Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

NANOARCHITECTURES: High‐Resolution Patterning of Various Large‐Area, Highly Ordered Structural Motifs by Directional Photofluidization Lithography: Sub‐30‐nm Line, Ellipsoid, Rectangle, and Circle Arrays (Adv. Funct. Mater. 10

Lee, Seungwoo,Kang, Hong Suk,Park, Jung‐,Ki WILEY‐VCH Verlag 2011 Advanced functional materials Vol.21 No.10

<P>A principal challenge in nanopatterning is to beat the resolution limit of established methods. On page 1770, Seungwoo Lee, Hong Suk Kang, and Jung‐Ki Park present the directional photofluidization of azopolymers, which allows the generation of large‐area, highly ordered nanoarchitectures with precisely controlled structural features. Additionally, this approach can offer unprecedented flexibility in control of the final feature size, and, simultaneously, its fluidic behavior under light irradiation signifi cantly reduces the line‐edge roughness </P>

홍화자 분획물이 사염화탄소 유발 간손상 흰쥐에서 지질과산화와 oxygen free radical 제거 효소 활성도에 미치는 영향

정기화,정춘식,정정숙 德成女子大學校 藥學硏究所 1999 藥學論文誌 Vol.10 No.1

저자들은 사염화탄소로 유발된 간손상에 대한 홍화자 메탄올 추출물과 이를 계통 분획한 분획물의 보호 효과를 이미 보고하였다. 본 실험에서는 홍화자 분획물의 간보호 작용에 대한 기전을 살펴보기 위하여 지질과산화와 oxygen free radical 제거 효소 활성을 측정하였고 조직병리학적 분석을 통하여 간보호 효과를 확인하였다. 홍화자 BS-5 분획물은 CCl_4로 간손상을 유발시킨 흰쥐에서 superoxide dismutase의 활성도를 유의적으로 증가시켰으며, in vitro에서의 1, 1-diphenyl -2-picrylhydrazyl radical를 직접적으로 제거하였다. 또한 조직병리학적 분석에서도 홍화자 BS-5분획투여군은 CCl_4 투여로 인한 중심정맥 주변의 ballooning degeneration, 염증 세포 침윤 및 괴사를 완화시켜 간손상 보호 작용을 나타내었으며, 이는 free radical scavenging 작용에 의한 것으로 생각된다. Previous studies have shown that methanol extract and its butanol fraction of Carthamus tinctorius L. Semen have the hepatoprotective effect on the CCl_4-induced hepatotoxicity. The hepatoprotective effect fo the subfractions of butanol fraction has been evaluated by analyzing oxygen free radical scavenging enzyme activities and histopathological examinations. In BS-5 subfraction treated group, the activity of superoxide dismutase has been significantly increased as compared with that of CCl_4 treated rats. Antioxidant activity has been evaluated by the examination of the scavenging ativity against 1,1-diphenyl-2-picrylhydrazyl radical. BS-5 subfraction has shown strong antioxidant activities. The histopathological examination showed that the treatment of BS-5 subfraction has relieved the ballooning degeneration of hepatocytes which had been generated by CCl_4. It appears that the protective effect of BS-5 subfraction would be mediated of the attenuation of lipid peroxidation by acting as a free radical scavenger. which were based on the increase of superoxide dismutase activity.

初期發熱患者에 대한 防風解毒湯의 經時的 解熱效果

정우상,문상관,조기호,김영석,배형섭,이경섭 경희대학교 1997 慶熙醫學 Vol.13 No.4

Nuss 방법에 의한 소아 오목가슴 수술 후 정맥 통증자가조절법을 사용한 Fentanyl 과 Fentanyl-Ketorolac의 진통효과 비교

안기량,서은정,김천숙,강규식,유시현,정진헌,정지원 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

..

한국인 관상동맥의 변화양상에 대한 형태학적 연구

권태정,이상용,이한영,고영창,권기석,조재홍,김태공,김유훈,조갑래,서중석,이원태 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

전해질 손상 및 Kanic Acid 을 사용한 편도체 중심핵 손상이 공포로 상승된 경악반응에 미치는 효과

한정수,김시현,김기석 한국심리학회 한국심리학회지 생물 및 생리 Vol.4 No.1

본 연구에서는 공포로 상승된 경악반응을 이용해, 공포나 불안을 담당하는 신경구조물인 편도체핵군 중에 하나인 편도체 중심핵의 역할을 알아보고자 하였다. 실험1에서는 조건화 전에 손상용 전극을 심은 후에 이틀에 걸쳐서 조건자극으로 빛(8w, 3700msec)과 무조건자극으로 발바닥 전기충격(1.0㎃, 500msec)을 20번 짝지워 제시한 후에, 편도체 중심핵을 전해질 손상(2.0㎃, 10sec)시켰다. 편도체 중심핵이 손상된 동물은 단순한 경악반응에 의한 반응크기와 조건자극과 경악자극 복합에 의한 반응크기간에 차이를 보이지 않았다. 전해질 손상은 세포체뿐만아니라 축색을 모두 손상하므로, 실험1의 결과는 편도체 중심핵의 세포체손상에 의해서가 아니라, 이 부위를 지나가는 축색의 손상에 의해서 야기된 결과일 수 있다. 그러므로 실험2에서는, 세포체만 손상시키는 카이닌 산(0.1㎍/0.2㎕)으로 조건화 후에 편도체 중심핵을 손상시켰다. 손상을 받은 동물은 조건자극에 대해 상승된 경악반응을 보이지 않았다. 이 결과로 보아, 편도체 중심핵내에 뉴론이 상승된 경악반응에 관여함을 알 수 있다. Of several amygdaloid nucleus, the central amygdaloid nucleus seems to be related to the expression of fear. This experiment is to examine effects of the central nucleus of amygdala on the fear-potentiated startle responses. In experiment 1, monopolar tungsten for lesioning were chronically implanted into the central amygdaloid nucleus in rats. After 7 days, rats received two conditioning sessions on consecutive day, each session consists of 10 light-footshock pairing(light of 8w incandescent bulbs, 3700msec: footshock of 1.0㎃, 500msec: ITI of 4min). After the conditioning, electrolytic lesion(2.0㎃, 10sec) was administered to the central nucleus. One day or seven days later, rats were tested for conditioned fear by comparing the magnitude of the startle reflex to a noise burst presented either alone or in the presence of the previously fear-conditioned light. Results were that the lesioned animals showed no fear-potentiated startle responses. In experiment 2, using kainic acid(0.1㎍/0.2㎕), we lesioned cell bodies without damaging any axons after the conditioning. Results showed that animals lesioned with the kainic acid did not showed potentiated startle responses to the conditioned stimuli. Taken together, it may be said that the intrinsic elements of central amygdaloid nucleus are involved in the expression of fear.

