한국인 심부전증 환자 심근에서의 인형 거대 세포 바이러스 감염

이명용,이무용,김영권,한성식,최성준,김효수,이영우,서정돈 단국대학교 1998 論文集 Vol.33 No.-

Objectives: In order to evaluated the prevalence and the site of infection of cytomegalovirus in terminally failing heart, cytomegaloviral DNA was detected in the explanted hearts of transplantation recipients. Methods: DNA extractions were performed from explanted failing hearts(N=22) and normal hearts(N=5) and polymerase cain reactions(PCRs) were done for detection of late gene sequence coding pp150 glycoprotein. The products were confirmed by electrophoresis on the 1% agarose gel. n order to improve the detectability of cytomegaloviral genome, nested PCRs were executed with the primers designed for the original 607 bp products. In situ PCRs also were done with the samples which were confirmed as positive for CMV viral genome by nested PCRs. Results: All patients had IgG anti-cytomegalovirus antibody and did not have IgM anti-cytomegalovirus antibody. Cytomegaloviral genomes in myocardium were detected by polymerase chain reaction. The 607bp products by PCRs were found in both explanted failing heart(3 cases/22. 13.5%) and normal hearts( 1 case/5, 20.0%). In nested PCRs, 186bp products were found in both failing hearts(LV 4/22, LA 3/2, RV 4/22, RA 0/17) and normal hearts(LV 2/5, LA 1/4, RV 2/5, RA 2/5). These was no significant change in positivity of cytomegaloviral DNA genome between failing and normal hearts. Total positivity of cytomegaloviral genome in explanted hearts was 44.4% according to the nested PCR results. The positivity of cytomegaloviral DNA by n situ PCR was 33.3%(4/12), and the site of positive reaction was the nuclei of the myocardial cells. Conclusion: Cytomegalovirus was rarely observed in explanted hearts of terminal heart failure and nested PCR could enhance the sensitivity of cytomegaloviral genome detection. The result of the in situ PCR showed the site of the cytomegaloviral infection was nuclei of the myocardial cells. Cytomegalovirus, however, might have no direct causal relationship in the development of terminal heart failure.

건축공간에 나타나는 오마주 기법에 대한 연구 -리차드 마이어의 건축물을 중심으로-

홍혜경 ( Hy다 Yung Hong ),이정민 ( Jung Min Lee ) 한국공간디자인학회 2014 한국공간디자인학회논문집 Vol.9 No.2

(연구배경 및 목적) 최근 여러 예술분야에서는 타 장르와의 협업이 빈번한데, 건축분야에서 영화계의 오마주라는 표현 기법을 대입하여 어떤 연관성이 나타나며 어떻게 적용되는지에 대해 알아보고자 한다. 오마주 기법을 통해 선·후대 건축가 사이의 상관관계를 알아보며 건축에서 일어나고 있는 오마주 현상에 대한 특성 및 적용 방법을 규명하고자 함이 연구의 목적이다. (연구방법)본 연구에서는 영화 속에서 표현되는 오마주의 표현적 특성을 다양한 시각으로 고찰한 후 비교·분석 틀을 마련하여 이 틀을 건축에 적용해 본다. 현대 건축가 리차드 마이어가 고찰의 대상이 되며 그의 건축이념에 영향을 끼친 프랭크 로이드 라이트, 르 코르뷔지에, 알바 알토와의 관련성과 건축적 영향에 대해 파악해보고자 한다. (결과)영화 기법인 오마주는 영화뿐만 아니라 건축에서도 선·후대 건축가 사이의 관계를 논하기에 충분한 비교의 틀이었고 이 틀을 통해 오마주란 기법이 단순한 모방의 개념을 넘어 과거와 현재를 연결해 주는 하나의 수단임을 알 수 있게 해준다. (Background and Purpose)As collaborations between different genres are frequently observed in artistic fields, this paper investigates how these collaborations proceed, and what correlations appear if we employ the Hommage technique from the film industry in the architecture sector. Furthermore, this study identifies the characteristics and method of application of the Hommage phenomenon in architecture by studying the correlation between earlier- and later-generation architects that have used the Hommage technique. (Method)We consider the characteristics of expression within Hommage found in films through a consideration of diverse points of view, establish a framework for comparison and analysis, and apply this framework to architecture. The modern architect Richard Meier is studied in detail. His correlations with Frank Lloyd Wright, Le Corbusier, and Alvar Aalto, who have all influenced Meier`s architectural ideology, are investigated. (Results)Hommage, a technique found in the film industry, can be adequately applied as a tool to investigate the relationship between earlier- and later-generation architects. Additionally, the Hommage technique goes beyond the concept of simple imitation, but also acts as a bridge to connect the past and present.

