자궁내막암 환자에서 복강경하 자궁적출술과 복식 자궁적출술의 비교 연구

김종혁,이상수,김천복,김대연,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

목적 : 자궁내막암 환자에서 시행된 복강경 수술의 임상적 결과를 평가하고 수술적 지표 및 재발률에 대하여 기존의 개복 수술과 비교하고자 하였다. 연구 방법 : 1997년 8월부터 2003년 11월까지 저자들은 임상적 병기 I기인 79명의 자궁내막암 환자에서 복강경하 자궁적출술과 골반 및 부대동맥 림프절 절제술을 시행하였다. 총 79명의 환자 중, 수술적 병기 I기와 II기로 판명된 74명의 환자를 연구 대상으로 하였다. 대조군으로는 같은 기간 동안에 개복수술을 시행한 환자중 복강경 수술군과 병기가 같은 168예를 선정하였다. 결과 : 평균 수술 기간, 수혈량은 양군에서 비슷하였으며, 평균 재원 기간은 복강경 수술군에서 유의하게 짧았다. 수술전후 및 만성 합병증의 발생은 개복 수술군에서 유의하게 증가되었으며, 획득한 림프절의 수는 복강경 수술군에서 유의하게 더 많았다. 복강경 수술군에서 1예, 개복 수술군에서는 2예에서 재발하였고, 2년 무병 생존률은 복강경 수술군과 개복 수술군에서 각각 97.5%와 98.6%으로 유의한 차이는 관찰되지 않았다. 결론 : 자궁내막암 치료로서 복강경 수술은 기존의 개복술을 대신할 수 있는 안전하고 효과적인 시술 방법이다. 개복 수술과 비교해 볼 때, 재발 및 생존율 면에서 차이가 없었지만, 향후 전향적이고 더 오랜 추적기간을 갖는 연구가 필요하다고 사료된다. Objective : To evaluate the outcomes of laparoscopic surgery and to compare surgical parameters and recurrence rate of these with those of conventional abdominal surgery in patients with endometrial cancer. Methods : From August 1997 to November 2003, we have performed 79 cases of LAVH (laparoscopically assisted vaginal hysterectomy) with or without lymph node dissection. Laparoscopic approach was adapted in patients with FIGO clinical stage I by imaging study. Of the 79 patients, 74 patients who were proved to be surgical stage I and II were enrolled in this comparative study. As a control group, We selected 168 cases for the laparotomy group of the same stages. Results : The mean duration of surgery, the amount of blood transfusion and hemoglobin chamges were similar in both the laparoscory and the convertional alparotomy group. The mean duration of hospital stay was significantly shorter in patients treated by laparoscopic surgery (10.2 vs. 15.5 days). The number of lymph node obtained was significantly higher in the laparoscopy group. Two year recurrence-free survival rates were 97.5% in laparoscopy group and 98.6% in laparotomy group (p=0.763). Conclusion : Laparoscopic surgery for the treatment of early stage endometrial cancer is safe and effective altematives in terms of perioperative complications. Overall and recurrence-free survival did not differ significantly in both groups however long term risk for recurrence and survival has yet to be defined.

자궁경부에 발생한 배아성 횡문근육종 2예

박정열,조준식,김대연,이동헌,김종혁,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2002 Journal of Gynecologic Oncology Vol.13 No.3

