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- 저자 : Lee HS (검색결과 342 건)
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황적준,이혜린,구태완,한길로,이용욱,이혜승,강일호,김성민 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1
Population genetic studies were carried out on randomly selected and unrelated individuals from Korean(n= 379) using 9 short tandem repeat loci FGA, VWA, D3S1358, D18S51, D21S11, D8S1179, D7S820, D13S317, and D5S818, respectively. After electrophoresis, 18 alleles were identified for FGA, 7 alleles for VWA, 8 alleles for D3S1358, 16 alleles for D18S51, 15 alleles for D21S11, 10 alleles for D8S1179, 9 alleles for D7S820, and 9 alleles for D13S317. No deviation from Hardy-Weinberg equilibrium was found. Some statistical parameters of forensic interest, such as observed/expected heterozygosity, mean exclusion channce, power of discrimination and polymorphism information content were determined. The results for RGA, D21S11, and VWA showed no differences of allele frequency between the different Korean population groups.
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이현식(HS Lee),이효표(HP Lee),이진용(JY Lee),목정은(JE Mok) 대한산부인과학회 1971 Obstetrics & Gynecology Science Vol.14 No.3
저자들은 만삭임신을 동반한 희유한 Naegele 골반의 1예를 보고하고 문헌적 고찰을 하였다. Franz Karl Naegele in 1803 first recognized the morphology of the obliquely contracted pelvis, and he published a monography which was based on the study of 37 specimens in 1838. As he recognized, this deformity is not produced by external violence, nor by constitutional diseases but is the results of an anomaly of development. A case of Naegele pelvis with term pregnancy was presented and a brief review on the literature is made.
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한국형 자궁경부 촬영진 ( New Cervicography ) , 세포검사 그리고 HPV-DNA 검사를 이용한 새로운 자궁경부암 검진 모델 ( Model ) 개발
김승조(SJ Kim),박찬규(CK Park),이효표(HP Lee),남궁성은(SE Namkoong),강순범(SB Kang),서호석(HS Saw),이재관(JK Lee),김수녕(SN Kim),김재원(JW Kim),배석년(SN Bae),김찬주(CJ Kim),이근호(KH Lee),이선영(SY Lee),김인호(IH Kim),이찬(C Lee),이정노(JN Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
N/A Objective : The false negative rate of conventional cytology is reported to range from 18 to 45%. It is necessary to develop more effective screening strategies that would ideally be more accurate than conventional cytology. This study is designed to investigate the potential of conventional cytology, cervicography, HPV-DNA testing and their combinations as primary screening techniques for cervical neoplasia. The purpose of this project is to develop the models and guidelines for screening tools of cervical cancer of the uterus by evaluating sensitivity, specificity and cost-effectiveness of all the screening methods. Study design : We conducted a screening of random sample of women who visited the department of OB-Gyn. of five different major university hospitals such as Catholic University Hospital, Korea University Hospital, Seoul National University Hospital, Yeonsei University Hospital and Pochon CHA University Bundang CHA Hospital, from May 1, 1996 to April 30, 1999. In a cohort women with an age range of 20 to 70 who underwent routine cytologic screening at Catholic University, Hospital Bundang CHA General Hospital and local clinics from April 1, 1996 to Decomber 31, 2000. cervicography (n=417,125) and testing for HPV-DNA (n=1,347) by the hybrid capture assay were studied for the ability of the cervical cancer screeuing. A new cervicography system with Kim's classification which was developed by Prof. Kim Seung Jo as an adjunctive method for the cervical cancer screening was applied in this cohort study. And then, accuracy, effectivencess, cost-effectiveness of the single or combined screening method were analysed. Result : Sensitivity and specificity of Pap smear were ranged from 55.6% to 83.1% and 72.8% to 88.3% respectively. The combination of Pap smear and cervicography had sensitivity from 89.7% to 98.6%, specificity from 68.2% to 93.2%. With combination of Pap smear, HPV DNA test and cervicography, sensitivity became also highest accuracy among all screening methods from 92.8% to 98.8%. Considering medical charges for diagnosis and social cost occurred by false positive and false negative results, the most cost-effective diagnostic modality was thought to be the combination of Pap smear and cervicography(91,433 won). In patients who were diagnosed as LSIL, colposcopic examination confirmed progression to high grade intraepithelial lesion(HSIL) in 10.7% patients, persistence of LSIL in 55% patients during the 3 year follow-up period. Accuracy of the screening for cervical cancer and CIN can significantly be improved by cytology with new cervicography rather than cytology alone. We concluded that cervicography can be important adjunctive tests for cervical cytology, improving the effectiveness of cervical screening by allowing a more sensitive detection of cervical neoplasia.
