당뇨병 환자에서 혈장 Thrombin-Antithrombin Ⅲ 및 Plasmin-α_2-Plasmin Inhibitor 복합체의 임상적 의의

김경욱,김은숙,정상수,윤수지,박우일,이준희,남수연,안철우,문병수,김경래,차봉수,송영득,임승길,이현철,허갑범 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.5

연구배경:당뇨병 환자에서 혈액응고 및 섬유소용해 체계의 이상경향이 있어 그 결과로 여러 혈관합병증의 발생위험이 높다는 사실은 널리 알려져 있다. 그 기전은 아직 확실히 밝혀지지 않았으나, 고혈당으로 인한 혈장 단백질들의 비효소성 당화작용이나 산화성 스트레스로 인한 유리 라티칼 작용으로 응고항진이나 섬유소용해 활성의 저하를 유발하는 것으로 생각되고 있다. 최근 응고 및 용해인자와 그 억제자의 복합체들의 증가가 이 상태를 비교적 예민하게 반영한다고 알려져 있다. 방법:본 연구에서는 당뇨병 환자 101명과 정상 대조군 20명에서 혈장내 thrombin­antithrombin complex(TAT)와 plasmin­α₂­plasmin inhibitor complex(PIC)를 측정하여 비교하고, 당뇨병 환자에서 미세혈관 합병증과 대혈관합병증의 유무에 따른 차이와, 이미 혈관 질환의 위험인자로 알려져 있는 인자들간의 상관성을 알아보고자 하였다. 결과:1. 환자의 분포를 살펴보면 혈관합병증이 있는 군은 85명, 혈관합병증이 없는 군은 16명이었고, 평균연령은 각각 57.9±14.1세, 49.9±16.6세로 혈관 합병증이 있는 군에서 더 나이가 많았고, 체질량지수는 23.2±3.4㎏/㎡, 24.1±3.4㎏/㎡로 두 군간 유의한 차이는 없었다. 또 두 군간의 혈압 및 HbA1c, 공복혈당 및 인슐린과 C­peptide, 총 콜레스테롤, 중성지방, HDL­콜레스테롤, Lp⒜는 유의한 차이가 없었고, 미세혈관합병증이 있는 군에서 당뇨병의 유병기간이 길었다. 2. TAT 및 PIC의 농도는 정상 대조군에서는 2.8±1.2 ng/mL, 240.4±69.7 ng/mL이었고, 당뇨병 환자군에서는 9.5±22.6 ng/mL, 472.2±258.7 ng/mL이었다. TAT와 PIC 모두 당뇨병 환자군에서 정상 대조군에 비해 유의하게 증가되어 있었고(p<0.001), TAT/PIC ratio는 두 군간 차이가 없었다. 3. 당뇨병 환자의 혈관합병증에 따른 TAT 및 PIC, fibrinogen 농도는 합병증이 없는 군은 각각 4.1±2.4ng/mL, 362.2±272.0ng/mL, 322.7±102.4mg/mL으로 PIC와 fibrinogen의 증가를 보였으나, 연령을 보정한 후에는 통계학적 유의성은 없었다. 또 대혈관 합병증군에서는 각각 6.0±4.9 ng/mL, 507.4±321.6 ng/mL, 427.1±194.7 mg/dL이었으며 미세·대혈관 합병증군에서는 10.4±6.4 ng/mL, 484.8±269.7 ng/mL, 388.4±132.4 mg/dL으로 TAT의 증가를 보였으나 역시 연령을 보정한 후에는 통계학적 유의성은 없었다. 4. 미세혈관합병증군에서 HbA1c(>8%)가 높은 군의 PIC 농도가 유의하게 높았고(p=0.049), 대혈관합병증군에서 HbA1c(>8%)가 높은 군의 총 콜레스테롤 농도가 유의하게 높았다(p=0.042). 5. 총 당뇨병 환자군에서 PIC는 fibrinogen과 HbA1c와 양의 상관관계를, BMI와 음의 상관관계를 보였으며(r=0.47, 0.31,-0.25), 혈관 합병증이 없는 당뇨병 환자군에서만 TAT는 HbA1c와 양의 상관관계를 보였다(r=0.67). 결론:이상의 결과에서 혈장 TAT 및 PIC 농도는 당뇨병 환자에서 정상 대조군에 비해 의미있게 증가되어 있었고, 당뇨병 환자군에서는 연령의 증가와 유병기간이 혈액응고항진 및 용해의 장애에 큰 역할을 함을 알 수 있었으며, 총 당뇨병 환자군에 PIC와 HbA1c와 양의 상관관계를, BMI와 음의 상관관계를 보였으며 혈관 합병증이 없는 당뇨병 환자군에서만 TAT는 HbA1c와 양의 상관관계를 보였다. 따라서 당뇨병 환자에서 혈액응고 및 용해의 장애가 동반되어 있다고 볼 수 있으며, 혈장 TAT 및 PIC는 혈관합병증으로의 진행을 예측하는 지표로서 유용하리라 생각된다. 또 혈당조절정도와 상관성이 있으므로 혈당조절후에 추적검사를 시행하여 합병증의 예방이 가능한지 추후 연구가 필요하리라 생각된다. Background : Abnormality of coagulation and fibrinolystic system is known as a predisposing factor of vascular complication in diabetes. Although the pathogenesis is not well known, non-enzymatic glycation reaction and the increase in production of free radicals due to an increased oxidative stress may be linked to the hypercoagulibility and hypofibrinolytic activity. As indices of abnormality in coagulation and firinolysis in peripheral blood, plasma thrombin-antithrombin Ⅲ complex (TAT) and plasmin-α_2-plasmin inhibitor complex (PIC) were measured. The purpose of this study was to clarify whether hypercoagulability exists in diabetic patients with or without vascular complication. Methods : In our study, we measured plasma thrombin-antithrombin Ⅲ compelx (TAT) and plasmin-α_2-plasmin inhibit or complex (PIC) in 101 diabetic subjects