퍼지이론을 이용한 구획배치 평가 기법에 관한 연구

김수영,신성철,박준규,박정기 부산대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.58 No.-

본 연구는 선박의 내부 공간에 대한 여러 구획 배치안들 중에서 최적의 배치안을 찾기 위해 배치안들을 평가하는 것을 목적으로 한다. 이런 공간에 대한 구획 배치 고려사항에 영향을 주고 컨트롤하는 두 가지 요소는 기능 구획간의 연관성과 공간이 위치하게 되는 환경이다. 여러 배치안들을 평가하기 위한 단계에서 수식화 하기 어려운 각종 설계 정보 및 이들 간의 상관관계를 파악하고 처리하기 위하여 퍼지 이론을 적용하는 기법을 제안한다. This study is objective to layout evaluation to find an optimal layout of the some compartment layouts in internal spaces of ship. In this compartment layout considerations about spaces, two factors which control and affect are association between functional compartments, and environment that space is located. At level to evaluate some layouts, we suggest method that applies to fuzzy theory to conduct and understand every design informations difficult formulating and their relationship.

栗谷의 思想과 文學 硏究

徐首生,金文基 경북대학교 교육대학원 1982 논문집 Vol.14 No.-

死六臣의 思想과 文學 硏究

徐首生,金文基 慶北大學校 東洋文化硏究所 1979 東洋文化硏究 Vol.6 No.-

Sa Yuk Sin (six great sacrificed loyalists) are a incarnation of loyalty, because they censured immorality of King Se-Jo(世祖) who fled his nephew, King Dan-jong(端宗), and fought for King Dan-Jong's reinstatement. As Baekchon(白村) Kim Mun-Ki(金文起), a great loyalist, was also loyal to his principle and died for his Lord's reinstatement, we must adore him as loyal as Sa Yuk Sin. And so, we may call them Sa Chil Sin(死七臣) (seven great sacrifced loyalists). The characteristics of Sa Chil Sin's thoughts and their literary works are summarized as following. (1) They practiced the principle of loyalty itself, for they died to correct immorality and unjustice. (2) They made effort actively to establish the moral society on the basis of In(仁), the oriental humanism, and the equality of all the people. (3) They sacrificed themselves to preserve their integrity and wished for the peace of their nation than their welfare. (4) The spirits of their loyalty is eminently expressed on their chinese poetry and Sijo(時調). (5) They expressed their minds chiefly with four-to-eight line verses of chinese poetry, especially Sung Sam-Mun and Lee Gae wrote well with Jeolgu(絶句, chinese quatrain), and Park Paeng-Nyeon wrote well with Yulsi(律詩). (6) The subjects of Sijo(時調) written by them are mostly loyalty. And they symbolized the ideas of loyalty by comparative poetic dictions.

대전광역시 양축농가의 축분뇨 관리 실태 및 VOCs 농도 조사

이봉덕,이수기,오홍록,허정민,정기철,김성복 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.1

This study was carried out to investigate the style of livestock house, concentration of malodorous substances of livestock feces and livestock houses in Daejeon area. Among the livestock houses investigated, as most of cow pens(94.5%) have sawdust or chaff on the bottom, there was no leakage of feces out of pen. Most pig pens adopted slury style, but some of them currently use buffering material on the bottom. It is thought that there will be no possible contamination leakage. When it comes to hen house, all the broiler house use litters on the bottom and all the layer house use scrapper. It is also thought that there will be no possible contamination leakage. 3 out of 12 deer pens used buffering material on the bottom, 10 places were maintained in a traditional method, and 7 places left possibility of contamination leakage considering whether the roof was installed or not. The contents of ammonia, amine and volatile fatty acid in fresh feces were lower compared to rotten feces, but the concentration of sulfur-containing matter - hydrogen sulfide, methylmercapthan and ethylmercapthan were higher compared to rotten feces. In the case of malodorous ingredient in livestock houses, only small amount of ammonia and hydrogen sulfide were detected in pig pen and hen house, and other ingredients were not detectable. And those who are engaged in animal husbandry reacted negatively to the use of feed additives for decreasing malodor. In conclusion, it is not worrisome that contamination can be leaked out of animal raising facilities. But if we take into consideration that the point of investigation time is wintry season, there should be more considerate attitude. And feed additives for decreasing malodor need establishing criteria in the manufacturing process.

