복막투석 환자에서 발생한 진균성 복막염의 임상적 특징

오국환,안규리,오윤규,김현리,정우경,김연수,한진석,김진석,김성권,이정상 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

목 적: 진균성 복막염은 지속적 외래 복막투석 환자의 이환율과 사망률을 증가시키는 중요한 질환이다. 저자들은 복막투석 환자에서 발생한 진균성 복막염의 원인 진균과 임상상, 치료 방법 및 결과 등을 살펴보고 동일한 기간에 발생한 세균성 복막염의 임상상과 비교 분석함으로써 진균성 복막염의 예방과 치료에 도움을 얻고자 하였다. 방 법: 1991년 1월부터 1999년 12월까지 서울대학교병원에서 복막투석을 시작한 환자 총376명 중 이 기간 동안에 진균성 복막염으로 진단 받은 환자 14명(총 15예)을 후향적으로 분석하였다. 결 과 : 대상 환자들의 평균 연령은 53.7±11.6세(이하 평균±표준편차)이었으며, 남·녀비는12 : 3이었다. 진균성 복막염을 진단 받은 당시까지의 복막투석 기간은 29.2±27.7개월이었다. 원인균은 Candida species가 10예(62.5%)로 가장 많았으며, Aspergillus 2예, Cryptococcus 1예, Penicillium 1예, Torulopsis 1예, Trichosporon beigelii 1예 등이었다. 5예에서 진균과 아울러 세균의 중복 감염이 확인되었다. 발병 당시의 증상은 일반적으로 알려진 세균성 복막염의증상과 유사하였다. 진균성 복막염 환자에서 복막투석 도관은 모두 제거하였으며, amphotericin B, fluconazole, flucytosine 등을 단독 혹은 병합 투여하였다. 질병의 경과 중에 4예(26.7%)에서 장폐색 또는 복막 유착이 합병되었다. 치료 결과로는, 완치 후 도관 재삽입 후 복막 투석을 지속한 경우가 3예(20%), 혈액투석으로 전환한 경우가 9예(60%)이었고, 3예(20%)는 진균성 복막염으로 인하여 사망하였다. 원인 진균이 Candida species인 환자군과 나머지 군에 있어서 사망률에 차이가 있었으나(33.3% vs 0%) 통계적으로 유의하지는 않았다(p=0.11). 투여한 항진균제의 종류에 따른 사망률의 차이는 없었다. 동일한 기간에 발생한 세균성 복막염과 진균성 복막염 환자들의 특성을 비교해 볼 때 도관 제거율과 기술적 실패율은 진균성 복막염에서 유의하게 더 높았다. 결 론 : 진균성 복막염은 드물게 발생하지만 일반적으로 알려진 세균성 복막염의 사망률보다 더 높은 사망률과 복막투석 중단의 원인이 되는 심각한 질환으로서, Candida species가 가장 흔한 원인균이었다. Purpose : Fungal peritonitis is a fatal disease with a high mortality and morbidity to the peritoneal dialysis(PD) patients. This study was implemented to provide a guideline for the prevention and treatment of fungal peritonitis in PD patients by analyzing the clinical and microbiologic features of fungal peritonitis cases. Methods : We analyzed retrospectively into the 15 cases(14 patients) of fungal peritonitis among 376 end stage renal disease(ESRD) patients who newly started PD in the Seoul National University Hospital from Jan. 1991 to Dec. 1999. Results : The patients' age was 53.6±11.6 years (mean±standard deviation) and their male to female ratio was 12:3. They have been on PD for 29.2±27.7 months before the fungal peritonitis developed. Candida species was the most common etiologic agent, accounting for 10(62.5%) out of the 16 fungal organisms isolated from our patients. Among others were two Aspergillus, one Cryptococcus, one Penicillium, one Torulopsis, and one Trichosporon beigelii cases. Bacterial agents were isolated simultaneously in five fungal peritonitis cases. Peritoneal catheters were all removed no later than 72 hours after the diagnosis was made. Patients were given a single or combined therapy with amphotericin B, fluconazole, or flucytosine on the physician's choice. The outcomes of fungal peritonitis were as follows; 20% continued PD, 60% converted to HD and 20% died of fungal peritonitis. We made a comparative analysis between the fungal and bacterial peritonitis cases which developed in the same 5-year period, which showed significantly higher catheter removal and technique failure rates in the fungal cases. Conclusion : Fungal peritonitis is a rare but a fatal disease with a high mortality and a technique failure rate. Candida species was the most prevalent microorganism in our study. (Korean J Nephrol 2002;21(2):303-311)

