is that reduce the running speed of vehicles. In the community road, we need a ensured safety of pedestrian ane exept of many kind of danger. And also it is very effective connect with improvement of residence enviroment or side of local traffic. By the way the problem in our case is the contents which provided present Road Traffic Law is took from standard of TRRL(Transport and Road Research Laboratory) in British without verification. So there are many kind of this construction removed primar function, reduce of running speed. The basic objective of this study is about to hump which has been used this traffic construction. (1) Standard of fundation, design criteria and all kind of condition. (2) After assessment including maintenance problem. 3) The study of driver's thought, considered driver's opinion. (4) Analogy of problem according to the actual conditions etc. We endeavored to find a guide of construct method, suit our actual circumstances on this study.

나노 기공의 탄소 멤브레인에서 기체의 선택적 분리를 위한 Monte Carlo 모사

이호수,금경호,서양곤 경상대학교 환경보전연구소 2000 環境保全硏究所報 Vol.8 No.-

The object of this study is to separate hydrocarbon selectively using MC method and carbon membrane. 12-6 Lennard-Jones potential function was used to describe reciprocal action of gas molecules. 10-4-3 potential function suggested by steele was used to calculate reciprocal action of molecules and pore walls. The membrane pore is composed of slit-like pores. it is include high-pressure region(H-region). low-pressure region(L-region) and M-region. between H-region and L-region. In the membrane. the transport of molecules with small size were high when the pore size is small. but in the case of molecules with large size were opposite to the transport of molecules with small size. we have found that the diffusion through surface effected on molecules transport by discussion of snapshots and density profiles. So. if the control of the pore size and surface diffusion were used to obtain high selectivity. it will be very useful method to improve the energy efficiency.

敎育實習을 通한 授業體制改善의 實踐的 硏究 : 指導案樣式의 開發 Centered on Lesson Plan Format

李慶燮,林在圭,琴種友,鄭浩杓 慶北大學校 師範大學 1979 敎育硏究誌 Vol.21 No.-

This study was undertaken to construct a lesson plan format appropriate for our educational status. To achieve this aim, the following two processes were pursued: first, to investigate the relation between curriculum and lesson plan format; second, to analyze and discuss the lesson plan model used practically in American Schools. Instructional objectives, Structure of contents, instructional processes, and width of instruction are regarded as the fundamental elements of proper lesson plans by this investigation. In terms of theoretical ground about each of the above-mentioned elements, the following lesson plan format, which can be put to a practical use in our educational status, was constructed.

재래시장에서의 접근성과 업종별 상관관계 : 광주광역시 대인시장과 남광주시장을 중심으로 Focused on Daein and Namgwangju markets in Gwangju

정금호,이계순,신남수 대한건축학회 2004 대한건축학회논문집 Vol.20 No.1

The conventional market places are the behavioral space by physical environment and human activity. We discuss ways and means of reviatalizing conventional market. Focused on consumer's aspect and physical improvement of building and equipment. In spite of it's small size, small area. Market is directly connected with daily life of citizen and plays a major role for urban activities and systems. Therefore is necessary to study the physical characteristics related to human activity for improving the physical environment of conventional market. This study base on an assumption that location of industrial classification depend on accessibility and relation with street. The purpose of this study is to analyze relation between street and industrial classification in conventional markets. For the logistic analysis, We investigated type of business, general road width, public land price, connection value, distance from a bus stop, distance between main street and the each store in Daein and Namgwangju markets. The statistical analysis says that 1. In the markets, food stores are located near from the main streets. 2. Clothing stores are located near from the main streets but far from the bus stops. 3. The culture type of business is located far from the main streets. 4. The neighboring facilities are located on the narrow roads and at the lands high in the public price.

