Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

Classical Swine Fever (Hog cholera) Virus 약독순화주 (Suri 주)의 gp55 Gene 염기서열 분석

김귀현,장경수,강경임,이병형,박종현,안수환,전무형 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

An attenuated classical swine fever virus (CSFV), Suri strain, is a variant derived from a vaccine virus, LOM strain. This study was performed to elucidate the molecular biologcal properties of CSFV Suri strain, and to obtain the basic data for molecular epidemiological approaches for the disease. The truncated form of gp55 gene without the C-terminal trasmembrane domain, in size of 1,023bp, was amplified by RT-PCR and sequenced by dye terminator cyclic sequencing method, and inserted into BamHI site of pAcGP67B baculovirus vector, establishing a cloned pAcHEG plasmid. By the nucleotide sequences determined, 341 amino acid sequences were predicted. As compard the nucleotide and amino acid sequences of gp55 of Suri with the various CSFV, Suri strain showed the high homology over 99.1% with ALD and LOM strains, but comparably the lower homology with Alfort and Brescia. In comparison of amino acid sequence in variable domain of gp55 protein, the similar tendency of homology was observed. In hydrophobicity analysis, all of four CSFV strains revealed the analogous patterns of hydrophobicity. The numbers and locations of N-glycosylation site and cysteine residuse in gp55 were analyzed, those of Suri strain being coincident with ALD and LOM strains. The results suggest that gp55 in Suri strain has the high similarity to those in ALD and LOM strains in terms of the nucleotide and amino acid sequences and the functional properties of gp55 protein.

국내 기능성 화장품의 생산 실태

김혜수,이경화 가톨릭대학교 생활과학연구소 2001 생활과학연구논집 Vol.21 No.1

The purpose of this study is to analyze the real state and problems of production characteristics in Korean Cosmeceuticals manufacturers. This Study accomplished the qualitative survey to Top three cosmetic manufacturers(태평양, LG, 코리아나) which have production lines of Cosmeceuticals. Interviewee are marketers and production managers who have careers in this areas. The results are as follows; 1.Most of market segmentations are focused on the younger generation(age 20 to 39). 2.All of cosmetic brands were offered the variations of skin types by brands and products, which are skin care and nutritional care. 3.It has shown that the evaluation of manufacturers about the consumers' understanding of cosmeceuticals was very low. However, the consumers' satisfaction after using cosmeceuticals was shown to be very high.

정상인에 있어서 Visual Suppression Test

김백순,구순권,방의경,고의경,전경명 釜算慶南耳鼻咽喉科學會 1991 임상이비인후과 Vol.2 No.1

보육시설 활동복에 대한 어머니들의 태도 연구

김수경,최선영 가톨릭대학교 생활과학연구소 1999 생활과학연구논집 Vol.19 No.1

The purpose of this study is to investigate the design elements to design functional and creative clothing for preschool children emphasizing the physical, psychological and aesthetic developments. Data were collected from 262 mothers of 2∼7 aged children, residing Pucheon and Seoul. The results of empirical studies were summarized as follows: 1) The clothing aspects considered important by mothers, in order of freqency, were: utility, price, child's attitude, comfort, symbolic, brand, fashionability, design. 2) Children's mothers considered more important, easiness for the child to put on and take off, the amount of clothing necessary for comfortable temperature, comfort of clothing rather than design and fashionability for children's kindergarten life. Mothers seem satisfactory about children's uniform at kindergarten. 3) Preschool children like some aspects of clothing. These were, in order of importance, were: color, activity, cartoon character, texture, prettiness, decoration detail