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Lee, YH,Lee, HS,Choi, SJ,Ji, JD,Song, GG SAGE Publications 2012 Lupus Vol.21 No.1
<P>The aim of this study was to determine whether the functional interleukin-6 (IL-6) promoter -174 G/C and -572 G/C polymorphisms confer susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. Meta-analysis was conducted on the associations between the IL-6 polymorphisms and SLE using; 1) allele contrast, 2) the recessive model, 3) the dominant model, and 4) the additive model. A total of 11 studies were considered in this study, and ethnicity-specific meta-analysis was performed on European and Asian populations. Meta-analysis of the IL-6 -174 G/C polymorphism showed an association between SLE and the IL-6 -174 G allele in all study subjects (odds ratio (OR)?=?1.344, 95% confidence interval (CI)?=?1.052-1.718, p?=?0.018). Furthermore, stratification by ethnicity indicated an association between the IL-6 -174 G allele and SLE in Europeans (OR?=?1.264, 95% CI?=?1.037-1.541, p?=?0.020). Meta-analysis of the IL-6 -572 G/C polymorphism revealed that an association was found between SLE and the IL-6 -572 G/C polymorphism using the recessive model, but ethnicity-specific meta-analysis revealed no association between SLE and the IL-6 -572 G/C polymorphism in Asians. In conclusion, this meta-analysis demonstrates that the IL-6 -174 G/C polymorphism may confer susceptibility to SLE in Europeans, but that the IL-6 -572 G/C polymorphism is not associated with susceptibility to SLE in Asians.</P>
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난소 및 자궁부속기 염전의 보존적 치료를 위한 색도플러 초음파검사의 의의
이은주,오기석,유희석,권혁찬,장기홍,황경주,이치형,이숙영 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.7
Torsion of the adnexa is a well-known gynecologic cause of an acute surgical abdomen. Delay in diagnosis, inability to distinguish strangulation from necrosis, and fear of embolus dislodgement have made adnexectomy the accepted method of management of adnexal torsion. This condition occurs most commonly in the reproductive years, yet methods to preserve viable ovarian tissue have not been routinely used or evaluated. Therefore, in order to ascertain if color Doppler sonography(CDS) can detect adnexal viability, ultrasonography with CDS of the ovarian pedicle was performed in 27 patients in whom torsion of the ovarian tumor was confirmed surgically. We were able to identify a twisted vascular pedicle of the ovarian tumor by ultrasonography in 24 of 27 patients(88% detectability). In 10 patients in which pedicle arterial and venous blood flow was observed, the pathology specimens revealed normal, or edema with congestion, or early hemorrhage, but in the 9 cases where only arterial blood flow was observed or where there was no blood flow at all, pathology revealed hemorrhagic necrosis in all cases. In 5 cases where there was arterial blood flow the tumor was managed conservatively, either by detorsion or cytectomy, after which there was no cases of embolism or tumor recurrence during follow up ultrasonography. Normal follicular development and ovulation was also observed in these patients. In conclusion, for young women who are of child-bearing age in whom torsion of benign adnexal tumors is suspected, CDS should be conducted to detect torsion of the tumor and ascertain whether pedicle venous blood flow is present or not. If such blood flow is detected, the adnexa is considered to be viable and detorsion or cystectomy may be performed, thus preserving the ovary.
