재발성 다발연골염 1례

이배혁,고의경,왕수건,전경명 釜算慶南耳鼻咽喉科學會 1994 임상이비인후과 Vol.5 No.1

소화성 궤양에서 삼제 병합 요법의 저용량에 의한 Helicobacter pylori 제균률과 궤양 치유효과

김예리,박봉안,이재동,이종혁,김인숙,박형석,진춘조,김상윤,박의우 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Helicobacter pylori is the major cause of histologic chronic gastritis and is strongly associated with peptic ulcer disease, gastric cancer and lymphoma. Several recommendations for the management of the Helicobacter pylori infection have been developed. However, there has been no clear therapeutic regimen for the optimal treatment of Helicobacter pylori infection. This study was desinged to evaluate the eradication rate and the ulcer healing rate of the triple regimen with low-dose clarithromycin(0.5g/day) in peptic ulcer patients. Forty three patients with gastric ulcer(n=15) and duodenal ulcer(n=28) were enrolled. The patients were treated either with omeprazole 20mg b.i.d. amoxicillin 0.5g b.i.d. and clarithromycin 250mg b.i.d. (low-dose regimen group, n=29) or with omeprazole 20mg b.i.d., amoxicillin 1.0g b.i.d. and clarithromycin 0.5g b.i.d.(high-dose regimen group, n= 14) for 2 weeks. After 4 weeks, the patients were evaluated for the eradication of Helicobacter pylori and the healing of ulcer. And gastritis scores according to the Sydney system were evaluated before and after 4 weeks from the end of the triple regimen. There was no significant difference in the eradication rate and the ulcer healing rate between the low-dose regimen group, group and the high-does regimen group. In the low-does regimen group, the mean initial scores of chronic inflammation and activity were decreased after the eradication of Helicobacter pylori. In conclusion, the low-dose triple regimen is as effective as the high-dose triple regimen on the eradication of Helicobacter pylori and the ulcer healing rate in peptic ulcer disease.

Three Temperature Model for Nonequilibrium Energy Transfer in Semiconductor Films Irradiated with Short Pulse Lasers

Lee, Seong Hyuk,Sim, Hyung Sub,Lee, Junghee,Kim, Jong Min,Shin, Young Eui The Japan Institute of Metals 2006 MATERIALS TRANSACTIONS Vol.47 No.11

<P>This article investigates numerically carrier-phonon interaction and nonequilibrium energy transfer in direct and indirect bandgap semiconductors during sub-picosecond pulse laser irradiation and also examines the recombination effects on energy transport from the microscopic viewpoint. In addition, the influence of laser fluence and pulse duration is studied by using the self-consistent three-temperature model, which involves carriers, longitudinal optical phonons, and acoustic phonons. It is found that a substantial non-equilibrium state exists between carriers and phonons during short pulse laser irradiation because of time scale difference between the relaxation time and the pulse duration. It is clear that the two-peak structure in carrier temperature exists and it depends mainly on laser pulses, fluences, and recombination processes. During laser irradiation, in particular, the Auger recombination for Si becomes dominant due to the increase in the carrier number density, whereas for GaAs, the Auger recombination process can be ignored due to an abrupt increase in SRH recombination rates at the initial stages of laser exposure.</P>

위 정맥류출혈에 대한 내시경적 결찰요법과 Histoacryl 치료 효과의 비교

이상우,김남재,서승원,이병석,이헌영,이엄석,김선문,양현웅,성재규,임의혁 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.5

