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Lim, JE,Lee, SJ,Kim, YJ,Lim, WH,Chun, YS Blackwell Publishing Ltd 2009 Orthodontics & craniofacial research Vol.12 No.4
<P>Structured Abstract</P><P>Authors – </P><P>Lim JE, Lee SJ, Kim YJ, Lim WH, Chun YS</P><P>Objectives – </P><P>To compare maxillary and mandibular cortical bone thickness and rootic proximity for optimal mini-implant placement.</P><P>Setting and Sample Population – </P><P>CT images from 14 men and 14 women were used to evaluate buccal interradicular cortical bone thickness and root proximity from mesial of the central incisor to the 2nd molar. Cortical bone thickness was measured at 0°, 15°, 30°, and 45° angles relative to the root surface using three-dimensional images.</P><P>Results – </P><P>For the cortical bone thickness, there was no statistically significant difference between the maxilla and the mandible in the anterior area; however, there was a significant difference in the posterior area. Cortical bone in the maxilla, mesial and distal to canine interradicular sites, was thickest while thickness in the mandible exhibited a gradual anterior to posterior increase. Cortical bone thickness in the maxilla increased as both level and angle increased, while the cortical bone thickness in the mandible was greatest at 4 mm from the alveolar crest. Root proximity mesial and distal to 2nd premolar interradicular sites was greatest.</P><P>Conclusion – </P><P>Based on our results, cortical bone thickness depends on the interradicular site rather than sex or individual differences.</P>
자궁경부암 세포주들에서 리포좀을 이용한 종양억제 유전자 [pRcCMVp53/liposome]의 직접 이입법에 의한 세포 성장 억제 효과
김승조,이헌영,남궁성은,김수평,이준모,안웅식,김종국,박순희,박용석,김진철,한유진,양재명,신봉영,서상용,김동재 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.4
목적: 자궁경부암 유전자 치료를 위하여 자궁경부암 세포주들에 리포좀을 이용한 종양억제 유전자[wild-type p53 gene]의 직접 이입을 통하여 세포성장 억제효과를 보고자 하였다. 방법: 자궁암세포주들 [CaSki, SiHa, HeLa, HeLaS3, C33A, HT3]을 12 well에 104, 96 well에 5×103의 수로 triplicate를 형성한 뒤 대조군, pRcCMVp53, lipofectin, pRcCMV/lipofectin, pRcCMVp53/lipofetin이 함유되있는 것 을 각기 12 well에 20 ㎕씩 96 well에는 10 ㎕씩을 투여한 다음 7일간 배양하였다. 세포수 측정, ELISA [neutral red] assay, MTT등을 이용하여 세포성장과 cell viability를 측정하고 이를 one-way ANOVA F-test, multiple comparison Tukey method에 의해 날짜별 서로 군의 차이를 비교 하였다. 결과: p53 유전자에 의한 자궁경부암 세포주의 성장억제를 확인하기 위하여 세포 수 측정, ELISA assay, MTT assay를 시행하였으며 각각의 assay에 대한 측정 마지막날인 6일째를 기준으로 정상대조군 세포와 비교한 결과 세 포수 측정에서는 CaSki[89%], SiHa[59.2%], HeLa[86%], HeLaS3[78%], C33A[91%] 그리고 HT3[74%] 성장억제를 나타냈다. 또한 Neutral red를 이용한 세포 viability assay 에서는 CaSki[70%], SiHa[93%], HeLa[73%], HeLaS3[50%], C33A[67%] 그리고 HT3[52%]에서 는 52%의 세포감소를 보여주었다. MTT assay를 통한 각각의 자궁경부암 세포주의 세포성장억제 결과는 CaSki[38%], SiHa[72%], HeLa[53%], HeLaS3[28%], C33A[33%]그리고 HT3[53%]였다. 결론: 자궁경부암 세포주에 직접 이입법을 통한 유전자 전달 후 세포성장 억제는 매우 유익하게 감소되었으며 이와같은 결과는 향후 유전자 직접 이입법에 의한 자궁경부암 환자에 있어서 유전자 치료를 실시할 수 있는 새로운 장으 로 생각이 되어진다. Purpose: We investigated cell growth inhibitory effect of the wild type p53 gene into the cervical cancer cells via the recombinant p53 plasmid, pRcCMVp53 with lipofectin. Method: Inhibition of the growth of cervical cells as determined by a cell count assay. The cells were inoculated at density of 104 cells/well in each 12 well plate, 24 hrs before infection. At each indicated point, cells