중증의 둔상환자에 대한 외상처치의 적정진료 평가

김영식,임경수,황성오 대한응급의학회 1993 대한응급의학회지 Vol.4 No.1

The trauma is the leading cause of death in the first four decades of life, but, in Korea, the trauma system and emergency medical services system are not develped well. Because the outcome of severely injured patients often depends on the severity of trauma and quality of trauma care, the verification of the institutional capability to care for trauma patients according to the "optimal care" guideline has been a natural sequel. And the quality assurance for evaluating outcome of trauma care is need to develop or upgrade trauma care furthermore. The present study is an prospective evaluation of trauma outcome and quality assurance of our hospital by use of TRISS and Z statics. Logistic function norms related TRISS values to patient`s survival probability(Ps). 155 patients, who were severely injured by blunt trauma(ISS≥16) and older than 15 years old, were analyzed. Among them, 38 patients(24.5%) were died. Ps of survivals was 0.9152 and deaths was 0.2501. Z static of deaths was -0.0494. Unpredicted deaths, who were died inspite of Ps≥0.5, were reviewed, and unapt trauma care was found in 4 cases. By using both TRISS and Z statics, emergency physician will be more accurate in assessing the quality assurance of severely injured patients.

건축 조형 교과 연구 : Aesthetic Viewpoints Upon the Resources of Form in Architecture 건축 형태의 원천에 관한 미학적 입장들의 모형 비교

김경수 明知大學校 産業技術硏究所 1998 産業技術硏究所論文集 Vol.17 No.-

Teachers of architectural form in their class(either Architectural Design or Architectural Form) has various viewpoints about the sources of architectural form. In this paper the author compares some very typical models of positions on architectural form. There can be three major resources from which the architects derive their architectural form, 1) nature, including the human body 2) artefacts and precedents, whether ordinary, artistic or architectural and 3) architectural project itself, with emphasis either on form or content. Deep concerns in nature brings out classic rules or organic spontaneity in architectural form. In this context, 'natural-ness' and 'abstraction' are some of major problematic themes. These themes cover also some domain of the second position which contains the typological approach. Kitch or straight revivalism might be some pitfalls in this position. In contrast the anti-aesthetic attitudes or the formalists emphasize the autonomy of either architectural program or form. These positions don't seem to be easily reconciled, and the students need some critical intelligence. Originality could be achieved with generosity and openness to these various views but not with some anarchistic relativism.

남성 정장류 생산업체의 개별주문생산 실태

김혜수,이경화 대한가정학회 2002 Family and Environment Research Vol.40 No.8

The research of the current situation of made-to-measure production by ready-made men's suit companies was done by interviewing and surveying the made-to-measure specialists. It was apparent that most frequently purchased items in Mass Customization were jackets of formal dress. The results of the research on the current situation of Mass Customization by ready-made clothes companies were as follows. The Mass Customization accounted for 3∼10%. The advantages of Mass Customization were more acceptable sizes, designs and details while the initial reasons for it were unusual physical figures and designs. The posture of a customer during measuring turned out to be critical enough to influence fitness after production. The companies in the research were found out to have materials for Mass Customization in storage and the sizes and other data of fixed circle of customers who would want Mass Customization saved in computer in most of the cases.