and 20 controls. Comparing TAT and PIC levels in diabetic microvascular complication group, diabetic macrovascular complication group and controls, we examined correlation between risk factors associated with diabetic vascular complication. Results : 1. The group with diabetic vascular complication was older than group without complication. There was no significant difference in BMI, blood pressure, HbA_ic, blood sugar level, insulin, C-peptide, serum creatinine, total cholesterol, triglyceride, HDL-cholesterol, Lp (a) between two groups. The group with diabetic microvascular complication had longer duration of diabetes. 2. Concentration of TAT and PIC were 2.8±1.2 ng/ mL, 240.4±69.7 ng/ mL in controls and 9.5±22.6 ng/ mL, 472.2±258.7 ng/ mL in diabetic patients, respectively. TAT and PIC were significantly higher in diabetic patients than in control (p<0.001). But TAT/PIC ratio was no significant difference between two groups. 3. In diabetic patients, concentration of TAT and PIC and fibrinogen were respectively 4.1±2.4 ng/ mL, 362.2±272.0 ng/ mL, 322.7±102.4 mg/ dL in group without vascular complication and 5.3±4.1 ng/ mL, 529.5±258.7 ng/ mL, 374.9±106.2 mg/ dL in group with microvascular complication, which group had increase in PIC and Fibrinogen but no significance after correction of age. Concentration of TAT and PIC and Fibrinogen were 60.±4.9 ng/ mL, 507.4±321.6 ng/ mL, 427.1±194.7 mg/ dL in macrovascular complication, and 10.4±6.7 mg/ mL, 484.8±269.7 ng/ mL, 388.4±132.4 mg/ dL in combined vascular complication which group showed increase of TAT but also had no significant increase after correction of age. 4. In diabetic microvascular complication patients, group of high HbA_1c (>8%) (p=0.049) had significant high PIC concentration. In diabetic macrovascular complication patients, group of high HbA_1c (>8%) (p=0.042) had significant high total cholesterol concentration. 5. In all diabetic patients, PIC was positively correlated with fibrinogen and HbA_1c and negatively correlated BMI (r=0.47, 0.31, -0.25). Only in daibetic patients without angiopathy, TAT was positively correlated with HbA_1c (r=0.67). Conclusion : In this study, plasma TAT and PIC concentration significantly increased in diabetic patients compared with controls, and PIC was increased in group with microvascular complication, TAT were increased in group with combined micro macrovascular complication. However, there was no significance relationship existed when correctinf for age. PIC was correlated with HbA_1c. TAT was correlated with HbA_1c only in the group without angiopathy. Abnormality of coagulation and fibrinolysis were combined in diabetes, plasma TAT and PIC can be used as an index of vascular complication. Also we found the correlation with the degree of the blood glucose control. Therefore we need follow up study for the possibility of prevention of vascular complication after controlling the blood glucose to age-matched patients (J Kor Diaabetes Asso 25:354~363, 2001).

