신이식에서 이식신의 생존분석

오선미,김종학,황평주,구영선,강민규,나기량,김종섭,김성숙,이강욱,신영태,설종구,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

To investigate the prognostic factors for the survival of transplanted kidney in patients with end-stage renal failure, 59 cases of renal transplantation from September 1986 to Feburary 1997 in Chungnam National University Hospital were analyzed retrospectively. The results were as follows: 1)The mean age of recipients was 33.8 years and that of doners was 38.9 years. The male to female ratio of recipients was 2.5:1, and that of donors was 1.03:1 2) Living related donore(LRD) were 79.6% and living non-related donors were 20.3%. The HLA-identical donors(ID) in LRD were 18.7% and HLA-haploidentical donors(HID) were 61.0%. In living non-related donors(LNRD), mean matched HLA-AB antigens were 1.56 and mean matched HLA-DR antigens were 0.56. 3) The average 5-year patient survival fate was 94%, and average 5-year graft survival rate was 70%. The 5-year graft survival fate of HLA-ID was 100%, and those HLA-HID and LNR were 70% and 36% respectively. 4) Total 33 episodes of acute rejection were found in 45.8% of transplanted patients. The number of acute rejection episode did not show significant difference between LRD and LNRD(P > 0.05). There was no significant difference in MLC between two groups(p > 0.05). 5) In comparison between the 18 patients who lost their graft function in 5 years and 17 patients who are maintaining graft function for more than 5 years, MLC was significantly lower in patients with functioning graft than of patients with non-functioning graft (p < 0.05). The number of rejection episode was also lower in patients with functioning graft than that of the patients with non-functioning graft(p < 0.05). However, there were no significant difference in recepient and donor age and history of pre-transplantation donor specific transfusion between two groups. With the results above, we can speculate that adequate donor selection according to good matched HLA typing and low MLC is very important for graft survival in renal transplantation. Prevention and treatment of acute rejection in renal transplantation is also na important factor for graft survival.

B형 간염 바이러스 단백질에 있어서 HLA-A2에 의해 표현되는 Epitope 펩타이드 들의 분석

이희구,임종석,김승목,이기영,김희수,김승호,권태종,최인성,정태화,김길현 이화여자대학교 생명과학연구소 1995 생명과학연구논문집 Vol.6 No.-

The cytotoxic T lymphocyte(CTL) are an important component in host defense mechanism against viral infection. They can recongnize virus-derived peptides presented by the ClassⅠ MHC molecule at the cell surface of the infected cells. On searching for effective CTL epitopes of hepatitis B virus(HBV), we synthesized a distinct set of 9-10 mer peptide containing amino acid sequence of hepatitis B virus surface proteion that are selected on the basis of a computer modeling and the previously described HLA-A2 specific motifs. Binding assay of the synthetic peptides to HLA-A2 molecules using human antigen processing defectantn T2 cells showed what 3 out of 4 synthetic peptides enhaced the expression of HLA-A2 molemule on T2 cell surface. Two anchor positions, namely P2 and P9(or P10) appeared to play a decisive role for binding. Structural chacteristics of the peptides addressed by molecular dynamics simulation was analysed and compared. These peptides also parially triggerd CTL isolatied frmo human peripheral blood mononuclear cells of HBV positive patients, and the response was peptide-specific. These results showed that negatively-charged amino acid residue at P2 hampered binding affinity of the peptides to HLA-A2 molecules, and that binding affinity of the peptides are not always reflected by thier immunogenicity among natural T cell repertoire.

B형 간염 바이러스 단백질에 있어서 HLA-A2에 의해 표현되는 Epitope 펩타이드 들의 분석

이희구,임종석,김승목,이기영,김희수,김승호,권태종,최인성,정태화,김길현 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

The cytotoxic T lymphocyte (CTL) are an important component in host defense mechanism against viral infection. They can recongnize virus-derived peptides presented by the Class I MHC molecule at the cell surface of the infected cells. On searching for effective CTL epitopes of hepatitis B virus(HBV), we synthesized a distinct set of 9-10 mer peptide containing amino acid sequence of hepatitis B virus surface protein that are selected on the basis of a computer modeling and the previously described HLA-A2 specific motifs.Binding assay of the synthetic peptides to HLA-A2 molecules using human antigen processing defectant T2 cells showed that 3 out of 4 synthetic peptides enhanced the expression of HLA-A2 molecule on T2 cell surface.Two anchor positions, namely P2 and P9(or P10) appeared to play a decisive role for binding.Structural. characteristics of the peptides addressed by molecular dynamics simulation was analysed and compared.These peptides also partially triggered CTL isolated from human peripheral blood mononuclear cells of HBV positive patients, and the response was peptide-spcific.These results showed that negatively-charged amino acid residue at P2 hampered binding affinity of the peptides to HLA-A2 molecules, and that binding affinity of the peptides are not always reflected by their immunogenicity among natural T cell repertoire.

근대문학작품의 도시풍경구도에 나타난 시·공간의 체험적 인식에 관한 연구 : 소설 "소설가 구보씨의 일일"을 중심으로 Focused on the novel entitled "a novelist Gubo's day"

김기범,김태영 淸州大學校 都市·地域開發硏究所 2000 都市·地域開發硏究 Vol.8 No.2

The purpose of this study aims to understanding a common mental image between architecture and literature work in the modem ages, and especially the experiential recognition of time·space described on townscape. Following the result, Kyong-song have been represented to compound emotion with modem architecture established in 1930s of Modem Ages. First of all, the experiential recognition have been connected to the conflict structure between past and present townscape in the novel entitled "a novelist Gubo's day" by Park Tai-Won. And so on, such townscape consciousness was one of the immediate causes of the reminiscence.