뇌수술 시 과호흡과 만니톨의 투여가 뇌혈류와 뇌산소대사에 미치는 영향

김지헌,김경식,문봉기,조경기,신용삼,이영주,김진수 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: There are therapies to lower intracranial pressure (ICP) including head elevation, hyperventilation, diuretics injection, intravenous mannitol, hypothermia, cerebrospinal fluid drainage, and cerebral resection in neurosurgical patients. However in recent reports, hyperventilation followed by mannitol administration may lead to cerebral ischemia. Therefore, we investigated the effect of 0.5-1.0 g/kg mannitol administration on jugular venous oxygen saturation (SjVO_2) and cerebral arterial-jugular venous oxygen content difference (AVDO_2) at PaCO_2 25-30 mmHg and 35-40 mmHg in patients undergoing neurosurgery. Methods: we studied 17 patients undergoing neurosurgery in the Ajou University Hospital. Anesthesia was induced with fentanyl, midazolam, thiopental, and vecuronium, and maintained with )_2-Air-Isoflorane, a continuous infusion of fentanyl, and vecuronium. Patients were divided into two groups. Group 1 (n = 10) which is PaCO_2 25-30 mmHg and Group 2 (n = 7) which is PaCO_2 35-40 mmHg by controlling ventilator. Measurements of SjVO_2 and AVDO_2 in following time intervals: Ⅰ = preinjection of mannitol, Ⅱ = postinjection 20 minutes of mannitol, Ⅲ = postinjection 40 minutes of mannitol were obtainde for each group. 0.5-1.0 g/kg mannitol was administered intravenously just at duramater opening. Results: Hemodynamics and hematologics were not significantly different among the two groups. SjVO_2 of each group are as follows; Group 1; Ⅰ (70.3 ± 8.1%), Ⅱ (66.3 ± 6.9%), Ⅲ (69.1 ± 7.9%) and Group 2; Ⅰ (78.6 ± 7.4%), Ⅱ (75.1 ± 8.1%), Ⅲ (76.0 ± 11.2%), Hyperventilation significantly decreased SjVO_2- AVDO_2 was not significantly different but SjVO_2 in Ⅱ was significantly decreased compared with Ⅰ and Ⅲ in Group 1 (20% patients). Conclusions: Mannitol produced a change of SjVO_2 during hyterventilation. Therefore, intravenous mannitol during hyperventilation should be given cautiously according to the patients status because it may cause cerebral ischemia in critical patients. (Korean J Anesthediol 2002; 43: 462~467)

PVdF-HFP를 이용한 전기이중층 커패시터에서 폴리피롤의 첨가 효과

김경민,강안수 한국공업화학회 2004 공업화학 Vol.15 No.1

단일 결합제 poly(vinylidenefluoride-co-hexafluoropropylene) (PVdF-HFP)를 분산매 n-methyl-2-pyrrolidinone (NMP)에 용해시킨 후 화학 중합법에 의하여 합성된 폴리피롤(polypyrrole, Ppy)과 활성탄을 배합하여 슬러리 상태의 활성물질로 전극을 제조하였다. 단위셀의 충ㆍ방전 특성, 등가직렬저항(equivalent series resistance, ESR), 비정전용량(specific capacitance), 에너지밀도, cyclic voltammetry (CV) 및 임피던스(impedance) 특성 등의 전기화학적 특성을 측정하였다. 결합제를 5 wt%로 고정하였을 때 우수한 전기화학적 특성을 갖는 전극을 제조하기 위하여 Ppy의 무게함량이 8 wt% 이내로 첨가하는 것이 적당하였다. 특히 BP-20의 전극에 첨가된 Ppy의 무게함량이 7 wt%일 때 전극의 전기전도도 19.0 S/㎝, 비정전용량 30.88 F/g, ESR (1 ㎑) 1.95 Ω, 에너지밀도 7.25 Wh/㎏ 및 동력밀도 624 W/㎏ 등으로 전기화학특성이 좋았고, 대용량 EDLC (electric double layer capacitor) 전극으로 사용할 수 있다는 것을 확인할 수 있었다. Electrodes were fabricated with activated carbons such as YP-17 and BP-20, conducting polymer of polypyrrole (Ppy) prepared by chemical polymerization in our laboratory and mono hinder of poly(vinylidenefluoride-co-hexafluoropropylene) (PVdF-HFP) in n-methyl-2-pyrolidinone (NMP). Electrochemical characteristics of unit cells such as charge-discharge, equivalent series resistance (ESR), specific capacitance, specific power, cyclic voltammetry(CV) and impedance were measured. It was noted that Ppy should be added within 8 wt.%, in order to fabricate electrode which had excellent electrochemical characteristics with the fixed 5 wt.% of mono binder. Especially, it was ascertained that the BP-20 electrode fabricated from 7 wt.% of Ppy exhibited good electrochemical characteristics with electric conductivity of 19.0 S/cm, specific capacitance of 30.88 F/g, ESR of 1.95 Ω at 1 kHz specific energy of 7.25 Wh/kg and specific power of 624 W/kg, and was compatible with EDLC(electric double layer capacitor) of large capacitance.