Greenhouse temperature management for the predatory mite establishment in the summer season

Seon-U Choi,Eun-Ju Song,Chang-Kyu Lee,Hy0-Jung Choi,Sang-Young,Min-Sil An 한국응용곤충학회 2022 한국응용곤충학회 학술대회논문집 Vol.2022 No.04

MLVA Genotyping of Brucella abortus isolated from cattle in Korea

Jin-Ju Lee(Jin-Ju Lee),Eun-Ji Yum(Eun-Ji Yum),Eun-Ji Park(Eun-Ji Park),Min-Kyeong Kim(Min-Kyeong Kim),Min-Hoe Lee(Min-Hoe Lee),So-Ra Sung(So-Ra Sung),Hee-Soo Lee(Hee-Soo Lee),Bang-Hun Hyun(Bang-Hun Hy 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-

A genome-wide association study of a coronary artery disease risk variant.

Lee, Ji-Young,Lee, Bok-Soo,Shin, Dong-Jik,Woo Park, Kyung,Shin, Young-Ah,Joong Kim, Kwang,Heo, Lyong,Young Lee, Ji,Kyoung Kim, Yun,Jin Kim, Young,Bum Hong, Chang,Lee, Sang-Hak,Yoon, Dankyu,Jung Ku, Hy Springer-Verlag 2013 Journal of human genetics Vol.58 No.3

<P>Although over 30 common genetic susceptibility loci have been identified to be independently associated with coronary artery disease (CAD) risk through genome-wide association studies (GWAS), genetic risk variants reported to date explain only a small fraction of heritability. To identify novel susceptibility variants for CAD and confirm those previously identified in European population, GWAS and a replication study were performed in the Koreans and Japanese. In the discovery stage, we genotyped 2123 cases and 3591 controls with 521 786 SNPs using the Affymetrix SNP Array 6.0 chips in Korean. In the replication, direct genotyping was performed using 3052 cases and 4976 controls from the KItaNagoya Genome study of Japan with 14 selected SNPs. To maximize the coverage of the genome, imputation was performed based on 1000 Genome JPT+CHB and 5.1 million SNPs were retained. CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans. From GWAS and a replication, SNP rs3782889 showed a strong association (combined P=3.95 10(-14)), although the association of SNP rs3782889 doesn't remain statistically significant after adjusting for SNP rs11066015 (proxy SNP with BRAP (r(2)=1)). But new possible CAD-associated variant was observed for rs9508025 (FLT1), even though its statistical significance did marginally reach at the genome-wide a significance level (combined P=6.07 10(-7)). This study shows that three CAD susceptibility loci, which were previously identified in European can be directly replicated in Koreans and also provides additional evidences implicating suggestive loci as risk variants for CAD in East Asian.</P>

導入 機器의 效率的 活用을 위한 敎授-學習 敎材의 開發 : 8 個 學科 共同 硏究

李昌甲,孟琦錫,李載元,朴萬植,廷吉煥,金鍾悟,朴景采,李英浩,李東周,邕章祐,柳盛淵,趙澤東,姜理錫,李殷雄,李興浩,金健中,韓相玉,金良模,張錫明,朴俊灝,洪鳳植,金太均,金再韓,宋海永,盧載星 충남대학교 공업교육연구소 1982 論文集 Vol.5 No.1

In this study, through the combined effort and collaboration of 8 engineering education departments, teaching-learning processes and models were reviewed, and printed and bound student manuals developed on 120 different tasks and subjects. Audio-visual supportive material, already in use in laboratories, was added to form a complete teaching-learning package. In addition to promoting the maximum use of the newly acquired equipment, this study will also contribute to the development of laboratory practice, the in-service training of technical high schools teachers and help in the development of their own instructional program.