Effect of Hydride Reorientation on Delayed Hydride Cracking In Zr-2.5Nb Tubes

Yun Yeo Bum,Kim Young Suk,Im Kyung Soo,Cheong Yong Moo,Kim Sung Soo Korean Nuclear Society 2003 Nuclear Engineering and Technology Vol.35 No.6

The objective of this study is to investigate the reorientation of hydrides with applied stress intensity factor, the peak temperature and the time when to apply the stress intensity factor in a Zr-2.5Nb pressure tube during its thermal cycle treatment. Cantilever beam (CB) specimens with a notch of 0.5 mm in depth made from the Zr-2.5Nb tube were subjected to electrolytic hydrogen charging to contain 60 ppm H and then to a thermal cycle involving heating to the peak temperature of either 310 or $380^{\circ}C$, holding there for 50 h and then cooling to the test temperature of $250^{\circ}C$. The stress intensity factor of either 6.13 or $18.4\;MPa\sqrt{m}$ was applied at the beginning of the thermal cycle, at the end of the hold at the peak temperatures and after cooling to the test temperature, respectively. The reorientation of hydrides in the Zr-2.5Nb tube was enhanced with the increased peak temperature and applied stress intensity factor. Furthermore, when the CB specimens were subjected to $18.4\;MPa\sqrt{m}$ from the beginning of the thermal cycle, the reoriented hydrides occurred almost all over the Zr-2.5Nb tube, surprisingly suppressing the growth of a DHC crack. In contrast, when the CB specimens were subjected to the stress intensity factor at the test temperature, little reorientation of hydrides was observed except the notch region, leading the Zr-2.5Nb to grow a large DHC crack. Based on the correlation between the reorientation of hydrides and the DHC crack growth, a governing factor for DHC is discussed along with the feasibility of the Kim's DHC model.

공동모금의 도입과 모금 확대방안

김범수 평택대학교 1999 論文集 Vol.13 No.-

본 논문은 우리사회에 공동모금이 도입되게 된 배경과, 모금의 확대방안을 제시하기 위한 목적으로 연구한 논문이다. 1975년부터 관 주도로 운영되어 오던 불우이웃돕기 성금이 23년만인 1998년에 사회복지공동모금법의 제정과 함께 민간주도의 사회복지공동모금회로 조직 개편되었다. 그러나 제정된 사회복지공동모금법은 1년 후인 1999년에 사회복지공동모금회법으로 개정된다. 공동모금의 주요기능은 모금과 배분의 기능이다. 본 논문에서 얻어진 결론은 다음과 같다. 첫째, 연말이웃돕기모금을 위해 철저한 준비와 전략이 필요하다는 점이다. 둘째는 시ㆍ군 단위의 기관ㆍ단체ㆍ시설과 공동모금회와 연계한 모금을 확대해 나가야 한다는 점이다. 셋째, 연말이웃돕기모금에 적극 참여한 기관ㆍ단체ㆍ시설에게 기여도에 따라 인센티브를 제공하여야 한다는 점이다. 넷째는, 공동모금에 대한 연수를 확대하여 모금전문가와 모금자원봉사자를 육성하여야 한다는 점이다. 다섯째, 기부금품모집규제법이 철폐되어야 한다는 점이다. 여섯째, 중앙모금회에서 현재 실시되고 있는 모금과 배분은 한시적이어야 하며 중앙모금회는 기획ㆍ홍보ㆍ훈련 업무에만 주력해야 한다.

