결핵 치료 중 발생한 부작용으로 약제 변경한 환자들에 대한 임상적 고찰

김호철,김호철,김이형,송재욱,고원중,전경만,송준휘,류연주,김우열,권용수,최재철,박소영 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

목적: 일차 항결핵제 치료 중 부작용으로 약제변경을 한 환자들의 임상적 특성과 치료 경과에 대하여 알아보고자 하였다. 방법: 2009년 1월부터 12월까지 국내 10개 병원에서 일차 항결핵제 치료를 시작한 환자들 중에서 부작용으로 인해 약제를 변경한 환자들을 대상으로 변경 원인과 임상적 특성, 치료경과에 대하여 후향적으로 조사하였다. 결과: 일차 항결핵제치료를 시작한 환자는 총 2,601명이었고, 남자는 1438명(55.3%), 평균나이는 49.8±19.1세였다. 이 환자들 중 부작용으로 약제 변경한 환자는 230명(8.8%)이었고 남자는 116명(50.4%)이었고, 평균나이는 50.9±19.6세였다. 발생한 부작용으로는 간독성이 99명(43.0%)으로 가장 많았고 피부 이상반응은 63명(27.4%), 위장관 증상 46명(20.0%), 시력장애 31명(13.5%), 발열 23명(10.0%%), 백혈구 또는 혈소판감소증 15명(6.5%) 신기능장애 8명(3.5%), 손발저림 5명(2.2%) 순이었다. 나이, 체질량지수는 관련이 없었고, 당뇨(19%, p=0.02), 만성간질환(9%, p=<0.001) 및 폐외결핵(40%, p=0.047)이 약제부작용 발생과 관련이 있었다. 치료기간은 평균 294.5±189.7일로 더 길었으나 최종 치료성적과 재발여부에는 차이가 없었다. 결론: 일차 항결핵제 치료를 받는 환자들 중에서 기저질환으로 당뇨, 만성간질환이 있거나, 폐외결핵의 환자들에서 약제 부작용이 더 많았고 이로 인해 약제변경이 필요하였다. 그러나 약제를 변경한 경우에도 치료 성적에는 큰 차이가 없었다.

經營計劃의 長期的 樹立에 對한 經營學的 考察

김호철 전주대학교 산업경영연구소 1985 産經論叢 Vol.- No.3

環境破壞와 社會的費用

金浩喆 東國大學校 1976 論文集 Vol.15 No.-

As the environmental disruption is a result of the complex process of the various elements, social and material, no single branch of the traditional learning, including economics, can cope with the problem successfully by itself. However, economics should play the important role in the problem, and thus, we see recent development of the Public Economics. To cope with the problem; ⅰ. we should determine the scope in which the disruption should be allowed and it is desirable if the disruption continues beyond the scope, to decide to limit the production. The limitation of production prevents the waste of resources, which is related to the proper allocation of the resources. ⅱ. for the new investment, there should be a comparision between social facilities (or conveniences) and social costs with such methods as PPBS. ⅲ. the problem of distribution should be examined. The disruption problem could not be solved completedy with those determination and comparison alone, however perfect they may be. The soultion is possible with the cooperation of the individual citizens. While those with the upper income can cope with the problem effectively, those with the lower income have much difficulty in moving to the pollution-free area of installing the facilities for the prevention of pollution. Therefore the relative equality of distribution is necessary to cope with the problem effectively. iiii. international cooperation is required when the disruption is no longer limited within the boundary of a nation.

設備 投資案의 經濟性 計算法에 關한 考察 : 動的設備投資計算法을 中心으로

金鎬喆 전주대학교 1974 論文集 Vol.1974 No.-

團體交涉과 勞使協議制의 關聯性에 대한 實質的 硏究

金鎬喆 전주대학교 산업경영연구소 1990 産經論叢 Vol.- No.7

원발성 담즙성 간경변증 1례

김호철,장윤식,이연재,이상혁,설상영,정정명,최하진,양영일 인제대학교 1996 仁濟醫學 Vol.17 No.2

원발성 담즙성 간경변증은 원인 미상의 담즙정체 질환으로 만성적인 간내 담관의 염증을 보이면서 간경변증으로 진행하는 드문 질환이다. 저자들은 황달과 소양증을 주소로 내원한 55세의 여자 환자에서 원발성 담즙성 간경변증 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Primary biliary cirrhosis is rare and a disease of unknown origin. It is a chronic cholestatic liver disease characterized by the presence of chronic inflammation, necrosis of hepatic bile duct and progression to liver crirhosis. We experienced a 55 year- old woman complained of jaundice and itching for 3 years. Her clinical symptoms, biochemistry, liver function test and liver biopsy were compatible with primary biliary cirrhosis. Thus we report a case of primary biliary cirrhosis with literature review.