培養鷄胚筋細胞分化에 미치는 細胞融合促進物質의 영향

朴映淳,朴鍾君,金賢玉,金鍾鎬,李東燁,金完柱 圓光大學校 1988 論文集 Vol.22 No.2

培養鷄胚筋細胸 分化에 미치는 促進物質의 영향을 알아보고자 2가양이온 (Ca2+, Mg2+) 胸胚抽出物 (EE), polyethylene glycol (PEG), 再生中인 도마뱀 (Lacertilia)꼬리 추출물 (BE)을 처리하여 細胸融合指數를 비교 조사하였다. 정상배양시의 細胸融合指數는 배양시작 70 시간에 최대에 달했으며 더이상 증가하지 않았고, Ca2+와 Mg2+ 처리할 경우에는 농도가 증가할수록 細胸融合指數는 저하되고, 근세포의 굵기도 정상세포보다 가늘고 핵이 모여있었다. Polyethylene Glycol (PEG)와 Blastemata Extract (BE) 처리군에서는 대조구와 큰 차이가 없는 것으로 나타났다. 鷄胚抽出物 (EE) 을 筋細胞分化에 필수적이나 과량으로 添加시에는 細胞融合은 억제되고 세포수는 증가되는것으로 나타났다. To study the effects of promoting factors on the differentiation of muscle cells, chick embryonic myoblasts were cultured with divalent cations (Ca2+, Mg2+) Chick embryo extract (EE), Polyethylene Glycol (PEG) and Blastema extract of Lacertilia (BE). Fusion index and Growth ratio were measured at various culture time. The fusion index of normal myoblast culture was reached maximum at 70 hours and the divalent cations (Ca2+, Mg2+) treated groups were decreased at higher concentration. The cellular formation of myoblasts treated with divalent cations was thiner and more aggregated between nuclei than that of normal myoblasts calture was. When polyethylene glycol (PEG) and Blastema extract of Lacertilia (BE) were treated to the myoblasts, tha fusion indices were similar to the control. Embryo Extract (EE) was seemed to be necessary for the fusion of chick embryonic myoblasts in culture, however, when excess of EE was added the fusion index was decreased and the number of cells was increased.

그레이브스병에서 방사성 요오드 치료에 따른 갑상선 자극 호르몬 수용체 결합억제 면역글로불린(Thyrotropin Binding Inhibitory Immunoglobulin, TBII)의 변화

조영석,권기현,이준철,나소영,이효진,홍우정,이유선,김군순,송민호,김영건,노흥규 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Prediction of thrapeutic response to radioiodine in Graves' disease is poorly understood. Although thyrotropin binding inhibitor immunoglobulin(TBII) level is a strong index for relapse after antithyroid drug medication, conflicting results are reported regarding its prognostic significance in Graves' disease treated with RAI. This study is dengned to evaluate possible relationship between post-treatment hypothyroidism and TBII in Graves' disease treated with RAI. Fourty two patient with Graves' disease after radioiodine treatment were studied retrospectively. The subject were divided into hypothyroid group and euthyroid or hyperthyroid group. We evaluated the association of hypothyroidism and TBII with radioiodine treatment dose. The mean age of hypothyroid group was 48±11 years and euthyroid or hyperthyroid group was 47±12 years. There was no difference in two groups. And there was no significant difference in post- treatment TBII between two groups(49.9±28.5%, 29.9±14.3%, p-value >0.05). The treatment-dose had no influence on post-treatment thyroid state. Euthyroid or hyperthyroid group was done with 13.6±6.9mCi and hypothyroid group was 17.0±10.4mCi(p-value > 0.05). TBII had no prognostic significance on long-term hypothyrodism in Graves' disease treated with radioiodine. And, treatment-dose had no influence on post-treatment thyroid state.