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상피성난소암에서 p53 및 HER-2/neu 유전자 관련 단백의 발현과 DNA 분포양상에 관한 연구
이규완,김혜선,이낙우,염범우,장기훈,이용호 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11
Expression of mutant p53 and HER-2/neu oncoprotein is thought to be prognostic indicies in patients with epithelial ovarian cancer. DNA ploidy and SPF(S-phase fraction) are also tho-ught to be biologic or prognostic indicies in epithelial ovarian cancer. The present study was carried out to investigate the expression and prognostic role of mutant p53, HER-2/neu oncopr-otein, and DNA ploidy in epithelial ovarian cancer. Another purpose of this study was to evalu-ate the relationship between these molecular characteristics(HER-2/neu, p53 dncoprotein and DNA ploidy) and other prognostic factors(stage, grade, histologic type). We reviewed archival specimens from 41 patients with epithelial ovarian cancer diagnosed during the period 1988∼1994. Immunohistochemistry was used to detect p53 and HER-2/neu oncoprotein expression. We used flow cytometry to calculate DNA ploidy and S-phase fraction. Kaplan-Meier method and log-rank test were used to analyze clinical and molecular data with respect to survival. The obtained results are summarized as follows: 1. Expression of p53 oncoprotein was demonstrated in 48.8% of the tumors and was associated with a 36.3% probability of 5-year survival, compared to a 67.4% probability of 5-year survival for the p53 oncoprotein negative cohort(p=0.019). 2. There was no significant relationship between overall survival and HER-2/neu oncoprotein expression. 3. Coexpression of p53 and HER-2/neu oncoprotein was associated with a 16.7% probability of 5-year survival, compared to a 66.7% probability of 5-year survival for the p53 and ER-2/neu oncoprotein negative cohort(p=0.021). 4. The percentage of p53 and HER-2/neu expression was higher in advanced ovarian cancer(stage Ⅲ, Ⅳ), although statistical evaluation was not significant. p53, HER-2/neu oncoprotein expression had no correlation with tumor grade or histologic type. 5. About 58.5% of tumors were aneuploidy, which was associated with poor prognosis(p=0.042). S-phase fraction greater than 15% showed similar trends(p=0.018). It is suggested that molecular charcteristics provide objective data that may be useful in predicting prognosis in patients with epithelial ovarian cancer. But further investigation of molecular and genetic characteristiics are needed to refind our diagnositc and treatment modalities.
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Lee, JB,Lee, JE,Park, JH,Kim, SJ,Kim, MK,Roh, SI,Yoon, HS Society for the Study of Reproduction 2005 BIOLOGY OF REPRODUCTION Vol.72 No.1
Human embryonic stem (hES) cells are usually established and maintained on mouse embryonic fibroblast (MEFs) feeder layers. However, it is desirable to develop human feeder cells because animal feeder cells are associated with risks such as viral infection and/or pathogen transmission. In this study, we attempted to establish new hES cell lines using human uterine endometrial cells (hUECs) to prevent the risks associated with animal feeder cells and for their eventual application in cell-replacement therapy. Inner cell masses (ICMs) of cultured blastocysts were isolated by immunosurgery and then cultured on mitotically inactivated hUEC feeder layers. Cultured ICMs formed colonies by continuous proliferation and were allowed to proliferate continuously for 40, 50, and 55 passages. The established hES cell lines (Miz-hES-14, -15, and -9, respectively) exhibited typical hES cells characteristics, including continuous growth, expression of specific markers, normal karyotypes, and differentiation capacity. The hUEC feeders have the advantage that they can be used for many passages, whereas MEF feeder cells can only be used as feeder cells for a limited number of passages. The hUECs are available to establish and maintain hES cells, and the high expression of embryotrophic factors and extracellular matrices by hUECs may be important to the efficient growth of hES cells. Clinical applications require the establishment and expansion of hES cells under stable xeno-free culture systems.
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염색체균형 전좌 보인자에 있어서 산전 세포유전학적 진단에 관한 연구
이권해,이순곤,김용진,김현승,이충일,오신정,최경준 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.9
Retrospective analysis of chromosomal abnormalities was performed on 75 couples who had recurrent spontaneous abortion. Karyotyping of their peripheral blood lymphocytes was made on 75 patients and 75 their husbands. The overall incidence of chromosomal aberrations was 22.7 %(17 in 75 couple). Number of chromosomal abnormalities in wives was twelve. Another chromosomal abnormalities were found in five husbands. All of them were balanced form and their phenotypes were normal. The incidence of translocations among total chromosomal abnormalities was 64.7 % (11/17). The incidence of reciprocal translocation(72.7 %) was higher than that of Robertsonian translocation (27.3 %). There were six other abnormalities including one case of inversion and five cases of polymorphisms. amniocentesis or chorionic villi sampling was performed during subsequent pregnancy to couples who had balanced chromosomal abnormalities. The karyotypes were classified as balanced translocation in seven cases, inversion in one case and normal karyotype in one case. This study suggests that prenatal diagnosis should be emphasized in couples in which one person is the carrier of a balanced chromosomal abnormality.
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