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김두일,이연재,신형규,조기정,설상영,정정명 인제대학교 1991 仁濟醫學 Vol.12 No.3
위암의 호발연령은 50∼60대로 알려져 있으나 약년자에서도 위암의 발생빈도가 증가하고 있다. 저자들은 만 7년간 부산백병원 내 과학교실에서 경험한 약년자위암 115례에 대한 임상적 고찰을 하였다. 115 cases of stomach cancer under the age of 35 years, seen in the period 1984 to 1990 are reviewed. The results were as follows 1) The incidence of stomach cancer under 35 years was 7.6% in all gastric malignancies. and male to female ratio was 1:1.3 2) Most of symptoms were nonspecific and epigastric pain was major symptom(89.7%). About 57.8% of the patients visited hospital within 3 months after onset of symptoms, and average duration of symptoms were 7.8months. 3) Physical examination revealed epigastric tenderness, anemia, ascites, and palpable mass in decreasing order of frequency 4) The majority of tumors located in the lesser curvature of body and antrum 5) Endoscopic findings in 91 cases of advanced stomach cancer were type III, type Iv, type II, type I in decreasing order of frequency, and the most common type of early stomach cancer were IIc 6) Histopathologic finding revealed that all cases were adenocarcinoma, and 88.7% (102 cases) showed low grade differention 7) Forty four of 55 cases of operable cancer underwent radical operation for cure
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김두일,천수빈,현인환 대한상하수도학회 2015 상하수도학회지 Vol.29 No.3
Particulate matters in a water distribution system are main causes of turbidity and discoloration of tap water. They could be removed by conventional or uni-directional flushing in a water distribution system. The behaviors and required flow velocity of particles are not well known for their flushing. A model water main and hydrant were made from transparent acrylic pipe of 30mm and 16mm in diameter, respectively. We analyzed the effect of flushing velocity, particle density, and particle diameter. We found that the existence of break-though velocities at which particles begin to be removed, and which are affected by their physical properties. The removal efficiencies seemed to be influenced by resuspension capabilities related to their upward movement from the bottom. Heavy particles like scale were hard to remove through upflow hydrant because the falling velocity, calculated using Stokes’ law, was higher. Particle removal efficiencies of upward hydrant and downward drain showed minor differences. Additionally, the length between hydrant and control valve affected flushing efficiency because the particulate matters were trapped in this space by inertia and recirculating flow.
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흰쥐 심장조직에서 식염부하에 의한 Natriuretic Peptides의 변화에 대한 면역조직화학적 연구
김두일,김동수 인제대학교 1998 仁濟醫學 Vol.19 No.2
Atrial natriuretic peptide(ANP)는 나트륨 이뇨, 이뇨 및 혈관 확장 등의 작용을 가지고 있는 심장 호르몬으로서 체액, 전해질 및 혈압의 항상성을 유지하며, brain natriuretic peptide(BNP) 역시 신경펩티드로서 ANP와 유사한 작용을 가지는 호르몬으로 알려져 있다. 본 연구에서 저자들은 흰쥐에서 식염부하를 시도하여 심장조직에서 면역조직화학염색법으로 ANP와 BNP의 면역반응성의 분포를 조사하여 그것의 활성도 및 반응의 지속 정도를 알아보고, 또한 혈장 삼투질 농도 및 Na+ 농도 변화를 관찰하였다. Objectives: Atrial natriuretic peptide(ANP) is a cardiac hormone with diuretic, natriuretic, and vasorelaxant activities, and it is implicated in the control of blood pressure, body fluid, and cardiovascular homeostasis. Brain natriuretic peptide(BNP) forms a peptide family with ANP and may be involved in the regulation of blood pressure and fluid volume, as is ANP. It has been reported that natriuretic responses are altered by changes in extracellular fluid(ECF) volume. Methods and Materials: To assess the compensatory mechanism of ANP and BNP in response to ECF volume alterations, we examined the distribution of immunohistochemically identified cells for ANP and BNP in the heart tissues of salt-loaded rats using immunohistochemical method and also investigated the process, activity, maintenance of reaction during salt intake. In addition, plasma osmolality, plasma sodium concentration were measured in association with changes in salt intake. Results: 1. Plasma osmolality increased wish advancing salt intake, but plasma sodium concentration was greater than the comparable values in the control group at the third day of salt intake. 2. The distribution of ANP-immunoreactivity in the heart was wider in the right atrial tissue. The ANP-immunoreactivity was more intense in right aerial tissue, interventricular septum and coronary sinus at the third day of salt intake and became weaker from the seventh day of salt intake. The BNP-immunoreactivity in the heart tissue was observed a group of many immunopositive cells in right atrial tissue, left ventricular tissue, interventricular septum at the fifth day of salt intake. Thereafter it was decreased gradually and seemed to be exhausted from the tenth day of salt intake. Conclusion: ANP and BNP are factors that maintain the homeostatic balance of body fluid during salt intake. However further investigation on these plasma levels, receptor binding, and biological activity is required to exactly understand its participation and importance in the natriuretic peptides hormonal system.
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