미숙분만에 관한 역학적 고찰

이영호,이봉구,이영혜,장부용,이형열,오병전,정두수 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.2

1986년 1월부터 1988년 6월까지 2년 6개월간 본원 산부인과에서 분만한 총 6275예의 분만중 미숙분만 519예에 대한 통계학적분석을 실시, 여러 위험인자에 대한 빈도를 조사하여 다음과 같은 결론을 얻었다. 1. 미숙분만율은 1986년 7.7%, 1987년 7.2%에서 1988년 10.0%로 최근 증가추세를 보이고 있다. 2. 최근 5년간 borderline preterm delivery는 54.5%를 차지하였으며, moderately preterm delivery는 32.2%, extremely preterm delivery는 13.3%를 차지하였다. 3. 미숙분만 산모의 연령분포는 35세이하 7.8%에 비해 35세이상에서 20.5%로 현저히 높았다. 4. 미숙분만 산모의 분만횟수는 분만횟수 4회이상 산모에서 28.9%로 초산부나 1회 경산부의 7.6%에 비해 현저하게 높았다. 5. 미숙분만 산모의 유산횟수는 유산경험이 없는 경우 6.6%에 비해 3회이상의 경우 17.1%로 현저히 증가되었다. 6. 산모의 교육정도와 미숙분만과 관련성은 교육기간이 길수록 적게 나타났다. 7. 미숙분만율과 최초 산전진찰시기와는 연관 관계가 없었다. 8. 분만과거력에 있어서는 과거 미숙분만 및 만기 유산력이 있는 경우 전체분만에 비해 8.2배의 높은 율을 보였으며, 과거 사산 및 주산기 영아 신생아 사망 예에서 1.9배로 높았으나, 제왕절개 수술력은 관련이 없었다. 9. 조산의 발생과 직접적 연관이 있는 원인으로는 다태임신, 선천성 태아기형, 전치태반, 태반조기박리, 자궁내 태아사망, 이상태위, 자궁경관내구무력증, 자궁기형, 양수조기파수 등이 있으며, 임신자간증 및 중증 자간전증의 경우는 의인성으로 조산을 시킨 경우도 있었으나 상당수 연관이 있었다. 10. 산모의 전신질환에는 결핵, 만성고혈압 등이 연관이 있고 심장질환, 신장질환 등에서는 별로 연관니 없었다. 11. 저 Apgar score(6) 신생아 발생율은 extremely preterm newborn에서 1분 71.2%, 5분 65.4%를 보였다. Although neonatal intensive care of the preterm newborn has improved the chances of healthy survival of infants, prematurity is still the major cause of neonatal mortality and morbidity. In order to investigate the various risk factors of preterm birth and contribute to prevention of preterm birth hereafter, we performed statistical analysis on 519 cases of preterm birth delivered at Department of Obstetrics and Gynecology, Presbyterian Medical Center from January 1986 to June 1988 per 6275 total delivery cases. The results of the study were as follows: 1. The incidence rate of preterm births was 7.7 % on 1986 and 7.2 % on 1987, and 10.0 % on 1988, increasing trends recently. 2. The rate of borderline preterm birth was 54.5 % and moderately preterm birth was 32.2 %, and extremely preterm birth was 13.3 % during 5 years, recently. 3. The rate of preterm birth to total birth by maternal age was 7.8 % in maternal age of under 35 years and 20.5 % in maternal age of over 35 years. 4. Number of preterm birth was increased as number of parity, and preterm birth rate to total birth by parity was 7.6 % in para 0.1, and 28.9 % in para above 4. 5. Number of preterm birth was increased as number of abortion, and preterm birth rate to total birth by abortion number was 6.6 % in no abortion group and 17.1 % in experienced abortion over 3 times. 6. Number of preterm birth was lesser in more 13 years education periods group than under 9 years education periods group. 7. There was no significant relationship of the preterm birth incidence rate and first antenatal care time. 8. As compared with previous obstetric history, preterm birth was 8.2 times more in cases with previous preterm birth and late abortion and 1.9 times more in cases with past still birth and postnatal death, but not related to past cesarean section. 9. Obstetric risk factors related to preterm birth was multiple pregnancy, congenital malformation, placenta previa, abruptio placenta, IUFD, abnormal presentation and IIOC, uterine anomaly, PROM and preeclampsia severe form and eclampsia. 10. High risk maternal disease was tuberculosis and chronic hypertension, but heart disease and renal discase was not related. 11. Incidence of low Apgar score($lt;6)rate was 71.2% at 1 minute and 65.4% at 5 minute on extremely preterm newborn.

