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Novel Methylation Biomarker for Non-invasive Diagnostics in Lung Cancer
오태정,( Chang Hun Lee2 ),( Min Ki Lee ),( Yeul Hong Kim ),( Sang Yull Lee ),( Hyo Sung Jeon ),( Shin Yup Lee ),( Seung Soo Yoo ),( Jae Yong Park ),( Sung Whan An ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
To identify aberrantly hypermethylated DNA in lung cancer cells we established a genome-wide analysis for hypermethylation sites, namely Methyl DNA Isolation and Amplification (MeDIA) coupled-CpG microarray analysis. In the comprehensive methyaltion profiling analysis between human lung cancer, A549 cells and normal NHBE cells, we observed that several clusters of genes show a significant level of aberrancy in CpG island methylation pattern in cancer cells compared to normal cells. We further identified PCDHGA12 gene as a new marker of non-invasive diagnostics for lung cancer based on followings. 1) Transcription of PCDHGA12 gene is reactivated after treatment of A549 cells with demethylating agent. 2) Bisulfide clonal-sequencing reveals that CpG island of PCDHGA12 shows a distinctive differential methylation between two cell lines. 3) Pyrosequencing-based quantitative methylation assay for such region in tumor and non-tumorous tissues from lung cancer patients shows aberrant hypermethylation in 37 (92%) of the 40 tumor tissues. In clinical validation by pyrosequencingin induced-sputum of lung cancer patients (n=87) and healthy controls (n=51), we observed aberrant hypermethylation incident at significantly elevated level in samples derived from lung cancer patients. According to the optimal threshold calculated by ROC curve analysis, sensitivity and specificity of PCDHGA12 was 86.2% and 82.4%, respectively. PCDHGA12 methylation status could be a potential methylation biomarker alone or combined with others for the screen and the detection of relapse of lung cancer.
Association between Metabolic Syndrome and Menstrual Irregularity in Middle-Aged Korean Women
Sang Su Lee,Do Hoon Kim,Ga-Eun Nam,Hyo-Yun Nam,Young Eun Kim,Sung Ho Lee,Kyung Do Han,박용규 대한가정의학회 2016 Korean Journal of Family Medicine Vol.37 No.1
Background: Menstrual irregularity is a common major complaint in women of reproductive age. It is also a known marker for underlying insulin resistance. We investigated the association between menstrual irregularity and metabolic syndrome in the general population of middle-aged women in Korea. Methods: This cross-sectional study used data from the Korea National Health and Nutrition Examination Survey 2010–2012. A total of 2,742 subjects were included in the analysis. Participants were divided into two categories based on their menstrual cycle regularity and the relationship between metabolic syndrome and its variables was investigated by multiple logistic regression analysis. Results: Adjusted analyses revealed significantly higher odds ratios for metabolic syndrome, high waist circumference, high triglyceride levels, and low high density lipoprotein cholesterol levels with the presence of menstrual irregularity. Conclusion: Metabolic syndrome and its components (high waist circumference, high triglyceride levels, and low high density lipoprotein cholesterol levels) were significantly associated with menstrual irregularity in women of reproductive age.
Design of the Automatic Flight and Guidance Controller for 50m Unmanned Airship Platform
Sang-Jong Lee,Seong-Pil Kim,Tae-Sik Kim,Dong-Min Kim,Hyo-Choong Bang 한국항공우주학회 2005 International Journal of Aeronautical and Space Sc Vol.6 No.2
The Stratospheric Airship Platform (SAP) has a capability of performing the autonomous and guidance flight to satisfy given missions. To be used as the High Altitude Platforms (HAPs), the capabilities of controlling platform's accurate position and keeping the station point are the most important features. Under this circumstances Autonomous Flight Control System (AFCS) is a critical system and plays a key role in achieving the given requirements and succeeding in missions. In this paper, the design and analysis results of the AFCS algorithms and controller are presented. The brief summary of the AFCS hardware structure is also explained. The autopilot controller and guidance logics were designed based on the linear dynamics of the unmanned airship platform and the full nonlinear dynamics was considered to evaluate and verify their performances.
( Hyo Bin Seo ),( In Ho Lee ),( Byung Duk Jeon ),( Tae Dong Kwon ),( Sung Pil Ryu ) 한국운동영양학회 2012 Journal of exercise nutrition & biochemistry Vol.16 No.4
This study was carried out to investigate the effect of Salicornia herbacea L. (SHL) intake and acute exercise on lipids metabolism in streptozotocin (STZ)-induced diabetic rats. Four different groups of 40 STZ-induced diabetic Sprague-Dawley male rats were given a diet of feed mixed with SHL powder for 6 weeks. To adapt to the acute swimming exercise, the exercise group went through a period of swimming induction over one week. Then, they performed the acute swimming exercise the next day. 24 hours after the acute swimming exercise, the rats were sacrificed and samples were collected and analyzed. There was no significant change in body weight as compared to the control group. Stored fat was found to have decreased in the group which was fed a diet supplemented with SHL powder. There was a significant reduction in blood glucose, triglyceride and total-cholesterol in the SHL intake group only. There was no change in L-FABP and CPT-1 protein expression determined to have occurred due to acute exercise, but there was a statistically significant increase in the expression of both proteins determined for the SHL grouip. Moreover, the SHL group with acute exercise exhibited an increase in cytochrome C oxidase. Based on the results above, it seems that SHL powder could help to prevent various diabetic complications. In addition, it seems necessary to prove the effectiveness of SHL as a healthy functional food by carrying out further research on its intake in relation to metabolic syndromes and exercise capabilities.
Predictors of candesartan's effect on vascular reactivity in patients with coronary artery disease
Lee, So‐,Ryoung,Chae, In‐,Ho,Kim, Hack‐,Lyoung,Kang, Do‐,Yoon,Kim, Sang‐,Hyun,Kim, Hyo‐,Soo BLACKWELLS 2017 CARDIOVASCULAR THERAPEUTICS Vol.35 No.5
<P><B>Summary</B></P><P><B>Introduction and Aims</B></P><P>Endothelial dysfunction and arterial stiffness have a prognostic value on adverse long‐term outcomes in coronary artery disease (CAD) patients. We evaluated the efficacy on vascular reactivity of candesartan and analyzed predictors to control the candesartan's effect on vascular reactivity in CAD patients.</P><P><B>Method</B></P><P>Patients were prospectively enrolled and prescribed candesartan for 6 months. The effect on vascular reactivity was evaluated by the change in flow‐mediated dilation (FMD) and pulse wave velocity (PWV).</P><P><B>Results</B></P><P>A total of 124 patients completed the study. The better responder in FMD change (≥1.3%) showed significantly lower baseline FMD than the poor responder (<I>P</I> < .001). In receiver operating characteristic analysis, baseline FMD 7.5% showed optimal predictive value (sensitivity 79%, specificity 79%) for predicting better responder. The baseline endothelial dysfunction (FMD <7.5%) was the only significant predictor of the better responder to candesartan. The better responder in PWV change (≤−100 cm/s) showed greater blood pressure lowering and significantly higher baseline PWV than the poor responder (both <I>P</I> < .05). The poor responder in both FMD and PWV showed a higher prevalence of previous myocardial infarction (38.7% vs 17.2%, <I>P</I> = .013).</P><P><B>Conclusion</B></P><P>The candesartan's effect on vascular reactivity is more pronounced in patients with more severe endothelial dysfunction and arterial stiffness. Poor responders on both FMD and PWV showed higher prevalence of previous myocardial infarction.</P>