횡문근육종은 소아와 청소년기에 가장 흔한 연부조직 육종이다. 발생 부위는 일반적으로 두부 및 경부, 그 다음으로 비뇨생식계이다 조직학적으로 배아성 횡문근육종, 국화상 육종, 폐포성 횡문근육종, 다형성 횡문근육종으로 나누어진다. 횡문근육종의 약 20%가 비뇨생식기에서 발생하고, 50% 이상이 배아성 횡문근육종이다. 여성 생식기의 배아성 횡문근육종은 드문 악성 종양으로,주로 유소아의 질에서 발생하며, 자궁경부에서 발생하는 횡문근육종은 청소년기에 흔하고, 질에서 기원하는 횡문근육종이 자궁경부에 기원하는 경우보다 5배 정도 많다. 폐경기여성에서는 자궁체부에서 가장 흔히 발생한다. 비뇨생식기의 횡문근육종의 치료는 과거에는 골반장기 적출술만으로 치료를 시도하였으나. 서서히 다중 항암화학요법, 방사선요법, 근치적 절제술을 포함한 병합요법으로 바뀌어가고 있으며, 이에 따라 생존율이 현저하게 향상되었다. 이에 저자들은 최근 본원 산부인과에서 자궁경부에 발생한 배아성 횡문근육종 2예를 경험하였기에 문헌 고찰과 아울러 보고하는 바이다. Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and young adult. Genitourinary tract is the econd most common site of rhabdomyosarcoma. Rhabdomyosarcoma can be classified into one of four major types; embryonal, alveolar, pleomorphic and undifferentiated. Embryonal rhabdomyosarcoma of the female genital tract is rare malignant tumor and usually occurs during childhood in the vagina. In rare cases, rhabdomyosarcoma can originate in the uterine cervix, with a peak incidence in the second decade. Recently we have experienced two cases of embryonal rhabdomyosarcoma of the uterine cervix. These cases are presented with a brief review of the literature.

자궁내막에 발생한 점막 연관 림프조직 (MALT) 림프종 1예

전균호,조현진,박성균,김천복,김대연,김종혁,김용만,김영탁,목정은,남주현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

Non-Hodgkin's 림프종의 약 40%는 결절외(extranodal) 림프종으로 대개 위장관에서 발생하며 이들 중 점막 연관 림프조직(mucosa-associated lymphoid tissue: MALT)에서 기원한 림프종은 MALT 림프종으로 분류된다. 위 외의 부위에서 원발성으로 발생하는 MALT 림프종은 매우 드물지만 실제 거의 모든 신체 장기에 발생하는 것으로 알려져 있는데, 가장 흔한 부위인 위 외에도 폐, 갑상선, 침샘, 눈물샘에 발생하고, 드물게 안구, 유방, 방광, 신장, 흉선 등에도 보고된 바 있다. MALT 림프종은 오랜 기간동안 원격 전이하지 않고 국소 병변으로 남아 있는 특징이 있어 치료 방향 또한 국소 병변의 치료에 집중되며, 예후도 림프절 기원의 림프종에 비해 양호한 것으로 알려져 있다. 본 저자 등은 자궁 내막에 원발성으로 발생한 MALT 림프종 1예를 경험하였기에 문헌 고찰과 함께 이를 보고하고자 한다. Mucosa associated lymphoid tissue (MALT) lymphoma can rarely develop primarily in extranodal sites other than stomach which is the most common site for it. Other rare primary sites are small intestine, colorectum, esophagus, lung, thyroid, salivary gland, lacrymal gland, breast and skin. MALT lymphoma represents a distinct clinicopathologic features: it is usually localized to their original site for a long time and shows much more favorable prognosis than lymphoma at other site, but some MALT lymphoma can arise simultaneously or successively in different organ or give rise to another MALT lymphoma of other organ and can be multifocally disseminated or recurred. We report a very rare case of high grade B-cell lymphoma of mucosa associated lymphoid tissue (MALT) of the uterine endometrium, which was confirmed by immunohistochemical assay.

하악골에 발생된 Low grade 골육종:증례보고

조현이,정종철,김호성,최재욱,성대경,서지훈,김성범,이계혁 大韓顎顔面成形再建外科學會 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1

Osteosarcoma is a primary malignant tumor arising most often in the long bone, but rare in jaw bone. Especially osteogenic sarcoma of the mandible is a rare tumor, comprising less than 0.5% of all head and neck tumors. Osteosarcoma occurs cheifly in young persons, and presenting very survival rates. Histopathologically this tumor can be classified three types, osteoblastic, fibroblastic, chondroblastic and classified from low grade to high grade by anaplasia or mitosis of the tumor cells. Sometimes, the exact diagnosis of osteosarcoma is difficult especially in low grade osteosarcoma, even if clinical or radiographical findings suggest to osteosarcoma. So suspcious to malignant bone tumor in clinical or radiological findings, biopsy should be taked from deep portion and multiple area, and sharing the patient history and radiographs with pathologist will assist in the development of the diagnosis. We report a case of low grade osteosarcoma on the mandible initially difficulty in accurate diagnosis. The patient visited our hospital for routine dental treatment but radiographic findings displayed ill-defined radiolucency with osteoid formation on the mandible. Final diagnosis was difficulty in initial biopsy but subsequent biopsy taked from deep portion presented infiltrative growth and mitosis of the tumor cell in some area with small osteoid bone formation, so we could reach final diagnosis as low grade sarcoma. We treated this patient with bloc resection of the mandible and immediate reconstruction with iliac corticocancellous block.