방사선학적 치근단병소의 크기와 특징에 대한 치근단낭종 및 육아종의 상관관계연구

최호식,이우철,손원준,금기연,배광식,백승호 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.1

The purpose of this study was to find out the relationship of radiographic lesion size, gender, age of patients and radiographic character to the diagnosis of periapical cyst and granuloma. The data was collected from 187 periapical lesions of 167 patients who undergone apical surgery at Department of Conservative Dentistry, Seoul National University Dental Hospital from 2003 to 2005. The lesion were surgically removed and send for biopsy to the Oral Pathology Laboratory. From the initial radiograph, lesion size was calculated using PiViweSTAR (INFINITT, Korea) program. The obtained data were statistically evaluated using SPSS (p<0.05). The result were as followings: 1. From 187 biopsy samples, the incidence of periapical cyst was 28.34% and granuloma was 65.24%. 2. There was a significant correlation between periapical cyst and the size of radiographic lesion (p<0.01). 3. There were no significant correlations between age, gender, location of lesion and the final diagnosis (p>0.05). 4. There was a significant correlation between the non-demarcation of the lesion and the incidence of periapical granuloma (p<0.01). 본 연구는 2003년부터 2005년까지 서울대학교 치과병원 보존과에 내원한 환자 중 치근단수술을 시행한 환자 167명에서 생검을 위해 적출한 187개의 치근단병소를 대상으로 하였다. 수술 후 조직검사 결과 얻은 진단명과 환자의 진단기록에서 환자의 성별, 나이, 발병 부위, 방사선 사진 상의 특징 그리고 병소의 크기와의 상관관계를 조사하였다. 초진시 방사선 사진에서 치근단병소의 크기를 PiViewSTAR (INFINITT, Korea)를 이용하여 화소를 계산함으로써 면적을 구하였다. 이를 바탕으로 통계 분석프로그램 SPSS (version 12.0K, SPSS Inc., Chicago, IL, USA)를 이용해 방사선사진상 크기와 진단명과의 상관관계를 조사하였다. 나이와 진단명과의 상관관계는 일원배치 분산분석을 시행하고 성별, 부위, 방사선사진상의 특징과 진단명과의 상관관계는 교차분석을 통해 카이제곱검정으로 조사하여 다음과 같은 결론을 얻었다. 1. 187의 치근단병소 조직검사결과 치근단병소 중 치근단낭종의 비율은 28.34%, 육아종의 비율은 65.24%, 기타병소의 비율은 6.42%로 나타났다. 2. 방사선사진상 병소의 크기가 커질수록 치근단 낭종일 확률이 높았다(p<0.01). 3. 나이, 성별, 발병부위와 진단명사이에서 유의 한 상관관계가 없었다(p>0.05). 4. 병소의 경계가 명확하지 않은 것과 치근단육아종의 발생빈도는 통계적으로 유의한 상관관계를 보였다(p<0.01).

급성신부전증 이환견에 대한 복막투석 치료 1례

김건우,이병희,김유수,심재현,김지용,이영원,김덕환,송근호 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

A fourteen-month-old intact female Poodle was referred to the Veterinary Teaching Hospital, College of Veterinary Medicine, Chungnam National University. The patient was presented with history of vomiting, inappetence, ataxia, insomnia, tachypnea and convulsion for 5 days. Biochemical examination revealed BUN (254.2 mg/dl), creatinine (9.22 mg/dl) and phosphate (14 mg/dl). Epithelial cells of urinary tract, neutrophils, macrophages, a large number of gram negative and smaller number of gram positive bacteria were presented on urine test. Ultrasonographic findings show hyperechogenic kidney and indistinguishableness of renal cortex and medulla. Based on the results of examination described above, this case was diagnosed as acute renal failure with interstitial nephritis by urinary tract infection (UTI). Treatments with fluids therapy, diuretics, and peritoneal dialysis during hospitalization showed good results with no clinical signs.

공조시스템을 적용한 석실 고분내 온ㆍ습도 분포

전용두,이금배,박진양,고석보,전희호 公州大學校 工學硏究院 生産技術硏究所 2005 論文集 Vol.13 No.-

Although the importance of good conservation of historic sites including ancient royal tombs is well aware, still not much attention has been paid for the facilities and systems to preserve those historic sites, which includes precious artifacts as wall paints and carved works, etc. Even the general understanding about the environment of the underground space of tombs is not satisfactory. In Korea, researchers have recently begun addressing the above issue and are making efforts to develop suitable HVAC(heating, ventilating and air-conditioning) systems for conservation of tombs. An experimental investigation was carried out to study the behavior of the HVAC system installed for a tomb. This tomb resembles in size and shape the original stone built tomb of Baek-je Dynasty, which dates back to 6th Century in southwest part of Korean peninsula. In this study, an HVAC system for a tomb(D×W×H=1.3m×3.0m×1.2m) was installed to maintain sui표 indoor conditions for conservation of tomb. The temperature and humidity inside the tomb were measured different of the setting. Finally, performance of the HVAC system is presented and discussed.

교통사고에 의해 발생한 뇌내 좌상 1례

박혜연,전소분,김선아,정금선,조종기,송근호,이영원 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

A two years old intact female Minature Schnauzer was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with an intermittent seizure by traffic accident. No specific finding was found by radiography and computer tomography (CT). Hematologic and blood chemical examination revealed that PCV (62.5%), BUN (72.6 mg/dl), CK (1769 U/l), ALT (169 U/l) and ALP (353 U/l) were increased. This dog was recovered by medical treatment.