방송의 사회통합 기능 수행 방안 연구 : 노무현 정부의 국민통합시대 선언을 중심으로

김기태 호남대학교 2003 호남대학교 학술논문집 Vol.24 No.1

This study was conducted to examine the activation of the broadcasting function for society consensus, which the new government laid great emphasis on. For the broadcasting function for society consensus, several suggestions have been made as follows: development of local broadcasting, development of programs for minority group, development of talk programs, activation of ombudsman programs, protection of audience rights, activation of mutual criticism programs among media and improvement of broadcasting regulation for program quality. Considering that the new government is aimed at achieving nation unity, it is critical to activate the broadcasting function for society consensus. Therefore, all people including broadcasting company, government and audience should cooperate in carrying out this goal.

용담댐 운영계획과 금강유황 및 대청댐 저수량의 변화

김태철,문종필,민진우,박승기 忠南大學校 環境問題硏究所 1997 環境硏究 Vol.15 No.-

Yongdam multipurpose dam is under construction to divert a part of Geum riverflow to Mankyung watershed and to supply the domestic water to the Chunju region and produce the hydro-electricity. Generally, construction of dam by the method of inter-regional water transfer affects the quantity and quality of water in the down streams and reservoirs. The impact of operation plan of Yongdam dam on the quantity and quality of water in the Geum river and Daechung dam was investigated. It was recommended that the discharge of water transfer from one watershed to another should be minimized as much as possible.

敎育大學圖書館의 發展方案에 관한 硏究

金基泰 仁川敎育大學校 1991 論文集 Vol.25 No.1

매체간 상호 비평 프로그램 연구 : MBC〈미디어비평〉프로그램 분석을 중심으로

김기태 호남대학교 인문사회과학연구소 2003 인문사회과학연구 Vol.10 No.-

시청자 피드백 메카니즘 활성화 방안 연구

김기태 호남대학교 2005 호남대학교 학술논문집 Vol.26 No.1

This study was aimed to examine the TV audience feedback systems for the rights of TV audience. Several questions about the opinions and needs of TV audience can be examined. Who is the subjects to put forth an opinion? what are the kind and contents of the opinion? How is the opinion suggested? Which channel is utilized to receive the opinion? A variety of topics associated with audience feedback mechanisms were evaluated as follows: the activities of broadcasting department related to TV audience services, service activities for audience in program production department, the activities of the Board of TV audience, TV audience critic programs, TV audience participation programs, the reciprocal critic programs among media, and broadcasting inquiry system. For the activation of TV audience feedback mechanisms, serveral solutions can be suggested, which are media education activation, the reinforcement of service education for TV audience, the improvement of service system for TV audience, the systemic arrangement of TV audience opinions and publication of a white paper, and the reinforcement of the exchange with TV audience movement groups.

부분 신절제 백서모델에서 Angiotensin Converting Enzyme Inhibitor 및 Angiotensin II ATI 수용체 길항제가 Plasma Renin Activity 및 Angiotensin II level에 미치는 영향

김종학,구영선,강민규,황평주,나기량,이강욱,서광선,신영태 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Renin-angiotensin-system(RAS) has been thought to have a pivotal role in renal injury mechanism. Many reports state that the inhibition of RAS prevents the progression of renal disease in 5/6 nephrectomized rats as a typical chronic renal failure model. Angiotensin converting enzyme inhibitor blocks the conversion from Angiotensin I to Angiotensin Ⅱ (A-Ⅱ ), and ATI RA inhibits the action of A-Ⅱ at the level of AT1 receptor. Therefore the PRA and A-Ⅱ level may be influenced independently by each treatment modality with these drugs. In this study, the influence of long term treatment with ACEI or AT1RA in these models on systolic blood pressure, PRA, and A-Ⅱ level was evaluated. Male Sprague-Dawley rats weighing 270-300 grams were anesthesized with thiopental sodium(50 mg/kg) and underwent right nephrectomy and partial(approximately two thirds) infarction of the left kidney by ligation of two-three segmental arterial branches. The rats were divided into four groups : sham group, control group, 5/6 subtotal nephrectomized and ACEI treated group (enalapril 100 mg/L in drinking water), 5/6 subtotal nephrectomized and ATIRA treated group (losartan, 200 mg/L in drinking water). They were treated for twelve weeks. In the twelve weeks, both groups treated with ACEI and AT1RA ingestion demonstrated a significant decrease in systolic blood pressure(165±23 vs. 132±9, mmHg, control vs. ACEI, M±SEM, p<0.05, 165±23 vs. 124±7 mmHg, control vs. ATIRA, M±SEM, p<0.01) compare to the control group. In both group treated with ACEI and AT1RA showed a significant increase in PRA(ACEI ; 7.2±2.9, AT1RA ; 4.7±0.4, control ; 2.7±1.1, sham ; 2.7±1.4, ng/ml/hr, ACEI vs. control and sham, M±SEM, p<0.05). However no significant differences were found in the sham vs. control(p>0.05), and in ACEI vs. control. The plasma A-II level was significantly increased in AT1RA treated group compared to sham and ACEI treated group(2,753±543 vs. 484±169.3, ng/ ml, AT1RA vs. Sham, p<0.01). In conclusion, treatment with ACEI and AT1RA for twelve weeks normalized systolic blood pressure, proteinuria and increased PRA compared to the control group; whereas plasma A-II level was increased only by AT1RA treatment.