캔디다균이 분비하는 단백질 분해효소의 순수 분리와 특성 및 교차 항원성

이경호,신운섭,박주영,김수기,박윤선,고춘명 연세대학교 원주의과대학 1995 원주의대논문집 Vol.8 No.1

경량 고강도 Mg-Zn계합금의 조직과 내식성에 관한 연구

안효준,남태현,임수근,안인섭,허보영,김기원 慶尙大學校 1995 論文集 Vol.34 No.1

The purpose in this study is to develope of high strength and corrosion reistant Mg-Zn system alloys by controlling microstructures and by adding of Cu elements. To produce optimum tesile strength,it is imperative to obtain effective grain refinment during casting. Optimal condition for grain size refining effect was obtained at the minmum composotion of 2wt% Cu or 1.5wt%So addition to Mg-6wt%Zn alloy.Age hardening behavior was experimented at the optimal compositions of the Mg-6wt%Zn, Mg-6wt%Zn-2wt%Cu and Mg-6wt%Zn-1.5wt%Si. The hardeness increment due to age hardening was at the Mg-Zn-Si alloy system. The improvement of corrosion resistanece by the addition with Cu is related to and increasing Zn/Cu ration in the intermatallic particles in the Mg-Zn system.Further improvements obtained by T6 treatment are related to the properties of the Mg-Zn phase,whih acts as a corrosion barrier by precipitating along the grainboundaries.Filiform corrosion observed soon after pit initiation and cellular form of pit propagation later in chloride media are explained in terms of solid solution matrix structure and the properties of air formed oxide.The information obtained from the fundamental research work is utilized in suggesting ways of improving the corrosion resistance of commercial AZ91.

Simultaneous detection of Prevotella intermedia and Prevotella nigrescens by 16S rDNA-directed multiplex PCR

Seong, Jin Hyo,Kim, Dong Kie,Shin, Kwang Yong,Kim, Byung Ock,Kim, Myong Soo,Kim, Mi Kwang,Kook, Joong Ki 대한구강보건학회 2002 大韓口腔保健學會誌 Vol.26 No.4

본 연구는 치주질환과 관련된 병원성 세균 중 그람 음성 협기성 세균 종인 Prevorella intermedia (P. intermedia)와 Prevotella nigrescens (P. nigrescens)를 동시에 동정 및 검출할 수 있는 중합효소연쇄반응 프라이머를 개발하기 위하여 시행하였다. 모든 세균 종에 있어서 165 라이보송 RNA의 염기서 열에는 잘 보존된 부위와 종에 따라 다양한 부위가 있다. 이러한 특성을 이용하여 P. nigrescens와 P. intermedia의 알려진 165라이보솜 RNA의 염기서 열을 분석하여 두 세균 종에 공동으로 존재하는 하나의 프라이머와 각각의 세균 종에 특이하게 존재하는 다른 프라이머를 설계 및 제작하였으며, 이때 설계된 프라이머의 이름을 각각 Pin-F, Pi-R 및 Pn-R이라고 명명하였다. 이들의 종 특이성을 조사하기 위해 두 균주의 P. intermedia와 P. nigrescens지놈 DNA를 추출하여, 종 특이성을 중합효소연쇄반응법으로 관찰하였다. 이때 구강 내 6가지 다른 세균 종에서 같은 방법으로 중합효소연쇄반응을 실시한 결과 P. nigrescens와 P. intermedia 두 종만을 특이하게 검출함을 알 수 있었다. 또한 민감도를 조사하기 위해 두 세균 종에서 추출한 지놈 DNA를 4 ng에서 4 fg까지 희석하여 중합효소연쇄반응을 실시한 결과 400 fg의 지놈 DNA까지도 검출할 수 있었다. 이러한 결과를 종합할 때 이들 Pin-F, Pi-R 및 Pn-R프라이머 쌍은 P. inermedia와 P. nigrescens를 동시에 종특이적이며, 민감도 높게 검출 및 동정할 수 있을 것으로 사료된다.