Background/Aims: The variceal bleeding has high rebleeding rate, and mortality rate was higher in gastrix varix. Managements of variceal bleeding were included such as drugs, endoscopic procedures, surgical management and radiological intervention. Recently histoacryl^(R) injection method has been introduced. We have compared the effects of the endoscopic ligation and Histoacryl^(R) injection therapy (HAI) in patient with gastric variceal bleeding. Methods: We analyzed the effects of hemostasis, complications, rebleeding rates, and survival rates in gastric varix bleeding of 22 patients with Histoacryl^(R) injection therapy and 20 patients with endoscopic ligation therapy, from January 1995 to March 1999. Results: There were no difference in the complication rate between the 2 stretigies (12/14). Most common complication was chest pain in EVL group, but fever was common in HAI group. Also early and post rebleeding rates were not different in both groups. The main cause of death during follow up period was rebleeding in both groups. The survival rates were 65.0% in EVL group and 77.0% in HAI group (p$gt;0.05, duration: 23±2, 28±4 month), and there was no difference in mortlity rate (p=0.77). Conclusions: There were no difference in the hemostatic effect, complications, rebleeding rate and survival rate in EVL group and HAI group. However, evaluation of larger numbers of patients and prospective studies were needed to define the effectiveness and complications of these therapies.

십이지장 궤양에 의한 유문 협착에서 풍선 확장술의 장기 효과

이상우,김남재,서승원,이승민,이병석,정현용,양현웅,성재규,임의혁,이경태 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.5

Background/Aims: Balloon dilatation is a useful alternative to surgery in patients with benign pyloric stenosis. However, little data are available on the long-term outcome of the procedure. This report was attempted to determine the safety and efficacy of endoscopic balloon dilatation for 14 patients with gastric outlet obstruction caused by duodenal ulcer. Methods: Review of medical records or telephone interview was performed retrospectively. Results: Follow-up was conducted for median 18.5 months (3-48 months). Gastric outlet strictures had a median diameter 6 mm (range, 2-9 mm). Five (35.7%) patients had active ulcer. 12 mm to 18 mm balloons were inflated a median of 1 times (range, 1-4 times) for a median of 4 minutes (range, 1 11 minutes). Thirty-two procedure (1.5/patient) were performed; 9 patients (64.3%) had one treatment and 5 patients (35.7%) had multiple treatment. Immediate symptomatic relief was achieved in 13 patients (92.8%) and 7 patients (50%) achieved sustained symptomatic relief. Dilatation failed only in 2 patients (14.3%) ultimately and both recovered by palliative bypass surgery. No complication was noted during treatment. Conclusions: Endoscopic balloon dilatation is safe and effective for most patients with gastric outlet obstruction induced by duodenal ulcer. And due to limitation of retrospective aspect of this report, further prospective, randomized studies must be performed.

Dynamic Filling Characteristics of a Capillary Driven Underfill Process in Flip-Chip Packaging

Lee, Seong Hyuk,Lee, Hyung Jun,Kim, Jong-Min,Shin, Young Eui The Japan Institute of Metals 2011 Materials transactions Vol.52 No.10

<P>This study investigates the dynamic flow characteristics of capillary-driven underfill flows in a flip chip package. In the present study, we used two different bump arrays using Sn-2.5Ag solder balls with 80 μm and 100 μm diameters on commercially available flip chips, which have different pitches of 150 μm and 180 μm. First, we measured surface tension and viscosity with a rheometer and a tensiometer, respectively, and conducted an experimental visualization of the dynamic filling behavior of the underfill flows. From the captured images, we estimated the filling times, which can be affected by two important factors: bump arrangements and resin viscosities. In addition, we conducted a FVM (finite volume method)-based numerical simulation using commercial CFD code (Fluent v. 6.3.26), and compared its numerical results to both the experimental data and the analytical solutions given by the previous model described by Wan <I>et al.</I> (2005). The numerical predictions and analytical solutions estimating filling time were in good agreement with the experimental data, and the increase in spatial density of solder bumps allowed the flow to fill more slowly due to the increase in flow resistance. We conclude that the non-Newtonian characteristics and bump arrangement are very important factors in the design of flip-chip packaging.</P>

Blood pressure–targeted stepwise resuscitation for hemorrhagic shock in rats

Lee, Jae Hyuk,Kim, Kyuseok,Jo, You Hwan,Kim, Min A,Lee, Kyoung-Bun,Rhee, Joong Eui,Doo, Ah-Reum,Lee, Min Ji,Park, Chan Jong,Kim, Joonghee,Chung, Heajin Lippincott Williams Wilkins, Inc. 2014 The journal of trauma and acute care surgery Vol.76 No.3