in three wells on each well plate were trypsinized and counted. The mean cell counts of triplicated well after transfection at day 1~6 was checked. Inhibition of the growth of cervical cells were checked by ELISA assay, MTT assay. The cells inoculated at densities of 5×103/well in each 96 plate 24 hrs before infection. At each indicated point cells of three wells were transfected for 6 days, harvested and counted by liquid scintillation counter the mean cpm per triplicate wells were plated for ELISA and MTT assay. One-way ANOVA F-test and multiple comparison Tukey method was used for statistical analysis. Result: Inhibition of the growth of cervical cells in cell count showed CaSki[89%], SiHa[59.2%], HeLa[86%], HeLaS3[78%], C33A[91%] and HT3[74%]. ELISA assay showed CaSki[70%], SiHa[53%], HeLa[73%], HeLaS3[50%], C33A[67%] and HT3[73%]. MTT assay showed HeLa[33%], HeLaS3[28%], SiHa[75%], CaSki[38%], C33A[33%] and HT3[53%]. Conclusion: These results indicate that transfection of cervical cancer cells with the wild type p53 gene via pRcCMVp53 with lipofectin is a potential novel approach to the gene therapy of cervical cancer.
김영수(YS Kim),김재욱(JU Kim),최영실(YS Chey) 대한산부인과학회 1972 Obstetrics & Gynecology Science Vol.15 No.5
병리조직학적으로 확진된 자궁경임신 5례를 치험하였기에 문헌적인 고찰과 아울러 보고하는 바이다. 본증의 경우 5례가 모두 인공임신중절수술을 받은 기왕력을 가지고 있으므로 경관임신의 성인과 관련있을 것으로 사료된다. 임신초기에 수술시 혹은 그 전후에 의심스러운 출혈이 있을시 본증을 고려해 봄이 의의가 있다고 본다. Five cases of pregnancy during a year, 1971 are presented with a brief review of literatures and have been analysed for gravity, abortion, parity, treatment, duration of gestation, and proved completely to be cervical pregnancy. Previous history of artificial termination of pregnancy may be one of the etiological factors since all the cases presented have had artificial termination at least two or more. Itis important to consider cervical pregnancy whenever there is any uneventful bleeding in early pregnancy and or during and after curettage.
김영식(YS Kim),김두표(DP Kim),김병언(BE Kim),유석권(SK Yoo),황익하(IH Whang) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.8
인천 기독병원 산부인과에서 복강경 불임시술 후에 발생한 흔적자궁임신 1례를 체험하였기에 간단한 문헌 고찰과 함께 보고하는 바이다. A case of spontaneous rupture of rudimentary uterine horn wiht 5month gestation after laparoscopic sterilization which was diagnosed as a intra-abdominal pregnancy is presented ad some articles concerned to this subjent are reviewed briefly.
김영수(YS Kim),김정록(CR Kim),김재욱(JU Kim),호삼수(SS Hoh) 대한산부인과학회 1969 Obstetrics & Gynecology Science Vol.12 No.3
B.C.S. 28-year old Korea women, paraii, gravidaiii, was admitted because of hydromnios and no fetal movement of approximately 10 day at 7 months` pregnancy. Labor was induced with artificial menbrane rupture and I.V.P. The stilborn fetus was anencephalus with two mouthes. Autopsy The body weight was 1,150 gm.
김태일(TI Kim),박용해(YH Park),김주병(JB Kim),김연신(YS Kim),정호순(HS Chung),김상철(SC Kim) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.15
최근 본원에서 태아와 동반하였던 부분포상기태 1예를 경험하였기에 약간의 문헌적 고찰과 함께 보고하는 바이다. A case of hydatidiform mole with coexistent fetus, and extremely rare condition, is reported. It was unsuspected until the vaginal bleeding had been done at the 12th weak of pregnancy. A review of literature on the hydatidiform mole with coexistent fetus is made briefly.