The Growth Inhibitiory Effect of New Pyrrolo[1,2-${\alpha}$]benzimidazole Derivatives on Human Gastric Cancer Cells

Kim, Soo-Kie,Ahn, Chan-Mug,Choi, Sun-Ju,Park, Yoon-Sun,Cho, Hyung-Chul,Koh, Choon-Myung The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.5

In the course of screening synthetic compounds to inhibit tumor cell growth, pyrrolo[1,2-.alpha.] benzimidazole (PBI), an intermediate of azamitosene, was found to inhibit a proliferation of gastric cancer cell lines. Despite a potential cytotoxic activity against solid tumor cells as opposed to that against rapidly-doubled leukemic cells, there has been no report on the inhibition of gastric cancer cell line by PBI and its' derivatives. The present experiment was designed to determine if PBI derivatives can effectively inhibit the cellular proliferation of gastric cancer cells by using in vitro as well as in vivo chemosensitivity system (MTT assay, clonogenic assay and human tumor xenografted assay). Of the tested PBI derivatives, PBI (18) and PBI (20), displayed the effective growth inhibition of cultured gastric cancer cells or even in the xenografted nude mouse model.

관상동맥질환을 동반한 모야모야병 1례

김동기,이영태,김기향,김성만,김대경,김두일,김동수 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Moyamoya disease is an occlusive intracranial arteriopathy with an abnormal cerebral vascular collateral networks. Although this disease is known to be associated with stenosis of extracranial arteries, such as the renal artery, a case associated with stenosis of the coronary artery is extremely rare. We report a case of coronary artery occlusive disease affected by Moyamoya disease. The patient was a 38-year-old female experiencing intermittent headache and exer tional chest pain. Cerebral MRI showed complete obstruction of both internal carotid arteries and abnormal cerebrovascular systems which confirmed Moyamoya disease. Coronary angiography showed a significant stenosis of left anterior descending coronary artery ostium with TIMI grade I collateral blood flow from the normal right coronary artery. After coronary artery stenting and medical treatment for headache, her subjective symptoms were relieved. In Moyamoya patient, an evaluation of the extracranial (especially coronary artery) vascular system should be considered if there are some evidences of coronary artery disease.

Cytotoxic and Apoptotic Activites of Echinomycin Derivative ( Echinomycin-7 ) on P388 Murine Leukemia Cells

Kim, Yoon Suk,Kim, Yong Hae,Kim, Tae Ue,Kim, Sung Su,Kim, Soo Kie,Jeon, Hyang,Park, Yil Sung,Choi, Sun Ju 생화학분자생물학회 2000 BMB Reports Vol.31 No.6

Echinomycin-7 is an echinomycin derivative, Smethylated sulfonium perchlorate of echinomycin. We studied the in vitro cytotoxicity and in vivo antitumor activity of echinomycin-7 against P388 leukemia cells and compared the results with echinomycin. With respect to the cytotoxic effects, echinomycin-7 had cell line-dependent IC_(50) values while echinomycin had similar values to several tumor cell lines. Also, in vivo antitumor activities were observed in tumor-bearing mice treated with both agents, which showed that echinomycin-7 had a broad therapeutic dose range. We also observed the apoptosis on leukemia cells treated with echinomycin-7 which exhibited the ladder pattern of DNA on electrophoresis. In addition to apoptosis, echinomycin-7 arrested G₁/S phases of the cell cycle at the same time. We then examined the signaling pathway of echinomycin-7-induced apoptosis and showed that ERK of the MAP kinase family was activated and translocated into the nucleus by echinomycin-7 stimulation. This study suggests that echinomycin-7 acts as an antitumor agent through in vitro cytotoxicity and has in vivo antitumor activity against leukemia cells, and that the echinomycin-7-induced apoptosis might involve signal transduction via MAP kinases.