대학 Campus의 외부공간 계획에 대한 기초적 연구(Ⅰ)- 지방대학 캠퍼스의 대학 구성원의 선호도 평가 비교

김범수 건국대학교 자연과학연구소 1998 建國自然科學硏究誌 Vol.9 No.2

This study was designed to evaluate the behavior and cognitive of the students and faculty members in a university located in a province to suggest better campus landscape planning. The followings are results of survey. Pine and Gingko trees were highly preferred by the respondents, even though they didn't mentioned any most preferred trees. On the other hands, rose and magnolia were mentioned as the most preferred flowers. Respondents preferred forests with broad-leaf trees and regenerated forests harmonious with surrounding environment naturally. Regarding to spatial perception and preference, all places except parking lot and surrounding environment were evaluated lowly. Generally, places for rest and green space were evaluated significantly low. Especially for the students, places for the rest and sports were much significantly evaluated lowly than faculty members. These places were suggested as the places for 'improvement required'. Results mentioned above indicated that environment around the university with relatively young aged were considered good. However, alternatives for increasing green spaces due to initial selection of species and changing the species were not existed. In addition, allocation of out-space were dissatisfied by respondents due to inconvenience of use. Conclusively, the campus planning should be considered improvement of architecture, parking and green spaces. Based on the results from this study, the alternatives for planning of campus as follows: Avoid confuse between driveway and sidewalk, and plan for efficient circulation through driveway, parking lot and sidewalk. For the rest and sports, be prepare small-scaled multi-purpose and green-space around college buildings. Share green and use beside building with small-scale, and allocate with large scale in the public spaces. Planting trees should be conducted with following guidelines. (1) Selecting spices having proper environmental function. (2) Selecting spices and number of trees according to the scale of area and usage. (3) Considering aesthetic and environmental functions according to out-factors of the buildings. (4) Considering harmony with surrounding natural environment and ecological function, and parsimony.

뇌 아밀로이드 혈관병과 고혈압성 뇌출혈의 감별에 있어서 Apolipoprotein Eε4와 점상 출혈 분포의 유용성

김용범,이광호,이수주,나덕렬,조수진,정진상,이원용 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

대학생의 건강·체력·영양섭취상태에 관한 연구

김범수,이종영 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

For the purpose of acquiring basic data regarding gudiance method for health improvement the following result could be obtained by conducting survey on physical strength test, blood pressure, urine, blood test and amount of nutrition absorption on 52 male and 51 female college students. 1) For physical strength test with males they were superior in running sidewise repetitiously, panel climbing than college students and in terms of hand gripping strength and running they were same as college students. With females running was same level as that of ordinary college students but they fell behind in terms of hand gripping strength, running sidewise repetitiously and panel climbing. 2) In terms of blood pressure male and female fell within the scope of normalcy. In terms of result of blood test females showed slight level of anemia of about 20% and there was not abnormalcy for males or females in connection with blood. Result of urine test showed there was only one person from whose urine sugar was detected. 3) In terms of amount of nutrition absorption amount of energy and nutrient was more or less satisfactory for male and female. In terms of absorption of micro nutrients male shows slight deficiency in calcium and female in calcium and iron and in terms of vitamins males and females showed considerable shortage in vitamin A and B₂.