先進國 景氣變東의 性格的 變化와 低開發國 및 韓國이 받은 영향

金浩喆 동국대학교 경영관리연구소 1975 經營經濟論叢 Vol.2 No.-

셀룰러 무선 통신망에서 슬롯 ALOHA 성능분석 ( Performance Evaluation of Slotted-ALOHA in Cellular Radio Mobile Networks )

김호철,곽경섭 대한전자공학회 1995 대한전자공학회 학술대회 Vol.1995 No.7

B형 만성 간질환 환자에서 HBV core promoter 변이에 대한 고찰

김호철,이연재,장윤식,이상혁,설상영,박영흥,정정명 인제대학교 2000 仁濟醫學 Vol.21 No.1

Objectives: Chronic hepatitis B virus(HBV) infection may cause various kinds of liver disease. The pathophysiologic mechanisms of such clinical manifestations are still not clearly understood. According to the recent reports, mutations in the HBV core promoter may have an impact on the progression of HBV-related liver disease. The aim of this study was to clarify the frequency and location of naturally occurring mutations in the core promoter region of HBV, and their possible effects on the clinical course of HBV -associated chronic liver diseases. Methods: and Materials: HBV DNA was extracted from the sera of 31 patients who had been HBsAg positive for more than 6 months. The core promoter/precore sequence was amplified via polymerase chain reaction, and direct sequenced. And in this study. 31 patients were divided into 3 groups according to the histopathological severity of liver disease i.e. Group 1 as minimal change and chronic persistent hepatitis, Group 2 as chronic active and lobular hepatitis, Group 3 as liver cirrhosis and hepatocellular carcinoma, respectively. Results: 1.Frequent mutated nucleotides(nt) were 1764(77.4%), 1762(58.1%) and 1753 (25.8%). 2.A double-nucleotide mutation at nt1762 and nt1764 (M1) was observed in 18 cases of 31 patients(58.1%), a single-nucleotide mutation at nt1764(M2) in 5 cases. But a single-nucleotide mutation at nt1753 or nt1762 were not observed at all. 3.M1 had nothing to do with the severity of hepatitis. In case of M2. there was association with severity of hepatitis only in comparisons among Group 2 vs. Group 3(p<0.05) 4.The frequency of mutation in core promoter region had little association with the status of HBeAg/Anti-HBe. 5.The frequency of mutation at nt1896(G→A) in precore region was related with status of HBeAg/Anti-HBe(p<0.01) rather than the severity of disease. Conclusion: We could not find the definite relationship between core promoter mutation and the histopathologic severity of HBV associated liver disease. Further investigations are needed with larger number of patients.

F-6 : Free Paper Presentation ; Characteristics of Undifferentiated Connective Tissue Disease Lung Involvement

김호철,지원준,김미영,장세진,이창근,한승봉,( Homas V Colby ),김동순 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

Introduction: Undifferentiated connective tissue disease (UCTD) defined as conditions characterised by the presence of signs and symptoms suggestive of connective tissue disease (CTD) with autoantibody but do not fulfill classification criteria of specific CTD. Although NSIP pattern was first described in UCTD, UIP pattern seems to be not infrequent, and then the differentiation from idiopathic pulmonary fibrosis may be difficult. The aim of this study was to investigate the frequency and prognosis of UIP and NSIP pattern in UCTD and prognostic difference between UCTD-UIP and IPF. Methods: The medical records including rheumatologic symptoms and serologic test for autoantibody of 788 patients diagnosed as IIP from January 2005 to December 2012 at AMC were retrospectively reviewed. UCTD was diagnosed according to narrow criteria and the prognosis was compared between UCTD-UIP and UCTD-NSIP and also between UCTD-UIP and IPF. Results: Total 105 patients (13.3%) diagnosed as UCTD and 44 patients had UIP pattern and 29 patients had NSIP pattern, 8 OP patterns and the pathologic pattern was not specified in remaining 24 patients. Overall survival of UCTD-UIP group was shorter than UCTD-NSIP group (p=0.021) but significantly better than that of IPF group(p=0.042). Definite CTD developed in 2.9% (3/105) of patients during follow-up days. Conclusion: UIP pattern is frequent in UCTD related interstitial pneumonia and the prognosis was worse than UCTD-NSIP. However, the prognosis of UCTD-UIP was better than IPF, it is important to search for UCTD in suspected IPF.Introduction: Undifferentiated connective tissue disease (UCTD) defined as conditions characterised by the presence of signs and symptoms suggestive of connective tissue disease (CTD) with autoantibody but do not fulfill classification criteria of specific CTD. Although NSIP pattern was first described in UCTD, UIP pattern seems to be not infrequent, and then the differentiation from idiopathic pulmonary fibrosis may be difficult. The aim of this study was to investigate the frequency and prognosis of UIP and NSIP pattern in UCTD and prognostic difference between UCTD-UIP and IPF. Methods: The medical records including rheumatologic symptoms and serologic test for autoantibody of 788 patients diagnosed as IIP from January 2005 to December 2012 at AMC were retrospectively reviewed. UCTD was diagnosed according to narrow criteria and the prognosis was compared between UCTD-UIP and UCTD-NSIP and also between UCTD-UIP and IPF. Results: Total 105 patients (13.3%) diagnosed as UCTD and 44 patients had UIP pattern and 29 patients had NSIP pattern, 8 OP patterns and the pathologic pattern was not specified in remaining 24 patients. Overall survival of UCTD-UIP group was shorter than UCTD-NSIP group (p=0.021) but significantly better than that of IPF group(p=0.042). Definite CTD developed in 2.9% (3/105) of patients during follow-up days. Conclusion: UIP pattern is frequent in UCTD related interstitial pneumonia and the prognosis was worse than UCTD-NSIP. However, the prognosis of UCTD-UIP was better than IPF, it is important to search for UCTD in suspected IPF.