Synthesis of nanoparticle-enhanced polyurethane foams and evaluation of mechanical characteristics

Kim, Jong-Min,Kim, Jeong-Hyeon,Ahn, Jae-Hyeok,Kim, Jeong-Dae,Park, Sungkyun,Park, Kang Hyun,Lee, Jae-Myung Elsevier Science Ltd 2018 Composites Part B, Engineering Vol.136 No.-

<P><B>Abstract</B></P> <P>Owing to their many advantageous properties, polyurethane-based insulating materials are suitable for liquefied natural gas carrier (LNGC) cargo containment systems (CCSs). Because an LNGC CCS, which has a 110 K operating temperature, is exposed to continuous sloshing impact loads from ocean waves, the insulating and mechanical capabilities should be simultaneously secured. However, cracking and failure problems have been consistently reported in shipyards owing to the performance limitations of current insulating materials. Therefore, for the present study, nanoparticle-enhanced polyurethane foams (PUFs) with various contents of graphene oxide (GO) and graphite were synthesized to resolve such industrial problems. A wt%-dependent SEM analysis was then carried out to understand the effects of nanoparticles on the cell morphologies of the developed materials. The mechanical properties were investigated at both ambient and boiling temperatures of LNG (110 K). In addition, the thermal conductivity of nanoparticle-enhanced PUF was evaluated. Finally, the macroscopic failure characteristics were also determined. The results indicate that the microstructure and mechanical strength are enhanced compared with neat PUFs, with a significant dependence on the weight percent of the nanoparticles.</P>

Inactivation of Brain myo-Inositol Monophosphate Phosphatase by Pyridoxal-5'-Phosphate

Kim, Dae-Won,Hong, Joung-Woo,Eum, Won-Sik,Choi, Hee-Soon,Choi, Soo-Hyun,Kim, So-Young,Lee, Byung-Ryong,An, Jae-Jin,Lee, Sun-Hwa,Lee, Seung-Ree,Kwon, Oh-Shin,Kwon, Hyeok-Yil,Cho, Sung-Woo,Lee, Kil-Soo Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.1

Myo-inositol monophosphate phosphatase (IMPP) is a key enzyme in the phosphoinositide cell-signaling system. This study found that incubating the IMPP from a porcine brain with pyridoxal-5'-phosphate (PLP) resulted in a time-dependent enzymatic inactivation. Spectral evidence showed that the inactivation proceeds via the formation of a Schiff's base with the amino groups of the enzyme. After the sodium borohydride reduction of the inactivated enzyme, it was observed that 1.8 mol phosphopyridoxyl residues per mole of the enzyme dimer were incorporated. The substrate, myo-inositol-1-phosphate, protected the enzyme against inactivation by PLP. After tryptic digestion of the enzyme modified with PLP, a radioactive peptide absorbing at 210 nm was isolated by reverse-phase HPLC. Amino acid sequencing of the peptide identified a portion of the PLP-binding site as being the region containing the sequence L-Q-V-S-Q-Q-E-D-I-T-X, where X indicates that phenylthiohydantoin amino acid could not be assigned. However, the result of amino acid composition of the peptide indicated that the missing residue could be designated as a phosphopyridoxyl lysine. This suggests that the catalytic function of IMPP is modulated by the binding of PLP to a specific lysyl residue at or near its substrate-binding site of the protein.