광중합형 글라스 아이오노머 시멘트의 개발에 관한 연구

김철위,윤수한,임범순 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.1

The object of this study was to synthesize the experimental light-activated glass ionomer cement change of glass components such as aluminum, fluorine, calcium, and strontium. To reinforce the glass ionomer cement, additions of metallic powder, ceramic powder, and light-activated composite resin to glass ionomer cements were performed. Radiopacity, comprehensive strength, bond strength, fracture toughness, sloubility, and cytotoxicity of the various experimental glass ionomer cements were investigated. From the experiment, the following results were obtained: 1. Experimental light-activated glass ionomer cement showed similar physical and mechanical properties to commercial glass ionomer cement. Radiopacity, resistance of solubility, fracture thoughness, and compressive strength of the experimental cement were superior to those of commercial cements, but bond strength and biocompatibility of the experimental cement were inferior to commercial cements. 2. Addition of amalgam powder to light-activated glass ionomer cement resulted in the lower compressive strength and fracture toughness, but addition of aluminium powder resulted in the enhanced the fracture toughness. 3. Addition of alumina powder (Al₂O₃) could enhance the compressive strength and fracture toughness of the glass ionomer cement without sacrificing of the esthetic property. 4. Physical mixing light-activated glass ionomer cement with light-activated composite resin could enhanced the physical properties except for bond strength.

회귀예측신경망을 이용한 음절인식

김주성,김상범,김수훈,허강인 東亞大學校 附設 情報通信硏究所 1996 情報通信硏究所論文誌 Vol.4 No.1

In this paper, we perform the recognition test for Korean 100 monosyllabes using RPNN(recurrent prediction neural networks). The RPNN is trained to nonlinear predictor, accoding to time variation of speech pattern, is not use time sequential algorithm. In recognition experiment we got the recognition rate 69.0%, 72.30% and 71.20% using RTRL(real-time recurrent learning) training algorithm when the predition order is 2, 3 and 4.

상태수 변화에 따른 NNPHMM의 성능비교

김창근,김상범,김수훈,허강인 東亞大學校 附設 情報通信硏究所 1997 情報通信硏究所論文誌 Vol.5 No.1

In this paper, we compose neural predictive HMM(NNPHMM) to provide the dynamic feature of the speech pattern for the HMM. The NNPHMM is the hybrid network of neural network and the HMM. The NNPHMM trained to predict the future vector, varies each time. It is used instead of the mean vector in the HMM. In the experiment, we compared the recognition abilities of the one hundred Korean syllables according to the variation of state number and prediction order. The state number of the NNPHMM increased from 4 to 6. And the prediction orders increased from 2nd to 4th order. The NNPHMM in the experiment is composed of multi-layer perceptron with one hidden layer and CMHMM. As a result of the experiment, the average recognition rates are 85.2%, 85.6% and 85.5% when the state number is 5, the prediction order is the 2nd, 3rd, 4th, and the hidden layer is 10 dimensions, respectively.

도심가로변 상업 종사자의 가로 녹화에 대한 의식조사

김범수 한국환경과학회 2005 한국환경과학회지 Vol.14 No.3

This study analyzes the recognition of commercial business men and employers who operate the commercial zone along the streets in the downtown area on the planting for the roadside green space forming the important frame of greening in the downtown among the open spaces. Through the analysis, this study attempts to get the basic data to suggest the recommendable directions in planting and managing the street trees in the downtown. The results of this study are summarized as described below. The street green spaces are very important in improving the environment of the downtown and their necessities are also very critical. It was found that the street trees were recognized as the critical factor to enhance the aesthetical values of the city, provide the green shades and purify the air. This study also identified that the street trees have the positive impacts on the business environment rather than negative impacts. In maintaining the street green spaces, the most necessity is the service facility such as resting areas, toilets and garbage bins with the street trees. The commercial business men and employers who operate the businesses along the streets preferred the double layer type that the tall trees and green walls are planted together along the streets for the street planting. For securing the green shades in the city, the planting of linear green spaces such as streets and waterways is critical. Moreover, the street trees accounts for the important position in the urban open spaces. The majority of commercial business men and employers consider the participation of citizens for greening as the very essential factor.