융모종양에 관한 임상적 고찰

이영호(HY Lee),이동식(DS Lee),이국(K Lee) 대한산부인과학회 1973 Obstetrics & Gynecology Science Vol.16 No.6

This study was undertaken for the clinical analysis and evaluation of the women with trophoblastic tumors who were admitted and treated at the Yonsei University Medical Center from Jan. 1,1961 to June 30, 1972. A total of 187 cases were seen with the following distribution: Hydatidiform mole 94, chorioadenoma destruens 17, and choriocarcinoma 76. The following features were the results of this study: 1. Hydatidiform mole occurred approximately once in every 186 pregnancies and 161 deliveries, chorioadenoma destruens once in every 1028 pregnancies and 889 deliveries, choriocarcinoma once in every 230 pregnancies and 199 deliveries, respectively. 2. While the rate of normal intrauterine pregnancy declines markedly after the age of 40, the occurrence of the trophoblastic tumor after this age become remarkably increased. It was noteworthy that the incidence of choriocarcinoma increased in proportion to the gravidity. 3. Among the patients with choriocarcinoma, 71 per cent of patient had lung metastasis, 21 per cent vagina, 8 per cent brain, and 4 per cent G-I tract. 4. In cases of choriocarcinoma, 33 per cent of cases occur after hydatidiform mole, 30 per cent after term pregnancies, 30 per cent after abortion. 5. Forty seven per cent of the patient with hydatidiform mole were managed by D & E, hysterectomy was done in 41 per cent of the patient with chorioadenoma destruens, and 53 per cent of the patient with choriocarcinoma were managed by chemotherapy with Methotrexate alone or Methotrexate and Actinomycin-D. 6. In the patient with chorioadenoma destruens, remission rate was 76 per cent. In patients with choriocarcinoma, remission rate was 51 per cent, mortality rate was 26 per cent and recurrence rate was 12 per cent respectively. In the cases of choriocarcinoma the earlier the treatment, the better the result. Among the patient with remission after chemotherapy, most of them had at least 3 kurs of therpapy, and the patient with multiple metastasis showed very poor remission rate compared with those without metastasis.

METABOLISM OF A NEW PROTON PUMP INHIBITOR DBM-819 by LC-MS/MS

Choi SJ,Ji HY,Lee JW,Lee HY,Choi JK,Lee DH,Lim H,Lee HS 대한약학회 2000 大韓藥學會 總會 및 學術大會 Vol.49 No.-

[S8-3] Dietary Supplement Intake of Children

YA Jang,JJ Moon,HS Lee,HJ Lee,Y Lee,DH Kim,JY Lee,HY Lee,YJ Kang,JW Hong,HS Nam,EJ Lee,C-I Kim 한국식품영양과학회 2008 한국식품영양과학회 학술대회발표집 Vol.2008 No.10