유 무산소성 운동종목선수들의 혈중지질, 호흡순환기능 및 신체구성성분의 비교

김종원,김태운,고기준,이재규,최재현,신군수 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

The purpose of this study was to compare and analyze the difference on blood constituents, cardiorespiratory function and body composition between runners and swimmers. All data were collected on 7 university runners(average 20 years) and 7 university swimmers(average 20 years).....

Guillain-Barre 증후군과 뇌경색 양상을 보인 신경정신 루푸스

김현승 ( Hyun Seung Kim ),이승찬 ( Seung Chan Lee ),홍현일 ( Hyun Il Hong ),한군희 ( Koon Hee Han ),이순금 ( Soon Keum Lee ),김성수 ( Sung Soo Kim ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4

Systemic lupus erythematosus (SLE) is a disease of unknown etiology in which tissues and cells damaged by pathogenic autoantibodies and immune complexes. Nervous system involvement in patients with SLE encompasses a wide spectrum of neurologic and psychiatric features and the frequency of neuropsychiatric manifestations has been estimated at around 25% to 70%. American College of Rheumatology Ad Hoc Committee on neuropsychiatric lupus nomenclature developed case definitions for 19 different neuropsychiatric manifestations observed in SLE in 1999. Among them, Guillain-Barre syndrome and cerebral infarction are very rare neuropsychiatric manifestation. We experienced a 28-year-old woman with neuropsychiatric lupus which presented as Guillain-Barre syndrome and cerebral infarction. She was recovered after treatment with intravenous immunoglobulin, high dose methylprednisolone, cyclophosphamide and anticoagulants.

한국산과 중국산 藁本중 정유성분의 정성·정량에 관한 연구

박호군(Ho-Koon Park),이상인(Sang-In Lee),이선현(Sun-Hyun Lee),박현미(Hyun-Mee Park),이재성(Jae-Seong Rhee) 한국식품과학회 1997 한국식품과학회지 Vol.29 No.2

Pathological and oncological features of Korean prostate cancer patients eligible for active surveillance: analysis from the K-CaP registry

Koo, Kyo Chul,Lee, Kwang Suk,Jeong, Jae Yong,Choi, In Young,Lee, Ji Youl,Hong, Jun Hyuk,Kim, Choung-Soo,Lee, Hyun Moo,Hong, Sung Kyu,Byun, Seok-Soo,Lee, Seung Hwan,Rha, Koon Ho,Chung, Byung Ha Foundation of Clinical Oncology 2017 Japanese journal of clinical oncology Vol.47 No.10

Effects of age and comorbidity on survival vary according to risk grouping among patients with prostate cancer treated using radical prostatectomy : A retrospective competing-risk analysis from the K-CaP registry

Hah, Yoon Soo,Lee, Kwang Suk,Choi, In Young,Lee, Ji Youl,Hong, Jun Hyuk,Kim, Choung-Soo,Lee, Hyun Moo,Hong, Sung Kyu,Byun, Seok-Soo,Lee, Seung Hwan,Rha, Koon Ho,Chung, Byung Ha,Koo, Kyo Chul Williams & Wilkins Co 2018 Medicine Vol.97 No.42