스프링강(SUP9A)과 SM25C의 마찰용접최적화에 관한연구

정석주,이기중 서울산업대학교 산업대학원 2000 大學院論文集 Vol.7 No.-

Friction welding is to jiin two materials by the frictional heat that occurs on the surface area of the two pressurized materials due to their relative motion. The pressurized welding method can be applied to the welding of the same material of different materials. The friction-welded SM25C can be selected as a substitute for the spring steel which is used in the machinery, airplane and automobile, etc. This substitution would provide cost reduction of material and the weight of the welded part. The results showed that friction welding could keep good mechanical properties of the welded part by applying optimum welding condition and proper heat treatment.

하악에 발생한 과잉치의 치험례 : A CASE REPORT

박정아,양규호,,최남기,김선미,장희숙 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.4

과잉치는 정상치판(dental lamina)의 과도한 증식이 결과로 발생되어, 가족적 성향을 보이며, 쇄골두개이형성(Cleidocranial dysplasia), Gardner 증후군 등의 여러 질환과 관련되어 나타나기도 한다. 그 빈도는 유치열에서 0.3~0.8%, 영구치열에서 1.0~3.5% 이고, 남성에서 호발되며(2:1), 상악에서 더 많이 발생한다(9:1). 상악에서는 mesiodens라고 불리는 중절치 사이의 위치가 가장 흔한 부위이고, 그 다음은 fourth molar와 측절치 부위이다. 하악에서는 소구치 부위가 가장 흔한 부위이고 전치부위에서는 약 2%로 매우 드물게 발생한다. 과잉치의 만기 잔존은 치간 이개, 인접한 치아의 맹출 장애, 치근 흡수 등을 야기하고 과잉치와 관련되어 함치성 낭종이 발생될 수 있으므로 조기진단과 적절한 치료가 중요하다. 본 두 증례는 비교적 드물게 나타나는 하악에 발생한 과잉치로, 하악 전치부와 소구치부에 발생한 과잉치를 발거하고 교정치료를 시행하여 양호한 결과를 얻었기에 보고하는 바이다. Supernumerary tooth was resulted from excessive proliferation of dental lamina and associated with familial tendency and a congenital syndrome such as Cleidocranial dysostosis or Gardner's syndrome. Incidence reports identify a range of 0.3~0.8% in primary dentition. 1.0~3.5% in permanent dentistion with males being affected twice as frequently as females. maxilla nine times as frequently as mandible. The most common supernumeraty tooth is the mesiodens, which located between the maxillary central incisors, and the next common site is the fourth molar and lateral incisors. Supernumerary teeth are uncommon in the mendible, but premolars are the most common supernumerary teeth and occurrence is very rare in the incisor region of the mandible of possibility of diastema and cruption failure displacement. rotation of the associated permanent teeth, root resorption and dentigerous cyst with presence of the supernumerary teeth. In this two case, one supernumerary tooth located in the mandibular incisor region, the other supernumerary tooth located in premolar region. We could get normal alignment of mandibular dentition by extraction and orthodontic treatment.

희토류 금속착물의 합성과 전기화학적 거동 : Dy(III)과 Tb(III) 유기물질의 착물들에 대한 환원 Reduction of dysprosium(III), and terbium(III) complexes with organo substance in nonaqueous media

尹哲珍,鄭榮基 조선대학교 기초과학연구소 1990 自然科學硏究 Vol.13 No.1

린탄나이드 3가〔Dy(Ⅲ), Tb(Ⅲ)〕와 유기리간드들의 착물을 전기화학적인 DC와 DP, SP 그리고 CV방법으로 조사하였다. 란탄나이드 착물들인 Dy(hafc)_3와 Tb(phen)_3의 전기화학적 환원을 비수용매 속에서 연구하였다. 란탄나이드 3가 착물들은 Ag/Agcl전극에서 이들 환원 피이크는 E_pc=-1.15V, 그리고 -1.45V의 비가역적인 일전자 환원과정이었고, 무거운 란탄나이드에서 원자번호가 증가함에 따라 안정도상수는 감소하였다. The electrochemical behavior of trivalent lanthanides, Dy(Ⅲ) and Tb(Ⅲ) Complexes were investigated by the use of direct current, differential pulse, stripping pulse polarography and cyclic voltammetry. The electrochemical reduction of lanthanide complexes 〔Dy(hafc)_3〕and 〔Tb(phen)_3〕were investigated in aprotic media. These reduction peak were irreversible one-electron processes at E_pc=-1.15V and -1.45V Vs. Ag/AgCl electrode and the behavior of the heavier lanthanides were decreased stability constant with increasing atomic number.