Multicast Extension to Proxy Mobile IPv6 for Mobile Multicast Services

Kim, Dae-Hyeok,Lim, Wan-Seon,Suh, Young-Joo Korean Institute of Information Scientists and Eng 2011 Journal of Computing Science and Engineering Vol.5 No.4

Recently, Proxy Mobile IPv6 (PMIPv6) has received much attention as a mobility management protocol in next-generation all-IP mobile networks. While the current research related to PMIPv6 mainly focuses on providing efficient handovers for unicast-based applications, there has been relatively little interest in supporting multicast services with PMIPv6. To provide support for multicast services with PMIPv6, there are two alternative approaches called Mobile Access Gateway (MAG)-based subscription and Local Mobility Anchor (LMA)-based subscription. However, MAG-based subscription causes a large overhead for multicast joining and LMA-based subscription provides non-optimal multicast routing paths. The two approaches may also cause a high packet loss rate. In this paper, we propose an efficient PMIPv6-based multicast protocol that aims to provide an optimal delivery path for multicast data and to reduce handover delay and packet loss rate. Through simulation studies, we found that the proposed protocol outperforms existing multicast solutions for PMIPv6 in terms of end-to-end delay, service disruption period, and the number of lost packets during handovers.

Inactivation of Brain myo-Inositol Monophosphate Phosphatase by Pyridoxal-5`-Phosphate

( Dae Won Kim ),( Joung Woo Hong ),( Won Sik Eum ),( Hee Soon Choi ),( Soo Hyun Choi ),( So Young Kim ),( Byung Ryong Lee ),( Jae Jin An ),( Sun Hwa Lee ),( Seung Ree Lee ),( Oh Shin Kwon ),( Hyeok Yi 생화학분자생물학회 2005 BMB Reports Vol.38 No.1

Myo-inositol monophosphate phosphatase (IMPP) is a key enzyme in the phosphoinositide cell-signaling system. This study found that incubating the 1MPP from a porcine brain with pyridoxal-5`-phosphate (PLP) resulted in a time-dependent enzymatic inactivation. Spectral evidence showed that the inactivation proceeds via the formation of a Schiff`s base with the amino groups of the enzyme. After the sodium borohydride reduction of the inactivated enzyme, it was observed that 1.8 mol phosphopyridoxyl residues per mole of the enzyme dimer were incorporated. The substrate, myo-inositol-l-phosphate, protected the enzyme against inactivation by PLP. After tryptic digestion of the enzyme modified with PLP, a radioactive peptide absorbing at 210 nm was isolated by reverse-phase HPLC. Amino acid sequencing of the peptide identified a portion of the PLP-binding site as being the region containing the sequence L-Q-V-S-Q-Q-E-D-I-T-X, where X indicates that phenylthiohydantoin amino acid could not be assigned. However, the result of amino acid composition of the peptide indicated that the missing residue could be designated as a phosphopyridoxyl lysine. This suggests that the catalytic function of IMPP is modulated by the binding of PLP to a specific lysyl residue at or near its substrate-binding site of the protein.

Additive-free electrode fabrication with reduced graphene oxide using supersonic kinetic spray for flexible lithium-ion batteries

Kim, Seong Dae,Lee, Jong-Gun,Kim, Tae-Gun,Rana, Kuldeep,Jeong, Jong Yeob,Park, Jong Hyeok,Yoon, Sam S.,Ahn, Jong-Hyun Elsevier 2018 Carbon Vol.139 No.-

<P><B>Abstract</B></P> <P>Thin, lightweight, and flexible lithium-ion batteries (LIBs) are emerging as a promising power source for high-performance flexible electronics. However, their technological drawbacks have hindered the development of fully flexible electronics because of a lack of reliable electrode materials that combine superior electrochemical properties with mechanical flexibility. As a solution to this problem, we herein demonstrate an additive-free electrode fabrication process, where reduced graphene oxide (rGO) is coated onto a current collector using a supersonic kinetic spray technique (spray-rGO). The spray-rGO demonstrates outstanding mechanical and electrochemical properties compared to those of rGO electrodes fabricated using the conventional process. Moreover, despite being fabricated without any binders, spray-rGO exhibits high adhesion energy, which enables the fabrication of highly flexible electrodes with no structural deterioration or capacity degradation. This approach to fabricate additive-free flexible electrodes, which results in electrodes that satisfy other important criteria such as high rate capability, long-term cyclability, and facile and fast fabrication, is a prospective method for developing high-performance flexible LIBs.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Honoring the Doctrinal Big Ideas of the Psalms for Text-Faithful Preaching

Kim Dae-Hyeok(김대혁) 신학지남사 2022 신학지남 Vol.89 No.4