<P><B>Abstract</B></P><P>A multicenter Korean Prostate Cancer Database (K-CaP) has been established to provide information regarding Korean patients with prostate cancer (PCa). We used the K-CaP registry to investigate the value of age and comorbidity for predicting cancer-specific mortality (CSM) and other-cause mortality (OCM) according to risk grouping.</P><P>The K-CaP registry includes 2253 patients who underwent radical prostatectomy (RP) between May 2001 and April 2013 at 5 institutions. Preoperative clinicopathologic data were collected and stratified according to the National Comprehensive Cancer Network risk criteria. Survival was evaluated using Gray's modified log-rank test according to risk category, age (<70 years vs ≥70 years), and Charlson comorbidity index (CCI) (0 vs ≥1).</P><P>The median follow-up was 55.0 months (interquartile range: 42.0–70.0 months). Competing-risk regression analysis revealed that, independent of CCI, ≥70-year-old high-risk patients had significantly greater CSM than <70-year-old high-risk patients (<I>P</I> = .019). However, <70-year-old high-risk patients with a CCI of ≥1 had similar CSM relative to ≥70-year-old patients. Survival was not affected by age or CCI among low-risk or intermediate-risk patients. Multivariate analysis revealed that a CCI of ≥1 was independently associated with a higher risk of CSM (<I>P</I> = .003), while an age of ≥70 years was independently associated with a higher risk of OCM (<I>P</I> = .005).</P><P>Age and comorbidity were associated with survival after RP among patients with high-risk PCa, although these associations were not observed among low-risk or intermediate-risk patients. Therefore, older patients with high-risk diseases and greater comorbidity may require alternative multidisciplinary treatment.</P>

황금(黃芩)의 4-VO로 유발한 흰쥐뇌허혈에 대한 신경방어효과

李秉哲,林康鉉,金榮玉,金善礪,安德均,朴虎君,金護哲 대한본초학회 1999 大韓本草學會誌 Vol.14 No.2

Scutellariae Radix(SR), the root of Scutellaria baicalensis G_EORGI, whose property, flavour and channel tropism is bitter in flavour, cold in property(寒), acting on the lung, gallbladder, stomach and large intestine channels(歸?,?,?,大??), has the effects of clearing away heat and dampness(淸熱??), purging fire, detoxicating(?火解?), stopping bleeding(止血) and preventing miscarriage(安?). This drug is one of the popular drugs in traditional Korean medicine, which has been used to antipyretic, antibacterial, antitoxic and antihypersensitive effects. So this study was planned to check the neuroprotective effect of SR on the global ischemia induced by 4-vessel occlusion in Wister rats. and SR extract was lyophilized after extraction with 70% methanol. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. The result obtained that in 4-VO ischemia, SR showed significantly neuroprotective effects(1,000 and 500 ㎎/㎏ of SR extracts, p<0.05) compared with control group. Each neuroprotective ratio was about 27.4 %, 23.2 % respectively. Consequently, Scutellariae Radix has neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats.

A Procedure for Statistical Thermal Margin Analysis Using Response Surface Method and Monte Carlo Technique

Hyun Koon Kim,Young Whan Lee,Tae Woon Kim,Soon Heung Chang Korean Nuclear Society 1986 Nuclear Engineering and Technology Vol.18 No.1

경수로심의 열 여유도를 분석하기 위하여 반응표면 및 Monte Carlo 방법을 이용하는 통계적 분석 방법이 제시되었다. 통계적인 열 여유도 분석 방법은 입력변수들의 불확실도를 확률론적으로 처리함으로써 열 여유도의 최적 평가를 수행한다. 이 방법은 원자력 1호기 정상상태의 원자로심 분석에 응용되었으며 또한 종래의 결정론적 방법 및 웨스팅하우스의 개선된 열설계 방법과도 비교되었다. 본 연구를 통하여 반응표면 분석 방법은 통계적인 열 여유도 분석에 유용함을 알 수 있었으며, 이 방법을 통한 열 여유도의 증가도 확인되었다. A statistical procedure, which uses response surface method and Monte Carlo simulation technique, is proposed for analyzing the thermal margin of light water reactor core. The statistical thermal margin analysis method performs the best.estimate thermal margin evaluation by the probabilistic treatment of uncertainties of input parameters. This methodology is applied to KNU-1 core thermal margin analysis under the steady state nominal operating condition. Also discussed are the comparisons with conventional deterministic method and Improved Thermal Design Procedure of Westinghouse. It is deduced from this study that the response surface method is useful for performing the statistical thermal margin analysis and that thermal margin improvement is assured through this procedure.