BACKGROUND: Generation of reactive oxygen species (ROS) is an important mechanism of ischemia-reperfusion injury. Abrupt reoxygenation compared with slow reoxygenation has been known to increase ROS generation. Thus, slow and stepwise reperfusion can reduce ROS generation and subsequent ischemia-reperfusion injury. This study investigated the effect of slow reperfusion by blood pressure–targeted stepwise resuscitation (PSR) in hemorrhagic shock. METHODS: Pressure-controlled hemorrhagic shock was induced in male Sprague-Dawley rats for 1 hour. Rats were then allocated to one of three groups (no-resuscitation group, n = 14; PSR group, n = 15; rapid normalization of blood pressure (RR) group, n = 15). Survival time and hemodynamic changes were recorded and compared. Blood samples and liver tissue were harvested after 6 hours of resuscitation in surviving rats. RESULTS: All of the rats in the no-resuscitation group were expired before the end of the 6-hour observation period. Survival times were significantly longer in the PSR group than in the RR group (survival rates, 11 of 15 vs. 5 of 15, log rank p = 0.032). Plasma amino alanine transferase, histologic liver injury, and ROS generation in the liver tissue were significantly lower in the PSR group than in the RR group (all findings significant, p < 0.05). In addition, PSR significantly decreased plasma nitric oxide, liver interleukin 1&bgr;, and liver interleukin 6 compared with rapid resuscitation in addition to augmenting Akt survival pathways (all p < 0.05). CONCLUSION: Slow reperfusion by PSR decreased mortality, ROS generation, and liver injury in rats undergoing hemorrhagic shock. Stepwise resuscitation also decreased inflammatory cytokine production and augmented Akt survival pathways.

Real Time Image Segmentation for Autonomous Land Vehicle System

Eui-Hyuk Lee,Hong Jeong 대한전자공학회 1997 대한전자공학회 학술대회 Vol.1997 No.11

Change of the Expression of Human Telomerase Reverse Transcriptase mRNA and Human Telomerase RNA after Cisplatin and 5-Fluorouracil Exposure in Head and Neck Squamous Cell Carcinoma Cell Lines

Lee, Byung-Joo,Lee, Bae-Hyuk,Wang, Soo-Geun,Lee, Jin-Choon,Roh, Hwan-Jung,Goh, Eui-Kyung,Kim, Cheol-Min,Jun, Eun-Sook The Korean Academy of Medical Sciences 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22//SUP No.-

<P>Telomerase activity appears to be associated with cell immortalization and malignant progression. Understanding how telomerase activity is regulated in vivo is important not only for understanding the molecular biology of telomerase but also for the potential clinical application of anticancer drugs. This study evaluated telomerase activity and quantified the expression of human telomerase reverse transcriptase (hTERT) mRNA and human telomerase RNA (hTR) using a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) method before and after the exposure of cisplatin and 5-fluorouracil (5-FU) in two head and neck squamous cell carcinoma (HNSCC) cell lines. Two human HNSCC cell lines (PNUH-12 and SNU-899) were studied. Cell cytotoxicity, the change of telomerase activity, and hTERT mRNA and hTR expression by 5-FU and cisplatin exposure were assessed by MTT assay, TRAP assay, and real-time RT-PCR, respectively. In two cell lines, after cisplatin exposure, the telomerase activity and hTERT mRNA expression decreased, but hTR expression increased according to the concentration of drug. However, in both cell lines, the telomerase activity and hTR did not show any significant change after 5-FU treatment, but the expression of hTERT mRNA decreased. These results suggest that there may be other important regulating mechanism except hTERT mRNA as the regulation factor of telomerase activity in HNSCC cell lines.</P>

[Hepato-Biliary and Pancreas] Cancer-specific Molecular Subtypes Show Clinical Relevance with Potential Therapeutic Opportunities in Resectable Pancreatic Cancer

Eui Hyuk Chong,Jiyeon Park,Hye Jung CHO,Incheon KANG,Sung Hoon CHOI,Sunyoung LEE,Ju-Seog LEE,Sung Hwan LEE 대한외과학회 2022 대한외과학회 학술대회 초록집 Vol.2022 No.5